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Locally Advanced Adenocarcinoma

MedGen UID:
1718547
•Concept ID:
C5239285
•
Neoplastic Process

Definition

Adenocarcinoma that has spread to nearby tissues or lymph nodes. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocally Advanced Adenocarcinoma

Professional guidelines

PubMed

Primary Surgery Not Inferior to Neoadjuvant Chemoradiotherapy for Esophageal Adenocarcinoma.
Bouckaert A, Moons J, Lerut T, Coosemans W, Depypere L, Van Veer H, Nafteux P
Ann Thorac Surg 2023 Sep;116(3):571-578. Epub 2023 Mar 30 doi: 10.1016/j.athoracsur.2023.02.060. PMID: 37003580
Management of Locally Advanced Adenocarcinoma of the Esophagus and Gastroesophageal Junction: Finally a Consensus.
Kleinberg L, Brock M, Gibson M
Curr Treat Options Oncol 2015 Jul;16(7):35. doi: 10.1007/s11864-015-0352-6. PMID: 26112428Free PMC Article
The role of neoadjuvant and adjuvant treatment for adenocarcinoma of the upper gastrointestinal tract.
Matuschek C, Bölke E, Peiper M, Knoefel WT, Budach W, Erhardt A, Scherer A, Gerber PA, Buhren BA, Gattermann N, Baldus SE, Rusnak E, Shukla V, Orth K
Eur J Med Res 2011 Jun 21;16(6):265-74. doi: 10.1186/2047-783x-16-6-265. PMID: 21810561Free PMC Article

Recent clinical studies

Etiology

Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial.
Reynolds JV, Preston SR, O'Neill B, Lowery MA, Baeksgaard L, Crosby T, Cunningham M, Cuffe S, Griffiths GO, Parker I, Risumlund SL, Roy R, Falk S, Hanna GB, Bartlett FR, Alvarez-Iglesias A, Achiam MP, Nilsson M, Piessen G, Ravi N, O'Toole D, Johnston C, McDermott RS, Turkington RC, Wahed S, Sothi S, Ford H, Wadley MS, Power D; Neo-AEGIS Investigators and Trial Group
Lancet Gastroenterol Hepatol 2023 Nov;8(11):1015-1027. Epub 2023 Sep 18 doi: 10.1016/S2468-1253(23)00243-1. PMID: 37734399Free PMC Article
The immune microenvironment landscape shows treatment-specific differences in rectal cancer patients.
Graham Martínez C, Barella Y, Kus Öztürk S, Ansems M, Gorris MAJ, van Vliet S, Marijnen CAM, Nagtegaal ID
Front Immunol 2022;13:1011498. Epub 2022 Sep 27 doi: 10.3389/fimmu.2022.1011498. PMID: 36238289Free PMC Article
Preoperative chemotherapy versus chemoradiotherapy in locally advanced adenocarcinomas of the oesophagogastric junction (POET): Long-term results of a controlled randomised trial.
Stahl M, Walz MK, Riera-Knorrenschild J, Stuschke M, Sandermann A, Bitzer M, Wilke H, Budach W
Eur J Cancer 2017 Aug;81:183-190. doi: 10.1016/j.ejca.2017.04.027. PMID: 28628843
Management of locally advanced adenocarcinoma of the pancreas.
Ryan DP, Willett CG
Hematol Oncol Clin North Am 2002 Feb;16(1):95-103. doi: 10.1016/s0889-8588(01)00009-0. PMID: 12063831
Combinations of hormones and local therapies in locally advanced prostate carcinoma.
Eulau SM, Corn BW
Oncology (Williston Park) 1996 Aug;10(8):1193-202; discussion 1207-14. PMID: 8869960

Diagnosis

Prognosis after neoadjuvant chemoradiation or chemotherapy for locally advanced gastro-oesophageal junctional adenocarcinoma.
Vos EL, Carr RA, Hsu M, Nakauchi M, Nobel T, Russo A, Barbetta A, Tan KS, Tang L, Ilson D, Ku GY, Wu AJ, Janjigian YY, Yoon SS, Bains MS, Jones DR, Coit D, Molena D, Strong VE
Br J Surg 2021 Nov 11;108(11):1332-1340. doi: 10.1093/bjs/znab228. PMID: 34476473Free PMC Article
Advanced-stage pancreatic cancer: therapy options.
Werner J, Combs SE, Springfeld C, Hartwig W, Hackert T, Büchler MW
Nat Rev Clin Oncol 2013 Jun;10(6):323-33. Epub 2013 Apr 30 doi: 10.1038/nrclinonc.2013.66. PMID: 23629472
Preoperative chemoradiation for resectable and locally advanced adenocarcinoma of the pancreas.
Evans DB
J Gastrointest Surg 2001 Jan-Feb;5(1):2-5. doi: 10.1016/s1091-255x(01)80002-0. PMID: 11370617
Optimising treatment for resectable rectal cancer: is preoperative therapy beneficial?
Ngan SY
Drugs Aging 2001;18(2):79-85. doi: 10.2165/00002512-200118020-00001. PMID: 11346129
Neoadjuvant chemoradiation treatment of locally advanced adenocarcinoma of the duodenum.
Kluger Y, Soffer D, Sorid D, Michowitz M, Schreiber L, Klausner JY
Isr Med Assoc J 2000 Dec;2(12):947-8. PMID: 11344785

