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Locally Advanced Breast Adenocarcinoma

MedGen UID:
1714254
Concept ID:
C5239505
Neoplastic Process

Definition

Breast adenocarcinoma that has spread from its original site of growth to nearby tissues or lymph nodes. [from NCI]

Professional guidelines

PubMed

Shaitelman SF, Anderson BM, Arthur DW, Bazan JG, Bellon JR, Bradfield L, Coles CE, Gerber NK, Kathpal M, Kim L, Laronga C, Meattini I, Nichols EM, Pierce LJ, Poppe MM, Spears PA, Vinayak S, Whelan T, Lyons JA
Pract Radiat Oncol 2024 Mar-Apr;14(2):112-132. Epub 2023 Nov 15 doi: 10.1016/j.prro.2023.11.001. PMID: 37977261
Thomas M, Kelly ED, Abraham J, Kruse M
Semin Oncol 2019 Apr;46(2):121-132. Epub 2019 Jun 17 doi: 10.1053/j.seminoncol.2019.03.002. PMID: 31239068
Weber E, Hellman S
JAMA 1975 Nov 10;234(6):608-11. PMID: 809597

Recent clinical studies

Etiology

Shaitelman SF, Anderson BM, Arthur DW, Bazan JG, Bellon JR, Bradfield L, Coles CE, Gerber NK, Kathpal M, Kim L, Laronga C, Meattini I, Nichols EM, Pierce LJ, Poppe MM, Spears PA, Vinayak S, Whelan T, Lyons JA
Pract Radiat Oncol 2024 Mar-Apr;14(2):112-132. Epub 2023 Nov 15 doi: 10.1016/j.prro.2023.11.001. PMID: 37977261
Risom T, Glass DR, Averbukh I, Liu CC, Baranski A, Kagel A, McCaffrey EF, Greenwald NF, Rivero-Gutiérrez B, Strand SH, Varma S, Kong A, Keren L, Srivastava S, Zhu C, Khair Z, Veis DJ, Deschryver K, Vennam S, Maley C, Hwang ES, Marks JR, Bendall SC, Colditz GA, West RB, Angelo M
Cell 2022 Jan 20;185(2):299-310.e18. doi: 10.1016/j.cell.2021.12.023. PMID: 35063072Free PMC Article
Aebi S, Karlsson P, Wapnir IL
Breast 2022 Mar;62 Suppl 1(Suppl 1):S58-S62. Epub 2021 Dec 15 doi: 10.1016/j.breast.2021.12.011. PMID: 34930650Free PMC Article
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Lønning PE, Børresen-Dale AL
Proc Natl Acad Sci U S A 2001 Sep 11;98(19):10869-74. doi: 10.1073/pnas.191367098. PMID: 11553815Free PMC Article

