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Benign Periampullary Neoplasm

MedGen UID:
1721208
•Concept ID:
C5418754
•
Neoplastic Process

Definition

A neoplasm that arises from the periampullary region and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign Periampullary Neoplasm

Professional guidelines

PubMed

Endoscopic management and clinical outcomes of obstructive jaundice.
Alatise OI, Owojuyigbe AM, Omisore AD, Ndububa DA, Aburime E, Dua KS, Asombang AW
Niger Postgrad Med J 2020 Oct-Dec;27(4):302-310. doi: 10.4103/npmj.npmj_242_20. PMID: 33154282
Management of gastric and duodenal neuroendocrine tumors.
Sato Y, Hashimoto S, Mizuno K, Takeuchi M, Terai S
World J Gastroenterol 2016 Aug 14;22(30):6817-28. doi: 10.3748/wjg.v22.i30.6817. PMID: 27570419Free PMC Article
The clinical utility of CA 19-9 in pancreatic adenocarcinoma: diagnostic and prognostic updates.
Poruk KE, Gay DZ, Brown K, Mulvihill JD, Boucher KM, Scaife CL, Firpo MA, Mulvihill SJ
Curr Mol Med 2013 Mar;13(3):340-51. doi: 10.2174/1566524011313030003. PMID: 23331006Free PMC Article

Recent clinical studies

Etiology

From Classic Whipple to Pylorus Preserving Pancreaticoduodenectomy and Ultimately to Pylorus Resecting - Stomach Preserving Pancreaticoduodenectomy: A Review.
Symeonidis D, Zacharoulis D, Kissa L, Samara AA, Petsa E, Tepetes K
Chirurgia (Bucur) 2023 Aug;118(4):335-347. doi: 10.21614/chirurgia.2023.v.118.i.4.p.335. PMID: 37697996
Prediction Model for Early-Stage Pancreatic Cancer Using Routinely Measured Blood Biomarkers.
Boyd LNC, Ali M, Comandatore A, Garajova I, Kam L, Puik JR, Fraga Rodrigues SM, Meijer LL, Le Large TYS, Besselink MG, Morelli L, Frampton A, van Laarhoven HWM, Giovannetti E, Kazemier G
JAMA Netw Open 2023 Aug 1;6(8):e2331197. doi: 10.1001/jamanetworkopen.2023.31197. PMID: 37639271Free PMC Article
Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours: a multicentre, open-label, randomised controlled trial.
Wang M, Li D, Chen R, Huang X, Li J, Liu Y, Liu J, Cheng W, Chen X, Zhao W, Li J, Tan Z, Huang H, Li D, Zhu F, Qin T, Ma J, Yu G, Zhou B, Zheng S, Tang Y, Han W, Meng L, Ke J, Feng F, Chen B, Yin X, Chen W, Ma H, Xu J, Liu Y, Lin R, Dong Y, Yu Y, Liu J, Zhang H, Qin R; Minimally Invasive Treatment Group in the Pancreatic Disease Branch of China's International Exchange and Promotion Association for Medicine and Healthcare (MITG-P-CPAM)
Lancet Gastroenterol Hepatol 2021 Jun;6(6):438-447. Epub 2021 Apr 27 doi: 10.1016/S2468-1253(21)00054-6. PMID: 33915091
Preoperative Stenting for Benign and Malignant Periampullary Diseases: Unnecessary if Not Harmful.
Gholami S, Brennan MF
Surg Clin North Am 2018 Feb;98(1):37-47. doi: 10.1016/j.suc.2017.09.005. PMID: 29191276Free PMC Article
Multiple tumors of the biliary tract.
Gertsch P, Thomas P, Baer H, Lerut J, Zimmermann A, Blumgart LH
Am J Surg 1990 Apr;159(4):386-8. doi: 10.1016/s0002-9610(05)81278-4. PMID: 2180336

