U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Retinopathy of prematurity threshold

MedGen UID:
1638063
Concept ID:
C4703703
Disease or Syndrome
Synonym: ROP threshold
 
HPO: HP:0500064

Definition

A retinopathy with a 50% likelihood of progressing to retinal detachment. Threshold disease is considered to be present when stage 3 retinopathy of prematurity (ROP) is present in either zone I or zone II, with at least 5 continuous or 8 total clock hours of disease, and the presence of plus disease. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRetinopathy of prematurity threshold

Professional guidelines

PubMed

Bancalari A, Schade R
Am J Perinatol 2022 Jan;39(1):22-30. Epub 2020 Jun 16 doi: 10.1055/s-0040-1713181. PMID: 32544962
Li Z, Zhang Y, Liao Y, Zeng R, Zeng P, Lan Y
BMC Ophthalmol 2018 Jan 30;18(1):19. doi: 10.1186/s12886-018-0685-6. PMID: 29378530Free PMC Article
McNamara JA
Curr Opin Ophthalmol 1993 Jun;4(3):76-80. doi: 10.1097/00055735-199306000-00013. PMID: 10146213

Recent clinical studies

Etiology

Jordan CO
Pediatr Clin North Am 2014 Jun;61(3):567-77. Epub 2014 Mar 26 doi: 10.1016/j.pcl.2014.03.003. PMID: 24852153
Houston SK, Wykoff CC, Berrocal AM, Hess DJ, Murray TG
Lasers Med Sci 2013 Feb;28(2):683-92. Epub 2011 Dec 2 doi: 10.1007/s10103-011-1021-z. PMID: 22134790
Chawla D, Agarwal R, Deorari A, Paul VK, Chandra P, Azad RV
Indian J Pediatr 2012 Apr;79(4):501-9. Epub 2010 Oct 27 doi: 10.1007/s12098-010-0279-7. PMID: 20978871
Clark D, Mandal K
Early Hum Dev 2008 Feb;84(2):95-9. doi: 10.1016/j.earlhumdev.2007.11.007. PMID: 18280405
Aggarwal R, Agarwal R, Deorari AK, Paul VK
Indian J Pediatr 2002 Jan;69(1):83-6. doi: 10.1007/BF02723783. PMID: 11876127

Diagnosis

Sternberg P Jr, Durrani AK
Am J Ophthalmol 2018 Feb;186:xxiii-xxxii. Epub 2017 Nov 3 doi: 10.1016/j.ajo.2017.10.027. PMID: 29109051
Houston SK, Wykoff CC, Berrocal AM, Hess DJ, Murray TG
Lasers Med Sci 2013 Feb;28(2):683-92. Epub 2011 Dec 2 doi: 10.1007/s10103-011-1021-z. PMID: 22134790
Chawla D, Agarwal R, Deorari A, Paul VK, Chandra P, Azad RV
Indian J Pediatr 2012 Apr;79(4):501-9. Epub 2010 Oct 27 doi: 10.1007/s12098-010-0279-7. PMID: 20978871
Aggarwal R, Agarwal R, Deorari AK, Paul VK
Indian J Pediatr 2002 Jan;69(1):83-6. doi: 10.1007/BF02723783. PMID: 11876127
Ticho BH, Dreger V
Insight 1997 Jun;22(2):57-61; quiz 62-3. doi: 10.1016/s1060-135x(97)90048-8. PMID: 9335711

Therapy

Holzapfel LF, Rysavy MA, Bell EF
Neoreviews 2023 Jun 1;24(6):e370-e376. doi: 10.1542/neo.24-6-e370. PMID: 37258497Free PMC Article
Bancalari A, Schade R
Am J Perinatol 2022 Jan;39(1):22-30. Epub 2020 Jun 16 doi: 10.1055/s-0040-1713181. PMID: 32544962
Tran KD, Cernichiaro-Espinosa LA, Berrocal AM
Asia Pac J Ophthalmol (Phila) 2018 Jan-Feb;7(1):56-62. Epub 2018 Jan 26 doi: 10.22608/APO.2017436. PMID: 29376233
Jordan CO
Pediatr Clin North Am 2014 Jun;61(3):567-77. Epub 2014 Mar 26 doi: 10.1016/j.pcl.2014.03.003. PMID: 24852153
Chawla D, Agarwal R, Deorari A, Paul VK, Chandra P, Azad RV
Indian J Pediatr 2012 Apr;79(4):501-9. Epub 2010 Oct 27 doi: 10.1007/s12098-010-0279-7. PMID: 20978871

