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Increased aromatic amino acid level in urine

MedGen UID:
1769248
•Concept ID:
C5421602
•
Finding
HPO: HP:0033090

Definition

An elevated level of an aromatic amino acid in the urine. [from HPO]

Professional guidelines

PubMed

Clinical utility of urinary levels of catecholamines and their fraction ratios related to heart rate and thyroid function.
Sunada N, Hanayama Y, Yamamoto K, Nakano Y, Nada T, Honda H, Hasegawa K, Hagiya H, Otsuka F
Endocr J 2022 Apr 28;69(4):417-425. Epub 2021 Nov 3 doi: 10.1507/endocrj.EJ21-0488. PMID: 34732615
Renal function improves with the treatment of hypothyroidism.
Bulur O, Dal K, Ertugrul DT, Eser M, Kaplan Efe F, Karakaya S, Şahin K, Baser S, Ata N, Aybal Kutlugun A, Beyan E
Endocr Res 2017 Aug;42(3):246-251. Epub 2017 Mar 13 doi: 10.1080/07435800.2017.1293686. PMID: 28287838
Tyrosinemia type 1 in Spain: mutational analysis, treatment and long-term outcome.
Couce ML, Dalmau J, del Toro M, Pintos-Morell G, Aldámiz-Echevarría L; Spanish Working Group on Tyrosinemia type 1
Pediatr Int 2011 Dec;53(6):985-9. doi: 10.1111/j.1442-200X.2011.03427.x. PMID: 21752152

Recent clinical studies

Etiology

Does fluoride exposure affect thyroid function? A systematic review and dose-response meta-analysis.
Iamandii I, De Pasquale L, Giannone ME, Veneri F, Generali L, Consolo U, Birnbaum LS, Castenmiller J, Halldorsson TI, Filippini T, Vinceti M
Environ Res 2024 Feb 1;242:117759. Epub 2023 Nov 28 doi: 10.1016/j.envres.2023.117759. PMID: 38029816
A ketogenic diet substantially reshapes the human metabolome.
Effinger D, Hirschberger S, Yoncheva P, Schmid A, Heine T, Newels P, Schütz B, Meng C, Gigl M, Kleigrewe K, Holdt LM, Teupser D, Kreth S
Clin Nutr 2023 Jul;42(7):1202-1212. Epub 2023 May 4 doi: 10.1016/j.clnu.2023.04.027. PMID: 37270344
Metabolomics and Type 2 Diabetes Risk: An Updated Systematic Review and Meta-analysis of Prospective Cohort Studies.
Morze J, Wittenbecher C, Schwingshackl L, Danielewicz A, Rynkiewicz A, Hu FB, Guasch-Ferré M
Diabetes Care 2022 Apr 1;45(4):1013-1024. doi: 10.2337/dc21-1705. PMID: 35349649Free PMC Article
The impact and toxicity of glyphosate and glyphosate-based herbicides on health and immunity.
Peillex C, Pelletier M
J Immunotoxicol 2020 Dec;17(1):163-174. doi: 10.1080/1547691X.2020.1804492. PMID: 32897110
Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome.
Pinto-Sanchez MI, Hall GB, Ghajar K, Nardelli A, Bolino C, Lau JT, Martin FP, Cominetti O, Welsh C, Rieder A, Traynor J, Gregory C, De Palma G, Pigrau M, Ford AC, Macri J, Berger B, Bergonzelli G, Surette MG, Collins SM, Moayyedi P, Bercik P
Gastroenterology 2017 Aug;153(2):448-459.e8. Epub 2017 May 5 doi: 10.1053/j.gastro.2017.05.003. PMID: 28483500

