Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Advanced Malignant Female Reproductive System Neoplasm

MedGen UID:: 1718080
•Concept ID:: C5238409
•: Neoplastic Process

Definition

A malignant female reproductive system neoplasm that has spread extensively from its original site of growth to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAdvanced Malignant Female Reproductive System Neoplasm

Neoplasm
- Neoplasm by Special Category
  - Metastatic neoplasm
    - Metastatic malignant neoplasm
      - Advanced Malignant Neoplasm
        Advanced Malignant Genitourinary System Neoplasm
        Advanced Malignant Female Reproductive System Neoplasm
        Advanced Cervical Carcinoma
        Advanced Cervical Adenocarcinoma
        Advanced Cervical Adenosquamous Carcinoma
        Advanced Cervical Squamous Cell Carcinoma
        Advanced Fallopian Tube Carcinoma
        Advanced Malignant Mixed Mesodermal (Mullerian) Tumor
        Advanced Ovarian Carcinosarcoma
        Advanced Uterine Corpus Carcinosarcoma
        Advanced Ovarian Carcinoma
        Advanced Microsatellite Stable Ovarian Carcinoma
        Advanced Ovarian Clear Cell Adenocarcinoma
        Advanced Ovarian Endometrioid Adenocarcinoma
        Advanced Ovarian Serous Adenocarcinoma
        Advanced Uterine Corpus Cancer
        Advanced Endometrial Carcinoma
        Advanced Endometrial Adenocarcinoma
        Advanced Microsatellite Stable Endometrial Carcinoma
        Advanced Vaginal Carcinoma
        Advanced Vaginal Adenocarcinoma
        Advanced Vaginal Adenosquamous Carcinoma
        Advanced Vaginal Squamous Cell Carcinoma
        Advanced Vaginal Squamous Cell Carcinoma, Not Otherwise Specified
        Advanced Vulvar Carcinoma

Professional guidelines

PubMed

ESMO-ESGO consensus conference recommendations on ovarian cancer: pathology and molecular biology, early and advanced stages, borderline tumours and recurrent disease†.

Colombo N, Sessa C, du Bois A, Ledermann J, McCluggage WG, McNeish I, Morice P, Pignata S, Ray-Coquard I, Vergote I, Baert T, Belaroussi I, Dashora A, Olbrecht S, Planchamp F, Querleu D; ESMO-ESGO Ovarian Cancer Consensus Conference Working Group
Ann Oncol 2019 May 1;30(5):672-705. doi: 10.1093/annonc/mdz062. PMID: 31046081

Advances in diagnosis and treatment of metastatic cervical cancer.

Li H, Wu X, Cheng X
J Gynecol Oncol 2016 Jul;27(4):e43. doi: 10.3802/jgo.2016.27.e43. PMID: 27171673 Free PMC Article

Consensus Recommendations for Radiation Therapy Contouring and Treatment of Vulvar Carcinoma.

Gaffney DK, King B, Viswanathan AN, Barkati M, Beriwal S, Eifel P, Erickson B, Fyles A, Goulart J, Harkenrider M, Jhingran A, Klopp A, Koh WJ, Lim K, Petersen I, Portelance L, Small W Jr, Stewart A, Wiebe E, Wolfson A, Yashar C, Bosch W
Int J Radiat Oncol Biol Phys 2016 Jul 15;95(4):1191-200. Epub 2016 Feb 21 doi: 10.1016/j.ijrobp.2016.02.043. PMID: 27130794 Free PMC Article

See all (2713)

Recent clinical studies

Etiology

Research progress of neoantigens in gynecologic cancers.

Song Y, Zhang Y
Int Immunopharmacol 2022 Nov;112:109236. Epub 2022 Sep 14 doi: 10.1016/j.intimp.2022.109236. PMID: 36113318

Extracutaneous Melanoma.

Carvajal R, Maniar R
Hematol Oncol Clin North Am 2021 Feb;35(1):85-98. Epub 2020 Oct 26 doi: 10.1016/j.hoc.2020.09.004. PMID: 33759775

Gynecologic Malignancies.

Suneja G, Viswanathan A
Hematol Oncol Clin North Am 2020 Feb;34(1):71-89. doi: 10.1016/j.hoc.2019.08.018. PMID: 31739953

Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.

Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760 Free PMC Article

Pelvic exenteration--reconsidering the procedure.

Bacalbasa N, Balescu I
J Med Life 2015 Apr-Jun;8(2):146-9. PMID: 25866569 Free PMC Article

See all (11660)

Diagnosis

Current update on vaginal malignancies.

Stein R, Ganeshan D, Gopireddy DR, Chaudhry A, Kumar S, Bande K, Bhosale P, Lall C
Abdom Radiol (NY) 2021 Nov;46(11):5353-5368. Epub 2021 Aug 2 doi: 10.1007/s00261-021-03228-z. PMID: 34338815

Extracutaneous Melanoma.

Carvajal R, Maniar R
Hematol Oncol Clin North Am 2021 Feb;35(1):85-98. Epub 2020 Oct 26 doi: 10.1016/j.hoc.2020.09.004. PMID: 33759775

Gynecologic cancer in pregnancy.

Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951 Free PMC Article

An update on post-treatment surveillance and diagnosis of recurrence in women with gynecologic malignancies: Society of Gynecologic Oncology (SGO) recommendations.

Salani R, Khanna N, Frimer M, Bristow RE, Chen LM
Gynecol Oncol 2017 Jul;146(1):3-10. Epub 2017 Mar 31 doi: 10.1016/j.ygyno.2017.03.022. PMID: 28372871

Bowenoid papulosis.

Schwartz RA, Janniger CK
J Am Acad Dermatol 1991 Feb;24(2 Pt 1):261-4. doi: 10.1016/0190-9622(91)70039-5. PMID: 1848870

See all (9528)

Therapy

Adding immunotherapy to first-line treatment of advanced and metastatic endometrial cancer.

Bogani G, Monk BJ, Powell MA, Westin SN, Slomovitz B, Moore KN, Eskander RN, Raspagliesi F, Barretina-Ginesta MP, Colombo N, Mirza MR
Ann Oncol 2024 May;35(5):414-428. Epub 2024 Feb 29 doi: 10.1016/j.annonc.2024.02.006. PMID: 38431043

Advances in antibody-drug conjugates for gynecologic malignancies.

Tymon-Rosario J, Gorman M, Richardson DL, Washington C, Santin AD
Curr Opin Obstet Gynecol 2023 Feb 1;35(1):6-14. Epub 2022 Dec 8 doi: 10.1097/GCO.0000000000000838. PMID: 36484278

Low-grade serous ovarian cancer: State of the science.

Slomovitz B, Gourley C, Carey MS, Malpica A, Shih IM, Huntsman D, Fader AN, Grisham RN, Schlumbrecht M, Sun CC, Ludemann J, Cooney GA, Coleman R, Sood AK, Mahdi H, Wong KK, Covens A, O'Malley DM, Lecuru F, Cobb LP, Caputo TA, May T, Huang M, Siemon J, Fernández ML, Ray-Coquard I, Gershenson DM
Gynecol Oncol 2020 Mar;156(3):715-725. Epub 2020 Jan 20 doi: 10.1016/j.ygyno.2019.12.033. PMID: 31969252

Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.

Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760 Free PMC Article

Epigenetic therapy for ovarian cancer: promise and progress.

Moufarrij S, Dandapani M, Arthofer E, Gomez S, Srivastava A, Lopez-Acevedo M, Villagra A, Chiappinelli KB
Clin Epigenetics 2019 Jan 15;11(1):7. doi: 10.1186/s13148-018-0602-0. PMID: 30646939 Free PMC Article

See all (9884)

Prognosis

Sentinel lymphatic mapping for gynecologic malignancies.

Hari AY, Tewari KS
Curr Opin Obstet Gynecol 2023 Feb 1;35(1):43-53. doi: 10.1097/GCO.0000000000000841. PMID: 36595648

Update on MRI in Evaluation and Treatment of Endometrial Cancer.

Maheshwari E, Nougaret S, Stein EB, Rauch GM, Hwang KP, Stafford RJ, Klopp AH, Soliman PT, Maturen KE, Rockall AG, Lee SI, Sadowski EA, Venkatesan AM
Radiographics 2022 Nov-Dec;42(7):2112-2130. Epub 2022 Aug 26 doi: 10.1148/rg.220070. PMID: 36018785

Gynecologic cancer in pregnancy.

