U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Platinum-Resistant Lung Small Cell Carcinoma

MedGen UID:
1679488
•Concept ID:
C4764254
•
Neoplastic Process

Definition

Lung small cell carcinoma that is resistant to platinum therapy. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPlatinum-Resistant Lung Small Cell Carcinoma

Professional guidelines

PubMed

Comparison of Efficacy and Safety of Second-Line Treatment Options for Advanced Small-Cell Lung Cancer: A Retrospective Analysis.
Zhao L, Zhao Z, Yan X, Hu X, Feng J, Yu S
Technol Cancer Res Treat 2024 Jan-Dec;23:15330338241227055. doi: 10.1177/15330338241227055. PMID: 38258375Free PMC Article
Lurbinectedin for the treatment of small cell lung cancer.
Li L, Zou C, Dong S, Wu ZX, Ashby CR Jr, Chen ZS, Qiu C
Drugs Today (Barc) 2021 Jun;57(6):377-385. doi: 10.1358/dot.2021.57.6.3294559. PMID: 34151904
Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors.
Di Cosimo S, Ferretti G, Papaldo P, Carlini P, Fabi A, Cognetti F
Drugs Today (Barc) 2003 Mar;39(3):157-74. doi: 10.1358/dot.2003.39.3.799451. PMID: 12730701

Recent clinical studies

Etiology

Second-line treatment outcomes after first-line chemotherapy plus immunotherapy in Extensive-Stage small cell lung cancer (ES-SCLC) patients: A large French multicenter study.
Pons-Tostivint E, Ezzedine R, Goronflot T, Crequit P, Chatellier T, Raimbourg J, Bennouna J, Giroux Leprieur E, Porte M
Lung Cancer 2024 Aug;194:107887. Epub 2024 Jul 8 doi: 10.1016/j.lungcan.2024.107887. PMID: 38991282
Comparison of Efficacy and Safety of Second-Line Treatment Options for Advanced Small-Cell Lung Cancer: A Retrospective Analysis.
Zhao L, Zhao Z, Yan X, Hu X, Feng J, Yu S
Technol Cancer Res Treat 2024 Jan-Dec;23:15330338241227055. doi: 10.1177/15330338241227055. PMID: 38258375Free PMC Article
Berzosertib Plus Topotecan vs Topotecan Alone in Patients With Relapsed Small Cell Lung Cancer: A Randomized Clinical Trial.
Takahashi N, Hao Z, Villaruz LC, Zhang J, Ruiz J, Petty WJ, Mamdani H, Riess JW, Nieva J, Pachecho JM, Fuld AD, Shum E, Chauhan A, Nichols S, Shimellis H, McGlone J, Sciuto L, Pinkiert D, Graham C, Shelat M, Kattappuram R, Abel M, Schroeder B, Upadhyay D, Krishnamurthy M, Sharma AK, Kumar R, Malin J, Schultz CW, Goyal S, Redon CE, Pommier Y, Aladjem MI, Gore SD, Steinberg SM, Vilimas R, Desai P, Thomas A
JAMA Oncol 2023 Dec 1;9(12):1669-1677. doi: 10.1001/jamaoncol.2023.4025. PMID: 37824137Free PMC Article
FOLFIRI in advanced platinum-resistant/refractory small-cell lung cancer: a retrospective study.
Roussel-Simonin C, Gougis P, Lassoued D, Vozy A, Veyri M, Morardet L, Wassermann J, Foka Tichoue H, Jaffrelot L, Hassani L, Perrier A, Bergeret S, Taillade L, Spano JP, Campedel L, Abbar B
Acta Oncol 2023 Jun;62(6):579-586. Epub 2023 Jun 5 doi: 10.1080/0284186X.2023.2216339. PMID: 37276270
Randomized phase III trial of docetaxel versus vinorelbine or ifosfamide in patients with advanced non-small-cell lung cancer previously treated with platinum-containing chemotherapy regimens. The TAX 320 Non-Small Cell Lung Cancer Study Group.
Fossella FV, DeVore R, Kerr RN, Crawford J, Natale RR, Dunphy F, Kalman L, Miller V, Lee JS, Moore M, Gandara D, Karp D, Vokes E, Kris M, Kim Y, Gamza F, Hammershaimb L
J Clin Oncol 2000 Jun;18(12):2354-62. doi: 10.1200/JCO.2000.18.12.2354. PMID: 10856094

