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Lung carcinoma

MedGen UID:
195765
Concept ID:
C0684249
Neoplastic Process
Synonyms: Cancer of Lung; Cancer of the Lung; Carcinoma of Lung; carcinoma of lung; Carcinoma of the Lung; carcinoma of the lung; Lung Cancer; Lung Carcinoma; lung carcinoma
 
Gene (location): FASLG (1q24.3)
 
Monarch Initiative: MONDO:0005138

Definition

Lung cancer is the leading cause of cancer deaths in the U.S. and worldwide. The 2 major forms of lung cancer are nonsmall cell lung cancer and small cell lung cancer (see 182280), which account for 85% and 15% of all lung cancers, respectively. Nonsmall cell lung cancer can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. Cigarette smoking causes all types of lung cancer, but it is most strongly linked with small cell lung cancer and squamous cell carcinoma. Adenocarcinoma is the most common type in patients who have never smoked. Nonsmall cell lung cancer is often diagnosed at an advanced stage and has a poor prognosis (summary by Herbst et al., 2008). [from OMIM]

Additional description

From MedlinePlus Genetics
Lung cancer is a disease in which certain cells in the lungs become abnormal and multiply uncontrollably to form a tumor. Lung cancer may not cause signs or symptoms in its early stages. Some people with lung cancer have chest pain, frequent coughing, blood in the mucus, breathing problems, trouble swallowing or speaking, loss of appetite and weight loss, fatigue, or swelling in the face or neck. Additional symptoms can develop if the cancer spreads (metastasizes) into other tissues. Lung cancer occurs most often in adults in their sixties or seventies. Most people who develop lung cancer have a history of long-term tobacco smoking; however, the condition can occur in people who have never smoked.

Lung cancer is generally divided into two types, small cell lung cancer and non-small cell lung cancer, based on the size of the affected cells when viewed under a microscope. Non-small cell lung cancer accounts for 85 percent of lung cancer, while small cell lung cancer accounts for the remaining 15 percent.

Small cell lung cancer grows quickly and in more than half of cases the cancer has spread beyond the lung by the time the condition is diagnosed. Small cell lung cancer often metastasizes, most commonly to the liver, brain, bones, and adrenal glands (small hormone-producing glands located on top of each kidney). After diagnosis, most people with small cell lung cancer survive for about 1 year; less than seven percent survive 5 years.

Non-small cell lung cancer is divided into three main subtypes: adenocarcinoma, squamous cell carcinoma, and large cell lung carcinoma. Adenocarcinoma arises from the cells that line the small air sacs (alveoli) located throughout the lungs. Squamous cell carcinoma arises from squamous cells that line the passages leading from the windpipe (trachea) to the lungs (bronchi). Large cell carcinoma arises from epithelial cells that line the lungs. Large cell carcinoma encompasses non-small cell lung cancers that do not appear to be adenocarcinomas or squamous cell carcinomas. The 5-year survival rate for people with non-small cell lung cancer is usually between 11 and 17 percent; it can be lower or higher depending on the subtype and stage of the cancer.  https://medlineplus.gov/genetics/condition/lung-cancer

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  

Professional guidelines

PubMed

Jiang Y, Wang C, Zhou S
Semin Cancer Biol 2023 Nov;96:82-99. Epub 2023 Sep 30 doi: 10.1016/j.semcancer.2023.09.005. PMID: 37783319
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Curated

UK NICE guideline NG122, Lung cancer: diagnosis and management, 2023

Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

Suggested Reading

PubMed

Pasche B, Grant SC
JAMA 2014 May 21;311(19):1975-6. doi: 10.1001/jama.2014.3742. PMID: 24846033

Recent clinical studies

Etiology

Wang Q, Gümüş ZH, Colarossi C, Memeo L, Wang X, Kong CY, Boffetta P
J Thorac Oncol 2023 Jan;18(1):31-46. Epub 2022 Oct 12 doi: 10.1016/j.jtho.2022.10.002. PMID: 36243387Free PMC Article
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Am J Respir Crit Care Med 2021 Dec 15;204(12):P21-P22. doi: 10.1164/rccm.20411P21. PMID: 34908517
Dingemans AC, Früh M, Ardizzoni A, Besse B, Faivre-Finn C, Hendriks LE, Lantuejoul S, Peters S, Reguart N, Rudin CM, De Ruysscher D, Van Schil PE, Vansteenkiste J, Reck M; ESMO Guidelines Committee. Electronic address: [email protected]
Ann Oncol 2021 Jul;32(7):839-853. Epub 2021 Apr 20 doi: 10.1016/j.annonc.2021.03.207. PMID: 33864941Free PMC Article
Lung Cancer OncoGuia Group, Manchon Walsh P, Manchon P, Borràs JM, Ferro T, Espinàs JA
Clin Transl Oncol 2009 Dec;11(12):805-24. doi: 10.1007/s12094-009-0449-0. PMID: 20045787

