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Refractory Microsatellite Stable Colorectal Carcinoma

MedGen UID:
1725658
•Concept ID:
C5420149
•
Neoplastic Process

Definition

Microsatellite stable colorectal carcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Microsatellite Stable Colorectal Carcinoma

Professional guidelines

PubMed

Profile of Fruquintinib in the Management of Advanced Refractory Metastatic Colorectal Cancer: Design, Development and Potential Place in Therapy.
Syaj S, Saeed A
Drug Des Devel Ther 2024;18:5203-5210. Epub 2024 Nov 15 doi: 10.2147/DDDT.S388577. PMID: 39568782Free PMC Article
Immune checkpoint inhibitor therapy in neoadjuvant and adjuvant treatment for cancer: A paradigm shift in the treatment of resectable gastrointestinal cancer 3)A paradigm shift in the treatment of colorectal cancer.
Oshima K, Yamazaki K
Int J Clin Oncol 2023 Nov;28(11):1442-1450. Epub 2023 Sep 5 doi: 10.1007/s10147-023-02387-x. PMID: 37668816
Combination Treatment of Intratumoral Vidutolimod, Radiosurgery, Nivolumab, and Ipilimumab for Microsatellite Stable Colorectal Carcinoma With Liver Metastases.
Margalit O, Lieberman S, Redinsky I, Halparin S, Honig N, Raskin S, Ben-Ayun M, Shacham-Shmueli E, Halpern N, Urban D, Ackerstein A, Shulman K, Ben-Ami E, Semenisty V, Purim O, Yarom N, Golan T, Boursi B, Appel S, Symon Z, Berger R, Mauro D, Krieg AM, Lawrence YR
Clin Colorectal Cancer 2023 Dec;22(4):442-449.e1. Epub 2023 Aug 9 doi: 10.1016/j.clcc.2023.08.004. PMID: 37657954

Recent clinical studies

Etiology

Liver Metastases and Immune Checkpoint Inhibitor Efficacy in Patients With Refractory Metastatic Colorectal Cancer: A Secondary Analysis of a Randomized Clinical Trial.
Chen EX, Loree JM, Titmuss E, Jonker DJ, Kennecke HF, Berry S, Couture F, Ahmad CE, Goffin JR, Kavan P, Harb M, Colwell B, Samimi S, Samson B, Abbas T, Aucoin N, Aubin F, Koski S, Wei AC, Tu D, O'Callaghan CJ
JAMA Netw Open 2023 Dec 1;6(12):e2346094. doi: 10.1001/jamanetworkopen.2023.46094. PMID: 38051531Free PMC Article
Phase II trial of nivolumab and metformin in patients with treatment-refractory microsatellite stable metastatic colorectal cancer.
Akce M, Farran B, Switchenko JM, Rupji M, Kang S, Khalil L, Ruggieri-Joyce A, Olson B, Shaib WL, Wu C, Alese OB, Diab M, Lesinski GB, El-Rayes BF
J Immunother Cancer 2023 Oct;11(10) doi: 10.1136/jitc-2023-007235. PMID: 37852737Free PMC Article
Assessment of Capecitabine and Bevacizumab With or Without Atezolizumab for the Treatment of Refractory Metastatic Colorectal Cancer: A Randomized Clinical Trial.
Mettu NB, Ou FS, Zemla TJ, Halfdanarson TR, Lenz HJ, Breakstone RA, Boland PM, Crysler OV, Wu C, Nixon AB, Bolch E, Niedzwiecki D, Elsing A, Hurwitz HI, Fakih MG, Bekaii-Saab T
JAMA Netw Open 2022 Feb 1;5(2):e2149040. doi: 10.1001/jamanetworkopen.2021.49040. PMID: 35179586Free PMC Article
Effect of Combined Immune Checkpoint Inhibition vs Best Supportive Care Alone in Patients With Advanced Colorectal Cancer: The Canadian Cancer Trials Group CO.26 Study.
Chen EX, Jonker DJ, Loree JM, Kennecke HF, Berry SR, Couture F, Ahmad CE, Goffin JR, Kavan P, Harb M, Colwell B, Samimi S, Samson B, Abbas T, Aucoin N, Aubin F, Koski SL, Wei AC, Magoski NM, Tu D, O'Callaghan CJ
JAMA Oncol 2020 Jun 1;6(6):831-838. doi: 10.1001/jamaoncol.2020.0910. PMID: 32379280Free PMC Article
Patient-reported Symptom Outcomes and Microsatellite Instability in Patients With Metastatic Colorectal Cancer.
Advani SM, Shi Q, Overman MJ, Loree JM, Lam M, Morris V, Shureiqi I, Kee B, Dasari A, Vilar E, Sarshekeh AM, Lin HK, Manuel S, Hamilton S, Raghav K, Maru D, Kopetz S, Wang XS
Clin Colorectal Cancer 2020 Mar;19(1):48-56.e2. Epub 2019 Oct 23 doi: 10.1016/j.clcc.2019.10.006. PMID: 32008976

