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Refractory Clear Cell Renal Cell Carcinoma

MedGen UID:
1715804
•Concept ID:
C5236081
•
Neoplastic Process

Definition

Clear cell renal cell carcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Clear Cell Renal Cell Carcinoma

Professional guidelines

PubMed

Research Progress on Mechanism and Management of Adverse Drug Reactions of Anlotinib.
Li S, Wang H
Drug Des Devel Ther 2023;17:3429-3437. Epub 2023 Nov 15 doi: 10.2147/DDDT.S426898. PMID: 38024530Free PMC Article
Antibody-Based Therapeutics for the Treatment of Renal Cell Carcinoma: Challenges and Opportunities.
Mahmoud AM, Nabavizadeh R, Rodrigues Pessoa R, Garg I, Orme J, Costello BA, Cheville J, Lucien F
Oncologist 2023 Apr 6;28(4):297-308. doi: 10.1093/oncolo/oyac263. PMID: 36745503Free PMC Article
Lenvatinib dose, efficacy, and safety in the treatment of multiple malignancies.
Motzer RJ, Taylor MH, Evans TRJ, Okusaka T, Glen H, Lubiniecki GM, Dutcus C, Smith AD, Okpara CE, Hussein Z, Hayato S, Tamai T, Makker V
Expert Rev Anticancer Ther 2022 Apr;22(4):383-400. Epub 2022 Apr 7 doi: 10.1080/14737140.2022.2039123. PMID: 35260027Free PMC Article

Recent clinical studies

Etiology

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.
Zou Y, Palte MJ, Deik AA, Li H, Eaton JK, Wang W, Tseng YY, Deasy R, Kost-Alimova M, Dančík V, Leshchiner ES, Viswanathan VS, Signoretti S, Choueiri TK, Boehm JS, Wagner BK, Doench JG, Clish CB, Clemons PA, Schreiber SL
Nat Commun 2019 Apr 8;10(1):1617. doi: 10.1038/s41467-019-09277-9. PMID: 30962421Free PMC Article
Everolimus.
Hasskarl J
Recent Results Cancer Res 2018;211:101-123. doi: 10.1007/978-3-319-91442-8_8. PMID: 30069763
Renal cell carcinoma.
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article
Temsirolimus.
Schulze M, Stock C, Zaccagnini M, Teber D, Rassweiler JJ
Recent Results Cancer Res 2014;201:393-403. doi: 10.1007/978-3-642-54490-3_24. PMID: 24756806
Everolimus.
Houghton PJ
Clin Cancer Res 2010 Mar 1;16(5):1368-72. Epub 2010 Feb 23 doi: 10.1158/1078-0432.CCR-09-1314. PMID: 20179227Free PMC Article

Diagnosis

Tazemetostat for tumors harboring SMARCB1/SMARCA4 or EZH2 alterations: results from NCI-COG pediatric MATCH APEC1621C.
Chi SN, Yi JS, Williams PM, Roy-Chowdhuri S, Patton DR, Coffey BD, Reid JM, Piao J, Saguilig L, Alonzo TA, Berg SL, Ramirez NC, Jaju A, Mhlanga JC, Fox E, Hawkins DS, Mooney MM, Takebe N, Tricoli JV, Janeway KA, Seibel NL, Parsons DW
J Natl Cancer Inst 2023 Nov 8;115(11):1355-1363. doi: 10.1093/jnci/djad085. PMID: 37228094Free PMC Article
A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis.
Zou Y, Palte MJ, Deik AA, Li H, Eaton JK, Wang W, Tseng YY, Deasy R, Kost-Alimova M, Dančík V, Leshchiner ES, Viswanathan VS, Signoretti S, Choueiri TK, Boehm JS, Wagner BK, Doench JG, Clish CB, Clemons PA, Schreiber SL
Nat Commun 2019 Apr 8;10(1):1617. doi: 10.1038/s41467-019-09277-9. PMID: 30962421Free PMC Article
Renal cell carcinoma.
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article
Renal cell carcinoma in pregnancy: a rare coexistence.
Boussios S, Pavlidis N
Clin Transl Oncol 2014 Feb;16(2):122-7. Epub 2013 Sep 4 doi: 10.1007/s12094-013-1105-2. PMID: 24002946
Everolimus.
Houghton PJ
Clin Cancer Res 2010 Mar 1;16(5):1368-72. Epub 2010 Feb 23 doi: 10.1158/1078-0432.CCR-09-1314. PMID: 20179227Free PMC Article

Therapy

CD70-Targeted Allogeneic CAR T-Cell Therapy for Advanced Clear Cell Renal Cell Carcinoma.
Pal SK, Tran B, Haanen JBAG, Hurwitz ME, Sacher A, Tannir NM, Budde LE, Harrison SJ, Klobuch S, Patel SS, Meza L, Dequeant ML, Ma A, He QA, Williams LM, Keegan A, Gurary EB, Dar H, Karnik S, Guo C, Heath H, Yuen RR, Morrow PK, Agarwal N, Srour SA
Cancer Discov 2024 Jul 1;14(7):1176-1189. doi: 10.1158/2159-8290.CD-24-0102. PMID: 38583184Free PMC Article
Lenvatinib dose, efficacy, and safety in the treatment of multiple malignancies.
Motzer RJ, Taylor MH, Evans TRJ, Okusaka T, Glen H, Lubiniecki GM, Dutcus C, Smith AD, Okpara CE, Hussein Z, Hayato S, Tamai T, Makker V
Expert Rev Anticancer Ther 2022 Apr;22(4):383-400. Epub 2022 Apr 7 doi: 10.1080/14737140.2022.2039123. PMID: 35260027Free PMC Article
CAR-T cells, from principle to clinical applications.
Bourbon E, Ghesquières H, Bachy E
Bull Cancer 2021 Oct;108(10S):S4-S17. doi: 10.1016/j.bulcan.2021.02.017. PMID: 34920806
Renal cell carcinoma.
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article
Temsirolimus.
Schulze M, Stock C, Zaccagnini M, Teber D, Rassweiler JJ
Recent Results Cancer Res 2014;201:393-403. doi: 10.1007/978-3-642-54490-3_24. PMID: 24756806

