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Locally Advanced Breast Carcinoma

MedGen UID:
1703295
•Concept ID:
C5205659
•
Neoplastic Process

Definition

A breast carcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Surgical management of locally advanced breast cancer: Recommendations of the Brazilian Society of Surgical Oncology.
da Costa Vieira RA, Andrade WP, Vieira SC, Romano M, Iglesias G, Oliveira AF
J Surg Oncol 2022 Jul;126(1):57-67. doi: 10.1002/jso.26890. PMID: 35689588
Treatment failure following sequential thermoradiotherapy of locally advanced breast carcinoma occurs primarily in poorly vascularized tumors.
Lyng H, Rofstad EK
Oncology 1995 Nov-Dec;52(6):443-7. doi: 10.1159/000227508. PMID: 7478428
Multimodality treatment of locally advanced breast carcinoma.
Hobar PC, Jones RC, Schouten J, Leitch AM, Hendler F
Arch Surg 1988 Aug;123(8):951-5. doi: 10.1001/archsurg.1988.01400320037006. PMID: 3395238

Recent clinical studies

Etiology

Surgical management of locally advanced breast cancer: Recommendations of the Brazilian Society of Surgical Oncology.
da Costa Vieira RA, Andrade WP, Vieira SC, Romano M, Iglesias G, Oliveira AF
J Surg Oncol 2022 Jul;126(1):57-67. doi: 10.1002/jso.26890. PMID: 35689588
Inflammatory breast carcinoma and locally advanced breast carcinoma: characterisation with MR imaging.
Girardi V, Carbognin G, Camera L, Bonetti F, Manfrin E, Pollini G, Pozzi Mucelli R
Radiol Med 2011 Feb;116(1):71-83. Epub 2010 Oct 6 doi: 10.1007/s11547-010-0590-4. PMID: 20927653
Locally advanced breast carcinoma: evaluation of mammography in the prediction of residual disease after induction chemotherapy.
Huber S, Wagner M, Zuna I, Medl M, Czembirek H, Delorme S
Anticancer Res 2000 Jan-Feb;20(1B):553-8. PMID: 10769724
Breast conservation following induction chemotherapy for locally advanced carcinoma of the breast (stages IIB and III). A surgical perspective.
Schwartz GF, Lange AK, Topham AK
Surg Oncol Clin N Am 1995 Oct;4(4):657-69. PMID: 8535903
M-VAC combination in locally advanced, locally recurrent or metastatic breast carcinoma. A phase II study.
Bisagni G, Cocconi G, Ceci G, De Lisi V, Di Blasio B, Lottici R, Passalacqua R, Finardi C
Ann Oncol 1994 Jan;5(1):93-4. doi: 10.1093/oxfordjournals.annonc.a058706. PMID: 8172801

Diagnosis

Association between mammographic features and response to neoadjuvant chemotherapy in locally advanced breast carcinoma.
Castaneda CA, Flores R, Rojas K, Flores C, Castillo M, Milla E
Hematol Oncol Stem Cell Ther 2014 Dec;7(4):149-56. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.001. PMID: 25300565
Inflammatory breast carcinoma and locally advanced breast carcinoma: characterisation with MR imaging.
Girardi V, Carbognin G, Camera L, Bonetti F, Manfrin E, Pollini G, Pozzi Mucelli R
Radiol Med 2011 Feb;116(1):71-83. Epub 2010 Oct 6 doi: 10.1007/s11547-010-0590-4. PMID: 20927653
FDG PET, PET/CT, and breast cancer imaging.
Rosen EL, Eubank WB, Mankoff DA
Radiographics 2007 Oct;27 Suppl 1:S215-29. doi: 10.1148/rg.27si075517. PMID: 18180228
Inflammatory breast carcinoma and noninflammatory locally advanced breast carcinoma: distinct clinicopathologic entities?
Anderson WF, Chu KC, Chang S
J Clin Oncol 2003 Jun 15;21(12):2254-9. doi: 10.1200/JCO.2003.07.082. PMID: 12805323
Locally advanced breast carcinoma: evaluation of mammography in the prediction of residual disease after induction chemotherapy.
Huber S, Wagner M, Zuna I, Medl M, Czembirek H, Delorme S
Anticancer Res 2000 Jan-Feb;20(1B):553-8. PMID: 10769724

