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Abnormal circulating androgen level

MedGen UID:
892717
•Concept ID:
C4072892
•
Finding
HPO: HP:0030347

Definition

An anomaly in the blood concentration of an androgen, that is, of a steroid hormone that controls development and maintenance of masculine characteristics. The androgens include testosterone and Dehydroepiandrosterone. [from HPO]

Professional guidelines

PubMed

MANAGEMENT OF ENDOCRINE DISEASE Hyperandrogenic states in women: pitfalls in laboratory diagnosis.
Pugeat M, Plotton I, de la Perrière AB, Raverot G, Déchaud H, Raverot V
Eur J Endocrinol 2018 Apr;178(4):R141-R154. Epub 2018 Feb 16 doi: 10.1530/EJE-17-0776. PMID: 29453202
Hirsutism: diagnosis and treatment.
Hohl A, Ronsoni MF, Oliveira Md
Arq Bras Endocrinol Metabol 2014 Mar;58(2):97-107. doi: 10.1590/0004-2730000002923. PMID: 24830586
Current recommendations for the diagnostic evaluation and follow-up of patients presenting with symptomatic polycystic ovary syndrome.
Fraser IS, Kovacs G
Best Pract Res Clin Obstet Gynaecol 2004 Oct;18(5):813-23. doi: 10.1016/j.bpobgyn.2004.06.009. PMID: 15380149

Recent clinical studies

Etiology

Polycystic ovary syndrome and adipose tissue.
Lemaitre M, Christin-Maitre S, Kerlan V
Ann Endocrinol (Paris) 2023 Apr;84(2):308-315. Epub 2023 Jan 7 doi: 10.1016/j.ando.2022.11.004. PMID: 36623807
Polycystic ovary syndrome and cardiovascular risk. Could trimethylamine N-oxide (TMAO) be a major player? A potential upgrade forward in the DOGMA theory.
Annunziata G, Ciampaglia R, Capò X, Guerra F, Sureda A, Tenore GC, Novellino E
Biomed Pharmacother 2021 Nov;143:112171. Epub 2021 Sep 15 doi: 10.1016/j.biopha.2021.112171. PMID: 34536755
Adrenal Hyperandrogenism and Polycystic Ovary Syndrome.
Luque-Ramírez M, Escobar-Morreale HF
Curr Pharm Des 2016;22(36):5588-5602. doi: 10.2174/1381612822666160720150625. PMID: 27510480
Polycystic ovary syndrome: current and future treatment paradigms.
Legro RS
Am J Obstet Gynecol 1998 Dec;179(6 Pt 2):S101-S108. doi: 10.1016/s0002-9378(98)70240-6. PMID: 9855616
Cyproterone acetate and the treatment of hirsutism.
Fraser IS, Shearman RP, Allen JK, McCarron G
Aust N Z J Obstet Gynaecol 1983 May;23(2):93-8. doi: 10.1111/j.1479-828x.1983.tb00172.x. PMID: 6226279

Diagnosis

Is idiopathic hirsutism idiopathic?
de Kroon RWPM, den Heijer M, Heijboer AC
Clin Chim Acta 2022 Jun 1;531:17-24. Epub 2022 Mar 12 doi: 10.1016/j.cca.2022.03.011. PMID: 35292252
Menopause-Associated Lipid Metabolic Disorders and Foods Beneficial for Postmenopausal Women.
Ko SH, Kim HS
Nutrients 2020 Jan 13;12(1) doi: 10.3390/nu12010202. PMID: 31941004Free PMC Article
Hirsutism: diagnosis and treatment.
Hohl A, Ronsoni MF, Oliveira Md
Arq Bras Endocrinol Metabol 2014 Mar;58(2):97-107. doi: 10.1590/0004-2730000002923. PMID: 24830586
Replacing testosterone in men.
Drug Ther Bull 1999 Jan;37(1):3-6. doi: 10.1136/dtb.1999.3713. PMID: 10562768
Polycystic ovary syndrome: current and future treatment paradigms.
Legro RS
Am J Obstet Gynecol 1998 Dec;179(6 Pt 2):S101-S108. doi: 10.1016/s0002-9378(98)70240-6. PMID: 9855616

