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Refractory Colon Carcinoma

MedGen UID:
1663185
•Concept ID:
C4727189
•
Neoplastic Process

Definition

Colon carcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Colon Carcinoma

Professional guidelines

PubMed

Combination Treatment of Intratumoral Vidutolimod, Radiosurgery, Nivolumab, and Ipilimumab for Microsatellite Stable Colorectal Carcinoma With Liver Metastases.
Margalit O, Lieberman S, Redinsky I, Halparin S, Honig N, Raskin S, Ben-Ayun M, Shacham-Shmueli E, Halpern N, Urban D, Ackerstein A, Shulman K, Ben-Ami E, Semenisty V, Purim O, Yarom N, Golan T, Boursi B, Appel S, Symon Z, Berger R, Mauro D, Krieg AM, Lawrence YR
Clin Colorectal Cancer 2023 Dec;22(4):442-449.e1. Epub 2023 Aug 9 doi: 10.1016/j.clcc.2023.08.004. PMID: 37657954
Clinical manifestations, pathophysiology, treatment and outcome of inflammatory bowel diseases in older people.
Butter M, Weiler S, Biedermann L, Scharl M, Rogler G, Bischoff-Ferrari HA, Misselwitz B
Maturitas 2018 Apr;110:71-78. Epub 2018 Jan 31 doi: 10.1016/j.maturitas.2018.01.015. PMID: 29563038
Molecular markers and targeted therapy with novel agents: prospects in the treatment of non-small cell lung cancer.
Rosell R, Fossella F, Milas L; Spanish Lung Cancer Group
Lung Cancer 2002 Dec;38 Suppl 4:43-9. doi: 10.1016/s0169-5002(02)00171-x. PMID: 12480194

Recent clinical studies

Etiology

Ulcerative Colitis-Diagnostic and Therapeutic Algorithms.
Kucharzik T, Koletzko S, Kannengiesser K, Dignass A
Dtsch Arztebl Int 2020 Aug 17;117(33-34):564-574. doi: 10.3238/arztebl.2020.0564. PMID: 33148393Free PMC Article
Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): a randomised, multicentre, open-label, phase 2 study.
Bekaii-Saab TS, Ou FS, Ahn DH, Boland PM, Ciombor KK, Heying EN, Dockter TJ, Jacobs NL, Pasche BC, Cleary JM, Meyers JP, Desnoyers RJ, McCune JS, Pedersen K, Barzi A, Chiorean EG, Sloan J, Lacouture ME, Lenz HJ, Grothey A
Lancet Oncol 2019 Aug;20(8):1070-1082. Epub 2019 Jun 28 doi: 10.1016/S1470-2045(19)30272-4. PMID: 31262657Free PMC Article
Inflammatory bowel disease in liver transplanted patients.
Filipec Kanizaj T, Mijic M
World J Gastroenterol 2017 May 14;23(18):3214-3227. doi: 10.3748/wjg.v23.i18.3214. PMID: 28566881Free PMC Article
Molecular markers and targeted therapy with novel agents: prospects in the treatment of non-small cell lung cancer.
Rosell R, Fossella F, Milas L; Spanish Lung Cancer Group
Lung Cancer 2002 Dec;38 Suppl 4:43-9. doi: 10.1016/s0169-5002(02)00171-x. PMID: 12480194
Colonic disorders in adult cystic fibrosis.
Chaun H
Can J Gastroenterol 2001 Sep;15(9):586-90. doi: 10.1155/2001/745361. PMID: 11573101