Therapy

Label-free multiphoton imaging to assess neoadjuvant therapy responses in breast carcinoma.
Li L, Han Z, Qiu L, Kang D, Zhan Z, Tu H, Chen J
Int J Biol Sci 2020;16(8):1376-1387. Epub 2020 Feb 21 doi: 10.7150/ijbs.41579. PMID: 32210726Free PMC Article
Locally advanced breast carcinoma: computer assisted semiquantitative analysis of color Doppler ultrasonography in the evaluation of tumor response to neoadjuvant chemotherapy (work in progress).
Huber S, Medl M, Helbich T, Taucher S, Wagner T, Rudas M, Zuna I, Delorme S
J Ultrasound Med 2000 Sep;19(9):601-7. doi: 10.7863/jum.2000.19.9.601. PMID: 10972556
Locally advanced breast carcinoma: evaluation of mammography in the prediction of residual disease after induction chemotherapy.
Huber S, Wagner M, Zuna I, Medl M, Czembirek H, Delorme S
Anticancer Res 2000 Jan-Feb;20(1B):553-8. PMID: 10769724
Breast conservation following induction chemotherapy for locally advanced carcinoma of the breast (stages IIB and III). A surgical perspective.
Schwartz GF, Lange AK, Topham AK
Surg Oncol Clin N Am 1995 Oct;4(4):657-69. PMID: 8535903
M-VAC combination in locally advanced, locally recurrent or metastatic breast carcinoma. A phase II study.
Bisagni G, Cocconi G, Ceci G, De Lisi V, Di Blasio B, Lottici R, Passalacqua R, Finardi C
Ann Oncol 1994 Jan;5(1):93-4. doi: 10.1093/oxfordjournals.annonc.a058706. PMID: 8172801

Prognosis

Locally advanced breast carcinoma treated with neoadjuvant chemotherapy: are the changes in serum levels of YKL-40, MMP-2 and MMP-9 correlated with tumor response?
Coskun U, Yamac D, Gulbahar O, Sancak B, Karaman N, Ozkan S
Neoplasma 2007;54(4):348-52. PMID: 17845129
Inflammatory breast carcinoma and noninflammatory locally advanced breast carcinoma: distinct clinicopathologic entities?
Anderson WF, Chu KC, Chang S
J Clin Oncol 2003 Jun 15;21(12):2254-9. doi: 10.1200/JCO.2003.07.082. PMID: 12805323
Locally advanced breast carcinoma: evaluation of mammography in the prediction of residual disease after induction chemotherapy.
Huber S, Wagner M, Zuna I, Medl M, Czembirek H, Delorme S
Anticancer Res 2000 Jan-Feb;20(1B):553-8. PMID: 10769724
M-VAC combination in locally advanced, locally recurrent or metastatic breast carcinoma. A phase II study.
Bisagni G, Cocconi G, Ceci G, De Lisi V, Di Blasio B, Lottici R, Passalacqua R, Finardi C
Ann Oncol 1994 Jan;5(1):93-4. doi: 10.1093/oxfordjournals.annonc.a058706. PMID: 8172801
Locally advanced breast carcinoma: results with combined regional therapy.
Toonkel LM, Fix I, Jacobson LH, Bamberg N, Wallach CB
Int J Radiat Oncol Biol Phys 1986 Sep;12(9):1583-7. doi: 10.1016/0360-3016(86)90281-6. PMID: 3759583

Clinical prediction guides

Association between mammographic features and response to neoadjuvant chemotherapy in locally advanced breast carcinoma.
Castaneda CA, Flores R, Rojas K, Flores C, Castillo M, Milla E
Hematol Oncol Stem Cell Ther 2014 Dec;7(4):149-56. Epub 2014 Oct 6 doi: 10.1016/j.hemonc.2014.09.001. PMID: 25300565
Clinical and radiological predictors of nipple-areola complex involvement in breast cancer patients.
D'Alonzo M, Martincich L, Biglia N, Pisacane A, Maggiorotto F, Rosa GD, Montemurro F, Kubatzki F, Sismondi P, Ponzone R
Eur J Cancer 2012 Oct;48(15):2311-8. Epub 2012 May 28 doi: 10.1016/j.ejca.2012.04.017. PMID: 22647686
Inflammatory breast carcinoma and noninflammatory locally advanced breast carcinoma: distinct clinicopathologic entities?
Anderson WF, Chu KC, Chang S
J Clin Oncol 2003 Jun 15;21(12):2254-9. doi: 10.1200/JCO.2003.07.082. PMID: 12805323
Locally advanced breast carcinoma: evaluation of mammography in the prediction of residual disease after induction chemotherapy.
Huber S, Wagner M, Zuna I, Medl M, Czembirek H, Delorme S
Anticancer Res 2000 Jan-Feb;20(1B):553-8. PMID: 10769724
Locally advanced breast carcinoma: accuracy of mammography versus clinical examination in the prediction of residual disease after chemotherapy.
Helvie MA, Joynt LK, Cody RL, Pierce LJ, Adler DD, Merajver SD
Radiology 1996 Feb;198(2):327-32. doi: 10.1148/radiology.198.2.8596826. PMID: 8596826

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