Therapy

Randomized Controlled Trial of Neurokinin 3 Receptor Antagonist Fezolinetant for Treatment of Polycystic Ovary Syndrome.
Fraser GL, Obermayer-Pietsch B, Laven J, Griesinger G, Pintiaux A, Timmerman D, Fauser BCJM, Lademacher C, Combalbert J, Hoveyda HR, Ramael S
J Clin Endocrinol Metab 2021 Aug 18;106(9):e3519-e3532. doi: 10.1210/clinem/dgab320. PMID: 34000049Free PMC Article
Melatonin, environmental light, and breast cancer.
Srinivasan V, Spence DW, Pandi-Perumal SR, Trakht I, Esquifino AI, Cardinali DP, Maestroni GJ
Breast Cancer Res Treat 2008 Apr;108(3):339-50. Epub 2007 May 31 doi: 10.1007/s10549-007-9617-5. PMID: 17541739
Androgens and fertility.
Lombardo F, Sgrò P, Salacone P, Gilio B, Gandini L, Dondero F, Jannini EA, Lenzi A
J Endocrinol Invest 2005;28(3 Suppl):51-5. PMID: 16042361
Replacing testosterone in men.
Drug Ther Bull 1999 Jan;37(1):3-6. doi: 10.1136/dtb.1999.3713. PMID: 10562768
Polycystic ovary syndrome: current and future treatment paradigms.
Legro RS
Am J Obstet Gynecol 1998 Dec;179(6 Pt 2):S101-S108. doi: 10.1016/s0002-9378(98)70240-6. PMID: 9855616

Prognosis

Testosterone therapy in diabetes and pre-diabetes.
Corona G, Vena W, Pizzocaro A, Vignozzi L, Sforza A, Maggi M
Andrology 2023 Feb;11(2):204-214. Epub 2022 Dec 29 doi: 10.1111/andr.13367. PMID: 36542412
Polycystic ovary syndrome and cardiovascular risk. Could trimethylamine N-oxide (TMAO) be a major player? A potential upgrade forward in the DOGMA theory.
Annunziata G, Ciampaglia R, Capò X, Guerra F, Sureda A, Tenore GC, Novellino E
Biomed Pharmacother 2021 Nov;143:112171. Epub 2021 Sep 15 doi: 10.1016/j.biopha.2021.112171. PMID: 34536755
Sex hormones and breast cancer risk and prognosis.
Folkerd E, Dowsett M
Breast 2013 Aug;22 Suppl 2:S38-43. doi: 10.1016/j.breast.2013.07.007. PMID: 24074790
Testosterone and heart failure.
Volterrani M, Rosano G, Iellamo F
Endocrine 2012 Oct;42(2):272-7. Epub 2012 Jun 24 doi: 10.1007/s12020-012-9725-9. PMID: 22729951
Variable expression of 5 alpha-reductase deficiency: presentation with male phenotype in a child of Greek origin.
Carpenter TO, Imperato-McGinley J, Boulware SD, Weiss RM, Shackleton C, Griffin JE, Wilson JD
J Clin Endocrinol Metab 1990 Aug;71(2):318-22. doi: 10.1210/jcem-71-2-318. PMID: 2143199

Clinical prediction guides

Testicular Dysfunction in 47,XXY Boys: When It All Begins. A Semilongitudinal Study.
Pozza C, Sesti F, Tenuta M, Spaziani M, Tarantino C, Carlomagno F, Minnetti M, Pofi R, Paparella R, Lenzi A, Radicioni A, Isidori AM, Tarani L, Gianfrilli D
J Clin Endocrinol Metab 2023 Sep 18;108(10):2486-2499. doi: 10.1210/clinem/dgad205. PMID: 37043499Free PMC Article
Polycystic ovary syndrome and cardiovascular risk. Could trimethylamine N-oxide (TMAO) be a major player? A potential upgrade forward in the DOGMA theory.
Annunziata G, Ciampaglia R, Capò X, Guerra F, Sureda A, Tenore GC, Novellino E
Biomed Pharmacother 2021 Nov;143:112171. Epub 2021 Sep 15 doi: 10.1016/j.biopha.2021.112171. PMID: 34536755
Testosterone and heart failure.
Volterrani M, Rosano G, Iellamo F
Endocrine 2012 Oct;42(2):272-7. Epub 2012 Jun 24 doi: 10.1007/s12020-012-9725-9. PMID: 22729951
Factors controlling testis descent.
Hughes IA, Acerini CL
Eur J Endocrinol 2008 Dec;159 Suppl 1:S75-82. Epub 2008 Jul 22 doi: 10.1530/EJE-08-0458. PMID: 18647820
The behavioural effects of testosterone undecanoate in adult men with Klinefelter's syndrome: a controlled study.
Wu FC, Bancroft J, Davidson DW, Nicol K
Clin Endocrinol (Oxf) 1982 May;16(5):489-97. doi: 10.1111/j.1365-2265.1982.tb02763.x. PMID: 7083601

Recent systematic reviews

Testosterone therapy in diabetes and pre-diabetes.
Corona G, Vena W, Pizzocaro A, Vignozzi L, Sforza A, Maggi M
Andrology 2023 Feb;11(2):204-214. Epub 2022 Dec 29 doi: 10.1111/andr.13367. PMID: 36542412
Animal models of hyperandrogenism and ovarian morphology changes as features of polycystic ovary syndrome: a systematic review.
Paixão L, Ramos RB, Lavarda A, Morsh DM, Spritzer PM
Reprod Biol Endocrinol 2017 Feb 10;15(1):12. doi: 10.1186/s12958-017-0231-z. PMID: 28183310Free PMC Article

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