Diagnosis

Liver Metastases and Immune Checkpoint Inhibitor Efficacy in Patients With Refractory Metastatic Colorectal Cancer: A Secondary Analysis of a Randomized Clinical Trial.
Chen EX, Loree JM, Titmuss E, Jonker DJ, Kennecke HF, Berry S, Couture F, Ahmad CE, Goffin JR, Kavan P, Harb M, Colwell B, Samimi S, Samson B, Abbas T, Aucoin N, Aubin F, Koski S, Wei AC, Tu D, O'Callaghan CJ
JAMA Netw Open 2023 Dec 1;6(12):e2346094. doi: 10.1001/jamanetworkopen.2023.46094. PMID: 38051531Free PMC Article
Tumor-intrinsic expression of the autophagy gene Atg16l1 suppresses anti-tumor immunity in colorectal cancer.
Taraborrelli L, Şenbabaoğlu Y, Wang L, Lim J, Blake K, Kljavin N, Gierke S, Scherl A, Ziai J, McNamara E, Owyong M, Rao S, Calviello AK, Oreper D, Jhunjhunwala S, Argiles G, Bendell J, Kim TW, Ciardiello F, Wongchenko MJ, de Sauvage FJ, de Sousa E Melo F, Yan Y, West NR, Murthy A
Nat Commun 2023 Sep 23;14(1):5945. doi: 10.1038/s41467-023-41618-7. PMID: 37741832Free PMC Article
ROS1 genomic rearrangements are rare actionable drivers in microsatellite stable colorectal cancer.
Akhoundova D, Hussung S, Sivakumar S, Töpfer A, Rechsteiner M, Kahraman A, Arnold F, Angst F, Britschgi C, Zoche M, Moch H, Weber A, Sokol E, Fritsch RM
Int J Cancer 2022 Dec 15;151(12):2161-2171. Epub 2022 Aug 30 doi: 10.1002/ijc.34257. PMID: 36053834Free PMC Article
Strategic enhancement of immune checkpoint inhibition in refractory Colorectal Cancer: Trends and future prospective.
Liu N, Shan F, Ma M
Int Immunopharmacol 2021 Oct;99:108017. Epub 2021 Aug 2 doi: 10.1016/j.intimp.2021.108017. PMID: 34352568
Patient-reported Symptom Outcomes and Microsatellite Instability in Patients With Metastatic Colorectal Cancer.
Advani SM, Shi Q, Overman MJ, Loree JM, Lam M, Morris V, Shureiqi I, Kee B, Dasari A, Vilar E, Sarshekeh AM, Lin HK, Manuel S, Hamilton S, Raghav K, Maru D, Kopetz S, Wang XS
Clin Colorectal Cancer 2020 Mar;19(1):48-56.e2. Epub 2019 Oct 23 doi: 10.1016/j.clcc.2019.10.006. PMID: 32008976