Diagnosis

Second-line treatment outcomes after first-line chemotherapy plus immunotherapy in Extensive-Stage small cell lung cancer (ES-SCLC) patients: A large French multicenter study.
Pons-Tostivint E, Ezzedine R, Goronflot T, Crequit P, Chatellier T, Raimbourg J, Bennouna J, Giroux Leprieur E, Porte M
Lung Cancer 2024 Aug;194:107887. Epub 2024 Jul 8 doi: 10.1016/j.lungcan.2024.107887. PMID: 38991282
Comparison of Efficacy and Safety of Second-Line Treatment Options for Advanced Small-Cell Lung Cancer: A Retrospective Analysis.
Zhao L, Zhao Z, Yan X, Hu X, Feng J, Yu S
Technol Cancer Res Treat 2024 Jan-Dec;23:15330338241227055. doi: 10.1177/15330338241227055. PMID: 38258375Free PMC Article
Berzosertib Plus Topotecan vs Topotecan Alone in Patients With Relapsed Small Cell Lung Cancer: A Randomized Clinical Trial.
Takahashi N, Hao Z, Villaruz LC, Zhang J, Ruiz J, Petty WJ, Mamdani H, Riess JW, Nieva J, Pachecho JM, Fuld AD, Shum E, Chauhan A, Nichols S, Shimellis H, McGlone J, Sciuto L, Pinkiert D, Graham C, Shelat M, Kattappuram R, Abel M, Schroeder B, Upadhyay D, Krishnamurthy M, Sharma AK, Kumar R, Malin J, Schultz CW, Goyal S, Redon CE, Pommier Y, Aladjem MI, Gore SD, Steinberg SM, Vilimas R, Desai P, Thomas A
JAMA Oncol 2023 Dec 1;9(12):1669-1677. doi: 10.1001/jamaoncol.2023.4025. PMID: 37824137Free PMC Article
Lurbinectedin for the treatment of small cell lung cancer.
Li L, Zou C, Dong S, Wu ZX, Ashby CR Jr, Chen ZS, Qiu C
Drugs Today (Barc) 2021 Jun;57(6):377-385. doi: 10.1358/dot.2021.57.6.3294559. PMID: 34151904
Bevacizumab: a review of its use in advanced cancer.
Keating GM
Drugs 2014 Oct;74(16):1891-1925. doi: 10.1007/s40265-014-0302-9. PMID: 25315029

