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Recurrent Breast Paget Disease

MedGen UID:
1667595
•Concept ID:
C4727376
•
Neoplastic Process
Synonyms: Recurrent Paget Disease of the Breast; Recurrent Paget's Disease of the Breast

Definition

The reemergence of Paget disease of the breast after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Breast Paget Disease

Professional guidelines

PubMed

Multidisciplinary management of mammary Paget's disease: recommendations to optimize oncological and aesthetic outcomes.
Franceschini G, Mason EJ, Di Leone A, Scardina L, Masetti R
Ann Ital Chir 2022;93:481-482. PMID: 36196555
The management of Paget's disease of the breast.
Marcus E
Curr Treat Options Oncol 2004 Apr;5(2):153-60. doi: 10.1007/s11864-004-0047-x. PMID: 14990209
Breast-conserving therapy for Paget disease of the nipple: a prospective European Organization for Research and Treatment of Cancer study of 61 patients.
Polgár C, Orosz Z, Kovács T, Fodor J
Cancer 2002 Mar 15;94(6):1904-5. doi: 10.1002/cncr.10405. PMID: 11920556

Recent clinical studies

Etiology

Paget's disease of the breast: Presentation, treatment, and outcomes in a modern cohort.
Mousa-Doust D, Warburton R, Pao JS, Dingee C, Bazzarelli A, Newman-Bremang J, McKevitt E
Am J Surg 2024 May;231:18-23. Epub 2024 Jan 25 doi: 10.1016/j.amjsurg.2024.01.026. PMID: 38641371
Treatment of Mammary Paget Disease: A systematic review and meta-analysis of real-world data.
Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
Cutaneous manifestations of breast cancer.
Tan AR
Semin Oncol 2016 Jun;43(3):331-4. Epub 2016 Feb 23 doi: 10.1053/j.seminoncol.2016.02.030. PMID: 27178684
Florid papillomatosis of the nipple: a rare presentation and review of the literature.
Salemis NS
Breast Dis 2015;35(2):153-6. doi: 10.3233/BD-150397. PMID: 25585841
Changes following nipple areolar complex reconstruction and tattooing resembling a recurrent Paget's disease of the breast.
Hanafiah M, Alhabshi SM, Mahin AH
BMJ Case Rep 2013 Oct 28;2013 doi: 10.1136/bcr-2013-201281. PMID: 24165504Free PMC Article

Diagnosis

Paget's disease of the breast: Presentation, treatment, and outcomes in a modern cohort.
Mousa-Doust D, Warburton R, Pao JS, Dingee C, Bazzarelli A, Newman-Bremang J, McKevitt E
Am J Surg 2024 May;231:18-23. Epub 2024 Jan 25 doi: 10.1016/j.amjsurg.2024.01.026. PMID: 38641371
Skin diseases of the breast and nipple: Benign and malignant tumors.
Waldman RA, Finch J, Grant-Kels JM, Stevenson C, Whitaker-Worth D
J Am Acad Dermatol 2019 Jun;80(6):1467-1481. Epub 2018 Nov 16 doi: 10.1016/j.jaad.2018.08.066. PMID: 30452954
Cutaneous manifestations of breast cancer.
Tan AR
Semin Oncol 2016 Jun;43(3):331-4. Epub 2016 Feb 23 doi: 10.1053/j.seminoncol.2016.02.030. PMID: 27178684
Mammary and extramammary Paget's disease.
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article
Changes following nipple areolar complex reconstruction and tattooing resembling a recurrent Paget's disease of the breast.
Hanafiah M, Alhabshi SM, Mahin AH
BMJ Case Rep 2013 Oct 28;2013 doi: 10.1136/bcr-2013-201281. PMID: 24165504Free PMC Article

Therapy

The role of HER2 as a therapeutic biomarker in gynaecological malignancy: potential for use beyond uterine serous carcinoma.
Talia KL, Banet N, Buza N
Pathology 2023 Feb;55(1):8-18. Epub 2022 Nov 23 doi: 10.1016/j.pathol.2022.11.004. PMID: 36503635
The Paget Trial: topical 5% imiquimod cream for noninvasive vulvar Paget disease.
van der Linden M, van Hees CL, van Beurden M, Bulten J, van Dorst EB, Esajas MD, Meeuwis KA, Boll D, van Poelgeest MI, de Hullu JA
Am J Obstet Gynecol 2022 Aug;227(2):250.e1-250.e8. Epub 2022 Apr 18 doi: 10.1016/j.ajog.2022.04.012. PMID: 35447145
Breast implant-associated anaplastic large cell lymphoma in a Li-FRAUMENI patient: a case report.
Pastorello RG, D'Almeida Costa F, Osório CABT, Makdissi FBA, Bezerra SM, de Brot M, Campos AHJFM, Soares FA, Vassallo J
Diagn Pathol 2018 Jan 25;13(1):10. doi: 10.1186/s13000-018-0688-x. PMID: 29370815Free PMC Article
Changes following nipple areolar complex reconstruction and tattooing resembling a recurrent Paget's disease of the breast.
Hanafiah M, Alhabshi SM, Mahin AH
BMJ Case Rep 2013 Oct 28;2013 doi: 10.1136/bcr-2013-201281. PMID: 24165504Free PMC Article
Effectiveness of photodynamic therapy for mammary and extra-mammary Paget's disease: a state of the science review.
Nardelli AA, Stafinski T, Menon D
BMC Dermatol 2011 Jun 15;11:13. doi: 10.1186/1471-5945-11-13. PMID: 21676258Free PMC Article