Diagnosis

Asif B, Sarvestani AL, Gamble LA, Samaranayake SG, Famiglietti AL, Fasaye GA, Quezado M, Miettinen M, Korman L, Koh C, Heller T, Davis JL
Lancet Oncol 2023 Apr;24(4):383-391. doi: 10.1016/S1470-2045(23)00057-8. PMID: 36990610Free PMC Article
Sedloev T, Spirdonov J, Terziev I, Spiridonova T, Usheva S
Br J Hosp Med (Lond) 2022 Dec 2;83(12):1-3. Epub 2022 Dec 29 doi: 10.12968/hmed.2022.0440. PMID: 36594771
Thomas M, Kelly ED, Abraham J, Kruse M
Semin Oncol 2019 Apr;46(2):121-132. Epub 2019 Jun 17 doi: 10.1053/j.seminoncol.2019.03.002. PMID: 31239068
Loktev A, Lindner T, Mier W, Debus J, Altmann A, Jäger D, Giesel F, Kratochwil C, Barthe P, Roumestand C, Haberkorn U
J Nucl Med 2018 Sep;59(9):1423-1429. Epub 2018 Apr 6 doi: 10.2967/jnumed.118.210435. PMID: 29626120Free PMC Article
Bettegowda C, Sausen M, Leary RJ, Kinde I, Wang Y, Agrawal N, Bartlett BR, Wang H, Luber B, Alani RM, Antonarakis ES, Azad NS, Bardelli A, Brem H, Cameron JL, Lee CC, Fecher LA, Gallia GL, Gibbs P, Le D, Giuntoli RL, Goggins M, Hogarty MD, Holdhoff M, Hong SM, Jiao Y, Juhl HH, Kim JJ, Siravegna G, Laheru DA, Lauricella C, Lim M, Lipson EJ, Marie SK, Netto GJ, Oliner KS, Olivi A, Olsson L, Riggins GJ, Sartore-Bianchi A, Schmidt K, Shih lM, Oba-Shinjo SM, Siena S, Theodorescu D, Tie J, Harkins TT, Veronese S, Wang TL, Weingart JD, Wolfgang CL, Wood LD, Xing D, Hruban RH, Wu J, Allen PJ, Schmidt CM, Choti MA, Velculescu VE, Kinzler KW, Vogelstein B, Papadopoulos N, Diaz LA Jr
Sci Transl Med 2014 Feb 19;6(224):224ra24. doi: 10.1126/scitranslmed.3007094. PMID: 24553385Free PMC Article

Therapy

Deng J, Pan T, Wang D, Hong Y, Liu Z, Zhou X, An Z, Li L, Alfano G, Li G, Dolcetti L, Evans R, Vicencio JM, Vlckova P, Chen Y, Monypenny J, Gomes CAC, Weitsman G, Ng K, McCarthy C, Yang X, Hu Z, Porter JC, Tape CJ, Yin M, Wei F, Rodriguez-Justo M, Zhang J, Tejpar S, Beatson R, Ng T
EMBO Mol Med 2024 Sep;16(9):2080-2108. Epub 2024 Aug 5 doi: 10.1038/s44321-024-00105-2. PMID: 39103698Free PMC Article
Aebi S, Karlsson P, Wapnir IL
Breast 2022 Mar;62 Suppl 1(Suppl 1):S58-S62. Epub 2021 Dec 15 doi: 10.1016/j.breast.2021.12.011. PMID: 34930650Free PMC Article
Deeks ED
Drugs 2021 Nov;81(16):1929-1935. doi: 10.1007/s40265-021-01614-x. PMID: 34661865
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Newman LA, Kuerer HM
J Clin Oncol 2005 Mar 10;23(8):1685-97. doi: 10.1200/JCO.2005.09.046. PMID: 15755977

Prognosis

Deng J, Pan T, Wang D, Hong Y, Liu Z, Zhou X, An Z, Li L, Alfano G, Li G, Dolcetti L, Evans R, Vicencio JM, Vlckova P, Chen Y, Monypenny J, Gomes CAC, Weitsman G, Ng K, McCarthy C, Yang X, Hu Z, Porter JC, Tape CJ, Yin M, Wei F, Rodriguez-Justo M, Zhang J, Tejpar S, Beatson R, Ng T
EMBO Mol Med 2024 Sep;16(9):2080-2108. Epub 2024 Aug 5 doi: 10.1038/s44321-024-00105-2. PMID: 39103698Free PMC Article
Loktev A, Lindner T, Mier W, Debus J, Altmann A, Jäger D, Giesel F, Kratochwil C, Barthe P, Roumestand C, Haberkorn U
J Nucl Med 2018 Sep;59(9):1423-1429. Epub 2018 Apr 6 doi: 10.2967/jnumed.118.210435. PMID: 29626120Free PMC Article
McCARTAN D, Gemignani ML
Clin Obstet Gynecol 2016 Dec;59(4):743-755. doi: 10.1097/GRF.0000000000000232. PMID: 27660930Free PMC Article
Noda M, Takahashi C
Cancer Sci 2007 Nov;98(11):1659-65. Epub 2007 Aug 28 doi: 10.1111/j.1349-7006.2007.00588.x. PMID: 17725805Free PMC Article
Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, Thorsen T, Quist H, Matese JC, Brown PO, Botstein D, Lønning PE, Børresen-Dale AL
Proc Natl Acad Sci U S A 2001 Sep 11;98(19):10869-74. doi: 10.1073/pnas.191367098. PMID: 11553815Free PMC Article