Diagnosis

Mono-(2-ethyl-5-hydroxyhexyl) phthalate promotes uterine leiomyoma cell survival through tryptophan-kynurenine-AHR pathway activation.
Iizuka T, Yin P, Zuberi A, Kujawa S, Coon JS 5th, Björvang RD, Damdimopoulou P, Pacyga DC, Strakovsky RS, Flaws JA, Bulun SE
Proc Natl Acad Sci U S A 2022 Nov 22;119(47):e2208886119. Epub 2022 Nov 14 doi: 10.1073/pnas.2208886119. PMID: 36375056Free PMC Article
Significance of 5-S-Cysteinyldopa as a Marker for Melanoma.
Wakamatsu K, Fukushima S, Minagawa A, Omodaka T, Hida T, Hatta N, Takata M, Uhara H, Okuyama R, Ihn H
Int J Mol Sci 2020 Jan 9;21(2) doi: 10.3390/ijms21020432. PMID: 31936623Free PMC Article
Specific Urinary Metabolites in Malignant Melanoma.
Valko-Rokytovská M, Hubková B, Birková A, Mašlanková J, Stupák M, Zábavníková M, Čižmárová B, Mareková M
Medicina (Kaunas) 2019 May 16;55(5) doi: 10.3390/medicina55050145. PMID: 31100919Free PMC Article
Exploratory metabolomics of nascent metabolic syndrome.
Shim K, Gulhar R, Jialal I
J Diabetes Complications 2019 Mar;33(3):212-216. Epub 2018 Dec 10 doi: 10.1016/j.jdiacomp.2018.12.002. PMID: 30611573
Monitoring myelomatosis.
Hobbs JR
Arch Intern Med 1975 Jan;135(1):125-30. PMID: 1111461

Therapy

The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
Sutanto CN, Xia X, Heng CW, Tan YS, Lee DPS, Fam J, Kim JE
Clin Nutr 2024 Mar;43(3):593-602. Epub 2024 Jan 17 doi: 10.1016/j.clnu.2024.01.010. PMID: 38309227
Does fluoride exposure affect thyroid function? A systematic review and dose-response meta-analysis.
Iamandii I, De Pasquale L, Giannone ME, Veneri F, Generali L, Consolo U, Birnbaum LS, Castenmiller J, Halldorsson TI, Filippini T, Vinceti M
Environ Res 2024 Feb 1;242:117759. Epub 2023 Nov 28 doi: 10.1016/j.envres.2023.117759. PMID: 38029816
A ketogenic diet substantially reshapes the human metabolome.
Effinger D, Hirschberger S, Yoncheva P, Schmid A, Heine T, Newels P, Schütz B, Meng C, Gigl M, Kleigrewe K, Holdt LM, Teupser D, Kreth S
Clin Nutr 2023 Jul;42(7):1202-1212. Epub 2023 May 4 doi: 10.1016/j.clnu.2023.04.027. PMID: 37270344
Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome.
Pinto-Sanchez MI, Hall GB, Ghajar K, Nardelli A, Bolino C, Lau JT, Martin FP, Cominetti O, Welsh C, Rieder A, Traynor J, Gregory C, De Palma G, Pigrau M, Ford AC, Macri J, Berger B, Bergonzelli G, Surette MG, Collins SM, Moayyedi P, Bercik P
Gastroenterology 2017 Aug;153(2):448-459.e8. Epub 2017 May 5 doi: 10.1053/j.gastro.2017.05.003. PMID: 28483500
Monitoring myelomatosis.
Hobbs JR
Arch Intern Med 1975 Jan;135(1):125-30. PMID: 1111461

Prognosis

Subclinical thyroid dysfunction and chronic kidney disease: a nationwide population-based study.
Kim HJ, Park SJ, Park HK, Byun DW, Suh K, Yoo MH
BMC Nephrol 2023 Mar 22;24(1):64. doi: 10.1186/s12882-023-03111-7. PMID: 36949396Free PMC Article
Proteinuria in Severe Hypothyroidism: A Prospective Study.
Gondil VS, Chandrasekaran A, Rastogi A, Yadav AK, Sood A, Ramachandran R, Kumar V, Rathi M, Kohli HS, Jha V, Gupta KL
J Clin Endocrinol Metab 2021 Jan 23;106(2):e749-e756. doi: 10.1210/clinem/dgaa871. PMID: 33245744
Significance of 5-S-Cysteinyldopa as a Marker for Melanoma.
Wakamatsu K, Fukushima S, Minagawa A, Omodaka T, Hida T, Hatta N, Takata M, Uhara H, Okuyama R, Ihn H
Int J Mol Sci 2020 Jan 9;21(2) doi: 10.3390/ijms21020432. PMID: 31936623Free PMC Article
Differences in Calcium Metabolism and Thyroid Physiology After Sleeve Gastrectomy and Roux-En-Y Gastric Bypass.
Duran İD, Gülçelik NE, Bulut B, Balcı Z, Berker D, Güler S
Obes Surg 2019 Feb;29(2):705-712. doi: 10.1007/s11695-018-3595-z. PMID: 30460439
Monitoring myelomatosis.
Hobbs JR
Arch Intern Med 1975 Jan;135(1):125-30. PMID: 1111461

