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Malignant Fundus Neoplasm

MedGen UID:
1754723
•Concept ID:
C0864946
•
Neoplastic Process

Definition

A primary or metastatic malignant neoplasm that affects the gastric fundus. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Fundus Neoplasm

Professional guidelines

PubMed

Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision.
Zaffaroni G, Mannucci A, Koskenvuo L, de Lacy B, Maffioli A, Bisseling T, Half E, Cavestro GM, Valle L, Ryan N, Aretz S, Brown K, Buttitta F, Carneiro F, Claber O, Blanco-Colino R, Collard M, Crosbie E, Cunha M, Doulias T, Fleming C, Heinrich H, Hüneburg R, Metras J, Nagtegaal I, Negoi I, Nielsen M, Pellino G, Ricciardiello L, Sagir A, Sánchez-Guillén L, Seppälä TT, Siersema P, Striebeck B, Sampson JR, Latchford A, Parc Y, Burn J, Möslein G
Br J Surg 2024 May 3;111(5) doi: 10.1093/bjs/znae070. PMID: 38722804Free PMC Article
Prenatal diagnosis of gastric duplication cyst at the fundus.
Chao MF, Chang YT, Jaw TS
Pediatr Neonatol 2022 Jan;63(1):89-90. Epub 2021 Sep 10 doi: 10.1016/j.pedneo.2021.07.008. PMID: 34565696
Properties and clinical utility of topotecan fluorescence: uses for retinoblastoma.
Francis JH, Marr BP, Schaiquevich P, Kellick MG, Abramson DH
Br J Ophthalmol 2015 Oct;99(10):1320-2. Epub 2015 Apr 29 doi: 10.1136/bjophthalmol-2015-306633. PMID: 25926516

Recent clinical studies

Etiology

Fundic gland adenocarcinoma.
Goel A, Agrawal K, Mukherjee U, Singla V
BMJ Case Rep 2024 Dec 3;17(12) doi: 10.1136/bcr-2024-261983. PMID: 39631917
Ophthalmic manifestations of acute leukaemias.
Němčanská S, Stepanov A, Němčanský J
Cesk Slov Oftalmol 2018 Winter;74(3):98-101. doi: 10.31348/2018/1/3-3-2018. PMID: 30650972
Multimodal imaging of suspicious choroidal neoplasms in a primary eye-care clinic.
Kaur G, Anthony SA
Clin Exp Optom 2017 Nov;100(6):549-562. Epub 2017 Mar 28 doi: 10.1111/cxo.12537. PMID: 28370509
Torpedo maculopathy.
Teitelbaum BA, Hachey DL, Messner LV
J Am Optom Assoc 1997 Jun;68(6):373-6. PMID: 9190137
Cryotherapy for retinoblastoma.
Shields JA, Shields CL, De Potter P
Int Ophthalmol Clin 1993 Summer;33(3):101-5. doi: 10.1097/00004397-199303330-00015. PMID: 8407173

Diagnosis

Intraocular Tumors: Angiographic Patterns.
Bowen RC, Raval V, Soto H, Singh AD
Asia Pac J Ophthalmol (Phila) 2020 Sep-Oct;9(5):449-460. doi: 10.1097/APO.0000000000000323. PMID: 32960821
Isolated Racemose Angioma.
Mohan S, Dabir S, Rajan M
Ophthalmology 2020 Oct;127(10):1370. doi: 10.1016/j.ophtha.2020.06.002. PMID: 32951672
Retinal meteor.
Venkatesh R, Gurav P, Dave PA, Roy S
Indian J Ophthalmol 2017 Sep;65(9):879-881. doi: 10.4103/ijo.IJO_68_17. PMID: 28905838Free PMC Article
Choroidal hemangioma.
Singh AD, Kaiser PK, Sears JE
Ophthalmol Clin North Am 2005 Mar;18(1):151-61, ix. doi: 10.1016/j.ohc.2004.07.004. PMID: 15763200
Peripapillary hemorrhage.
Winterkorn JM
Surv Ophthalmol 1993 Mar-Apr;37(5):362-72. doi: 10.1016/0039-6257(93)90066-g. PMID: 8484169

Therapy

I Can't See.
Leung EH, Stout JT
J Pediatr Ophthalmol Strabismus 2019 Mar 19;56(2):71. doi: 10.3928/01913913-20190212-01. PMID: 30889258
Macular edema. Miscellaneous.
Creuzot-Garcher C, Wolf S
Dev Ophthalmol 2010;47:183-198. Epub 2010 Aug 10 doi: 10.1159/000320081. PMID: 20703051
Interferon-associated retinopathy.
Guyer DR, Tiedeman J, Yannuzzi LA, Slakter JS, Parke D, Kelley J, Tang RA, Marmor M, Abrams G, Miller JW
Arch Ophthalmol 1993 Mar;111(3):350-6. doi: 10.1001/archopht.1993.01090030068041. PMID: 8447745
Photocoagulation of retinoblastoma.
Shields JA, Shields CL, De Potter P
Int Ophthalmol Clin 1993 Summer;33(3):95-9. doi: 10.1097/00004397-199303330-00014. PMID: 8407197
Cryotherapy for retinoblastoma.
Shields JA, Shields CL, De Potter P
Int Ophthalmol Clin 1993 Summer;33(3):101-5. doi: 10.1097/00004397-199303330-00015. PMID: 8407173

