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Barrett Esophagus With Metaplastic Non-Goblet Cell Columnar Epithelium

MedGen UID:
1680187
•Concept ID:
C4764325
•
Finding

Definition

A finding in an esophageal biopsy specimen indicating the diagnosis of Barrett esophagus associated with the presence of metaplastic non-goblet cell columnar epithelium. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBarrett Esophagus With Metaplastic Non-Goblet Cell Columnar Epithelium

Recent clinical studies

Etiology

CDX2, COX2 and MUC2 expressions in Barrett's esophagus: can they be useful in determination of the dysplasia?
Türkmen IÇ, Başsüllü N, Uraz S, Yerdel MA, Memışoğlu R, Bülbül Doğusoy G
Turk Patoloji Derg 2012;28(3):251-8. doi: 10.5146/tjpath.2012.01132. PMID: 23011828
Expression of Sonic hedgehog (SHH) and CDX2 in the columnar epithelium of the lower oesophagus.
Yamanaka Y, Shiotani A, Fujimura Y, Ishii M, Fujita M, Matsumoto H, Tarumi K, Kamada T, Hata J, Haruma K
Dig Liver Dis 2011 Jan;43(1):54-9. Epub 2010 Jul 8 doi: 10.1016/j.dld.2010.04.014. PMID: 20619754
Intestinal differentiation in metaplastic, nongoblet columnar epithelium in the esophagus.
Hahn HP, Blount PL, Ayub K, Das KM, Souza R, Spechler S, Odze RD
Am J Surg Pathol 2009 Jul;33(7):1006-15. doi: 10.1097/PAS.0b013e31819f57e9. PMID: 19363439Free PMC Article
Metaplastic esophageal columnar epithelium without goblet cells shows DNA content abnormalities similar to goblet cell-containing epithelium.
Liu W, Hahn H, Odze RD, Goyal RK
Am J Gastroenterol 2009 Apr;104(4):816-24. Epub 2009 Mar 17 doi: 10.1038/ajg.2009.85. PMID: 19293780Free PMC Article
Non-goblet cell population of Barrett's esophagus: an immunohistochemical demonstration of intestinal differentiation.
Chaves P, Cardoso P, de Almeida JC, Pereira AD, Leitao CN, Soares J
Hum Pathol 1999 Nov;30(11):1291-5. doi: 10.1016/s0046-8177(99)90058-8. PMID: 10571507

Diagnosis

CDX2, COX2 and MUC2 expressions in Barrett's esophagus: can they be useful in determination of the dysplasia?
Türkmen IÇ, Başsüllü N, Uraz S, Yerdel MA, Memışoğlu R, Bülbül Doğusoy G
Turk Patoloji Derg 2012;28(3):251-8. doi: 10.5146/tjpath.2012.01132. PMID: 23011828
Mucin core peptide expression can help differentiate Barrett's esophagus from intestinal metaplasia of the stomach.
Glickman JN, Shahsafaei A, Odze RD
Am J Surg Pathol 2003 Oct;27(10):1357-65. doi: 10.1097/00000478-200310000-00008. PMID: 14508397
Enterocytic columnar non-goblet cells of Barrett's esophagus--an immunohistochemical demonstration of association with malignant evolution.
Chaves P, Cruz C, Cardoso P, Suspiro A, Pereira AD, de Almeida JC, Leitão CN, Soares J
J Exp Clin Cancer Res 2003 Jun;22(2):273-8. PMID: 12866578
Non-goblet cell population of Barrett's esophagus: an immunohistochemical demonstration of intestinal differentiation.
Chaves P, Cardoso P, de Almeida JC, Pereira AD, Leitao CN, Soares J
Hum Pathol 1999 Nov;30(11):1291-5. doi: 10.1016/s0046-8177(99)90058-8. PMID: 10571507

Clinical prediction guides

Intestinal differentiation in metaplastic, nongoblet columnar epithelium in the esophagus.
Hahn HP, Blount PL, Ayub K, Das KM, Souza R, Spechler S, Odze RD
Am J Surg Pathol 2009 Jul;33(7):1006-15. doi: 10.1097/PAS.0b013e31819f57e9. PMID: 19363439Free PMC Article

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