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Neonatal disorder

MedGen UID:: 9460
•Concept ID:: C0021290
•: Disease or Syndrome

Synonyms:	Disease, Neonatal; Diseases, Neonatal; Infant, Newborn, Diseases; Neonatal Disease; Neonatal Diseases
SNOMED CT:	Neonatal disorder (22925008); Neonatal disease (22925008)

Definition

A non-neoplastic or neoplastic disorder which occurs during the neonatal period. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVNeonatal disorder

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
- Neonatal disorder

Professional guidelines

PubMed

The Assessment and Management of Biliary Atresia in Hawai'i, 2009-2023.

Singh SA, Balaraman KK, Johnson MI, Balaraman V, Puapong DP, Johnson SM, Tabak BD, Woo RK
Hawaii J Health Soc Welf 2024 Oct;83(10):268-273. doi: 10.62547/NUOX8943. PMID: 39371585 Free PMC Article

Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2B6 Genotype and Methadone Therapy.

Robinson KM, Eum S, Desta Z, Tyndale RF, Gaedigk A, Crist RC, Haidar CE, Myers AL, Samer CF, Somogyi AA, Zubiaur P, Iwuchukwu OF, Whirl-Carrillo M, Klein TE, Caudle KE, Donnelly RS, Kharasch ED
Clin Pharmacol Ther 2024 Oct;116(4):932-938. Epub 2024 Jun 11 doi: 10.1002/cpt.3338. PMID: 38863207 Free PMC Article

Phelan McDermid Syndrome: From Genetic Discoveries to Animal Models and Treatment.

Harony-Nicolas H, De Rubeis S, Kolevzon A, Buxbaum JD
J Child Neurol 2015 Dec;30(14):1861-70. Epub 2015 Sep 8 doi: 10.1177/0883073815600872. PMID: 26350728 Free PMC Article

See all (6)

Recent clinical studies

Etiology

Neonatal sepsis as a cause of retinopathy of prematurity: An etiological explanation.

Dammann O, Stansfield BK
Prog Retin Eye Res 2024 Jan;98:101230. Epub 2023 Nov 19 doi: 10.1016/j.preteyeres.2023.101230. PMID: 37984792 Free PMC Article

Nicotinamide nucleotide transhydrogenase mutation analysis in Chinese patients with thyroid dysgenesis.

Li M, Tian W, Wang F, Yang C, Zhang L, Tang Q, Liu S, Wang F
Am J Med Genet A 2022 Jan;188(1):89-98. Epub 2021 Sep 21 doi: 10.1002/ajmg.a.62493. PMID: 34545694

The use of IVIg in fetal and neonatal alloimmune thrombocytopenia- Principles and mechanisms.

Wabnitz H, Khan R, Lazarus AH
Transfus Apher Sci 2020 Feb;59(1):102710. Epub 2019 Dec 31 doi: 10.1016/j.transci.2019.102710. PMID: 31926738

Thrombocytopenia in late preterm and term neonates after perinatal asphyxia.

Christensen RD, Baer VL, Yaish HM
Transfusion 2015 Jan;55(1):187-96. Epub 2014 Aug 1 doi: 10.1111/trf.12777. PMID: 25082082

Congenital hypothyroidism: an analysis of persisting deficits and associated factors.

Rovet JF
Child Neuropsychol 2002 Sep;8(3):150-62. doi: 10.1076/chin.8.3.150.13501. PMID: 12759831

See all (11)

Diagnosis

The Assessment and Management of Biliary Atresia in Hawai'i, 2009-2023.

Singh SA, Balaraman KK, Johnson MI, Balaraman V, Puapong DP, Johnson SM, Tabak BD, Woo RK
Hawaii J Health Soc Welf 2024 Oct;83(10):268-273. doi: 10.62547/NUOX8943. PMID: 39371585 Free PMC Article

Stem Cell Based Models in Congenital Hyperinsulinism - Perspective on Practicalities and Possibilities.

Lithovius V, Otonkoski T
Front Endocrinol (Lausanne) 2022;13:837450. Epub 2022 Feb 18 doi: 10.3389/fendo.2022.837450. PMID: 35250887 Free PMC Article

Hypotonia at Birth: A Case Study of ACTA-1 Mutation, a Congenital Myopathy.

Gelardi L
Neonatal Netw 2018 Jul;37(4):212-217. Epub 2018 Jul 1 doi: 10.1891/0730-0832.37.4.212. PMID: 30567918

Genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy (ALDH7A1 deficiency).

Mills PB, Footitt EJ, Mills KA, Tuschl K, Aylett S, Varadkar S, Hemingway C, Marlow N, Rennie J, Baxter P, Dulac O, Nabbout R, Craigen WJ, Schmitt B, Feillet F, Christensen E, De Lonlay P, Pike MG, Hughes MI, Struys EA, Jakobs C, Zuberi SM, Clayton PT
Brain 2010 Jul;133(Pt 7):2148-59. Epub 2010 Jun 16 doi: 10.1093/brain/awq143. PMID: 20554659 Free PMC Article

Congenital hypothyroidism: an analysis of persisting deficits and associated factors.

