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Locally Advanced Gastric Adenocarcinoma

MedGen UID:
1689661
Concept ID:
C5206810
Neoplastic Process

Definition

A gastric adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Gastric Adenocarcinoma

Professional guidelines

PubMed

Srikumar T, Sundar R
Surg Clin North Am 2025 Feb;105(1):75-94. Epub 2024 Oct 15 doi: 10.1016/j.suc.2024.06.007. PMID: 39523078
Nurczyk K, Nowak N, Orczykowski T, Bojar P, Duma D, Gieroba R, Wallner G, Skoczylas T
Pol Przegl Chir 2023 Sep 20;96(2):44-49. doi: 10.5604/01.3001.0053.8925. PMID: 38629280
Lumish MA, Ku GY
Curr Treat Options Oncol 2022 Jul;23(7):1044-1058. Epub 2022 May 7 doi: 10.1007/s11864-021-00917-1. PMID: 35524838

Recent clinical studies

Etiology

Wang L, Sun M, Li J, Wan L, Tan Y, Tian S, Hou Y, Wu L, Peng Z, Hu X, Zhang Q, Huang Z, Han M, Peng S, Pan Y, Ren Y, Zhang M, Chen D, Liu Q, Li X, Qin ZY, Xiang J, Li M, Zhu J, Chen Q, Luo H, Wang S, Wang T, Li F, Bian XW, Wang B
Clin Cancer Res 2025 Jan 6;31(1):74-86. doi: 10.1158/1078-0432.CCR-24-2436. PMID: 39495175
Tian Y, Yang P, Guo H, Liu Y, Zhang Z, Ding P, Zheng T, Deng H, Ma W, Li Y, Fan L, Zhang Z, Wang D, Zhao X, Tan B, Liu Y, Zhao Q
Int J Surg 2023 Dec 1;109(12):4000-4008. doi: 10.1097/JS9.0000000000000692. PMID: 37678277Free PMC Article
Vos EL, Maron SB, Krell RW, Nakauchi M, Fiasconaro M, Capanu M, Walch HS, Chatila WK, Schultz N, Ilson DH, Janjigian YY, Ku GY, Yoon SS, Coit DG, Vanderbilt CM, Tang LH, Strong VE
Ann Surg 2023 May 1;277(5):798-805. Epub 2022 Jun 29 doi: 10.1097/SLA.0000000000005501. PMID: 35766391Free PMC Article
Margalit O, Yu S, Shacham-Shmueli E, Strauss G, Yang YX, Lawrence YR, Reiss KA, Golan T, Halpern N, Aderka D, Giantonio B, Mamtani R, Boursi B
J Cancer Res Clin Oncol 2022 Jul;148(7):1703-1708. Epub 2022 Jan 23 doi: 10.1007/s00432-021-03911-0. PMID: 35066662
Papageorge MV, de Geus SWL, Zheng J, Woods AP, Ng SC, Cassidy MR, McAneny D, Tseng JF, Sachs TE
J Gastrointest Surg 2021 Jun;25(6):1363-1369. Epub 2021 Apr 12 doi: 10.1007/s11605-021-04993-4. PMID: 33846934

Diagnosis

Srikumar T, Sundar R
Surg Clin North Am 2025 Feb;105(1):75-94. Epub 2024 Oct 15 doi: 10.1016/j.suc.2024.06.007. PMID: 39523078
Wang L, Sun M, Li J, Wan L, Tan Y, Tian S, Hou Y, Wu L, Peng Z, Hu X, Zhang Q, Huang Z, Han M, Peng S, Pan Y, Ren Y, Zhang M, Chen D, Liu Q, Li X, Qin ZY, Xiang J, Li M, Zhu J, Chen Q, Luo H, Wang S, Wang T, Li F, Bian XW, Wang B
Clin Cancer Res 2025 Jan 6;31(1):74-86. doi: 10.1158/1078-0432.CCR-24-2436. PMID: 39495175
Lumish MA, Ku GY
Curr Treat Options Oncol 2022 Jul;23(7):1044-1058. Epub 2022 May 7 doi: 10.1007/s11864-021-00917-1. PMID: 35524838
Papageorge MV, de Geus SWL, Zheng J, Woods AP, Ng SC, Cassidy MR, McAneny D, Tseng JF, Sachs TE
J Gastrointest Surg 2021 Jun;25(6):1363-1369. Epub 2021 Apr 12 doi: 10.1007/s11605-021-04993-4. PMID: 33846934
Lin JX, Yoon C, Desiderio J, Yi BC, Li P, Zheng CH, Parisi A, Huang CM, Strong VE, Yoon SS
Br J Surg 2019 Aug;106(9):1187-1196. Epub 2019 Jun 13 doi: 10.1002/bjs.11181. PMID: 31197829Free PMC Article