Clinical prediction guides

The impact of 5-hydroxytryptophan supplementation on sleep quality and gut microbiota composition in older adults: A randomized controlled trial.
Sutanto CN, Xia X, Heng CW, Tan YS, Lee DPS, Fam J, Kim JE
Clin Nutr 2024 Mar;43(3):593-602. Epub 2024 Jan 17 doi: 10.1016/j.clnu.2024.01.010. PMID: 38309227
Metabolomics and Type 2 Diabetes Risk: An Updated Systematic Review and Meta-analysis of Prospective Cohort Studies.
Morze J, Wittenbecher C, Schwingshackl L, Danielewicz A, Rynkiewicz A, Hu FB, Guasch-Ferré M
Diabetes Care 2022 Apr 1;45(4):1013-1024. doi: 10.2337/dc21-1705. PMID: 35349649Free PMC Article
Significance of 5-S-Cysteinyldopa as a Marker for Melanoma.
Wakamatsu K, Fukushima S, Minagawa A, Omodaka T, Hida T, Hatta N, Takata M, Uhara H, Okuyama R, Ihn H
Int J Mol Sci 2020 Jan 9;21(2) doi: 10.3390/ijms21020432. PMID: 31936623Free PMC Article
Probiotic Bifidobacterium longum NCC3001 Reduces Depression Scores and Alters Brain Activity: A Pilot Study in Patients With Irritable Bowel Syndrome.
Pinto-Sanchez MI, Hall GB, Ghajar K, Nardelli A, Bolino C, Lau JT, Martin FP, Cominetti O, Welsh C, Rieder A, Traynor J, Gregory C, De Palma G, Pigrau M, Ford AC, Macri J, Berger B, Bergonzelli G, Surette MG, Collins SM, Moayyedi P, Bercik P
Gastroenterology 2017 Aug;153(2):448-459.e8. Epub 2017 May 5 doi: 10.1053/j.gastro.2017.05.003. PMID: 28483500
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor.
Rothhammer V, Mascanfroni ID, Bunse L, Takenaka MC, Kenison JE, Mayo L, Chao CC, Patel B, Yan R, Blain M, Alvarez JI, Kébir H, Anandasabapathy N, Izquierdo G, Jung S, Obholzer N, Pochet N, Clish CB, Prinz M, Prat A, Antel J, Quintana FJ
Nat Med 2016 Jun;22(6):586-97. Epub 2016 May 9 doi: 10.1038/nm.4106. PMID: 27158906Free PMC Article

Recent systematic reviews

Does fluoride exposure affect thyroid function? A systematic review and dose-response meta-analysis.
Iamandii I, De Pasquale L, Giannone ME, Veneri F, Generali L, Consolo U, Birnbaum LS, Castenmiller J, Halldorsson TI, Filippini T, Vinceti M
Environ Res 2024 Feb 1;242:117759. Epub 2023 Nov 28 doi: 10.1016/j.envres.2023.117759. PMID: 38029816
The tryptophan catabolite or kynurenine pathway in autism spectrum disorder; a systematic review and meta-analysis.
Almulla AF, Thipakorn Y, Tunvirachaisakul C, Maes M
Autism Res 2023 Dec;16(12):2302-2315. Epub 2023 Nov 1 doi: 10.1002/aur.3044. PMID: 37909397
Metabolomics and Type 2 Diabetes Risk: An Updated Systematic Review and Meta-analysis of Prospective Cohort Studies.
Morze J, Wittenbecher C, Schwingshackl L, Danielewicz A, Rynkiewicz A, Hu FB, Guasch-Ferré M
Diabetes Care 2022 Apr 1;45(4):1013-1024. doi: 10.2337/dc21-1705. PMID: 35349649Free PMC Article
Environmental arsenic exposure and its toxicological effect on thyroid function: a systematic review.
Esform A, Farkhondeh T, Samarghandian S, Rezaei M, Naghizadeh A
Rev Environ Health 2022 Jun 27;37(2):281-289. Epub 2021 Jun 7 doi: 10.1515/reveh-2021-0025. PMID: 34090316

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