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Steroid Resistant Gastrointestinal Tract Acute Graft Versus Host Disease

MedGen UID:
1716865
•Concept ID:
C5238929
•
Disease or Syndrome
Synonym: Steroid Refractory Gastrointestinal Tract Acute Graft Versus Host Disease

Definition

Acute graft versus host disease occurring in the gastrointestinal tract that is resistant to treatment with steroids. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSteroid Resistant Gastrointestinal Tract Acute Graft Versus Host Disease

Professional guidelines

PubMed

Prophylaxis and management of graft versus host disease after stem-cell transplantation for haematological malignancies: updated consensus recommendations of the European Society for Blood and Marrow Transplantation.
Penack O, Marchetti M, Ruutu T, Aljurf M, Bacigalupo A, Bonifazi F, Ciceri F, Cornelissen J, Malladi R, Duarte RF, Giebel S, Greinix H, Holler E, Lawitschka A, Mielke S, Mohty M, Arat M, Nagler A, Passweg J, Schoemans H, Socié G, Solano C, Vrhovac R, Zeiser R, Kröger N, Basak GW
Lancet Haematol 2020 Feb;7(2):e157-e167. doi: 10.1016/S2352-3026(19)30256-X. PMID: 32004485
Intra-arterial methylprednisolone for the management of steroid-refractory acute gastrointestinal and hepatic graft versus host disease.
Milner LA, Becker MW, Bernstein SH, Bruckner L, Friedberg JW, Holland GA, Ifthikharuddin JJ, Liesveld JL, Mathes EJ, Menchel HL, Mullen CA, Sasson T, Phillips GL 2nd
Am J Hematol 2011 Aug;86(8):712-4. Epub 2011 May 31 doi: 10.1002/ajh.22075. PMID: 21630317
Acute graft-vs-host disease: pathobiology and management.
Goker H, Haznedaroglu IC, Chao NJ
Exp Hematol 2001 Mar;29(3):259-77. doi: 10.1016/s0301-472x(00)00677-9. PMID: 11274753

Recent clinical studies

Etiology

Vedolizumab plus basiliximab as second-line therapy for steroid-refractory lower gastrointestinal acute graft-versus-host disease.
Gao Z, Fan Z, Liu Z, Ye X, Zeng Y, Xuan L, Huang F, Lin R, Sun J, Liu Q, Xu N
Front Immunol 2024;15:1408211. Epub 2024 Jul 3 doi: 10.3389/fimmu.2024.1408211. PMID: 39021571Free PMC Article
Fecal microbiota transplantation in capsules for the treatment of steroid refractory and steroid dependent acute graft vs. host disease: a pilot study.
Youngster I, Eshel A, Geva M, Danylesko I, Henig I, Zuckerman T, Fried S, Yerushalmi R, Shem-Tov N, Fein JA, Bomze D, Shimoni A, Koren O, Shouval R, Nagler A
Bone Marrow Transplant 2024 Mar;59(3):409-416. Epub 2024 Jan 11 doi: 10.1038/s41409-024-02198-2. PMID: 38212672
Ileostomy for steroid-resistant acute graft-versus-host disease of the gastrointestinal tract.
Turki AT, Bayraktar E, Basu O, Benkö T, Yi JH, Kehrmann J, Tzalavras A, Liebregts T, Beelen DW, Steckel NK
Ann Hematol 2019 Oct;98(10):2407-2419. Epub 2019 Jul 23 doi: 10.1007/s00277-019-03754-3. PMID: 31338570Free PMC Article
Intra-arterial methylprednisolone for the management of steroid-refractory acute gastrointestinal and hepatic graft versus host disease.
Milner LA, Becker MW, Bernstein SH, Bruckner L, Friedberg JW, Holland GA, Ifthikharuddin JJ, Liesveld JL, Mathes EJ, Menchel HL, Mullen CA, Sasson T, Phillips GL 2nd
Am J Hematol 2011 Aug;86(8):712-4. Epub 2011 May 31 doi: 10.1002/ajh.22075. PMID: 21630317
Acute graft-vs-host disease: pathobiology and management.
Goker H, Haznedaroglu IC, Chao NJ
Exp Hematol 2001 Mar;29(3):259-77. doi: 10.1016/s0301-472x(00)00677-9. PMID: 11274753