Therapy

Tian Y, Yang P, Guo H, Liu Y, Zhang Z, Ding P, Zheng T, Deng H, Ma W, Li Y, Fan L, Zhang Z, Wang D, Zhao X, Tan B, Liu Y, Zhao Q
Int J Surg 2023 Dec 1;109(12):4000-4008. doi: 10.1097/JS9.0000000000000692. PMID: 37678277Free PMC Article
Tang Z, Wang Y, Liu D, Wang X, Xu C, Yu Y, Cui Y, Tang C, Li Q, Sun J, Zhang Q, Ji Y, Ma G, Li H, Shen Z, Shen K, Zheng R, Hou Z, Liu T, Wang J, Sun Y
Nat Commun 2022 Nov 10;13(1):6807. doi: 10.1038/s41467-022-34403-5. PMID: 36357415Free PMC Article
Lumish MA, Ku GY
Curr Treat Options Oncol 2022 Jul;23(7):1044-1058. Epub 2022 May 7 doi: 10.1007/s11864-021-00917-1. PMID: 35524838
Margalit O, Yu S, Shacham-Shmueli E, Strauss G, Yang YX, Lawrence YR, Reiss KA, Golan T, Halpern N, Aderka D, Giantonio B, Mamtani R, Boursi B
J Cancer Res Clin Oncol 2022 Jul;148(7):1703-1708. Epub 2022 Jan 23 doi: 10.1007/s00432-021-03911-0. PMID: 35066662
Dornellas AFL, Ramos MFKP, Pereira MA, Cardili L, Dias AR, de Castria TB
J Gastrointest Cancer 2021 Jun;52(2):788-791. Epub 2020 Sep 21 doi: 10.1007/s12029-020-00520-x. PMID: 32954464

Prognosis

Tian Y, Yang P, Guo H, Liu Y, Zhang Z, Ding P, Zheng T, Deng H, Ma W, Li Y, Fan L, Zhang Z, Wang D, Zhao X, Tan B, Liu Y, Zhao Q
Int J Surg 2023 Dec 1;109(12):4000-4008. doi: 10.1097/JS9.0000000000000692. PMID: 37678277Free PMC Article
Yoon C, Lu J, Kim BJ, Cho SJ, Kim JH, Moy RH, Ryeom SW, Yoon SS
J Gastrointest Surg 2023 Apr;27(4):666-676. Epub 2023 Jan 10 doi: 10.1007/s11605-022-05568-7. PMID: 36627466
Vos EL, Maron SB, Krell RW, Nakauchi M, Fiasconaro M, Capanu M, Walch HS, Chatila WK, Schultz N, Ilson DH, Janjigian YY, Ku GY, Yoon SS, Coit DG, Vanderbilt CM, Tang LH, Strong VE
Ann Surg 2023 May 1;277(5):798-805. Epub 2022 Jun 29 doi: 10.1097/SLA.0000000000005501. PMID: 35766391Free PMC Article
Lumish MA, Ku GY
Curr Treat Options Oncol 2022 Jul;23(7):1044-1058. Epub 2022 May 7 doi: 10.1007/s11864-021-00917-1. PMID: 35524838
Papageorge MV, de Geus SWL, Zheng J, Woods AP, Ng SC, Cassidy MR, McAneny D, Tseng JF, Sachs TE
J Gastrointest Surg 2021 Jun;25(6):1363-1369. Epub 2021 Apr 12 doi: 10.1007/s11605-021-04993-4. PMID: 33846934

Clinical prediction guides

Wang L, Sun M, Li J, Wan L, Tan Y, Tian S, Hou Y, Wu L, Peng Z, Hu X, Zhang Q, Huang Z, Han M, Peng S, Pan Y, Ren Y, Zhang M, Chen D, Liu Q, Li X, Qin ZY, Xiang J, Li M, Zhu J, Chen Q, Luo H, Wang S, Wang T, Li F, Bian XW, Wang B
Clin Cancer Res 2025 Jan 6;31(1):74-86. doi: 10.1158/1078-0432.CCR-24-2436. PMID: 39495175
Yoon C, Lu J, Kim BJ, Cho SJ, Kim JH, Moy RH, Ryeom SW, Yoon SS
J Gastrointest Surg 2023 Apr;27(4):666-676. Epub 2023 Jan 10 doi: 10.1007/s11605-022-05568-7. PMID: 36627466
Park KB, Jun KH, Song KY, Chin H, Lee HH
Int J Surg 2022 May;101:106629. Epub 2022 Apr 20 doi: 10.1016/j.ijsu.2022.106629. PMID: 35460886
Margalit O, Yu S, Shacham-Shmueli E, Strauss G, Yang YX, Lawrence YR, Reiss KA, Golan T, Halpern N, Aderka D, Giantonio B, Mamtani R, Boursi B
J Cancer Res Clin Oncol 2022 Jul;148(7):1703-1708. Epub 2022 Jan 23 doi: 10.1007/s00432-021-03911-0. PMID: 35066662
Papageorge MV, de Geus SWL, Zheng J, Woods AP, Ng SC, Cassidy MR, McAneny D, Tseng JF, Sachs TE
J Gastrointest Surg 2021 Jun;25(6):1363-1369. Epub 2021 Apr 12 doi: 10.1007/s11605-021-04993-4. PMID: 33846934

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