Diagnosis

N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy.
Krug J, Rodrian G, Petter K, Yang H, Khoziainova S, Guo W, Bénard A, Merkel S, Gellert S, Maschauer S, Spermann M, Waldner M, Bailey P, Pilarsky C, Liebl A, Tripal P, Christoph J, Naschberger E, Croner R, Schellerer VS, Becker C, Hartmann A, Tüting T, Prante O, Grützmann R, Grivennikov SI, Stürzl M, Britzen-Laurent N
Gastroenterology 2023 Mar;164(3):392-406.e5. Epub 2022 Nov 17 doi: 10.1053/j.gastro.2022.11.018. PMID: 36402190Free PMC Article
Ulcerative Colitis-Diagnostic and Therapeutic Algorithms.
Kucharzik T, Koletzko S, Kannengiesser K, Dignass A
Dtsch Arztebl Int 2020 Aug 17;117(33-34):564-574. doi: 10.3238/arztebl.2020.0564. PMID: 33148393Free PMC Article
Thrombospondin-1 counteracts the p97 inhibitor CB-5083 in colon carcinoma cells.
Her NG, Kesari S, Nurmemmedov E
Cell Cycle 2020 Jul;19(13):1590-1601. Epub 2020 May 19 doi: 10.1080/15384101.2020.1754584. PMID: 32423265Free PMC Article
The KRAS(G12C) Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients.
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG
Cancer Discov 2020 Jan;10(1):54-71. Epub 2019 Oct 28 doi: 10.1158/2159-8290.CD-19-1167. PMID: 31658955Free PMC Article
Molecular markers and targeted therapy with novel agents: prospects in the treatment of non-small cell lung cancer.
Rosell R, Fossella F, Milas L; Spanish Lung Cancer Group
Lung Cancer 2002 Dec;38 Suppl 4:43-9. doi: 10.1016/s0169-5002(02)00171-x. PMID: 12480194

Therapy

Ulcerative Colitis-Diagnostic and Therapeutic Algorithms.
Kucharzik T, Koletzko S, Kannengiesser K, Dignass A
Dtsch Arztebl Int 2020 Aug 17;117(33-34):564-574. doi: 10.3238/arztebl.2020.0564. PMID: 33148393Free PMC Article
The KRAS(G12C) Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients.
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG
Cancer Discov 2020 Jan;10(1):54-71. Epub 2019 Oct 28 doi: 10.1158/2159-8290.CD-19-1167. PMID: 31658955Free PMC Article
Regorafenib dose-optimisation in patients with refractory metastatic colorectal cancer (ReDOS): a randomised, multicentre, open-label, phase 2 study.
Bekaii-Saab TS, Ou FS, Ahn DH, Boland PM, Ciombor KK, Heying EN, Dockter TJ, Jacobs NL, Pasche BC, Cleary JM, Meyers JP, Desnoyers RJ, McCune JS, Pedersen K, Barzi A, Chiorean EG, Sloan J, Lacouture ME, Lenz HJ, Grothey A
Lancet Oncol 2019 Aug;20(8):1070-1082. Epub 2019 Jun 28 doi: 10.1016/S1470-2045(19)30272-4. PMID: 31262657Free PMC Article
TroVax in colorectal cancer.
Rowe J, Cen P
Hum Vaccin Immunother 2014;10(11):3196-200. doi: 10.4161/21645515.2014.973323. PMID: 25483641Free PMC Article
Thalidomide in cancer.
Singhal S, Mehta J
Biomed Pharmacother 2002 Feb;56(1):4-12. doi: 10.1016/s0753-3322(01)00146-9. PMID: 11905508