Diagnosis

Rekhtman N
Mod Pathol 2022 Jan;35(Suppl 1):36-50. Epub 2021 Oct 18 doi: 10.1038/s41379-021-00943-2. PMID: 34663914Free PMC Article
Longo V, Catino A, Montrone M, Pizzutilo P, Annese T, Pesola F, Marech I, Cassiano S, Ribatti D, Galetta D
Int J Mol Sci 2021 Oct 15;22(20) doi: 10.3390/ijms222011123. PMID: 34681779Free PMC Article
Thai AA, Solomon BJ, Sequist LV, Gainor JF, Heist RS
Lancet 2021 Aug 7;398(10299):535-554. Epub 2021 Jul 21 doi: 10.1016/S0140-6736(21)00312-3. PMID: 34273294
Dingemans AC, Früh M, Ardizzoni A, Besse B, Faivre-Finn C, Hendriks LE, Lantuejoul S, Peters S, Reguart N, Rudin CM, De Ruysscher D, Van Schil PE, Vansteenkiste J, Reck M; ESMO Guidelines Committee. Electronic address: [email protected]
Ann Oncol 2021 Jul;32(7):839-853. Epub 2021 Apr 20 doi: 10.1016/j.annonc.2021.03.207. PMID: 33864941Free PMC Article
Jonna S, Subramaniam DS
Discov Med 2019 Mar;27(148):167-170. PMID: 31095926

Therapy

Zhang X, Shao M, Yao J, Zhao L, Li L, Chen M, Zhang Y, Liu H, Chen Z, Li B, Wu Z, Fan J, Qiu F
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Bradbury PA, Shepherd FA
J Thorac Oncol 2008 Jun;3(6 Suppl 2):S164-70. doi: 10.1097/JTO.0b013e318174e9a7. PMID: 18520304

Prognosis

Kamigaichi A, Hamada A, Tsuboi M, Yoshimura K, Okamoto I, Yamamoto N, Tsutani Y
Clin Lung Cancer 2024 Jun;25(4):384-388.e1. Epub 2024 Jan 26 doi: 10.1016/j.cllc.2024.01.004. PMID: 38360496
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National Lung Screening Trial Research Team
J Thorac Oncol 2019 Oct;14(10):1732-1742. Epub 2019 Jun 28 doi: 10.1016/j.jtho.2019.05.044. PMID: 31260833Free PMC Article
Kalemkerian GP, Schneider BJ
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Clinical prediction guides

Jain D, Nambirajan A, Borczuk A, Chen G, Minami Y, Moreira AL, Motoi N, Papotti M, Rekhtman N, Russell PA, Savic Prince S, Yatabe Y, Bubendorf L; IASLC Pathology Committee
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Leong TL, Loveland PM, Gorelik A, Irving L, Steinfort DP
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Zhang H, Gao L, Zhang B, Zhang L, Wang C
Sci Rep 2016 Mar 4;6:22618. doi: 10.1038/srep22618. PMID: 26939789Free PMC Article
Abi-Jaoudeh N, Duffy AG, Greten TF, Kohn EC, Clark TW, Wood BJ
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Jakobsen JN, Sørensen JB
Lung Cancer 2013 Jan;79(1):1-7. Epub 2012 Nov 6 doi: 10.1016/j.lungcan.2012.10.008. PMID: 23137549

Recent systematic reviews

Borgeaud M, Parikh K, Banna GL, Kim F, Olivier T, Le X, Addeo A
J Thorac Oncol 2024 Jul;19(7):973-983. Epub 2024 Mar 16 doi: 10.1016/j.jtho.2024.03.016. PMID: 38499147
Dong Y, Xu J, Sun B, Wang J, Wang Z
Mol Diagn Ther 2022 Mar;26(2):203-227. Epub 2022 Mar 10 doi: 10.1007/s40291-021-00568-w. PMID: 35266116Free PMC Article
Caini S, Del Riccio M, Vettori V, Scotti V, Martinoli C, Raimondi S, Cammarata G, Palli D, Banini M, Masala G, Gandini S
J Thorac Oncol 2022 May;17(5):623-636. Epub 2022 Jan 4 doi: 10.1016/j.jtho.2021.12.005. PMID: 34995798
Yuan T, Sun S, Cao Z, Feng X, Gao Y
Pathol Res Pract 2021 Jan;217:153311. Epub 2020 Dec 4 doi: 10.1016/j.prp.2020.153311. PMID: 33310282
Ravenel JG
J Thorac Imaging 2012 Sep;27(5):315-24. doi: 10.1097/RTI.0b013e318254a198. PMID: 22914125

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NICE, 2023
      UK NICE guideline NG122, Lung cancer: diagnosis and management, 2023
    • AHRQ, 2013
      Technology Assessment on Genetic Testing or Molecular Pathology Testing of Cancers with Unknown Primary Site to Determine Origin (ARCHIVED)

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