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Increased HDL3b concentration

MedGen UID:
1705857
•Concept ID:
C5139342
•
Finding
HPO: HP:0032430

Definition

An elevation above the normal concentration of the HDL3b subfraction in the blood circulation. An HDL3b particle is defined as an HDL particle with a size of 7.8-8.19 nm. [from HPO]

Professional guidelines

PubMed

Plasma high density lipoprotein particle size alteration by simvastatin treatment in patients with hypercholesterolaemia.
Johansson J, Mölgaard J, Olsson AG
Atherosclerosis 1991 Dec;91(3):175-84. doi: 10.1016/0021-9150(91)90165-y. PMID: 1789802
The effects of nicotinic acid treatment on high density lipoprotein particle size subclass levels in hyperlipidaemic subjects.
Johansson J, Carlson LA
Atherosclerosis 1990 Aug;83(2-3):207-16. doi: 10.1016/0021-9150(90)90166-g. PMID: 2242098

Recent clinical studies

Etiology

HDL particle size is a critical determinant of ABCA1-mediated macrophage cellular cholesterol export.
Du XM, Kim MJ, Hou L, Le Goff W, Chapman MJ, Van Eck M, Curtiss LK, Burnett JR, Cartland SP, Quinn CM, Kockx M, Kontush A, Rye KA, Kritharides L, Jessup W
Circ Res 2015 Mar 27;116(7):1133-42. Epub 2015 Jan 14 doi: 10.1161/CIRCRESAHA.116.305485. PMID: 25589556
Shift of high-density lipoprotein size distribution toward large particles in patients with proteinuria.
Soto-Miranda E, Carreón-Torres E, Lorenzo K, Bazán-Salinas B, García-Sánchez C, Franco M, Posadas-Romero C, Fragoso JM, López-Olmos V, Madero M, Rodriguez-Pérez JM, Vargas-Alarcón G, Pérez-Méndez O
Clin Chim Acta 2012 Dec 24;414:241-5. Epub 2012 Oct 2 doi: 10.1016/j.cca.2012.09.028. PMID: 23041214
Relationship between apolipoprotein C-III concentrations and high-density lipoprotein subclass distribution.
Tian L, Wu J, Fu M, Xu Y, Jia L
Metabolism 2009 May;58(5):668-74. doi: 10.1016/j.metabol.2009.01.007. PMID: 19375590
Effects of weight-loss by exercise and by diet on apolipoproteins A-I and A-II and the particle-size distribution of high-density lipoproteins in men.
Williams PT, Krauss RM, Vranizan KM, Albers JJ, Wood PD
Metabolism 1992 Apr;41(4):441-9. doi: 10.1016/0026-0495(92)90082-l. PMID: 1556953Free PMC Article
Effect of total parenteral nutrition with intravenous fat on lipids and high density lipoprotein heterogeneity in neonates.
Forte TM, Genzel-Boroviczeny O, Austin MA, Kao LC, Scott C, Albers JJ, D'Harlingue AE
JPEN J Parenter Enteral Nutr 1989 Sep-Oct;13(5):490-500. doi: 10.1177/0148607189013005490. PMID: 2514290

Diagnosis

The Correlation between Blood HbA1c and HDL Subclasses in Patients with Metabolic Syndrome.
Xiao L, Tian Y, Wu J, Li N, Zhang C, Chen W, Long S
Clin Lab 2020 Sep 1;66(9) doi: 10.7754/Clin.Lab.2020.191247. PMID: 32902228
The relationship between high density lipoprotein subclass profile and apolipoprotein concentrations.
Tian L, Fu M
J Endocrinol Invest 2011 Jun;34(6):461-72. doi: 10.1007/BF03346714. PMID: 21747218
The inherent accuracy of 1H NMR spectroscopy to quantify plasma lipoproteins is subclass dependent.
Ala-Korpela M, Lankinen N, Salminen A, Suna T, Soininen P, Laatikainen R, Ingman P, Jauhiainen M, Taskinen MR, Héberger K, Kaski K
Atherosclerosis 2007 Feb;190(2):352-8. Epub 2006 May 30 doi: 10.1016/j.atherosclerosis.2006.04.020. PMID: 16730730

Therapy

Changes of HDL subfractions by eicosapentaenoic acid intake and physical load in 20- to 25-year-old men.
Sakamoto N, Yoshimoto S, Nishiike T, Iguchi H, Sakamoto K
Ann Nutr Metab 2000;44(3):115-20. doi: 10.1159/000012832. PMID: 11053897
Effects of low-fat diet, calorie restriction, and running on lipoprotein subfraction concentrations in moderately overweight men.
Williams PT, Krauss RM, Stefanick ML, Vranizan KM, Wood PD
Metabolism 1994 May;43(5):655-63. doi: 10.1016/0026-0495(94)90210-0. PMID: 8177056Free PMC Article
Effects of weight-loss by exercise and by diet on apolipoproteins A-I and A-II and the particle-size distribution of high-density lipoproteins in men.
Williams PT, Krauss RM, Vranizan KM, Albers JJ, Wood PD
Metabolism 1992 Apr;41(4):441-9. doi: 10.1016/0026-0495(92)90082-l. PMID: 1556953Free PMC Article
Plasma high density lipoprotein particle size alteration by simvastatin treatment in patients with hypercholesterolaemia.
Johansson J, Mölgaard J, Olsson AG
Atherosclerosis 1991 Dec;91(3):175-84. doi: 10.1016/0021-9150(91)90165-y. PMID: 1789802
Changes in the distribution and composition of high-density lipoproteins in primary hypothyroidism.
Muls E, Rosseneu M, Lamberigts G, De Moor P
Metabolism 1985 Apr;34(4):345-53. doi: 10.1016/0026-0495(85)90224-0. PMID: 3920475

Prognosis

Relations between particle size of HDL and LDL lipoproteins and cholesterol esterification rate.
Dobiásová M, Urbanová Z, Samánek M
Physiol Res 2005;54(2):159-65. PMID: 15544423

Clinical prediction guides

Shift of high-density lipoprotein size distribution toward large particles in patients with proteinuria.
Soto-Miranda E, Carreón-Torres E, Lorenzo K, Bazán-Salinas B, García-Sánchez C, Franco M, Posadas-Romero C, Fragoso JM, López-Olmos V, Madero M, Rodriguez-Pérez JM, Vargas-Alarcón G, Pérez-Méndez O
Clin Chim Acta 2012 Dec 24;414:241-5. Epub 2012 Oct 2 doi: 10.1016/j.cca.2012.09.028. PMID: 23041214
The relationship between high density lipoprotein subclass profile and apolipoprotein concentrations.
Tian L, Fu M
J Endocrinol Invest 2011 Jun;34(6):461-72. doi: 10.1007/BF03346714. PMID: 21747218
Influence of apolipoproteinCII concentrations on HDL subclass distribution.
Tian L, Xu Y, Fu M, Jia L, Yang Y
J Atheroscler Thromb 2009 Oct;16(5):611-20. Epub 2009 Sep 3 doi: 10.5551/jat.1156. PMID: 19729871
Relations between particle size of HDL and LDL lipoproteins and cholesterol esterification rate.
Dobiásová M, Urbanová Z, Samánek M
Physiol Res 2005;54(2):159-65. PMID: 15544423
High-density lipoprotein subclasses and esterification rate of cholesterol in children: effect of gender and age.
Dobiásová M, Urbanová Z, Rauchová H, Samánek M, Frohlich JJ
Acta Paediatr 1998 Sep;87(9):918-23. doi: 10.1080/080352598750031545. PMID: 9764883

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