Prognosis

N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy.
Krug J, Rodrian G, Petter K, Yang H, Khoziainova S, Guo W, Bénard A, Merkel S, Gellert S, Maschauer S, Spermann M, Waldner M, Bailey P, Pilarsky C, Liebl A, Tripal P, Christoph J, Naschberger E, Croner R, Schellerer VS, Becker C, Hartmann A, Tüting T, Prante O, Grützmann R, Grivennikov SI, Stürzl M, Britzen-Laurent N
Gastroenterology 2023 Mar;164(3):392-406.e5. Epub 2022 Nov 17 doi: 10.1053/j.gastro.2022.11.018. PMID: 36402190Free PMC Article
Ulcerative Colitis-Diagnostic and Therapeutic Algorithms.
Kucharzik T, Koletzko S, Kannengiesser K, Dignass A
Dtsch Arztebl Int 2020 Aug 17;117(33-34):564-574. doi: 10.3238/arztebl.2020.0564. PMID: 33148393Free PMC Article
The KRAS(G12C) Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients.
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG
Cancer Discov 2020 Jan;10(1):54-71. Epub 2019 Oct 28 doi: 10.1158/2159-8290.CD-19-1167. PMID: 31658955Free PMC Article
Inflammatory bowel disease in liver transplanted patients.
Filipec Kanizaj T, Mijic M
World J Gastroenterol 2017 May 14;23(18):3214-3227. doi: 10.3748/wjg.v23.i18.3214. PMID: 28566881Free PMC Article
Molecular markers and targeted therapy with novel agents: prospects in the treatment of non-small cell lung cancer.
Rosell R, Fossella F, Milas L; Spanish Lung Cancer Group
Lung Cancer 2002 Dec;38 Suppl 4:43-9. doi: 10.1016/s0169-5002(02)00171-x. PMID: 12480194

Clinical prediction guides

N-glycosylation Regulates Intrinsic IFN-γ Resistance in Colorectal Cancer: Implications for Immunotherapy.
Krug J, Rodrian G, Petter K, Yang H, Khoziainova S, Guo W, Bénard A, Merkel S, Gellert S, Maschauer S, Spermann M, Waldner M, Bailey P, Pilarsky C, Liebl A, Tripal P, Christoph J, Naschberger E, Croner R, Schellerer VS, Becker C, Hartmann A, Tüting T, Prante O, Grützmann R, Grivennikov SI, Stürzl M, Britzen-Laurent N
Gastroenterology 2023 Mar;164(3):392-406.e5. Epub 2022 Nov 17 doi: 10.1053/j.gastro.2022.11.018. PMID: 36402190Free PMC Article
Clinicopathological and Molecular Characteristics of Colorectal Signet Ring Cell Carcinoma: A Review.
An Y, Zhou J, Lin G, Wu H, Cong L, Li Y, Qiu X, Shi W
Pathol Oncol Res 2021;27:1609859. Epub 2021 Jul 26 doi: 10.3389/pore.2021.1609859. PMID: 34381313Free PMC Article
The KRAS(G12C) Inhibitor MRTX849 Provides Insight toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients.
Hallin J, Engstrom LD, Hargis L, Calinisan A, Aranda R, Briere DM, Sudhakar N, Bowcut V, Baer BR, Ballard JA, Burkard MR, Fell JB, Fischer JP, Vigers GP, Xue Y, Gatto S, Fernandez-Banet J, Pavlicek A, Velastagui K, Chao RC, Barton J, Pierobon M, Baldelli E, Patricoin EF 3rd, Cassidy DP, Marx MA, Rybkin II, Johnson ML, Ou SI, Lito P, Papadopoulos KP, Jänne PA, Olson P, Christensen JG
Cancer Discov 2020 Jan;10(1):54-71. Epub 2019 Oct 28 doi: 10.1158/2159-8290.CD-19-1167. PMID: 31658955Free PMC Article
TroVax in colorectal cancer.
Rowe J, Cen P
Hum Vaccin Immunother 2014;10(11):3196-200. doi: 10.4161/21645515.2014.973323. PMID: 25483641Free PMC Article
Molecular markers and targeted therapy with novel agents: prospects in the treatment of non-small cell lung cancer.
Rosell R, Fossella F, Milas L; Spanish Lung Cancer Group
Lung Cancer 2002 Dec;38 Suppl 4:43-9. doi: 10.1016/s0169-5002(02)00171-x. PMID: 12480194

Recent systematic reviews

Systematic review of cuff and pouch cancer in patients with ileal pelvic pouch for ulcerative colitis.
Selvaggi F, Pellino G, Canonico S, Sciaudone G
Inflamm Bowel Dis 2014 Jul;20(7):1296-308. doi: 10.1097/MIB.0000000000000026. PMID: 24681656

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