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Graft versus host disease(GVHD)

MedGen UID:
9082
•Concept ID:
C0018133
•
Disease or Syndrome
Synonyms: Graft vs Host Disease; GVHD; Late acute graft versus host disease
SNOMED CT: Graft versus host disease (234646005); GVHD - Graft-versus-host disease (234646005); Graft-versus-host disease (234646005)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
•Concept ID:
CN307044
•
Finding
Source: Orphanet
clinical entity without genetic inheritance.
See: This record
Not genetically inherited (Orphanet)
 
Monarch Initiative: MONDO:0013730
Orphanet: ORPHA39812

Definition

A rare disease that occurs after allogeneic hematopoietic stem cell transplant and is a reaction of donor immune cells against host tissues. Activated donor T cells damage host epithelial cells after an inflammatory cascade that begins with the preparative regimen. [from ORDO]

Professional guidelines

PubMed

Prophylaxis and management of graft-versus-host disease after stem-cell transplantation for haematological malignancies: updated consensus recommendations of the European Society for Blood and Marrow Transplantation.
Penack O, Marchetti M, Aljurf M, Arat M, Bonifazi F, Duarte RF, Giebel S, Greinix H, Hazenberg MD, Kröger N, Mielke S, Mohty M, Nagler A, Passweg J, Patriarca F, Ruutu T, Schoemans H, Solano C, Vrhovac R, Wolff D, Zeiser R, Sureda A, Peric Z
Lancet Haematol 2024 Feb;11(2):e147-e159. Epub 2024 Jan 3 doi: 10.1016/S2352-3026(23)00342-3. PMID: 38184001
Updates in chronic graft-versus-host disease management.
Malard F, Mohty M
Am J Hematol 2023 Oct;98(10):1637-1644. Epub 2023 Jul 22 doi: 10.1002/ajh.27040. PMID: 37483142
Prophylaxis and management of graft versus host disease after stem-cell transplantation for haematological malignancies: updated consensus recommendations of the European Society for Blood and Marrow Transplantation.
Penack O, Marchetti M, Ruutu T, Aljurf M, Bacigalupo A, Bonifazi F, Ciceri F, Cornelissen J, Malladi R, Duarte RF, Giebel S, Greinix H, Holler E, Lawitschka A, Mielke S, Mohty M, Arat M, Nagler A, Passweg J, Schoemans H, Socié G, Solano C, Vrhovac R, Zeiser R, Kröger N, Basak GW
Lancet Haematol 2020 Feb;7(2):e157-e167. doi: 10.1016/S2352-3026(19)30256-X. PMID: 32004485

Recent clinical studies

Etiology

Novel approaches to acute graft-versus-host disease prevention.
Watkins B, Qayed M
Hematology Am Soc Hematol Educ Program 2023 Dec 8;2023(1):155-163. doi: 10.1182/hematology.2023000426. PMID: 38066861Free PMC Article
New therapeutic targets and biomarkers for acute graft-versus-host disease (GVHD).
Choe H, Ferrara JLM
Expert Opin Ther Targets 2021 Sep;25(9):761-771. Epub 2021 Nov 1 doi: 10.1080/14728222.2021.1992383. PMID: 34669521Free PMC Article
Graft-versus-host disease risk after chimeric antigen receptor T-cell therapy: the diametric opposition of T cells.
Sanber K, Savani B, Jain T
Br J Haematol 2021 Dec;195(5):660-668. Epub 2021 May 25 doi: 10.1111/bjh.17544. PMID: 34036558
Current Concepts and Advances in Graft-Versus-Host Disease Immunology.
Hill GR, Betts BC, Tkachev V, Kean LS, Blazar BR
Annu Rev Immunol 2021 Apr 26;39:19-49. Epub 2021 Jan 11 doi: 10.1146/annurev-immunol-102119-073227. PMID: 33428454Free PMC Article
Acute Graft-Versus-Host Disease: A Brief Review.
Aladağ E, Kelkitli E, Göker H
Turk J Haematol 2020 Feb 20;37(1):1-4. Epub 2019 Sep 2 doi: 10.4274/tjh.galenos.2019.2019.0157. PMID: 31475512Free PMC Article