Prognosis

Glypican-3 Differentiates Intraductal Carcinoma and Paget's Disease from Other Types of Breast Cancer.
Alshammari FO, Satari AO, Aljabali AS, Al-Mahdy YS, Alabdallat YJ, Al-Sarayra YM, Alkhojah MA, Alwardat ARM, Haddad M, Al-Sarayreh SA, Al-Saraireh YM
Medicina (Kaunas) 2022 Dec 30;59(1) doi: 10.3390/medicina59010086. PMID: 36676710Free PMC Article
Treatment of Mammary Paget Disease: A systematic review and meta-analysis of real-world data.
Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
Skin diseases of the breast and nipple: Benign and malignant tumors.
Waldman RA, Finch J, Grant-Kels JM, Stevenson C, Whitaker-Worth D
J Am Acad Dermatol 2019 Jun;80(6):1467-1481. Epub 2018 Nov 16 doi: 10.1016/j.jaad.2018.08.066. PMID: 30452954
Mammary and extramammary Paget's disease.
Lopes Filho LL, Lopes IM, Lopes LR, Enokihara MM, Michalany AO, Matsunaga N
An Bras Dermatol 2015 Mar-Apr;90(2):225-31. doi: 10.1590/abd1806-4841.20153189. PMID: 25830993Free PMC Article
Changes following nipple areolar complex reconstruction and tattooing resembling a recurrent Paget's disease of the breast.
Hanafiah M, Alhabshi SM, Mahin AH
BMJ Case Rep 2013 Oct 28;2013 doi: 10.1136/bcr-2013-201281. PMID: 24165504Free PMC Article

Clinical prediction guides

The role of HER2 as a therapeutic biomarker in gynaecological malignancy: potential for use beyond uterine serous carcinoma.
Talia KL, Banet N, Buza N
Pathology 2023 Feb;55(1):8-18. Epub 2022 Nov 23 doi: 10.1016/j.pathol.2022.11.004. PMID: 36503635
Treatment of Mammary Paget Disease: A systematic review and meta-analysis of real-world data.
Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
The Paget Trial: topical 5% imiquimod cream for noninvasive vulvar Paget disease.
van der Linden M, van Hees CL, van Beurden M, Bulten J, van Dorst EB, Esajas MD, Meeuwis KA, Boll D, van Poelgeest MI, de Hullu JA
Am J Obstet Gynecol 2022 Aug;227(2):250.e1-250.e8. Epub 2022 Apr 18 doi: 10.1016/j.ajog.2022.04.012. PMID: 35447145
Axillary Paget disease with a visible satellite: a case report and literature review.
Ji WY, Luo B, Wang XW, Xiao Y, Tian JY
Diagn Pathol 2021 Aug 1;16(1):69. doi: 10.1186/s13000-021-01131-1. PMID: 34334143Free PMC Article
Nonsurgical Treatments for Extramammary Paget Disease: A Systematic Review and Meta-Analysis.
Snast I, Sharon E, Kaftory R, Noyman Y, Oren-Shabtai M, Lapidoth M, Hodak E, Mimouni D, Mazor S, Levi A
Dermatology 2020;236(6):493-499. Epub 2020 Apr 14 doi: 10.1159/000506832. PMID: 32289785

Recent systematic reviews

Treatment of Mammary Paget Disease: A systematic review and meta-analysis of real-world data.
Lin CW, Chiang MH, Tam KW
Int J Surg 2022 Nov;107:106964. Epub 2022 Oct 26 doi: 10.1016/j.ijsu.2022.106964. PMID: 36309195
Nonsurgical Treatments for Extramammary Paget Disease: A Systematic Review and Meta-Analysis.
Snast I, Sharon E, Kaftory R, Noyman Y, Oren-Shabtai M, Lapidoth M, Hodak E, Mimouni D, Mazor S, Levi A
Dermatology 2020;236(6):493-499. Epub 2020 Apr 14 doi: 10.1159/000506832. PMID: 32289785
Effectiveness of photodynamic therapy for mammary and extra-mammary Paget's disease: a state of the science review.
Nardelli AA, Stafinski T, Menon D
BMC Dermatol 2011 Jun 15;11:13. doi: 10.1186/1471-5945-11-13. PMID: 21676258Free PMC Article

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