Therapy

Botensilimab plus balstilimab in relapsed/refractory microsatellite stable metastatic colorectal cancer: a phase 1 trial.
Bullock AJ, Schlechter BL, Fakih MG, Tsimberidou AM, Grossman JE, Gordon MS, Wilky BA, Pimentel A, Mahadevan D, Balmanoukian AS, Sanborn RE, Schwartz GK, Abou-Alfa GK, Segal NH, Bockorny B, Moser JC, Sharma S, Patel JM, Wu W, Chand D, Rosenthal K, Mednick G, Delepine C, Curiel TJ, Stebbing J, Lenz HJ, O'Day SJ, El-Khoueiry AB
Nat Med 2024 Sep;30(9):2558-2567. Epub 2024 Jun 13 doi: 10.1038/s41591-024-03083-7. PMID: 38871975Free PMC Article
Combined anti-PD-1, HDAC inhibitor and anti-VEGF for MSS/pMMR colorectal cancer: a randomized phase 2 trial.
Wang F, Jin Y, Wang M, Luo HY, Fang WJ, Wang YN, Chen YX, Huang RJ, Guan WL, Li JB, Li YH, Wang FH, Hu XH, Zhang YQ, Qiu MZ, Liu LL, Wang ZX, Ren C, Wang DS, Zhang DS, Wang ZQ, Liao WT, Tian L, Zhao Q, Xu RH
Nat Med 2024 Apr;30(4):1035-1043. Epub 2024 Mar 4 doi: 10.1038/s41591-024-02813-1. PMID: 38438735
Liver Metastases and Immune Checkpoint Inhibitor Efficacy in Patients With Refractory Metastatic Colorectal Cancer: A Secondary Analysis of a Randomized Clinical Trial.
Chen EX, Loree JM, Titmuss E, Jonker DJ, Kennecke HF, Berry S, Couture F, Ahmad CE, Goffin JR, Kavan P, Harb M, Colwell B, Samimi S, Samson B, Abbas T, Aucoin N, Aubin F, Koski S, Wei AC, Tu D, O'Callaghan CJ
JAMA Netw Open 2023 Dec 1;6(12):e2346094. doi: 10.1001/jamanetworkopen.2023.46094. PMID: 38051531Free PMC Article
Assessment of Capecitabine and Bevacizumab With or Without Atezolizumab for the Treatment of Refractory Metastatic Colorectal Cancer: A Randomized Clinical Trial.
Mettu NB, Ou FS, Zemla TJ, Halfdanarson TR, Lenz HJ, Breakstone RA, Boland PM, Crysler OV, Wu C, Nixon AB, Bolch E, Niedzwiecki D, Elsing A, Hurwitz HI, Fakih MG, Bekaii-Saab T
JAMA Netw Open 2022 Feb 1;5(2):e2149040. doi: 10.1001/jamanetworkopen.2021.49040. PMID: 35179586Free PMC Article
Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer.
Picard E, Verschoor CP, Ma GW, Pawelec G
Front Immunol 2020;11:369. Epub 2020 Mar 6 doi: 10.3389/fimmu.2020.00369. PMID: 32210966Free PMC Article

