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Extrahepatic bile duct clear cell adenocarcinoma

MedGen UID:
167829
•Concept ID:
C0861855
•
Neoplastic Process
Synonyms: Bile Duct Clear Cell Adenocarcinoma; bile duct clear cell adenocarcinoma; bile duct clear cell carcinoma; Clear Cell Adenocarcinoma of Bile Duct; clear cell adenocarcinoma of bile duct; Clear Cell Adenocarcinoma of the Bile Duct; clear cell adenocarcinoma of the bile duct; Clear Cell Bile Duct Adenocarcinoma; clear cell bile duct adenocarcinoma; Extrahepatic Bile Duct Clear Cell Adenocarcinoma; extrahepatic bile duct clear cell adenocarcinoma
 
Monarch Initiative: MONDO:0004081

Definition

A morphologic variant of extrahepatic bile duct adenocarcinoma characterized by the presence of malignant glandular epithelium composed of clear cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtrahepatic bile duct clear cell adenocarcinoma

Professional guidelines

PubMed

CD56 expression aids in the differential diagnosis of cholangiocarcinomas and benign cholangiocellular lesions.
Gütgemann I, Haas S, Berg JP, Zhou H, Büttner R, Fischer HP
Virchows Arch 2006 Apr;448(4):407-11. Epub 2006 Jan 13 doi: 10.1007/s00428-005-0145-6. PMID: 16411132

Recent clinical studies

Etiology

From Krukenberg to today: the ever present problems posed by metastatic tumors in the ovary. Part II.
Young RH
Adv Anat Pathol 2007 May;14(3):149-77. doi: 10.1097/PAP.0b013e3180504abf. PMID: 17452813
Clear cell carcinoid tumor of the distal common bile duct.
Todoroki T, Sano T, Yamada S, Hirahara N, Toda N, Tsukada K, Motojima R, Motojima T
World J Surg Oncol 2007 Jan 17;5:6. doi: 10.1186/1477-7819-5-6. PMID: 17227590Free PMC Article
Biliary cystic disease: the risk of cancer.
Benjamin IS
J Hepatobiliary Pancreat Surg 2003;10(5):335-9. doi: 10.1007/s00534-002-0696-8. PMID: 14598132

Diagnosis

Enteroblastic cholangiocarcinoma: An uncommon, underrecognized subtype of bile duct cancer.
Chun J, Moore M, Kelly P, Kanzawa M, Itoh T, Hong SM, Zen Y
Hum Pathol 2024 Feb;144:46-52. Epub 2024 Jan 30 doi: 10.1016/j.humpath.2024.01.011. PMID: 38301963
Clear cell carcinoid tumor of the distal common bile duct.
Todoroki T, Sano T, Yamada S, Hirahara N, Toda N, Tsukada K, Motojima R, Motojima T
World J Surg Oncol 2007 Jan 17;5:6. doi: 10.1186/1477-7819-5-6. PMID: 17227590Free PMC Article
Alpha-fetoprotein-producing clear cell carcinoma of the extrahepatic bile ducts.
Miyazawa M, Torii T, Toshimitsu Y, Kamizasa N, Suzuki T, Shinozuka N, Ishizawa K, Koyama I
J Clin Gastroenterol 2006 Jul;40(6):555-7. doi: 10.1097/00004836-200607000-00016. PMID: 16825940
Biliary cystic disease: the risk of cancer.
Benjamin IS
J Hepatobiliary Pancreat Surg 2003;10(5):335-9. doi: 10.1007/s00534-002-0696-8. PMID: 14598132
Clear cell carcinomas of the gallbladder and extrahepatic bile ducts.
Vardaman C, Albores-Saavedra J
Am J Surg Pathol 1995 Jan;19(1):91-9. doi: 10.1097/00000478-199501000-00011. PMID: 7802141

Therapy

Perihilar clear cell cholangiocarcinoma: an often-diagnostic challenge.
Marzouk O, Lakshmaiah S, Anjarwalla S
BMJ Case Rep 2020 Dec 22;13(12) doi: 10.1136/bcr-2020-237683. PMID: 33370986Free PMC Article

Prognosis

Perihilar clear cell cholangiocarcinoma: an often-diagnostic challenge.
Marzouk O, Lakshmaiah S, Anjarwalla S
BMJ Case Rep 2020 Dec 22;13(12) doi: 10.1136/bcr-2020-237683. PMID: 33370986Free PMC Article
Signet ring cell carcinoma of the ampulla of vater. A case report.
Ishibashi Y, Ito Y, Omori K, Wakabayashi K
JOP 2009 Nov 5;10(6):690-3. PMID: 19890196
Clear cell carcinoid tumor of the distal common bile duct.
Todoroki T, Sano T, Yamada S, Hirahara N, Toda N, Tsukada K, Motojima R, Motojima T
World J Surg Oncol 2007 Jan 17;5:6. doi: 10.1186/1477-7819-5-6. PMID: 17227590Free PMC Article
Cholangiocarcinoma at the cystic duct discovered by lymph node metastases with clear cell transformation.
Tajiri K, Shimizu Y, Mihara H, Kawanishi Y, Orihara T, Takahashi H, Ishizawa S, Kawai S, Sugiyama T
Intern Med 2006;45(18):1045-8. Epub 2006 Oct 16 doi: 10.2169/internalmedicine.45.1608. PMID: 17043375

Clinical prediction guides

Enteroblastic cholangiocarcinoma: An uncommon, underrecognized subtype of bile duct cancer.
Chun J, Moore M, Kelly P, Kanzawa M, Itoh T, Hong SM, Zen Y
Hum Pathol 2024 Feb;144:46-52. Epub 2024 Jan 30 doi: 10.1016/j.humpath.2024.01.011. PMID: 38301963
Inhibin-expressing clear cell neuroendocrine tumor of the ampulla: an unusual presentation of von Hippel-Lindau disease.
Gucer H, Szentgyorgyi E, Ezzat S, Asa SL, Mete O
Virchows Arch 2013 Oct;463(4):593-7. Epub 2013 Aug 4 doi: 10.1007/s00428-013-1465-6. PMID: 23913169
Fine needle aspiration cytology of clear cell carcinoma of the gallbladder with hepatic infiltration: a case report.
Vaíllo A, Rodríguez-Recio FJ, Gutiérrez-Martín A, Ballestín C, Ruiz-Liso JM
Acta Cytol 2004 Jul-Aug;48(4):560-4. doi: 10.1159/000326418. PMID: 15296347

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