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Metastatic Endometrial Clear Cell Adenocarcinoma

MedGen UID:
1783987
•Concept ID:
C5446647
•
Neoplastic Process

Definition

Endometrial clear cell adenocarcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Endometrial Clear Cell Adenocarcinoma

Professional guidelines

PubMed

International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Utility and limitations of abdominal radiotherapy in the management of endometrial carcinomas.
Dusenbery KE, Potish RA, Gold DG, Boente MP
Gynecol Oncol 2005 Mar;96(3):635-42. doi: 10.1016/j.ygyno.2004.11.048. PMID: 15721405
Clear-cell and papillary serous cancer: treatment options.
Tropé C, Kristensen GB, Abeler VM
Best Pract Res Clin Obstet Gynaecol 2001 Jun;15(3):433-46. doi: 10.1053/beog.2000.0187. PMID: 11476564

Recent clinical studies

Etiology

Extended Pelvic Resections as Part of Secondary Cytoreduction for Relapsed Ovarian Adenocarcinoma.
Bacalbasa N, Balescu I, Dima S, Vilcu M, Brezean I
In Vivo 2020 Jan-Feb;34(1):397-400. doi: 10.21873/invivo.11787. PMID: 31882505Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Cervical Adenocarcinoma: Diagnosis of Human Papillomavirus-Positive and Human Papillomavirus-Negative Tumors.
Pirog EC
Arch Pathol Lab Med 2017 Dec;141(12):1653-1667. Epub 2017 Jun 23 doi: 10.5858/arpa.2016-0356-RA. PMID: 28644686
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer.
Hamanishi J, Mandai M, Ikeda T, Minami M, Kawaguchi A, Murayama T, Kanai M, Mori Y, Matsumoto S, Chikuma S, Matsumura N, Abiko K, Baba T, Yamaguchi K, Ueda A, Hosoe Y, Morita S, Yokode M, Shimizu A, Honjo T, Konishi I
J Clin Oncol 2015 Dec 1;33(34):4015-22. Epub 2015 Sep 8 doi: 10.1200/JCO.2015.62.3397. PMID: 26351349

Diagnosis

18F-FDG and 68Ga-FAPI-04 PET/CT in Evaluating Clear-Cell Endometrial Cancer.
Kiran MY, Has Simsek D, Sanli Y, Kuyumcu S
Clin Nucl Med 2023 Feb 1;48(2):e87-e88. doi: 10.1097/RLU.0000000000004532. PMID: 36607380
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
Cervical Adenocarcinoma: Diagnosis of Human Papillomavirus-Positive and Human Papillomavirus-Negative Tumors.
Pirog EC
Arch Pathol Lab Med 2017 Dec;141(12):1653-1667. Epub 2017 Jun 23 doi: 10.5858/arpa.2016-0356-RA. PMID: 28644686
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
Endometrial carcinomas: a review emphasizing overlapping and distinctive morphological and immunohistochemical features.
Bartosch C, Manuel Lopes J, Oliva E
Adv Anat Pathol 2011 Nov;18(6):415-37. doi: 10.1097/PAP.0b013e318234ab18. PMID: 21993268

Therapy

A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer.
Hamanishi J, Mandai M, Ikeda T, Minami M, Kawaguchi A, Murayama T, Kanai M, Mori Y, Matsumoto S, Chikuma S, Matsumura N, Abiko K, Baba T, Yamaguchi K, Ueda A, Hosoe Y, Morita S, Yokode M, Shimizu A, Honjo T, Konishi I
J Clin Oncol 2015 Dec 1;33(34):4015-22. Epub 2015 Sep 8 doi: 10.1200/JCO.2015.62.3397. PMID: 26351349
The predictors of response to neoadjuvant chemotherapy in advanced epithelial ovarian cancer.
Yildirim Y, Ertas IE, Dogan A, Gultekin OE, Gultekin E
J Surg Oncol 2012 Feb;105(2):200-5. Epub 2011 Aug 3 doi: 10.1002/jso.22053. PMID: 21815151
Systemic therapy in metastatic or recurrent endometrial cancer.
Pectasides D, Pectasides E, Economopoulos T
Cancer Treat Rev 2007 Apr;33(2):177-90. Epub 2006 Dec 29 doi: 10.1016/j.ctrv.2006.10.007. PMID: 17196749
Clear-cell and papillary serous cancer: treatment options.
Tropé C, Kristensen GB, Abeler VM
Best Pract Res Clin Obstet Gynaecol 2001 Jun;15(3):433-46. doi: 10.1053/beog.2000.0187. PMID: 11476564