Diagnosis

Vedolizumab plus basiliximab as second-line therapy for steroid-refractory lower gastrointestinal acute graft-versus-host disease.
Gao Z, Fan Z, Liu Z, Ye X, Zeng Y, Xuan L, Huang F, Lin R, Sun J, Liu Q, Xu N
Front Immunol 2024;15:1408211. Epub 2024 Jul 3 doi: 10.3389/fimmu.2024.1408211. PMID: 39021571Free PMC Article
Spatial transcriptomics reveals distinct tissue niches linked with steroid responsiveness in acute gastrointestinal GVHD.
Patel BK, Raabe MJ, Lang ER, Song Y, Lu C, Deshpande V, Nieman LT, Aryee MJ, Chen YB, Ting DT, DeFilipp Z
Blood 2023 Nov 23;142(21):1831-1844. doi: 10.1182/blood.2023020644. PMID: 37699201Free PMC Article
Crypt loss is a marker of clinical severity of acute gastrointestinal graft-versus-host disease.
Melson J, Jakate S, Fung H, Arai S, Keshavarzian A
Am J Hematol 2007 Oct;82(10):881-6. doi: 10.1002/ajh.20976. PMID: 17570511

Therapy

Spatial transcriptomics reveals distinct tissue niches linked with steroid responsiveness in acute gastrointestinal GVHD.
Patel BK, Raabe MJ, Lang ER, Song Y, Lu C, Deshpande V, Nieman LT, Aryee MJ, Chen YB, Ting DT, DeFilipp Z
Blood 2023 Nov 23;142(21):1831-1844. doi: 10.1182/blood.2023020644. PMID: 37699201Free PMC Article
Glucagon-like peptide 2 for intestinal stem cell and Paneth cell repair during graft-versus-host disease in mice and humans.
Norona J, Apostolova P, Schmidt D, Ihlemann R, Reischmann N, Taylor G, Köhler N, de Heer J, Heeg S, Andrieux G, Siranosian BA, Schmitt-Graeff A, Pfeifer D, Catalano A, Frew IJ, Proietti M, Grimbacher B, Bulashevska A, Bhatt AS, Brummer T, Clauditz T, Zabelina T, Kroeger N, Blazar BR, Boerries M, Ayuk F, Zeiser R
Blood 2020 Sep 17;136(12):1442-1455. doi: 10.1182/blood.2020005957. PMID: 32542357Free PMC Article
Ruxolitinib for the treatment of steroid-refractory acute GVHD (REACH1): a multicenter, open-label phase 2 trial.
Jagasia M, Perales MA, Schroeder MA, Ali H, Shah NN, Chen YB, Fazal S, Dawkins FW, Arbushites MC, Tian C, Connelly-Smith L, Howell MD, Khoury HJ
Blood 2020 May 14;135(20):1739-1749. doi: 10.1182/blood.2020004823. PMID: 32160294Free PMC Article
Prophylaxis and management of graft versus host disease after stem-cell transplantation for haematological malignancies: updated consensus recommendations of the European Society for Blood and Marrow Transplantation.
Penack O, Marchetti M, Ruutu T, Aljurf M, Bacigalupo A, Bonifazi F, Ciceri F, Cornelissen J, Malladi R, Duarte RF, Giebel S, Greinix H, Holler E, Lawitschka A, Mielke S, Mohty M, Arat M, Nagler A, Passweg J, Schoemans H, Socié G, Solano C, Vrhovac R, Zeiser R, Kröger N, Basak GW
Lancet Haematol 2020 Feb;7(2):e157-e167. doi: 10.1016/S2352-3026(19)30256-X. PMID: 32004485
Intra-arterial methylprednisolone for the management of steroid-refractory acute gastrointestinal and hepatic graft versus host disease.
Milner LA, Becker MW, Bernstein SH, Bruckner L, Friedberg JW, Holland GA, Ifthikharuddin JJ, Liesveld JL, Mathes EJ, Menchel HL, Mullen CA, Sasson T, Phillips GL 2nd
Am J Hematol 2011 Aug;86(8):712-4. Epub 2011 May 31 doi: 10.1002/ajh.22075. PMID: 21630317

