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Hyperplasia and Hyperkeratosis

MedGen UID:
1729044
•Concept ID:
C5418672
•
Finding

Definition

A finding that generally has features of hyperplasia and hyperkeratosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHyperplasia and Hyperkeratosis

Professional guidelines

PubMed

Dihydrochalcone Derivatives from Populus balsamifera L. Buds for the Treatment of Psoriasis.
Bélanger A, Grenier A, Simard F, Gendreau I, Pichette A, Legault J, Pouliot R
Int J Mol Sci 2019 Dec 30;21(1) doi: 10.3390/ijms21010256. PMID: 31905943Free PMC Article
Treatment of angiokeratoma of Mibelli alone or in combination with pulsed dye laser and long-pulsed Nd: YAG laser.
Zeng Y, Li XQ, Lin QZ, Zhan K
Dermatol Ther 2014 Nov-Dec;27(6):348-51. Epub 2014 Jun 9 doi: 10.1111/dth.12138. PMID: 24911941
Targeting epidermal lipids for treatment of Mendelian disorders of cornification.
Kiritsi D, Schauer F, Wölfle U, Valari M, Bruckner-Tuderman L, Has C, Happle R
Orphanet J Rare Dis 2014 Mar 7;9:33. doi: 10.1186/1750-1172-9-33. PMID: 24607067Free PMC Article

Recent clinical studies

Etiology

Oral epithelial dysplasia: Recognition, grading and clinical significance.
Odell E, Kujan O, Warnakulasuriya S, Sloan P
Oral Dis 2021 Nov;27(8):1947-1976. Epub 2021 Sep 14 doi: 10.1111/odi.13993. PMID: 34418233
Psoriasis on the Leg: Site-specific Histopathological and Immuno-histochemical Features and Diagnostic Difficulties.
Fülle M, Metze D, Böer-Auer A, Osada N, Braun SA
Acta Derm Venereol 2021 May 10;101(5):adv00453. doi: 10.2340/00015555-3817. PMID: 33928396Free PMC Article
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499
Oral findings in glassblowers.
Schiödt M, Larsen V, Bessermann M
Community Dent Oral Epidemiol 1980 Aug;8(4):195-200. doi: 10.1111/j.1600-0528.1980.tb01285.x. PMID: 6936119

Diagnosis

Oral epithelial dysplasia: Recognition, grading and clinical significance.
Odell E, Kujan O, Warnakulasuriya S, Sloan P
Oral Dis 2021 Nov;27(8):1947-1976. Epub 2021 Sep 14 doi: 10.1111/odi.13993. PMID: 34418233
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Periodontol 2018 Jun;89 Suppl 1:S74-S84. doi: 10.1002/JPER.17-0719. PMID: 29926944
Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.
Chapple ILC, Mealey BL, Van Dyke TE, Bartold PM, Dommisch H, Eickholz P, Geisinger ML, Genco RJ, Glogauer M, Goldstein M, Griffin TJ, Holmstrup P, Johnson GK, Kapila Y, Lang NP, Meyle J, Murakami S, Plemons J, Romito GA, Shapira L, Tatakis DN, Teughels W, Trombelli L, Walter C, Wimmer G, Xenoudi P, Yoshie H
J Clin Periodontol 2018 Jun;45 Suppl 20:S68-S77. doi: 10.1111/jcpe.12940. PMID: 29926499
Porokeratoma.
Walsh SN, Hurt MA, Santa Cruz DJ
Am J Surg Pathol 2007 Dec;31(12):1897-901. doi: 10.1097/PAS.0b013e31806910c7. PMID: 18043046
Stucco keratosis.
Willoughby C, Soter NA
Arch Dermatol 1972 Jun;105(6):859-61. PMID: 4555326

Therapy

Systematic review of randomized controlled trials of topicals for actinic keratosis field therapy.
Patel P, Wang J, Bitterman D, Mineroff J, Austin E, Jagdeo J
Arch Dermatol Res 2024 Mar 18;316(4):108. doi: 10.1007/s00403-024-02839-y. PMID: 38498070
Evidence-based review of aetiopathogenic theories of congenital and acquired cholesteatoma.
Persaud R, Hajioff D, Trinidade A, Khemani S, Bhattacharyya MN, Papadimitriou N, Kalan A, Bhattacharyya AK
J Laryngol Otol 2007 Nov;121(11):1013-9. Epub 2007 Aug 15 doi: 10.1017/S0022215107000503. PMID: 17697435
Psoriasis.
Baden HP, Pugliese MM
Dis Mon 1973 Sep:3-47. PMID: 4590327
Cytokinetics in diseases of epidermal hyperplasia.
Weinstein GD, McCullough JL
Annu Rev Med 1973;24:345-52. doi: 10.1146/annurev.me.24.020173.002021. PMID: 4581910
Stucco keratosis.
Willoughby C, Soter NA
Arch Dermatol 1972 Jun;105(6):859-61. PMID: 4555326