Prognosis

Macular edema. Miscellaneous.
Creuzot-Garcher C, Wolf S
Dev Ophthalmol 2010;47:183-198. Epub 2010 Aug 10 doi: 10.1159/000320081. PMID: 20703051
Choroidal hemangioma.
Singh AD, Kaiser PK, Sears JE
Ophthalmol Clin North Am 2005 Mar;18(1):151-61, ix. doi: 10.1016/j.ohc.2004.07.004. PMID: 15763200
Cryotherapy for retinoblastoma.
Shields JA, Shields CL, De Potter P
Int Ophthalmol Clin 1993 Summer;33(3):101-5. doi: 10.1097/00004397-199303330-00015. PMID: 8407173
Choroidal malignant melanoma.
Murphy SF, Mahl CF, Bloom SM
Optom Clin 1993;3(3):63-77. PMID: 8199451
Optic nerve sheath meningiomas.
Dutton JJ
Surv Ophthalmol 1992 Nov-Dec;37(3):167-83. doi: 10.1016/0039-6257(92)90135-g. PMID: 1475751

Clinical prediction guides

Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing.
Zhang M, Hu S, Min M, Ni Y, Lu Z, Sun X, Wu J, Liu B, Ying X, Liu Y
Gut 2021 Mar;70(3):464-475. Epub 2020 Jun 12 doi: 10.1136/gutjnl-2019-320368. PMID: 32532891Free PMC Article
Retinoblastoma, the visible CNS tumor: A review.
Dimaras H, Corson TW
J Neurosci Res 2019 Jan;97(1):29-44. Epub 2018 Jan 3 doi: 10.1002/jnr.24213. PMID: 29314142Free PMC Article
Gastric adenocarcinoma of fundic gland type with signet-ring cell carcinoma component: A case report and review of the literature.
Kai K, Satake M, Tokunaga O
World J Gastroenterol 2018 Jul 14;24(26):2915-2920. doi: 10.3748/wjg.v24.i26.2915. PMID: 30018486Free PMC Article
Macular edema. Miscellaneous.
Creuzot-Garcher C, Wolf S
Dev Ophthalmol 2010;47:183-198. Epub 2010 Aug 10 doi: 10.1159/000320081. PMID: 20703051
Amelanotic choroidal nevi.
Brown GC, Shields JA, Augsburger JJ
Ophthalmology 1981 Nov;88(11):1116-21. doi: 10.1016/s0161-6420(81)34896-9. PMID: 7335317

Recent systematic reviews

Updated European guidelines for clinical management of familial adenomatous polyposis (FAP), MUTYH-associated polyposis (MAP), gastric adenocarcinoma, proximal polyposis of the stomach (GAPPS) and other rare adenomatous polyposis syndromes: a joint EHTG-ESCP revision.
Zaffaroni G, Mannucci A, Koskenvuo L, de Lacy B, Maffioli A, Bisseling T, Half E, Cavestro GM, Valle L, Ryan N, Aretz S, Brown K, Buttitta F, Carneiro F, Claber O, Blanco-Colino R, Collard M, Crosbie E, Cunha M, Doulias T, Fleming C, Heinrich H, Hüneburg R, Metras J, Nagtegaal I, Negoi I, Nielsen M, Pellino G, Ricciardiello L, Sagir A, Sánchez-Guillén L, Seppälä TT, Siersema P, Striebeck B, Sampson JR, Latchford A, Parc Y, Burn J, Möslein G
Br J Surg 2024 May 3;111(5) doi: 10.1093/bjs/znae070. PMID: 38722804Free PMC Article
Consensus Guidelines for Ocular Surveillance of von Hippel-Lindau Disease.
Daniels AB, Chang EY, Chew EY, Gombos DS, Gorin MB, Shields CL, Wiley HE
Ophthalmology 2024 May;131(5):622-633. Epub 2023 Dec 12 doi: 10.1016/j.ophtha.2023.12.014. PMID: 38092079
The risk of glaucoma associated with phacomatosis cesioflammea and phacomatosis cesioflammeo-marmorata.
Huang S, Yang Y, Ouyang Z, Guo X, Zhan Z, Liu X, Chen Z, Xu J, Yu M
Eur J Dermatol 2022 Sep 1;32(5):589-596. doi: 10.1684/ejd.2022.4317. PMID: 36468718
Pediatric Cataract Surgery Following Treatment for Retinoblastoma: A Case Series and Systematic Review.
Kletke SN, Mallipatna A, Mireskandari K, Gallie BL, Ali A
Am J Ophthalmol 2022 Jul;239:130-141. Epub 2022 Feb 13 doi: 10.1016/j.ajo.2022.02.001. PMID: 35172168
Use of Proton Pump Inhibitors and Risks of Fundic Gland Polyps and Gastric Cancer: Systematic Review and Meta-analysis.
Tran-Duy A, Spaetgens B, Hoes AW, de Wit NJ, Stehouwer CD
Clin Gastroenterol Hepatol 2016 Dec;14(12):1706-1719.e5. Epub 2016 May 20 doi: 10.1016/j.cgh.2016.05.018. PMID: 27211501

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