Diagnosis

Chronic graft-versus-host disease. Part I: Epidemiology, pathogenesis, and clinical manifestations.
Baumrin E, Loren AW, Falk SJ, Mays JW, Cowen EW
J Am Acad Dermatol 2024 Jan;90(1):1-16. Epub 2022 Dec 23 doi: 10.1016/j.jaad.2022.12.024. PMID: 36572065Free PMC Article
Ocular graft-versus-host disease (oGVHD): From A to Z.
Soleimani M, Mahdavi Sharif P, Cheraqpour K, Koganti R, Masoumi A, Baharnoori SM, Salabati M, Djalilian AR
Surv Ophthalmol 2023 Jul-Aug;68(4):697-712. Epub 2023 Mar 2 doi: 10.1016/j.survophthal.2023.02.006. PMID: 36870423Free PMC Article
Acute Graft-Versus-Host Disease: A Brief Review.
Aladağ E, Kelkitli E, Göker H
Turk J Haematol 2020 Feb 20;37(1):1-4. Epub 2019 Sep 2 doi: 10.4274/tjh.galenos.2019.2019.0157. PMID: 31475512Free PMC Article
Review of Graft-Versus-Host Disease.
Ramachandran V, Kolli SS, Strowd LC
Dermatol Clin 2019 Oct;37(4):569-582. Epub 2019 Jul 10 doi: 10.1016/j.det.2019.05.014. PMID: 31466596
Graft-versus-host disease.
Moreno DF, Cid J
Med Clin (Barc) 2019 Jan 4;152(1):22-28. Epub 2018 Oct 9 doi: 10.1016/j.medcli.2018.07.012. PMID: 30309668

Therapy

Graft-versus-host disease prophylaxis: Pathophysiology-based review on current approaches and future directions.
Martinez-Cibrian N, Zeiser R, Perez-Simon JA
Blood Rev 2021 Jul;48:100792. Epub 2020 Dec 26 doi: 10.1016/j.blre.2020.100792. PMID: 33386151
Stem Cell Therapies in Clinical Trials: Progress and Challenges.
Trounson A, McDonald C
Cell Stem Cell 2015 Jul 2;17(1):11-22. doi: 10.1016/j.stem.2015.06.007. PMID: 26140604
National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: I. The 2014 Diagnosis and Staging Working Group report.
Jagasia MH, Greinix HT, Arora M, Williams KM, Wolff D, Cowen EW, Palmer J, Weisdorf D, Treister NS, Cheng GS, Kerr H, Stratton P, Duarte RF, McDonald GB, Inamoto Y, Vigorito A, Arai S, Datiles MB, Jacobsohn D, Heller T, Kitko CL, Mitchell SA, Martin PJ, Shulman H, Wu RS, Cutler CS, Vogelsang GB, Lee SJ, Pavletic SZ, Flowers ME
Biol Blood Marrow Transplant 2015 Mar;21(3):389-401.e1. Epub 2014 Dec 18 doi: 10.1016/j.bbmt.2014.12.001. PMID: 25529383Free PMC Article
Inolimomab (OPi).
Winkler M
Curr Opin Investig Drugs 2002 Oct;3(10):1464-7. PMID: 12431019
Graft-versus-host disease.
Gale RP
Immunol Rev 1985 Dec;88:193-214. doi: 10.1111/j.1600-065x.1985.tb01159.x. PMID: 3910557

Prognosis

Posttransplant cyclophosphamide is associated with increased cytomegalovirus infection: a CIBMTR analysis.
Goldsmith SR, Abid MB, Auletta JJ, Bashey A, Beitinjaneh A, Castillo P, Chemaly RF, Chen M, Ciurea S, Dandoy CE, Díaz MÁ, Fuchs E, Ganguly S, Kanakry CG, Kanakry JA, Kim S, Komanduri KV, Krem MM, Lazarus HM, Liu H, Ljungman P, Masiarz R, Mulroney C, Nathan S, Nishihori T, Page KM, Perales MA, Taplitz R, Romee R, Riches M
Blood 2021 Jun 10;137(23):3291-3305. doi: 10.1182/blood.2020009362. PMID: 33657221Free PMC Article
Late Events after Treatment with CD19-Targeted Chimeric Antigen Receptor Modified T Cells.
Cordeiro A, Bezerra ED, Hirayama AV, Hill JA, Wu QV, Voutsinas J, Sorror ML, Turtle CJ, Maloney DG, Bar M
Biol Blood Marrow Transplant 2020 Jan;26(1):26-33. Epub 2019 Aug 13 doi: 10.1016/j.bbmt.2019.08.003. PMID: 31419568Free PMC Article
Hosting an Unruly Guest: The Impact of Late Acute and Chronic Graft-versus-Host Disease.
Byrne M, Savani BN
Biol Blood Marrow Transplant 2016 May;22(5):779-80. Epub 2016 Feb 20 doi: 10.1016/j.bbmt.2016.02.014. PMID: 26903379
Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multicenter survey.
Zeiser R, Burchert A, Lengerke C, Verbeek M, Maas-Bauer K, Metzelder SK, Spoerl S, Ditschkowski M, Ecsedi M, Sockel K, Ayuk F, Ajib S, de Fontbrune FS, Na IK, Penter L, Holtick U, Wolf D, Schuler E, Meyer E, Apostolova P, Bertz H, Marks R, Lübbert M, Wäsch R, Scheid C, Stölzel F, Ordemann R, Bug G, Kobbe G, Negrin R, Brune M, Spyridonidis A, Schmitt-Gräff A, van der Velden W, Huls G, Mielke S, Grigoleit GU, Kuball J, Flynn R, Ihorst G, Du J, Blazar BR, Arnold R, Kröger N, Passweg J, Halter J, Socié G, Beelen D, Peschel C, Neubauer A, Finke J, Duyster J, von Bubnoff N
Leukemia 2015 Oct;29(10):2062-8. Epub 2015 Jul 31 doi: 10.1038/leu.2015.212. PMID: 26228813Free PMC Article
How we treat chronic graft-versus-host disease.
Flowers ME, Martin PJ
Blood 2015 Jan 22;125(4):606-15. Epub 2014 Nov 14 doi: 10.1182/blood-2014-08-551994. PMID: 25398933Free PMC Article

