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Morphologic finding

MedGen UID:
147104
•Concept ID:
C0700329
•
Finding
Synonyms: Morphologic Finding; Morphology findings
SNOMED CT: Morphologic finding (72724002); Morphology findings (72724002)

Definition

A light microscopic finding that describes the cellular characteristics and architectural patterns of cell populations in a tissue sample. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMorphologic finding

Professional guidelines

PubMed

VisualDx: decision-support software for the diagnosis and management of dermatologic disorders.
Tleyjeh IM, Nada H, Baddour LM
Clin Infect Dis 2006 Nov 1;43(9):1177-84. Epub 2006 Sep 21 doi: 10.1086/508283. PMID: 17029139
Surgical treatment of phyllodes tumors of the breast: retrospective review of 172 cases.
Chen WH, Cheng SP, Tzen CY, Yang TL, Jeng KS, Liu CL, Liu TP
J Surg Oncol 2005 Sep 1;91(3):185-94. doi: 10.1002/jso.20334. PMID: 16118768
The differential diagnosis of eosinophilic esophagitis.
Ahmad M, Soetikno RM, Ahmed A
J Clin Gastroenterol 2000 Apr;30(3):242-4. doi: 10.1097/00004836-200004000-00007. PMID: 10777180

Recent clinical studies

Etiology

Evaluation of the sense of taste and smell in patients with Neurofibromatosis Type 1.
Speth US, König D, Burg S, Gosau M, Friedrich RE
J Stomatol Oral Maxillofac Surg 2023 Feb;124(1):101271. Epub 2022 Aug 28 doi: 10.1016/j.jormas.2022.08.014. PMID: 36038126
Monitoring jaw osteomyelitis therapy with single-photon emission computed tomography/computed tomography.
Heimann I, Kuttenberger J, Della Chiesa A, Bhure U, Del Sol Pérez-Lago M, Roos JE, Lima TVM, Strobel K
Nucl Med Commun 2021 Jan;42(1):51-57. doi: 10.1097/MNM.0000000000001297. PMID: 32991397
Langerhans cell histiocytosis in children: A retrospective case series of 126 cases.
Dhar S, Srinivas SM, Dhar S, Basu S, Banerjee R, Malakar R, Ghosh A, Bhattacharya A, Ray SK, Bhattacharya A, Chowdhury J
Pediatr Dermatol 2020 Nov;37(6):1085-1089. Epub 2020 Sep 27 doi: 10.1111/pde.14389. PMID: 32981115
Cytomorphology, immunoprofile, and management of renal oncocytic neoplasms.
Zhu B, Rohan SM, Lin X
Cancer Cytopathol 2020 Dec;128(12):962-970. Epub 2020 Jul 22 doi: 10.1002/cncy.22330. PMID: 32697415
Peters' anomaly and combination with other malformations (series of 16 patients).
Mayer UM
Ophthalmic Paediatr Genet 1992 Jun;13(2):131-5. doi: 10.3109/13816819209087613. PMID: 1495763

Diagnosis

Amyloid-like Fibronectin Deposits in the Liver: A Novel Morphologic Finding.
Yasir S, Rech KL, Chen ZE, Torbenson MS
Am J Surg Pathol 2021 Feb 1;45(2):205-208. doi: 10.1097/PAS.0000000000001585. PMID: 32925193Free PMC Article
Langerhans cell histiocytosis in children: A retrospective case series of 126 cases.
Dhar S, Srinivas SM, Dhar S, Basu S, Banerjee R, Malakar R, Ghosh A, Bhattacharya A, Ray SK, Bhattacharya A, Chowdhury J
Pediatr Dermatol 2020 Nov;37(6):1085-1089. Epub 2020 Sep 27 doi: 10.1111/pde.14389. PMID: 32981115
High-sensitivity flow cytometric analysis for the evaluation of systemic mastocytosis including the identification of a new flow cytometric criterion for bone marrow involvement.
Pozdnyakova O, Kondtratiev S, Li B, Charest K, Dorfman DM
Am J Clin Pathol 2012 Sep;138(3):416-24. doi: 10.1309/AJCP5PJWK4QFHWHM. PMID: 22912359
Historical perspective and clinical implications of the Pelger-Hüet cell.
Cunningham JM, Patnaik MM, Hammerschmidt DE, Vercellotti GM
Am J Hematol 2009 Feb;84(2):116-9. doi: 10.1002/ajh.21320. PMID: 19021122
The differential diagnosis of eosinophilic esophagitis.
Ahmad M, Soetikno RM, Ahmed A
J Clin Gastroenterol 2000 Apr;30(3):242-4. doi: 10.1097/00004836-200004000-00007. PMID: 10777180