Diagnosis

Prediction Model for Early-Stage Pancreatic Cancer Using Routinely Measured Blood Biomarkers.
Boyd LNC, Ali M, Comandatore A, Garajova I, Kam L, Puik JR, Fraga Rodrigues SM, Meijer LL, Le Large TYS, Besselink MG, Morelli L, Frampton A, van Laarhoven HWM, Giovannetti E, Kazemier G
JAMA Netw Open 2023 Aug 1;6(8):e2331197. doi: 10.1001/jamanetworkopen.2023.31197. PMID: 37639271Free PMC Article
Preoperative Stenting for Benign and Malignant Periampullary Diseases: Unnecessary if Not Harmful.
Gholami S, Brennan MF
Surg Clin North Am 2018 Feb;98(1):37-47. doi: 10.1016/j.suc.2017.09.005. PMID: 29191276Free PMC Article
Management of gastric and duodenal neuroendocrine tumors.
Sato Y, Hashimoto S, Mizuno K, Takeuchi M, Terai S
World J Gastroenterol 2016 Aug 14;22(30):6817-28. doi: 10.3748/wjg.v22.i30.6817. PMID: 27570419Free PMC Article
Imaging features of benign and malignant ampullary and periampullary lesions.
Nikolaidis P, Hammond NA, Day K, Yaghmai V, Wood CG 3rd, Mosbach DS, Harmath CB, Taffel MT, Horowitz JM, Berggruen SM, Miller FH
Radiographics 2014 May-Jun;34(3):624-41. doi: 10.1148/rg.343125191. PMID: 24819785
Benign duodenal tumors.
Chong KC, Cheah WK, Lenzi JE, Goh PM
Hepatogastroenterology 2000 Sep-Oct;47(35):1298-300. PMID: 11100336

Therapy

Effect of robotic versus open pancreaticoduodenectomy on postoperative length of hospital stay and complications for pancreatic head or periampullary tumours: a multicentre, open-label randomised controlled trial.
Liu Q, Li M, Gao Y, Jiang T, Han B, Zhao G, Lin C, Lau WY, Zhao Z, Liu R
Lancet Gastroenterol Hepatol 2024 May;9(5):428-437. Epub 2024 Feb 28 doi: 10.1016/S2468-1253(24)00005-0. PMID: 38428441
Gastric outlet obstruction as an unusual presentation of metastatic breast carcinoma.
Misra S, Mudgal P, Ahuja A
J Cancer Res Ther 2023 Jul-Sep;19(5):1430-1432. doi: 10.4103/jcrt.jcrt_1377_21. PMID: 37787322
From Classic Whipple to Pylorus Preserving Pancreaticoduodenectomy and Ultimately to Pylorus Resecting - Stomach Preserving Pancreaticoduodenectomy: A Review.
Symeonidis D, Zacharoulis D, Kissa L, Samara AA, Petsa E, Tepetes K
Chirurgia (Bucur) 2023 Aug;118(4):335-347. doi: 10.21614/chirurgia.2023.v.118.i.4.p.335. PMID: 37697996
Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours: a multicentre, open-label, randomised controlled trial.
Wang M, Li D, Chen R, Huang X, Li J, Liu Y, Liu J, Cheng W, Chen X, Zhao W, Li J, Tan Z, Huang H, Li D, Zhu F, Qin T, Ma J, Yu G, Zhou B, Zheng S, Tang Y, Han W, Meng L, Ke J, Feng F, Chen B, Yin X, Chen W, Ma H, Xu J, Liu Y, Lin R, Dong Y, Yu Y, Liu J, Zhang H, Qin R; Minimally Invasive Treatment Group in the Pancreatic Disease Branch of China's International Exchange and Promotion Association for Medicine and Healthcare (MITG-P-CPAM)
Lancet Gastroenterol Hepatol 2021 Jun;6(6):438-447. Epub 2021 Apr 27 doi: 10.1016/S2468-1253(21)00054-6. PMID: 33915091
Preoperative Stenting for Benign and Malignant Periampullary Diseases: Unnecessary if Not Harmful.
Gholami S, Brennan MF
Surg Clin North Am 2018 Feb;98(1):37-47. doi: 10.1016/j.suc.2017.09.005. PMID: 29191276Free PMC Article

Prognosis

Triglyceride-glucose index and glycemic dynamics in pancreatic ductal adenocarcinoma: implications for disease progression and prognosis.
Song Y, Jiang L, Han Y, Zhang S, Li S
J Transl Med 2024 Jul 30;22(1):708. doi: 10.1186/s12967-024-05524-w. PMID: 39080703Free PMC Article
Prediction Model for Early-Stage Pancreatic Cancer Using Routinely Measured Blood Biomarkers.
Boyd LNC, Ali M, Comandatore A, Garajova I, Kam L, Puik JR, Fraga Rodrigues SM, Meijer LL, Le Large TYS, Besselink MG, Morelli L, Frampton A, van Laarhoven HWM, Giovannetti E, Kazemier G
JAMA Netw Open 2023 Aug 1;6(8):e2331197. doi: 10.1001/jamanetworkopen.2023.31197. PMID: 37639271Free PMC Article
Gangliocytic paraganglioma: case report and review of the literature.
Witkiewicz A, Galler A, Yeo CJ, Gross SD
J Gastrointest Surg 2007 Oct;11(10):1351-4. Epub 2007 Jul 25 doi: 10.1007/s11605-007-0217-9. PMID: 17653595
Duodenal villous tumors.
Bjork KJ, Davis CJ, Nagorney DM, Mucha P Jr
Arch Surg 1990 Aug;125(8):961-5. doi: 10.1001/archsurg.1990.01410200019001. PMID: 2378560
Carcinoma of the duodenum.
Gaddy M, Max MH
South Med J 1985 Feb;78(2):150-2. doi: 10.1097/00007611-198502000-00007. PMID: 2983438