Clinical prediction guides

Clinical response to belumosudil in bronchiolitis obliterans syndrome: a combined analysis from 2 prospective trials.
DeFilipp Z, Kim HT, Yang Z, Noonan J, Blazar BR, Lee SJ, Pavletic SZ, Cutler C
Blood Adv 2022 Dec 27;6(24):6263-6270. doi: 10.1182/bloodadvances.2022008095. PMID: 36083121Free PMC Article
Graft versus host disease-related eosinophilic fasciitis: cohort description and literature review.
Hidalgo Calleja C, Martín Hidalgo D, Román Curto C, Vázquez López L, Pérez López E, Cabrero Calvo M, Martín López AÁ, Caballero Barrigón MD, Lopez-Corral L
Adv Rheumatol 2022 Aug 23;62(1):33. doi: 10.1186/s42358-022-00262-3. PMID: 35999577
Minnesota acute graft-versus-host disease risk score predicts survival at onset of graft-versus-host disease after post-transplant cyclophosphamide prophylaxis.
Ardizzoia F, Lorentino F, Bruno A, Marktel S, Giglio F, Clerici D, Farina F, Mastaglio S, Piemontese S, Assanelli AA, Carrabba MG, Bernardi M, Corti C, Peccatori J, Ciceri F, Greco R, Lupo-Stanghellini MT
Haematologica 2022 Nov 1;107(11):2748-2751. doi: 10.3324/haematol.2022.281269. PMID: 35899390Free PMC Article
Histopathologic Features of Colitis Due to Immunotherapy With Anti-PD-1 Antibodies.
Chen JH, Pezhouh MK, Lauwers GY, Masia R
Am J Surg Pathol 2017 May;41(5):643-654. doi: 10.1097/PAS.0000000000000829. PMID: 28296676
Obliterative Bronchiolitis.
Aguilar PR, Michelson AP, Isakow W
Transplantation 2016 Feb;100(2):272-83. doi: 10.1097/TP.0000000000000892. PMID: 26335918

Recent systematic reviews

Pharmacokinetics and Pharmacodynamics of Ruxolitinib: A Review.
Appeldoorn TYJ, Munnink THO, Morsink LM, Hooge MNL, Touw DJ
Clin Pharmacokinet 2023 Apr;62(4):559-571. Epub 2023 Mar 31 doi: 10.1007/s40262-023-01225-7. PMID: 37000342Free PMC Article
Efficacy and safety of ruxolitinib in steroid-refractory graft-versus-host disease: A meta-analysis.
Fan S, Huo WX, Yang Y, Shen MZ, Mo XD
Front Immunol 2022;13:954268. Epub 2022 Aug 4 doi: 10.3389/fimmu.2022.954268. PMID: 35990629Free PMC Article
Systematic Review of Safety and Efficacy of IL-1-Targeted Biologics in Treating Immune-Mediated Disorders.
Arnold DD, Yalamanoglu A, Boyman O
Front Immunol 2022;13:888392. Epub 2022 Jul 6 doi: 10.3389/fimmu.2022.888392. PMID: 35874710Free PMC Article
Mycophenolate mofetil vs. methotrexate for the prevention of graft-versus-host-disease--systematic review and meta-analysis.
Ram R, Yeshurun M, Vidal L, Shpilberg O, Gafter-Gvili A
Leuk Res 2014 Mar;38(3):352-60. Epub 2013 Dec 25 doi: 10.1016/j.leukres.2013.12.012. PMID: 24418750
Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations.
Al-Hashimi I, Schifter M, Lockhart PB, Wray D, Brennan M, Migliorati CA, Axéll T, Bruce AJ, Carpenter W, Eisenberg E, Epstein JB, Holmstrup P, Jontell M, Lozada-Nur F, Nair R, Silverman B, Thongprasom K, Thornhill M, Warnakulasuriya S, van der Waal I
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2007 Mar;103 Suppl:S25.e1-12. Epub 2007 Jan 29 doi: 10.1016/j.tripleo.2006.11.001. PMID: 17261375

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