Therapy

Phase 1a dose escalation study of ivonescimab (AK112/SMT112), an anti-PD-1/VEGF-A bispecific antibody, in patients with advanced solid tumors.
Frentzas S, Austria Mislang AR, Lemech C, Nagrial A, Underhill C, Wang W, Wang ZM, Li B, Xia Y, Coward JIG
J Immunother Cancer 2024 Apr 19;12(4) doi: 10.1136/jitc-2023-008037. PMID: 38642937Free PMC Article
Berzosertib Plus Topotecan vs Topotecan Alone in Patients With Relapsed Small Cell Lung Cancer: A Randomized Clinical Trial.
Takahashi N, Hao Z, Villaruz LC, Zhang J, Ruiz J, Petty WJ, Mamdani H, Riess JW, Nieva J, Pachecho JM, Fuld AD, Shum E, Chauhan A, Nichols S, Shimellis H, McGlone J, Sciuto L, Pinkiert D, Graham C, Shelat M, Kattappuram R, Abel M, Schroeder B, Upadhyay D, Krishnamurthy M, Sharma AK, Kumar R, Malin J, Schultz CW, Goyal S, Redon CE, Pommier Y, Aladjem MI, Gore SD, Steinberg SM, Vilimas R, Desai P, Thomas A
JAMA Oncol 2023 Dec 1;9(12):1669-1677. doi: 10.1001/jamaoncol.2023.4025. PMID: 37824137Free PMC Article
FOLFIRI in advanced platinum-resistant/refractory small-cell lung cancer: a retrospective study.
Roussel-Simonin C, Gougis P, Lassoued D, Vozy A, Veyri M, Morardet L, Wassermann J, Foka Tichoue H, Jaffrelot L, Hassani L, Perrier A, Bergeret S, Taillade L, Spano JP, Campedel L, Abbar B
Acta Oncol 2023 Jun;62(6):579-586. Epub 2023 Jun 5 doi: 10.1080/0284186X.2023.2216339. PMID: 37276270
First-in-Human Study of PF-06647020 (Cofetuzumab Pelidotin), an Antibody-Drug Conjugate Targeting Protein Tyrosine Kinase 7, in Advanced Solid Tumors.
Maitland ML, Sachdev JC, Sharma MR, Moreno V, Boni V, Kummar S, Stringer-Reasor E, Lakhani N, Moreau AR, Xuan D, Li R, Powell EL, Jackson-Fisher A, Bowers M, Alekar S, Xin X, Tolcher AW, Calvo E
Clin Cancer Res 2021 Aug 15;27(16):4511-4520. Epub 2021 Jun 3 doi: 10.1158/1078-0432.CCR-20-3757. PMID: 34083232Free PMC Article
Randomized phase III trial of docetaxel versus vinorelbine or ifosfamide in patients with advanced non-small-cell lung cancer previously treated with platinum-containing chemotherapy regimens. The TAX 320 Non-Small Cell Lung Cancer Study Group.
Fossella FV, DeVore R, Kerr RN, Crawford J, Natale RR, Dunphy F, Kalman L, Miller V, Lee JS, Moore M, Gandara D, Karp D, Vokes E, Kris M, Kim Y, Gamza F, Hammershaimb L
J Clin Oncol 2000 Jun;18(12):2354-62. doi: 10.1200/JCO.2000.18.12.2354. PMID: 10856094

Prognosis

Lost at SCLC: a review of potential platinum sensitizers.
Oronsky B, Abrouk N, Mao L, Shen Y, Wang X, Zhao L, Caroen S, Reid T
Cancer Metastasis Rev 2024 Dec;43(4):1573-1578. Epub 2024 Aug 23 doi: 10.1007/s10555-024-10207-5. PMID: 39177894Free PMC Article
Berzosertib Plus Topotecan vs Topotecan Alone in Patients With Relapsed Small Cell Lung Cancer: A Randomized Clinical Trial.
Takahashi N, Hao Z, Villaruz LC, Zhang J, Ruiz J, Petty WJ, Mamdani H, Riess JW, Nieva J, Pachecho JM, Fuld AD, Shum E, Chauhan A, Nichols S, Shimellis H, McGlone J, Sciuto L, Pinkiert D, Graham C, Shelat M, Kattappuram R, Abel M, Schroeder B, Upadhyay D, Krishnamurthy M, Sharma AK, Kumar R, Malin J, Schultz CW, Goyal S, Redon CE, Pommier Y, Aladjem MI, Gore SD, Steinberg SM, Vilimas R, Desai P, Thomas A
JAMA Oncol 2023 Dec 1;9(12):1669-1677. doi: 10.1001/jamaoncol.2023.4025. PMID: 37824137Free PMC Article
FOLFIRI in advanced platinum-resistant/refractory small-cell lung cancer: a retrospective study.
Roussel-Simonin C, Gougis P, Lassoued D, Vozy A, Veyri M, Morardet L, Wassermann J, Foka Tichoue H, Jaffrelot L, Hassani L, Perrier A, Bergeret S, Taillade L, Spano JP, Campedel L, Abbar B
Acta Oncol 2023 Jun;62(6):579-586. Epub 2023 Jun 5 doi: 10.1080/0284186X.2023.2216339. PMID: 37276270
First-in-Human Study of PF-06647020 (Cofetuzumab Pelidotin), an Antibody-Drug Conjugate Targeting Protein Tyrosine Kinase 7, in Advanced Solid Tumors.
Maitland ML, Sachdev JC, Sharma MR, Moreno V, Boni V, Kummar S, Stringer-Reasor E, Lakhani N, Moreau AR, Xuan D, Li R, Powell EL, Jackson-Fisher A, Bowers M, Alekar S, Xin X, Tolcher AW, Calvo E
Clin Cancer Res 2021 Aug 15;27(16):4511-4520. Epub 2021 Jun 3 doi: 10.1158/1078-0432.CCR-20-3757. PMID: 34083232Free PMC Article
Erlotinib or gefitinib for the treatment of relapsed platinum pretreated non-small cell lung cancer and ovarian cancer: a systematic review.
Murphy M, Stordal B
Drug Resist Updat 2011 Jun;14(3):177-90. Epub 2011 Mar 24 doi: 10.1016/j.drup.2011.02.004. PMID: 21435938