Prognosis

Spatial transcriptomics reveals distinct tissue niches linked with steroid responsiveness in acute gastrointestinal GVHD.
Patel BK, Raabe MJ, Lang ER, Song Y, Lu C, Deshpande V, Nieman LT, Aryee MJ, Chen YB, Ting DT, DeFilipp Z
Blood 2023 Nov 23;142(21):1831-1844. doi: 10.1182/blood.2023020644. PMID: 37699201Free PMC Article
Eosinophilic gastroenteritis and graft-versus-host disease induced by transmission of Norovirus with fecal microbiota transplant.
Bilinski J, Lis K, Tomaszewska A, Pechcinska A, Grzesiowski P, Dzieciatkowski T, Walesiak A, Gierej B, Ziarkiewicz-Wróblewska B, Tyszka M, Kacprzyk P, Chmielewska L, Waszczuk-Gajda A, Wiktor-Jedrzejczak W, Basak GW
Transpl Infect Dis 2021 Feb;23(1):e13386. Epub 2021 Feb 18 doi: 10.1111/tid.13386. PMID: 32574415
Ruxolitinib for the treatment of steroid-refractory acute GVHD (REACH1): a multicenter, open-label phase 2 trial.
Jagasia M, Perales MA, Schroeder MA, Ali H, Shah NN, Chen YB, Fazal S, Dawkins FW, Arbushites MC, Tian C, Connelly-Smith L, Howell MD, Khoury HJ
Blood 2020 May 14;135(20):1739-1749. doi: 10.1182/blood.2020004823. PMID: 32160294Free PMC Article
Treating Steroid Refractory Intestinal Acute Graft-vs.-Host Disease With Fecal Microbiota Transplantation: A Pilot Study.
Qi X, Li X, Zhao Y, Wu X, Chen F, Ma X, Zhang F, Wu D
Front Immunol 2018;9:2195. Epub 2018 Sep 25 doi: 10.3389/fimmu.2018.02195. PMID: 30319644Free PMC Article
Graft-versus-host disease in allogeneic bone marrow transplantation: the role of monoclonal antibodies in prevention and treatment.
Hiscott A, McLellan DS
Br J Biomed Sci 2000;57(2):163-9. PMID: 10912294

Clinical prediction guides

Spatial transcriptomics reveals distinct tissue niches linked with steroid responsiveness in acute gastrointestinal GVHD.
Patel BK, Raabe MJ, Lang ER, Song Y, Lu C, Deshpande V, Nieman LT, Aryee MJ, Chen YB, Ting DT, DeFilipp Z
Blood 2023 Nov 23;142(21):1831-1844. doi: 10.1182/blood.2023020644. PMID: 37699201Free PMC Article
Glucagon-like peptide 2 for intestinal stem cell and Paneth cell repair during graft-versus-host disease in mice and humans.
Norona J, Apostolova P, Schmidt D, Ihlemann R, Reischmann N, Taylor G, Köhler N, de Heer J, Heeg S, Andrieux G, Siranosian BA, Schmitt-Graeff A, Pfeifer D, Catalano A, Frew IJ, Proietti M, Grimbacher B, Bulashevska A, Bhatt AS, Brummer T, Clauditz T, Zabelina T, Kroeger N, Blazar BR, Boerries M, Ayuk F, Zeiser R
Blood 2020 Sep 17;136(12):1442-1455. doi: 10.1182/blood.2020005957. PMID: 32542357Free PMC Article
Ruxolitinib for the treatment of steroid-refractory acute GVHD (REACH1): a multicenter, open-label phase 2 trial.
Jagasia M, Perales MA, Schroeder MA, Ali H, Shah NN, Chen YB, Fazal S, Dawkins FW, Arbushites MC, Tian C, Connelly-Smith L, Howell MD, Khoury HJ
Blood 2020 May 14;135(20):1739-1749. doi: 10.1182/blood.2020004823. PMID: 32160294Free PMC Article
Ileostomy for steroid-resistant acute graft-versus-host disease of the gastrointestinal tract.
Turki AT, Bayraktar E, Basu O, Benkö T, Yi JH, Kehrmann J, Tzalavras A, Liebregts T, Beelen DW, Steckel NK
Ann Hematol 2019 Oct;98(10):2407-2419. Epub 2019 Jul 23 doi: 10.1007/s00277-019-03754-3. PMID: 31338570Free PMC Article
Graft-versus-host disease in allogeneic bone marrow transplantation: the role of monoclonal antibodies in prevention and treatment.
Hiscott A, McLellan DS
Br J Biomed Sci 2000;57(2):163-9. PMID: 10912294

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