Clinical prediction guides

Long-Term Oncologic Outcome following Duodenum-Preserving Pancreatic Head Resection for Benign Tumors, Cystic Neoplasms, and Neuroendocrine Tumors: Systematic Review and Meta-analysis.
Beger HG, Mayer B, Poch B
Ann Surg Oncol 2024 Jul;31(7):4637-4653. Epub 2024 Apr 5 doi: 10.1245/s10434-024-15222-y. PMID: 38578553Free PMC Article
Prediction Model for Early-Stage Pancreatic Cancer Using Routinely Measured Blood Biomarkers.
Boyd LNC, Ali M, Comandatore A, Garajova I, Kam L, Puik JR, Fraga Rodrigues SM, Meijer LL, Le Large TYS, Besselink MG, Morelli L, Frampton A, van Laarhoven HWM, Giovannetti E, Kazemier G
JAMA Netw Open 2023 Aug 1;6(8):e2331197. doi: 10.1001/jamanetworkopen.2023.31197. PMID: 37639271Free PMC Article
Differentiating between benign and malignant ampullary strictures: a prediction model using a nomogram based on CT imaging and clinical findings.
Lee JE, Choi SY, Lee MH, Lim S, Min JH, Hwang JA, Lee S, Kim JH
Eur Radiol 2022 Nov;32(11):7566-7577. Epub 2022 May 19 doi: 10.1007/s00330-022-08856-7. PMID: 35585200
Laparoscopic versus open pancreatoduodenectomy for pancreatic or periampullary tumours: a multicentre, open-label, randomised controlled trial.
Wang M, Li D, Chen R, Huang X, Li J, Liu Y, Liu J, Cheng W, Chen X, Zhao W, Li J, Tan Z, Huang H, Li D, Zhu F, Qin T, Ma J, Yu G, Zhou B, Zheng S, Tang Y, Han W, Meng L, Ke J, Feng F, Chen B, Yin X, Chen W, Ma H, Xu J, Liu Y, Lin R, Dong Y, Yu Y, Liu J, Zhang H, Qin R; Minimally Invasive Treatment Group in the Pancreatic Disease Branch of China's International Exchange and Promotion Association for Medicine and Healthcare (MITG-P-CPAM)
Lancet Gastroenterol Hepatol 2021 Jun;6(6):438-447. Epub 2021 Apr 27 doi: 10.1016/S2468-1253(21)00054-6. PMID: 33915091
Multiple tumors of the biliary tract.
Gertsch P, Thomas P, Baer H, Lerut J, Zimmermann A, Blumgart LH
Am J Surg 1990 Apr;159(4):386-8. doi: 10.1016/s0002-9610(05)81278-4. PMID: 2180336

Recent systematic reviews

Long-Term Oncologic Outcome following Duodenum-Preserving Pancreatic Head Resection for Benign Tumors, Cystic Neoplasms, and Neuroendocrine Tumors: Systematic Review and Meta-analysis.
Beger HG, Mayer B, Poch B
Ann Surg Oncol 2024 Jul;31(7):4637-4653. Epub 2024 Apr 5 doi: 10.1245/s10434-024-15222-y. PMID: 38578553Free PMC Article
Robotic-assisted versus open pancreaticoduodenectomy for patients with benign and malignant periampullary disease: a systematic review and meta-analysis of short-term outcomes.
Podda M, Gerardi C, Di Saverio S, Marino MV, Davies RJ, Pellino G, Pisanu A
Surg Endosc 2020 Jun;34(6):2390-2409. Epub 2020 Feb 18 doi: 10.1007/s00464-020-07460-4. PMID: 32072286
Parenchyma-Sparing, Limited Pancreatic Head Resection for Benign Tumors and Low-Risk Periampullary Cancer--a Systematic Review.
Beger HG, Mayer B, Rau BM
J Gastrointest Surg 2016 Jan;20(1):206-17. Epub 2015 Nov 2 doi: 10.1007/s11605-015-2981-2. PMID: 26525207
Local endoscopic removal of duodenal carcinoid tumors.
Dalenbäck J, Havel G
Endoscopy 2004 Jul;36(7):651-5. doi: 10.1055/s-2004-814539. PMID: 15243891

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