Prognosis

Wolf in sheep's clothing - Oral proliferative verrucous leukoplakia: Progression with longitudinal molecular insights.
Afkhami M, Maghami E, Gernon TJ, Villaflor V, Bell D
Ann Diagn Pathol 2023 Apr;63:152104. Epub 2023 Jan 6 doi: 10.1016/j.anndiagpath.2023.152104. PMID: 36640643
Oral epithelial dysplasia: Recognition, grading and clinical significance.
Odell E, Kujan O, Warnakulasuriya S, Sloan P
Oral Dis 2021 Nov;27(8):1947-1976. Epub 2021 Sep 14 doi: 10.1111/odi.13993. PMID: 34418233
Lesions With an Epidermal Hyperplastic Pattern: Morphologic Clues in the Differential Diagnosis.
Fernandez-Flores A
Am J Dermatopathol 2016 Jan;38(1):1-16; quiz 17-9. doi: 10.1097/DAD.0000000000000324. PMID: 26730692
Topical retinoids: in vivo predictive assays.
Lowe NJ
J Am Acad Dermatol 1986 Oct;15(4 Pt 2):766-72. doi: 10.1016/s0190-9622(86)70232-6. PMID: 2945843
Adult onset laryngeal papillomatosis.
Johnson JT, Barnes EL, Justice W
Otolaryngol Head Neck Surg 1981 Sep-Oct;89(5):867-73. doi: 10.1177/019459988108900533. PMID: 6799924

Clinical prediction guides

Tranexamic acid improves psoriasis-like skin inflammation: Evidence from in vivo and in vitro studies.
Hseu JH, Chan CI, Vadivalagan C, Chen SJ, Yen HR, Hseu YC, Yang HL, Wu PY
Biomed Pharmacother 2023 Oct;166:115307. Epub 2023 Aug 11 doi: 10.1016/j.biopha.2023.115307. PMID: 37573659
Actinic keratoses contiguous with squamous cell carcinomas are mostly non-hyperkeratotic and with severe dysplasia.
Heerfordt IM, Poulsen T, Wulf HC
J Clin Pathol 2022 Aug;75(8):560-563. Epub 2021 Apr 16 doi: 10.1136/jclinpath-2021-207497. PMID: 33863749
Oral epithelial dysplasia: Recognition, grading and clinical significance.
Odell E, Kujan O, Warnakulasuriya S, Sloan P
Oral Dis 2021 Nov;27(8):1947-1976. Epub 2021 Sep 14 doi: 10.1111/odi.13993. PMID: 34418233
A role for TGFbeta signaling in the pathogenesis of psoriasis.
Han G, Williams CA, Salter K, Garl PJ, Li AG, Wang XJ
J Invest Dermatol 2010 Feb;130(2):371-7. Epub 2009 Aug 27 doi: 10.1038/jid.2009.252. PMID: 19710682Free PMC Article
Disseminated spiked hyperkeratosis.
Nedwich JA, Sullivan JJ
Int J Dermatol 1987 Jul-Aug;26(6):358-61. doi: 10.1111/j.1365-4362.1987.tb00559.x. PMID: 3623792

Recent systematic reviews

Systematic review of randomized controlled trials of topicals for actinic keratosis field therapy.
Patel P, Wang J, Bitterman D, Mineroff J, Austin E, Jagdeo J
Arch Dermatol Res 2024 Mar 18;316(4):108. doi: 10.1007/s00403-024-02839-y. PMID: 38498070
A systematic review and critical evaluation of immunohistochemical associations in hidradenitis suppurativa.
Frew JW, Hawkes JE, Krueger JG
F1000Res 2018;7:1923. Epub 2018 Dec 11 doi: 10.12688/f1000research.17268.2. PMID: 31281635Free PMC Article
Application of intense pulsed light in the treatment of dermatologic disease: a systematic review.
Wat H, Wu DC, Rao J, Goldman MP
Dermatol Surg 2014 Apr;40(4):359-77. Epub 2014 Feb 4 doi: 10.1111/dsu.12424. PMID: 24495252

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