Prognosis

Extended Pelvic Resections as Part of Secondary Cytoreduction for Relapsed Ovarian Adenocarcinoma.
Bacalbasa N, Balescu I, Dima S, Vilcu M, Brezean I
In Vivo 2020 Jan-Feb;34(1):397-400. doi: 10.21873/invivo.11787. PMID: 31882505Free PMC Article
International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer.
Hamanishi J, Mandai M, Ikeda T, Minami M, Kawaguchi A, Murayama T, Kanai M, Mori Y, Matsumoto S, Chikuma S, Matsumura N, Abiko K, Baba T, Yamaguchi K, Ueda A, Hosoe Y, Morita S, Yokode M, Shimizu A, Honjo T, Konishi I
J Clin Oncol 2015 Dec 1;33(34):4015-22. Epub 2015 Sep 8 doi: 10.1200/JCO.2015.62.3397. PMID: 26351349
Estrogen receptor 1 mRNA is a prognostic factor in ovarian carcinoma: determination by kinetic PCR in formalin-fixed paraffin-embedded tissue.
Darb-Esfahani S, Wirtz RM, Sinn BV, Budczies J, Noske A, Weichert W, Faggad A, Scharff S, Sehouli J, Oskay-Ozcelik G, Zamagni C, De Iaco P, Martoni A, Dietel M, Denkert C
Endocr Relat Cancer 2009 Dec;16(4):1229-39. Epub 2009 Aug 12 doi: 10.1677/ERC-08-0338. PMID: 19675076

Clinical prediction guides

International Endocervical Adenocarcinoma Criteria and Classification (IECC): A New Pathogenetic Classification for Invasive Adenocarcinomas of the Endocervix.
Stolnicu S, Barsan I, Hoang L, Patel P, Terinte C, Pesci A, Aviel-Ronen S, Kiyokawa T, Alvarado-Cabrero I, Pike MC, Oliva E, Park KJ, Soslow RA
Am J Surg Pathol 2018 Feb;42(2):214-226. doi: 10.1097/PAS.0000000000000986. PMID: 29135516Free PMC Article
A comparison of sentinel lymph node biopsy to lymphadenectomy for endometrial cancer staging (FIRES trial): a multicentre, prospective, cohort study.
Rossi EC, Kowalski LD, Scalici J, Cantrell L, Schuler K, Hanna RK, Method M, Ade M, Ivanova A, Boggess JF
Lancet Oncol 2017 Mar;18(3):384-392. Epub 2017 Feb 1 doi: 10.1016/S1470-2045(17)30068-2. PMID: 28159465
The predictors of response to neoadjuvant chemotherapy in advanced epithelial ovarian cancer.
Yildirim Y, Ertas IE, Dogan A, Gultekin OE, Gultekin E
J Surg Oncol 2012 Feb;105(2):200-5. Epub 2011 Aug 3 doi: 10.1002/jso.22053. PMID: 21815151
Endometrial giant cell carcinoma: a case series and review of the spectrum of endometrial neoplasms containing giant cells.
Mulligan AM, Plotkin A, Rouzbahman M, Soslow RA, Gilks CB, Clarke BA
Am J Surg Pathol 2010 Aug;34(8):1132-8. doi: 10.1097/PAS.0b013e3181e6579c. PMID: 20588176
Secondary cytoreductive surgery in patients with platinum-sensitive recurrent ovarian cancer.
Benedetti Panici P, De Vivo A, Bellati F, Manci N, Perniola G, Basile S, Muzii L, Angioli R
Ann Surg Oncol 2007 Mar;14(3):1136-42. Epub 2006 Dec 31 doi: 10.1245/s10434-006-9273-8. PMID: 17195909

Recent systematic reviews

Histologic Subtypes in Endometriosis-Associated Ovarian Cancer and Ovarian Cancer Arising in Endometriosis: A Systematic Review and Meta-Analysis.
Chiaffarino F, Cipriani S, Ricci E, Esposito G, Parazzini F, Vercellini P
Reprod Sci 2024 Jun;31(6):1642-1650. Epub 2024 Mar 4 doi: 10.1007/s43032-024-01489-9. PMID: 38438776Free PMC Article

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