Therapy

Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-AEGIS): an open-label, randomised, phase 3 trial.
Reynolds JV, Preston SR, O'Neill B, Lowery MA, Baeksgaard L, Crosby T, Cunningham M, Cuffe S, Griffiths GO, Parker I, Risumlund SL, Roy R, Falk S, Hanna GB, Bartlett FR, Alvarez-Iglesias A, Achiam MP, Nilsson M, Piessen G, Ravi N, O'Toole D, Johnston C, McDermott RS, Turkington RC, Wahed S, Sothi S, Ford H, Wadley MS, Power D; Neo-AEGIS Investigators and Trial Group
Lancet Gastroenterol Hepatol 2023 Nov;8(11):1015-1027. Epub 2023 Sep 18 doi: 10.1016/S2468-1253(23)00243-1. PMID: 37734399Free PMC Article
Preoperative chemotherapy versus chemoradiotherapy in locally advanced adenocarcinomas of the oesophagogastric junction (POET): Long-term results of a controlled randomised trial.
Stahl M, Walz MK, Riera-Knorrenschild J, Stuschke M, Sandermann A, Bitzer M, Wilke H, Budach W
Eur J Cancer 2017 Aug;81:183-190. doi: 10.1016/j.ejca.2017.04.027. PMID: 28628843
Management of locally advanced adenocarcinoma of the pancreas.
Ryan DP, Willett CG
Hematol Oncol Clin North Am 2002 Feb;16(1):95-103. doi: 10.1016/s0889-8588(01)00009-0. PMID: 12063831
Preoperative chemoradiation for resectable and locally advanced adenocarcinoma of the pancreas.
Evans DB
J Gastrointest Surg 2001 Jan-Feb;5(1):2-5. doi: 10.1016/s1091-255x(01)80002-0. PMID: 11370617
Combinations of hormones and local therapies in locally advanced prostate carcinoma.
Eulau SM, Corn BW
Oncology (Williston Park) 1996 Aug;10(8):1193-202; discussion 1207-14. PMID: 8869960

Prognosis

Prognosis after neoadjuvant chemoradiation or chemotherapy for locally advanced gastro-oesophageal junctional adenocarcinoma.
Vos EL, Carr RA, Hsu M, Nakauchi M, Nobel T, Russo A, Barbetta A, Tan KS, Tang L, Ilson D, Ku GY, Wu AJ, Janjigian YY, Yoon SS, Bains MS, Jones DR, Coit D, Molena D, Strong VE
Br J Surg 2021 Nov 11;108(11):1332-1340. doi: 10.1093/bjs/znab228. PMID: 34476473Free PMC Article
Management of Locally Advanced Adenocarcinoma of the Esophagus and Gastroesophageal Junction: Finally a Consensus.
Kleinberg L, Brock M, Gibson M
Curr Treat Options Oncol 2015 Jul;16(7):35. doi: 10.1007/s11864-015-0352-6. PMID: 26112428Free PMC Article
CPT-11 and concomitant hyperfractionated accelerated radiotherapy induce efficient local control in rectal cancer patients: results from a phase II.
Voelter V, Zouhair A, Vuilleumier H, Matter M, Bouzourene H, Leyvraz S, Bauer J, Coucke P, Stupp R
Br J Cancer 2006 Sep 18;95(6):710-6. Epub 2006 Aug 29 doi: 10.1038/sj.bjc.6603322. PMID: 16940980Free PMC Article
Surgical management of locally advanced adenocarcinoma of the rectum.
Devine RM, Dozois RR
World J Surg 1992 May-Jun;16(3):486-9. doi: 10.1007/BF02104452. PMID: 1589985
Preliminary results of biopsies following irradiation for locally advanced adenocarcinoma of the prostate.
Cox JD, Tijerina A
Radiology 1974 Jul;112(1):215-6. doi: 10.1148/112.1.215. PMID: 4832498

Clinical prediction guides

Locally Advanced Adenocarcinoma of the Esophagus: Is Esophagectomy Associated with Improved Overall Survival?
Kramer SP, Swanson J, Fernando M, Park S, Verm R, Abdelsattar Z, Cohn T, Luchette FA, Baker MS
J Am Coll Surg 2024 Jul 1;239(1):68-75. Epub 2024 Mar 14 doi: 10.1097/XCS.0000000000001073. PMID: 38483131
Multicenter analysis on the value of standard (chemo)radiotherapy in elderly patients with locally advanced adenocarcinoma of the esophagus or gastroesophageal junction.
Bostel T, Nikolaidou E, Wollschläger D, Mayer A, Kaufmann J, Hopprich A, Rühle A, Grosu AL, Debus J, Fottner C, Moehler M, Grimminger P, Schmidberger H, Nicolay NH
Radiat Oncol 2024 Mar 4;19(1):28. doi: 10.1186/s13014-024-02414-9. PMID: 38433231Free PMC Article
Primary Surgery Not Inferior to Neoadjuvant Chemoradiotherapy for Esophageal Adenocarcinoma.
Bouckaert A, Moons J, Lerut T, Coosemans W, Depypere L, Van Veer H, Nafteux P
Ann Thorac Surg 2023 Sep;116(3):571-578. Epub 2023 Mar 30 doi: 10.1016/j.athoracsur.2023.02.060. PMID: 37003580
Advanced-stage pancreatic cancer: therapy options.
Werner J, Combs SE, Springfeld C, Hartwig W, Hackert T, Büchler MW
Nat Rev Clin Oncol 2013 Jun;10(6):323-33. Epub 2013 Apr 30 doi: 10.1038/nrclinonc.2013.66. PMID: 23629472
Hormones and radiation therapy in locally advanced adenocarcinoma of the prostate.
Lawton CA
Semin Radiat Oncol 2003 Apr;13(2):141-51. doi: 10.1053/srao.2003.50013. PMID: 12728443

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