Therapy

Prognostic value of AML 1/ETO fusion transcripts in patients with acute myelogenous leukemia.
Cho EK, Bang SM, Ahn JY, Yoo SM, Park PW, Seo YH, Shin DB, Lee JH
Korean J Intern Med 2003 Mar;18(1):13-20. doi: 10.3904/kjim.2003.18.1.13. PMID: 12760263Free PMC Article
Red cell fragmentation (schistocytosis) after bone marrow transplantation.
Zomas A, Saso R, Powles R, Mackay H, Singhal S, Treleaven J, Mehta J
Bone Marrow Transplant 1998 Oct;22(8):777-80. doi: 10.1038/sj.bmt.1701442. PMID: 9827975
Platelet cancer cell interaction in metastasis formation. Platelet aggregation inhibitors: a possible approach to metastasis prevention.
Gastpar H, Ambrus JL, Ambrus CM
Prog Clin Biol Res 1982;89:63-82. PMID: 7111310
Crystalline deposits of calcium and phosphorus: their appearance in glomerular basement membranes in a patient with renal failure.
Sanfilippo F, Wisseman C, Ingram P, Shelburne J
Arch Pathol Lab Med 1981 Nov;105(11):594-8. PMID: 6895298
Eosinophilic fibrohistiocytic lesion of bone marrow: a distinctive new morphologic finding, probably related to drug hypersensitivity.
Rywlin AM, Hoffman EP, Ortega RS
Blood 1972 Oct;40(4):464-72. PMID: 5075294

Prognosis

Interobserver Reproducibility in Assessing Eosinophilic Cells in Ovarian Serous Borderline Tumors to Predict BRAF Mutational Status.
Chui MH, Murali R, Soslow RA, Matrai C, Xing D, Vang R
Int J Gynecol Pathol 2023 Sep 1;42(5):472-481. Epub 2023 Jan 23 doi: 10.1097/PGP.0000000000000933. PMID: 36867514Free PMC Article
Monitoring jaw osteomyelitis therapy with single-photon emission computed tomography/computed tomography.
Heimann I, Kuttenberger J, Della Chiesa A, Bhure U, Del Sol Pérez-Lago M, Roos JE, Lima TVM, Strobel K
Nucl Med Commun 2021 Jan;42(1):51-57. doi: 10.1097/MNM.0000000000001297. PMID: 32991397
Langerhans cell histiocytosis in children: A retrospective case series of 126 cases.
Dhar S, Srinivas SM, Dhar S, Basu S, Banerjee R, Malakar R, Ghosh A, Bhattacharya A, Ray SK, Bhattacharya A, Chowdhury J
Pediatr Dermatol 2020 Nov;37(6):1085-1089. Epub 2020 Sep 27 doi: 10.1111/pde.14389. PMID: 32981115
Cytomorphology, immunoprofile, and management of renal oncocytic neoplasms.
Zhu B, Rohan SM, Lin X
Cancer Cytopathol 2020 Dec;128(12):962-970. Epub 2020 Jul 22 doi: 10.1002/cncy.22330. PMID: 32697415
Sphingomyelin lipidosis variant with cirrhosis in the pediatric age group.
Witzleben CL, Palmieri MJ, Watkins JB, Hogan P
Arch Pathol Lab Med 1986 Jun;110(6):508-12. PMID: 3085631

Clinical prediction guides

Interobserver Reproducibility in Assessing Eosinophilic Cells in Ovarian Serous Borderline Tumors to Predict BRAF Mutational Status.
Chui MH, Murali R, Soslow RA, Matrai C, Xing D, Vang R
Int J Gynecol Pathol 2023 Sep 1;42(5):472-481. Epub 2023 Jan 23 doi: 10.1097/PGP.0000000000000933. PMID: 36867514Free PMC Article
Genetic and Clinical Studies of Patients With Increased Multinucleated Megakaryocytes in Bone Marrow as an Isolated Finding: A Diagnostic Pitfall for Myelodysplastic Syndrome.
Zheng G, He R, Reichard KK, Peterson JF, Olteanu H, Oliveira JL, Rangan A, Chen D, Shi M
Am J Surg Pathol 2021 Nov 1;45(11):1534-1540. doi: 10.1097/PAS.0000000000001732. PMID: 33999554
Peters' anomaly and combination with other malformations (series of 16 patients).
Mayer UM
Ophthalmic Paediatr Genet 1992 Jun;13(2):131-5. doi: 10.3109/13816819209087613. PMID: 1495763
Giant neutrophils with increased peroxidase activity. Another evidence of dysgranulopoiesis in AIDS.
d'Onofrio G, Mancini S, Tamburrini E, Mango G, Ortona L
Am J Clin Pathol 1987 May;87(5):584-91. doi: 10.1093/ajcp/87.5.584. PMID: 3034051
Erythrocytic ecdysis. An unusual morphologic finding in a case of sickle cell anemia with intercurrent cold-agglutinin syndrome.
Ward PC, Smith CM, White JG
Am J Clin Pathol 1979 Sep;72(3):479-85. doi: 10.1093/ajcp/72.3.479. PMID: 474528

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