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Abnormal circulating sex hormone concentration

MedGen UID:
1779099
Concept ID:
C5539818
Finding
Synonyms: Abnormal circulating gonadal steroid concentration; Abnormal circulating gonadocorticoid concentration; Abnormal circulating sex steroid concentration
 
HPO: HP:0033799

Definition

Any deviation from the normal concentration of a sex hormone in the blood circulation [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating sex hormone concentration

Professional guidelines

PubMed

Pugeat M, Plotton I, de la Perrière AB, Raverot G, Déchaud H, Raverot V
Eur J Endocrinol 2018 Apr;178(4):R141-R154. Epub 2018 Feb 16 doi: 10.1530/EJE-17-0776. PMID: 29453202
Hjerrild BE, Mortensen KH, Gravholt CH
Br Med Bull 2008;86:77-93. Epub 2008 Apr 9 doi: 10.1093/bmb/ldn015. PMID: 18400842
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574

Recent clinical studies

Etiology

Cozzolino M, Alsbjerg B, Pellicer A, Garcia-Velasco JA, Humaidan P
Reprod Biomed Online 2024 Apr;48(4):103737. Epub 2023 Nov 25 doi: 10.1016/j.rbmo.2023.103737. PMID: 38342076
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Voutilainen R, Jääskeläinen J
J Steroid Biochem Mol Biol 2015 Jan;145:226-36. Epub 2014 Jun 9 doi: 10.1016/j.jsbmb.2014.06.004. PMID: 24923732
Poppe K, Velkeniers B, Glinoer D
Nat Clin Pract Endocrinol Metab 2008 Jul;4(7):394-405. Epub 2008 May 27 doi: 10.1038/ncpendmet0846. PMID: 18506157
Levitz M, Kadner S, Young BK
J Steroid Biochem 1984 Apr;20(4B):971-4. doi: 10.1016/0022-4731(84)90006-2. PMID: 6727356

Diagnosis

Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Lecoq AL, Chaumet-Riffaud P, Blanchard A, Dupeux M, Rothenbuhler A, Lambert B, Durand E, Boros E, Briot K, Silve C, Francou B, Piketty M, Chanson P, Brailly-Tabard S, Linglart A, Kamenický P
J Bone Miner Res 2020 Jul;35(7):1263-1273. Epub 2020 Mar 27 doi: 10.1002/jbmr.3992. PMID: 32101626
Karbowska J, Kochan Z
Horm Mol Biol Clin Investig 2013 Aug;14(2):65-74. doi: 10.1515/hmbci-2013-0009. PMID: 25436721
Aksglaede L, Christiansen P, Sørensen K, Boas M, Linneberg A, Main KM, Andersson AM, Skakkebaek NE, Juul A
Acta Paediatr 2011 Jun;100(6):839-45. Epub 2011 Feb 25 doi: 10.1111/j.1651-2227.2011.02148.x. PMID: 21251056
Haynes BP, Dowsett M, Miller WR, Dixon JM, Bhatnagar AS
J Steroid Biochem Mol Biol 2003 Oct;87(1):35-45. doi: 10.1016/s0960-0760(03)00384-4. PMID: 14630089

Therapy

Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
McCormack SE, Blevins JE, Lawson EA
Endocr Rev 2020 Apr 1;41(2):121-45. doi: 10.1210/endrev/bnz012. PMID: 31803919Free PMC Article
Aksglaede L, Christiansen P, Sørensen K, Boas M, Linneberg A, Main KM, Andersson AM, Skakkebaek NE, Juul A
Acta Paediatr 2011 Jun;100(6):839-45. Epub 2011 Feb 25 doi: 10.1111/j.1651-2227.2011.02148.x. PMID: 21251056
Maninger N, Wolkowitz OM, Reus VI, Epel ES, Mellon SH
Front Neuroendocrinol 2009 Jan;30(1):65-91. Epub 2008 Dec 3 doi: 10.1016/j.yfrne.2008.11.002. PMID: 19063914Free PMC Article
Hjerrild BE, Mortensen KH, Gravholt CH
Br Med Bull 2008;86:77-93. Epub 2008 Apr 9 doi: 10.1093/bmb/ldn015. PMID: 18400842

Prognosis

Luque-Ramírez M, Nattero-Chávez L, Rodríguez-Rubio Corona C, Ortiz-Flores AE, García-Cano AM, Rosillo Coronado M, Pérez Mies B, Ruz Caracuel I, Escobar-Morreale HF
J Endocrinol Invest 2024 Aug;47(8):2007-2020. Epub 2024 Feb 13 doi: 10.1007/s40618-023-02297-9. PMID: 38349517Free PMC Article
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908
Johansson H, Bonanni B, Gandini S, Guerrieri-Gonzaga A, Cazzaniga M, Serrano D, Macis D, Puccio A, Sandri MT, Gulisano M, Formelli F, Decensi A
Breast Cancer Res Treat 2013 Dec;142(3):569-78. Epub 2013 Nov 17 doi: 10.1007/s10549-013-2768-7. PMID: 24241787
Reyes H, Sjövall J
Ann Med 2000 Mar;32(2):94-106. doi: 10.3109/07853890009011758. PMID: 10766400
Hamilton-Fairley D, White D, Griffiths M, Anyaoku V, Koistinen R, Seppälä M, Franks S
Clin Endocrinol (Oxf) 1995 Aug;43(2):159-65. doi: 10.1111/j.1365-2265.1995.tb01910.x. PMID: 7554310

Clinical prediction guides

Lecoq AL, Chaumet-Riffaud P, Blanchard A, Dupeux M, Rothenbuhler A, Lambert B, Durand E, Boros E, Briot K, Silve C, Francou B, Piketty M, Chanson P, Brailly-Tabard S, Linglart A, Kamenický P
J Bone Miner Res 2020 Jul;35(7):1263-1273. Epub 2020 Mar 27 doi: 10.1002/jbmr.3992. PMID: 32101626
McCormack SE, Blevins JE, Lawson EA
Endocr Rev 2020 Apr 1;41(2):121-45. doi: 10.1210/endrev/bnz012. PMID: 31803919Free PMC Article
Parks JS, Brown MR, Faase ME
J Pediatr 1997 Jul;131(1 Pt 2):S45-50. doi: 10.1016/s0022-3476(97)70011-8. PMID: 9255228
Pugeat M, Crave JC, Tourniaire J, Forest MG
Horm Res 1996;45(3-5):148-55. doi: 10.1159/000184778. PMID: 8964574
Kofman-Alfaro S, Valdés E, Terán J, Wachtel SS, Chávez B, Bassol S, Medina M, Pérez-Palacios G
Acta Endocrinol (Copenh) 1985 Mar;108(3):421-7. doi: 10.1530/acta.0.1080421. PMID: 3920857

Recent systematic reviews

Ren M, Wang L, Wen L, Chen J, Quan S, Shi X
Front Endocrinol (Lausanne) 2023;14:1216507. Epub 2023 Aug 29 doi: 10.3389/fendo.2023.1216507. PMID: 37711903Free PMC Article
Millán-de-Meer M, Luque-Ramírez M, Nattero-Chávez L, Escobar-Morreale HF
Hum Reprod Update 2023 Nov 2;29(6):741-772. doi: 10.1093/humupd/dmad015. PMID: 37353908

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