Clinical prediction guides

Phase 1a dose escalation study of ivonescimab (AK112/SMT112), an anti-PD-1/VEGF-A bispecific antibody, in patients with advanced solid tumors.
Frentzas S, Austria Mislang AR, Lemech C, Nagrial A, Underhill C, Wang W, Wang ZM, Li B, Xia Y, Coward JIG
J Immunother Cancer 2024 Apr 19;12(4) doi: 10.1136/jitc-2023-008037. PMID: 38642937Free PMC Article
FOLFIRI in advanced platinum-resistant/refractory small-cell lung cancer: a retrospective study.
Roussel-Simonin C, Gougis P, Lassoued D, Vozy A, Veyri M, Morardet L, Wassermann J, Foka Tichoue H, Jaffrelot L, Hassani L, Perrier A, Bergeret S, Taillade L, Spano JP, Campedel L, Abbar B
Acta Oncol 2023 Jun;62(6):579-586. Epub 2023 Jun 5 doi: 10.1080/0284186X.2023.2216339. PMID: 37276270
First-in-Human Study of PF-06647020 (Cofetuzumab Pelidotin), an Antibody-Drug Conjugate Targeting Protein Tyrosine Kinase 7, in Advanced Solid Tumors.
Maitland ML, Sachdev JC, Sharma MR, Moreno V, Boni V, Kummar S, Stringer-Reasor E, Lakhani N, Moreau AR, Xuan D, Li R, Powell EL, Jackson-Fisher A, Bowers M, Alekar S, Xin X, Tolcher AW, Calvo E
Clin Cancer Res 2021 Aug 15;27(16):4511-4520. Epub 2021 Jun 3 doi: 10.1158/1078-0432.CCR-20-3757. PMID: 34083232Free PMC Article
Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress.
Thomas A, Takahashi N, Rajapakse VN, Zhang X, Sun Y, Ceribelli M, Wilson KM, Zhang Y, Beck E, Sciuto L, Nichols S, Elenbaas B, Puc J, Dahmen H, Zimmermann A, Varonin J, Schultz CW, Kim S, Shimellis H, Desai P, Klumpp-Thomas C, Chen L, Travers J, McKnight C, Michael S, Itkin Z, Lee S, Yuno A, Lee MJ, Redon CE, Kindrick JD, Peer CJ, Wei JS, Aladjem MI, Figg WD, Steinberg SM, Trepel JB, Zenke FT, Pommier Y, Khan J, Thomas CJ
Cancer Cell 2021 Apr 12;39(4):566-579.e7. doi: 10.1016/j.ccell.2021.02.014. PMID: 33848478Free PMC Article
Second line treatments in advanced platinum-resistant non small cell lung cancer. A critical review of literature.
Tassinari D, Carloni F, Santelmo C, Tamburini E, Lazzari Agli L, Tombesi P, Sartori S
Rev Recent Clin Trials 2009 Jan;4(1):27-33. doi: 10.2174/157488709787047549. PMID: 19149760

Recent systematic reviews

Erlotinib or gefitinib for the treatment of relapsed platinum pretreated non-small cell lung cancer and ovarian cancer: a systematic review.
Murphy M, Stordal B
Drug Resist Updat 2011 Jun;14(3):177-90. Epub 2011 Mar 24 doi: 10.1016/j.drup.2011.02.004. PMID: 21435938
Second line treatments in advanced platinum-resistant non small cell lung cancer. A critical review of literature.
Tassinari D, Carloni F, Santelmo C, Tamburini E, Lazzari Agli L, Tombesi P, Sartori S
Rev Recent Clin Trials 2009 Jan;4(1):27-33. doi: 10.2174/157488709787047549. PMID: 19149760

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...