Clinical prediction guides

Deng J, Pan T, Wang D, Hong Y, Liu Z, Zhou X, An Z, Li L, Alfano G, Li G, Dolcetti L, Evans R, Vicencio JM, Vlckova P, Chen Y, Monypenny J, Gomes CAC, Weitsman G, Ng K, McCarthy C, Yang X, Hu Z, Porter JC, Tape CJ, Yin M, Wei F, Rodriguez-Justo M, Zhang J, Tejpar S, Beatson R, Ng T
EMBO Mol Med 2024 Sep;16(9):2080-2108. Epub 2024 Aug 5 doi: 10.1038/s44321-024-00105-2. PMID: 39103698Free PMC Article
Ten Haaft BH, Pedregal M, Prato J, Klümpen HJ, Moreno V, Lamarca A
Eur J Cancer 2024 Mar;199:113564. Epub 2024 Jan 20 doi: 10.1016/j.ejca.2024.113564. PMID: 38266541
Llinàs-Arias P, Ensenyat-Mendez M, Íñiguez-Muñoz S, Orozco JIJ, Valdez B, Salomon MP, Matsuba C, Solivellas-Pieras M, Bedoya-López AF, Sesé B, Mezger A, Ormestad M, Unzueta F, Strand SH, Boiko AD, Hwang ES, Cortés J, DiNome ML, Esteller M, Lupien M, Marzese DM
Mol Cancer 2023 Nov 28;22(1):190. doi: 10.1186/s12943-023-01906-8. PMID: 38017545Free PMC Article
Sokol ES, Feng YX, Jin DX, Tizabi MD, Miller DH, Cohen MA, Sanduja S, Reinhardt F, Pandey J, Superville DA, Jaenisch R, Gupta PB
Proc Natl Acad Sci U S A 2017 Apr 18;114(16):4153-4158. Epub 2017 Apr 4 doi: 10.1073/pnas.1703931114. PMID: 28377514Free PMC Article
McCARTAN D, Gemignani ML
Clin Obstet Gynecol 2016 Dec;59(4):743-755. doi: 10.1097/GRF.0000000000000232. PMID: 27660930Free PMC Article

Recent systematic reviews

Jing R, Wu N, Wu Y, Zhang Q, Liang Q, Huang P, Yi S
J Clin Endocrinol Metab 2024 Sep 16;109(10):2658-2672. doi: 10.1210/clinem/dgae454. PMID: 38970485
Blanckaert M, Vranckx J
Acta Chir Belg 2021 Jun;121(3):155-163. Epub 2021 May 5 doi: 10.1080/00015458.2021.1922829. PMID: 33929924
Choi B, Jegatheeswaran L, Nakhoul M, Haria P, Srivastava R, Karki S, Lupi M, Patel V, Chakravorty A, Babu E
Surg Oncol 2021 Jun;37:101557. Epub 2021 Mar 31 doi: 10.1016/j.suronc.2021.101557. PMID: 33819852
Rebelatto TF, Falavigna M, Pozzari M, Spada F, Cella CA, Laffi A, Pellicori S, Fazio N
Cancer Treat Rev 2019 Nov;80:101895. Epub 2019 Sep 6 doi: 10.1016/j.ctrv.2019.101895. PMID: 31542591
Stuart KE, Houssami N, Taylor R, Hayen A, Boyages J
BMC Cancer 2015 Nov 10;15:890. doi: 10.1186/s12885-015-1904-7. PMID: 26555555Free PMC Article

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