Prognosis

Renal cell carcinoma.
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article
TroVax in colorectal cancer.
Rowe J, Cen P
Hum Vaccin Immunother 2014;10(11):3196-200. doi: 10.4161/21645515.2014.973323. PMID: 25483641Free PMC Article
Temsirolimus.
Schulze M, Stock C, Zaccagnini M, Teber D, Rassweiler JJ
Recent Results Cancer Res 2014;201:393-403. doi: 10.1007/978-3-642-54490-3_24. PMID: 24756806
Renal cell carcinoma in pregnancy: a rare coexistence.
Boussios S, Pavlidis N
Clin Transl Oncol 2014 Feb;16(2):122-7. Epub 2013 Sep 4 doi: 10.1007/s12094-013-1105-2. PMID: 24002946
Everolimus.
Houghton PJ
Clin Cancer Res 2010 Mar 1;16(5):1368-72. Epub 2010 Feb 23 doi: 10.1158/1078-0432.CCR-09-1314. PMID: 20179227Free PMC Article

Clinical prediction guides

Tazemetostat for tumors harboring SMARCB1/SMARCA4 or EZH2 alterations: results from NCI-COG pediatric MATCH APEC1621C.
Chi SN, Yi JS, Williams PM, Roy-Chowdhuri S, Patton DR, Coffey BD, Reid JM, Piao J, Saguilig L, Alonzo TA, Berg SL, Ramirez NC, Jaju A, Mhlanga JC, Fox E, Hawkins DS, Mooney MM, Takebe N, Tricoli JV, Janeway KA, Seibel NL, Parsons DW
J Natl Cancer Inst 2023 Nov 8;115(11):1355-1363. doi: 10.1093/jnci/djad085. PMID: 37228094Free PMC Article
Renal cell carcinoma.
Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M, Heng DY, Larkin J, Ficarra V
Nat Rev Dis Primers 2017 Mar 9;3:17009. doi: 10.1038/nrdp.2017.9. PMID: 28276433Free PMC Article
Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates.
Brahmer JR, Drake CG, Wollner I, Powderly JD, Picus J, Sharfman WH, Stankevich E, Pons A, Salay TM, McMiller TL, Gilson MM, Wang C, Selby M, Taube JM, Anders R, Chen L, Korman AJ, Pardoll DM, Lowy I, Topalian SL
J Clin Oncol 2010 Jul 1;28(19):3167-75. Epub 2010 Jun 1 doi: 10.1200/JCO.2009.26.7609. PMID: 20516446Free PMC Article
Everolimus.
Houghton PJ
Clin Cancer Res 2010 Mar 1;16(5):1368-72. Epub 2010 Feb 23 doi: 10.1158/1078-0432.CCR-09-1314. PMID: 20179227Free PMC Article
Sorafenib.
Rini BI
Expert Opin Pharmacother 2006 Mar;7(4):453-61. doi: 10.1517/14656566.7.4.453. PMID: 16503817

Recent systematic reviews

The integration of immune checkpoint inhibitors with VEGF targeted agents in advanced gastric and gastroesophageal adenocarcinoma: a review on the rationale and results of early phase trials.
Saeed A, Park R, Sun W
J Hematol Oncol 2021 Jan 12;14(1):13. doi: 10.1186/s13045-021-01034-0. PMID: 33436042Free PMC Article
Position of cytoreductive nephrectomy in the setting of metastatic renal cell carcinoma patients: does the CARMENA trial lead to a paradigm shift?
Dariane C, Timsit MO, Méjean A
Bull Cancer 2018 Dec;105 Suppl 3:S229-S234. doi: 10.1016/S0007-4551(18)30377-1. PMID: 30595151
Small molecule targeted therapies for the second-line treatment for metastatic renal cell carcinoma: a systematic review and indirect comparison of safety and efficacy.
Dranitsaris G, Schmitz S, Broom RJ
J Cancer Res Clin Oncol 2013 Nov;139(11):1917-26. Epub 2013 Sep 14 doi: 10.1007/s00432-013-1510-5. PMID: 24037486
Chemotherapy in metastatic renal cell carcinoma today? A systematic review.
Buti S, Bersanelli M, Sikokis A, Maines F, Facchinetti F, Bria E, Ardizzoni A, Tortora G, Massari F
Anticancer Drugs 2013 Jul;24(6):535-54. doi: 10.1097/CAD.0b013e3283609ec1. PMID: 23552469
Will targeted therapy hold its promise? An evidence-based review.
Murdoch D, Sager J
Curr Opin Oncol 2008 Jan;20(1):104-11. doi: 10.1097/CCO.0b013e3282f44b12. PMID: 18043264

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