Korenaga TK, Tewari KS
Gynecol Oncol 2020 Jun;157(3):799-809. Epub 2020 Apr 5 doi: 10.1016/j.ygyno.2020.03.015. PMID: 32268951 Free PMC Article

Gynecologic malignancies.

Whitcomb BP
Surg Clin North Am 2008 Apr;88(2):301-17, vi. doi: 10.1016/j.suc.2008.01.004. PMID: 18381115

Cervical cancer.

Moore DH
Obstet Gynecol 2006 May;107(5):1152-61. doi: 10.1097/01.AOG.0000215986.48590.79. PMID: 16648423

See all (11090)

Clinical prediction guides

Systematic review and meta-analysis of prediction models used in cervical cancer.

Jha AK, Mithun S, Sherkhane UB, Jaiswar V, Osong B, Purandare N, Kannan S, Prabhash K, Gupta S, Vanneste B, Rangarajan V, Dekker A, Wee L
Artif Intell Med 2023 May;139:102549. Epub 2023 Apr 11 doi: 10.1016/j.artmed.2023.102549. PMID: 37100501

Evaluation of immunotherapy efficacy in gynecologic cancer.

Jiang G, Wu Q, Li B
Front Immunol 2023;14:1061761. Epub 2023 Jan 31 doi: 10.3389/fimmu.2023.1061761. PMID: 36793735 Free PMC Article

Machine learning applications in gynecological cancer: A critical review.

Fiste O, Liontos M, Zagouri F, Stamatakos G, Dimopoulos MA
Crit Rev Oncol Hematol 2022 Nov;179:103808. Epub 2022 Sep 7 doi: 10.1016/j.critrevonc.2022.103808. PMID: 36087852

CircRNA in cancer: Fundamental mechanism and clinical potential.

Chen L, Shan G
Cancer Lett 2021 May 1;505:49-57. Epub 2021 Feb 18 doi: 10.1016/j.canlet.2021.02.004. PMID: 33609610

Ovarian cancer: risk factors, treatment and management.

Rooth C
Br J Nurs 2013 Sep 12-25;22(17):S23-30. doi: 10.12968/bjon.2013.22.Sup17.S23. PMID: 24067270

See all (7702)

Recent systematic reviews

Systematic review and meta-analysis of prediction models used in cervical cancer.

Hyperthermic intraperitoneal chemotherapy (HIPEC) for the management of primary advanced and recurrent ovarian cancer: a systematic review and meta-analysis of randomized trials.

Filis P, Mauri D, Markozannes G, Tolia M, Filis N, Tsilidis K
ESMO Open 2022 Oct;7(5):100586. Epub 2022 Sep 16 doi: 10.1016/j.esmoop.2022.100586. PMID: 36116421 Free PMC Article

Progress in the management of ovarian granulosa cell tumor: A review.

Li J, Chu R, Chen Z, Meng J, Yao S, Song K, Kong B
Acta Obstet Gynecol Scand 2021 Oct;100(10):1771-1778. Epub 2021 Jul 16 doi: 10.1111/aogs.14189. PMID: 34027996

ESGO/ESTRO/ESP Guidelines for the management of patients with endometrial carcinoma.

Concin N, Creutzberg CL, Vergote I, Cibula D, Mirza MR, Marnitz S, Ledermann JA, Bosse T, Chargari C, Fagotti A, Fotopoulou C, González-Martín A, Lax SF, Lorusso D, Marth C, Morice P, Nout RA, O'Donnell DE, Querleu D, Raspollini MR, Sehouli J, Sturdza AE, Taylor A, Westermann AM, Wimberger P, Colombo N, Planchamp F, Matias-Guiu X
Virchows Arch 2021 Feb;478(2):153-190. doi: 10.1007/s00428-020-03007-z. PMID: 33604759

Breastfeeding and maternal health outcomes: a systematic review and meta-analysis.

Chowdhury R, Sinha B, Sankar MJ, Taneja S, Bhandari N, Rollins N, Bahl R, Martines J
Acta Paediatr 2015 Dec;104(467):96-113. doi: 10.1111/apa.13102. PMID: 26172878 Free PMC Article

See all (483)

MedGen

National Center for Biotechnology Information