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Abrupt Nuclear Anaplasia

MedGen UID:
1757391
•Concept ID:
C5419804
•
Finding

Definition

A morphologic finding indicating the presence of small clusters of tumor cells with marked nuclear anaplasia in a background of tumor cells with bland nuclear cytology. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbrupt Nuclear Anaplasia

Recent clinical studies

Etiology

Malignant solitary fibrous tumour of the prostate: four cases emphasising significant histological and immunophenotypical overlap with sarcomatoid carcinoma.
Bakhshwin A, Berry RS, Cox RM, Li R, Reynolds JP, Rubin BP, McKenney JK
Pathology 2020 Oct;52(6):643-648. Epub 2020 Aug 2 doi: 10.1016/j.pathol.2020.06.004. PMID: 32758370
Chromophobe hepatocellular carcinoma with abrupt anaplasia: a proposal for a new subtype of hepatocellular carcinoma with unique morphological and molecular features.
Wood LD, Heaphy CM, Daniel HD, Naini BV, Lassman CR, Arroyo MR, Kamel IR, Cosgrove DP, Boitnott JK, Meeker AK, Torbenson MS
Mod Pathol 2013 Dec;26(12):1586-93. Epub 2013 May 3 doi: 10.1038/modpathol.2013.68. PMID: 23640129Free PMC Article

Diagnosis

Malignant solitary fibrous tumour of the prostate: four cases emphasising significant histological and immunophenotypical overlap with sarcomatoid carcinoma.
Bakhshwin A, Berry RS, Cox RM, Li R, Reynolds JP, Rubin BP, McKenney JK
Pathology 2020 Oct;52(6):643-648. Epub 2020 Aug 2 doi: 10.1016/j.pathol.2020.06.004. PMID: 32758370

Prognosis

Malignant solitary fibrous tumour of the prostate: four cases emphasising significant histological and immunophenotypical overlap with sarcomatoid carcinoma.
Bakhshwin A, Berry RS, Cox RM, Li R, Reynolds JP, Rubin BP, McKenney JK
Pathology 2020 Oct;52(6):643-648. Epub 2020 Aug 2 doi: 10.1016/j.pathol.2020.06.004. PMID: 32758370
Chromophobe hepatocellular carcinoma with abrupt anaplasia: a proposal for a new subtype of hepatocellular carcinoma with unique morphological and molecular features.
Wood LD, Heaphy CM, Daniel HD, Naini BV, Lassman CR, Arroyo MR, Kamel IR, Cosgrove DP, Boitnott JK, Meeker AK, Torbenson MS
Mod Pathol 2013 Dec;26(12):1586-93. Epub 2013 May 3 doi: 10.1038/modpathol.2013.68. PMID: 23640129Free PMC Article

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