Prognosis

Seliniotaki AK, Haidich AB, Moutzouri S, Lithoxopoulou M, Ziakas N, Lundgren P, Hellström A, Mataftsi A
Acta Paediatr 2022 Nov;111(11):2056-2070. Epub 2022 Jul 10 doi: 10.1111/apa.16472. PMID: 35778901
Kardaras D, Papageorgiou E, Gaitana K, Grivea I, Dimitriou VA, Androudi S, Gounaris A, Tsironi EE
Invest Ophthalmol Vis Sci 2019 Jan 2;60(1):98-106. doi: 10.1167/iovs.18-24776. PMID: 30640977
Jordan CO
Pediatr Clin North Am 2014 Jun;61(3):567-77. Epub 2014 Mar 26 doi: 10.1016/j.pcl.2014.03.003. PMID: 24852153
Chawla D, Agarwal R, Deorari A, Paul VK, Chandra P, Azad RV
Indian J Pediatr 2012 Apr;79(4):501-9. Epub 2010 Oct 27 doi: 10.1007/s12098-010-0279-7. PMID: 20978871
Reynolds JD
Paediatr Drugs 2001;3(4):263-72. doi: 10.2165/00128072-200103040-00003. PMID: 11354698

Clinical prediction guides

Seliniotaki AK, Haidich AB, Moutzouri S, Lithoxopoulou M, Ziakas N, Lundgren P, Hellström A, Mataftsi A
Acta Paediatr 2022 Nov;111(11):2056-2070. Epub 2022 Jul 10 doi: 10.1111/apa.16472. PMID: 35778901
Franz AR, Engel C, Bassler D, Rüdiger M, Thome UH, Maier RF, Krägeloh-Mann I, Kron M, Essers J, Bührer C, Rellensmann G, Rossi R, Bittrich HJ, Roll C, Höhn T, Ehrhardt H, Avenarius S, Körner HT, Stein A, Buxmann H, Vochem M, Poets CF; ETTNO Investigators
JAMA 2020 Aug 11;324(6):560-570. doi: 10.1001/jama.2020.10690. PMID: 32780138Free PMC Article
Kardaras D, Papageorgiou E, Gaitana K, Grivea I, Dimitriou VA, Androudi S, Gounaris A, Tsironi EE
Invest Ophthalmol Vis Sci 2019 Jan 2;60(1):98-106. doi: 10.1167/iovs.18-24776. PMID: 30640977
McCourt EA, Ying GS, Lynch AM, Palestine AG, Wagner BD, Wymore E, Tomlinson LA, Binenbaum G; G-ROP Study Group
JAMA Ophthalmol 2018 Apr 1;136(4):409-416. doi: 10.1001/jamaophthalmol.2018.0376. PMID: 29543944Free PMC Article
Chawla D, Agarwal R, Deorari A, Paul VK, Chandra P, Azad RV
Indian J Pediatr 2012 Apr;79(4):501-9. Epub 2010 Oct 27 doi: 10.1007/s12098-010-0279-7. PMID: 20978871

Recent systematic reviews

Backes CH, Rivera BK, Pavlek L, Beer LJ, Ball MK, Zettler ET, Smith CV, Bridge JA, Bell EF, Frey HA
Am J Obstet Gynecol 2021 Feb;224(2):158-174. Epub 2020 Jul 31 doi: 10.1016/j.ajog.2020.07.051. PMID: 32745459
Stritzke A, Kabra N, Kaur S, Robertson HL, Lodha A
J Perinatol 2019 Dec;39(12):1584-1594. Epub 2019 Sep 30 doi: 10.1038/s41372-019-0503-x. PMID: 31570797
Liang J
Eur J Ophthalmol 2019 Mar;29(2):223-228. Epub 2018 Jul 19 doi: 10.1177/1120672118770557. PMID: 30022693
Lloyd J, Askie L, Smith J, Tarnow-Mordi W
Cochrane Database Syst Rev 2003;2003(2):CD003482. doi: 10.1002/14651858.CD003482. PMID: 12804470Free PMC Article
Andersen CC, Phelps DL
Cochrane Database Syst Rev 2000;1999(2):CD001693. doi: 10.1002/14651858.CD001693. PMID: 10796444Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...