Rovet JF
Child Neuropsychol 2002 Sep;8(3):150-62. doi: 10.1076/chin.8.3.150.13501. PMID: 12759831

See all (16)

Therapy

The use of IVIg in fetal and neonatal alloimmune thrombocytopenia- Principles and mechanisms.

Wabnitz H, Khan R, Lazarus AH
Transfus Apher Sci 2020 Feb;59(1):102710. Epub 2019 Dec 31 doi: 10.1016/j.transci.2019.102710. PMID: 31926738

Brain malformations associated to Aldh7a1 gene mutations: Report of a novel homozygous mutation and literature review.

Toldo I, Bonardi CM, Bettella E, Polli R, Talenti G, Burlina A, Sartori S, Murgia A
Eur J Paediatr Neurol 2018 Nov;22(6):1042-1053. Epub 2018 Jul 3 doi: 10.1016/j.ejpn.2018.06.010. PMID: 30005813

Sclerema neonatorum treated with intravenous immunoglobulin: a case report and review of treatments.

Buster KJ, Burford HN, Stewart FA, Sellheyer K, Hughey LC
Cutis 2013 Aug;92(2):83-7. PMID: 24087781

Genotypic and phenotypic spectrum of pyridoxine-dependent epilepsy (ALDH7A1 deficiency).

Therapy for persistent hyperinsulinemic hypoglycemia of infancy. Understanding the responsiveness of beta cells to diazoxide and somatostatin.

Kane C, Lindley KJ, Johnson PR, James RF, Milla PJ, Aynsley-Green A, Dunne MJ
J Clin Invest 1997 Oct 1;100(7):1888-93. doi: 10.1172/JCI119718. PMID: 9312191 Free PMC Article

See all (7)

Prognosis

Global burden and inequality of maternal and neonatal disorders: based on data from the 2019 Global Burden of Disease study.

Peng R, Tong Y, Yang M, Wang J, Yang L, Zhu J, Liu Y, Wang H, Shi Z, Liu Y
QJM 2024 Feb 7;117(1):24-37. doi: 10.1093/qjmed/hcad220. PMID: 37773990 Free PMC Article

Global trends in incidence and death of neonatal disorders and its specific causes in 204 countries/territories during 1990-2019.

Ou Z, Yu D, Liang Y, He H, He W, Li Y, Zhang M, Gao Y, Wu F, Chen Q
BMC Public Health 2022 Feb 19;22(1):360. doi: 10.1186/s12889-022-12765-1. PMID: 35183143 Free PMC Article

Thrombocytopenia in late preterm and term neonates after perinatal asphyxia.

Christensen RD, Baer VL, Yaish HM
Transfusion 2015 Jan;55(1):187-96. Epub 2014 Aug 1 doi: 10.1111/trf.12777. PMID: 25082082

A review of evidence for a role of magnesium and possibly copper deficiency in necrotizing enterocolitis.

Caddell JL
Magnes Res 1996 Mar;9(1):55-66. PMID: 8819095

Management of meconium stained amniotic fluid: a team approach.

Narang A, Nair PM, Bhakoo ON, Vashisht K
Indian Pediatr 1993 Jan;30(1):9-13. PMID: 8406722

See all (9)

Clinical prediction guides

Global trends in incidence and death of neonatal disorders and its specific causes in 204 countries/territories during 1990-2019.

Ou Z, Yu D, Liang Y, He H, He W, Li Y, Zhang M, Gao Y, Wu F, Chen Q
BMC Public Health 2022 Feb 19;22(1):360. doi: 10.1186/s12889-022-12765-1. PMID: 35183143 Free PMC Article

An immunohistochemical study of placental syncytiotrophoblasts in neonatal hemochromatosis.

Shimono A, Imoto Y, Sakamoto H, Chiba Y, Matsumoto K, Kawauchi M, Kusaka T, Tanaka H, Hata T, Kushida Y, Ueno M
Placenta 2016 Dec;48:49-55. Epub 2016 Oct 12 doi: 10.1016/j.placenta.2016.10.005. PMID: 27871472

Infantile seborrheic dermatitis: a pediatric Siddha medicine treatise.

Thambyayah M, Amuthan A
Clin Dermatol 2015 May-Jun;33(3):355-61. Epub 2014 Dec 8 doi: 10.1016/j.clindermatol.2014.12.013. PMID: 25889138

Congenital hypothyroidism: an analysis of persisting deficits and associated factors.

Rovet JF
Child Neuropsychol 2002 Sep;8(3):150-62. doi: 10.1076/chin.8.3.150.13501. PMID: 12759831

Iron-overload disease in infants involving fetal growth retardation, lactic acidosis, liver haemosiderosis, and aminoaciduria.

Fellman V, Rapola J, Pihko H, Varilo T, Raivio KO
Lancet 1998 Feb 14;351(9101):490-3. doi: 10.1016/S0140-6736(97)09272-6. PMID: 9482441

See all (8)