Prognosis

ROS1 genomic rearrangements are rare actionable drivers in microsatellite stable colorectal cancer.
Akhoundova D, Hussung S, Sivakumar S, Töpfer A, Rechsteiner M, Kahraman A, Arnold F, Angst F, Britschgi C, Zoche M, Moch H, Weber A, Sokol E, Fritsch RM
Int J Cancer 2022 Dec 15;151(12):2161-2171. Epub 2022 Aug 30 doi: 10.1002/ijc.34257. PMID: 36053834Free PMC Article
Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer.
Westcott PMK, Sacks NJ, Schenkel JM, Ely ZA, Smith O, Hauck H, Jaeger AM, Zhang D, Backlund CM, Beytagh MC, Patten JJ, Elbashir R, Eng G, Irvine DJ, Yilmaz OH, Jacks T
Nat Cancer 2021 Oct;2(10):1071-1085. Epub 2021 Sep 30 doi: 10.1038/s43018-021-00247-z. PMID: 34738089Free PMC Article
Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer.
Picard E, Verschoor CP, Ma GW, Pawelec G
Front Immunol 2020;11:369. Epub 2020 Mar 6 doi: 10.3389/fimmu.2020.00369. PMID: 32210966Free PMC Article
Patient-reported Symptom Outcomes and Microsatellite Instability in Patients With Metastatic Colorectal Cancer.
Advani SM, Shi Q, Overman MJ, Loree JM, Lam M, Morris V, Shureiqi I, Kee B, Dasari A, Vilar E, Sarshekeh AM, Lin HK, Manuel S, Hamilton S, Raghav K, Maru D, Kopetz S, Wang XS
Clin Colorectal Cancer 2020 Mar;19(1):48-56.e2. Epub 2019 Oct 23 doi: 10.1016/j.clcc.2019.10.006. PMID: 32008976
Efficacy of PD-1 Blockade in Refractory Microsatellite-Stable Colorectal Cancer With High Tumor Mutation Burden.
Gong J, Robertson MD, Kim E, Fakih M, Schrock AB, Tam KW, Burugapalli B, Monjazeb AM, Hendifar AE, Hitchins M, Klempner SJ, Cho M
Clin Colorectal Cancer 2019 Dec;18(4):307-309. Epub 2019 Sep 4 doi: 10.1016/j.clcc.2019.08.001. PMID: 31563511

Clinical prediction guides

A Phase II Study of Potentiation of Pembrolizumab with Binimetinib and Bevacizumab in Refractory Microsatellite-Stable Colorectal Cancer.
Lentz RW, Friedrich TJ, Blatchford PJ, Jordan KR, Pitts TM, Robinson HR, Davis SL, Kim SS, Leal AD, Lee MR, Waring MRN, Martin AC, Dominguez ATA, Bagby SM, Hartman SJ, Eckhardt SG, Messersmith WA, Lieu CH
Clin Cancer Res 2024 Sep 3;30(17):3768-3778. doi: 10.1158/1078-0432.CCR-24-0090. PMID: 38869830Free PMC Article
Combined anti-PD-1, HDAC inhibitor and anti-VEGF for MSS/pMMR colorectal cancer: a randomized phase 2 trial.
Wang F, Jin Y, Wang M, Luo HY, Fang WJ, Wang YN, Chen YX, Huang RJ, Guan WL, Li JB, Li YH, Wang FH, Hu XH, Zhang YQ, Qiu MZ, Liu LL, Wang ZX, Ren C, Wang DS, Zhang DS, Wang ZQ, Liao WT, Tian L, Zhao Q, Xu RH
Nat Med 2024 Apr;30(4):1035-1043. Epub 2024 Mar 4 doi: 10.1038/s41591-024-02813-1. PMID: 38438735
Pembrolizumab and maraviroc in refractory mismatch repair proficient/microsatellite-stable metastatic colorectal cancer - The PICCASSO phase I trial.
Haag GM, Springfeld C, Grün B, Apostolidis L, Zschäbitz S, Dietrich M, Berger AK, Weber TF, Zoernig I, Schaaf M, Waberer L, Müller DW, Al-Batran SE, Halama N, Jaeger D
Eur J Cancer 2022 May;167:112-122. Epub 2022 Apr 12 doi: 10.1016/j.ejca.2022.03.017. PMID: 35427833
Low neoantigen expression and poor T-cell priming underlie early immune escape in colorectal cancer.
Westcott PMK, Sacks NJ, Schenkel JM, Ely ZA, Smith O, Hauck H, Jaeger AM, Zhang D, Backlund CM, Beytagh MC, Patten JJ, Elbashir R, Eng G, Irvine DJ, Yilmaz OH, Jacks T
Nat Cancer 2021 Oct;2(10):1071-1085. Epub 2021 Sep 30 doi: 10.1038/s43018-021-00247-z. PMID: 34738089Free PMC Article
Relationships Between Immune Landscapes, Genetic Subtypes and Responses to Immunotherapy in Colorectal Cancer.
Picard E, Verschoor CP, Ma GW, Pawelec G
Front Immunol 2020;11:369. Epub 2020 Mar 6 doi: 10.3389/fimmu.2020.00369. PMID: 32210966Free PMC Article

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