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Non-restorative sleep

MedGen UID:
1853275
•Concept ID:
C5872987
•
Finding
Synonym: Non-refreshing sleep
 
HPO: HP:5200292

Definition

Perception of feeling unrefreshed after sleep. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-restorative sleep

Professional guidelines

PubMed

Sleep Delta power, age, and sex effects in treatment-resistant depression.
Hejazi NS, Duncan WC Jr, Kheirkhah M, Kowalczyk A, Riedner B, Oppenheimer M, Momenan R, Yuan Q, Kerich M, Goldman D, Zarate CA Jr
J Psychiatr Res 2024 Jun;174:332-339. Epub 2024 Apr 17 doi: 10.1016/j.jpsychires.2024.04.028. PMID: 38697012Free PMC Article
Effectiveness of change from suvorexant to lemborexant drug in the treatment of sleep disorders.
Okino K, Suzuki H, Kondo S, Tomioka H, Tokumasu T, Yamada H, Iwanami A, Inamoto A
Psychogeriatrics 2022 Sep;22(5):595-604. Epub 2022 Jun 10 doi: 10.1111/psyg.12858. PMID: 35689366
Sleep coaching: non-pharmacological treatment of non-restorative sleep in Austrian railway shift workers.
Holzinger B, Mayer L, Levec K, Munzinger MM, Klösch G
Arh Hig Rada Toksikol 2019 Sep 1;70(3):186-193. doi: 10.2478/aiht-2019-70-3244. PMID: 32597126

Recent clinical studies

Etiology

Dysautonomia: A Forgotten Condition - Part 1.
Rocha EA, Mehta N, Távora-Mehta MZP, Roncari CF, Cidrão AAL, Elias Neto J
Arq Bras Cardiol 2021 Apr;116(4):814-835. doi: 10.36660/abc.20200420. PMID: 33886735Free PMC Article
A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults.
Deshpande A, Irani N, Balkrishnan R, Benny IR
Sleep Med 2020 Aug;72:28-36. Epub 2020 Mar 21 doi: 10.1016/j.sleep.2020.03.012. PMID: 32540634
Sleep-related breathing disorders and dentistry: What is the relationship?
Santander P, Sievers D, Moser N
Quintessence Int 2016;47(7):617-21. doi: 10.3290/j.qi.a36172. PMID: 27319815
Pediatric fibromyalgia.
Buskila D, Ablin J
Reumatismo 2012 Sep 28;64(4):230-7. doi: 10.4081/reumatismo.2012.230. PMID: 23024967
The hyperarousal model of insomnia: a review of the concept and its evidence.
Riemann D, Spiegelhalder K, Feige B, Voderholzer U, Berger M, Perlis M, Nissen C
Sleep Med Rev 2010 Feb;14(1):19-31. Epub 2009 May 28 doi: 10.1016/j.smrv.2009.04.002. PMID: 19481481

Diagnosis

Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
Lacasa M, Alegre-Martin J, Sentañes RS, Varela-Sende L, Jurek J, Castro-Marrero J
Nutrients 2023 Oct 24;15(21) doi: 10.3390/nu15214504. PMID: 37960157Free PMC Article
Dysautonomia: A Forgotten Condition - Part 1.
Rocha EA, Mehta N, Távora-Mehta MZP, Roncari CF, Cidrão AAL, Elias Neto J
Arq Bras Cardiol 2021 Apr;116(4):814-835. doi: 10.36660/abc.20200420. PMID: 33886735Free PMC Article
Ozone therapy in 65 patients with fibromyalgia: an effective therapy.
Tirelli U, Cirrito C, Pavanello M, Piasentin C, Lleshi A, Taibi R
Eur Rev Med Pharmacol Sci 2019 Feb;23(4):1786-1788. doi: 10.26355/eurrev_201902_17141. PMID: 30840304
Pediatric fibromyalgia.
Buskila D, Ablin J
Reumatismo 2012 Sep 28;64(4):230-7. doi: 10.4081/reumatismo.2012.230. PMID: 23024967
The hyperarousal model of insomnia: a review of the concept and its evidence.
Riemann D, Spiegelhalder K, Feige B, Voderholzer U, Berger M, Perlis M, Nissen C
Sleep Med Rev 2010 Feb;14(1):19-31. Epub 2009 May 28 doi: 10.1016/j.smrv.2009.04.002. PMID: 19481481

Therapy

Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
Lacasa M, Alegre-Martin J, Sentañes RS, Varela-Sende L, Jurek J, Castro-Marrero J
Nutrients 2023 Oct 24;15(21) doi: 10.3390/nu15214504. PMID: 37960157Free PMC Article
A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults.
Deshpande A, Irani N, Balkrishnan R, Benny IR
Sleep Med 2020 Aug;72:28-36. Epub 2020 Mar 21 doi: 10.1016/j.sleep.2020.03.012. PMID: 32540634
Ozone therapy in 65 patients with fibromyalgia: an effective therapy.
Tirelli U, Cirrito C, Pavanello M, Piasentin C, Lleshi A, Taibi R
Eur Rev Med Pharmacol Sci 2019 Feb;23(4):1786-1788. doi: 10.26355/eurrev_201902_17141. PMID: 30840304
New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation.
Zisapel N
Br J Pharmacol 2018 Aug;175(16):3190-3199. Epub 2018 Jan 15 doi: 10.1111/bph.14116. PMID: 29318587Free PMC Article
Fibromyalgia and sleep.
Spaeth M, Rizzi M, Sarzi-Puttini P
Best Pract Res Clin Rheumatol 2011 Apr;25(2):227-39. doi: 10.1016/j.berh.2011.03.004. PMID: 22094198

Prognosis

Association between kidney stones and poor sleep factors in U.S. adults.
Yan B, Yu J, Fang Q, Qiu H, Shen C, Wang J, Li J, Huang Y, Dai L, Zhi Y, Li W
Medicine (Baltimore) 2024 May 17;103(20):e38210. doi: 10.1097/MD.0000000000038210. PMID: 38758878Free PMC Article
Stress, non-restorative sleep, and physical inactivity as risk factors for chronic pain in young adults: A cohort study.
Lindell M, Grimby-Ekman A
PLoS One 2022;17(1):e0262601. Epub 2022 Jan 21 doi: 10.1371/journal.pone.0262601. PMID: 35061825Free PMC Article
Sleep duration and sleep difficulties as predictors of occupational injuries: a cohort study.
Alhainen M, Härmä M, Pentti J, Ervasti JM, Kivimäki M, Vahtera J, Stenholm S
Occup Environ Med 2022 Apr;79(4):224-232. Epub 2021 Oct 14 doi: 10.1136/oemed-2021-107516. PMID: 34650000
Dysautonomia: A Forgotten Condition - Part 1.
Rocha EA, Mehta N, Távora-Mehta MZP, Roncari CF, Cidrão AAL, Elias Neto J
Arq Bras Cardiol 2021 Apr;116(4):814-835. doi: 10.36660/abc.20200420. PMID: 33886735Free PMC Article
Insomnia and risk of mortality from all-cause, cardiovascular disease, and cancer: Systematic review and meta-analysis of prospective cohort studies.
Ge L, Guyatt G, Tian J, Pan B, Chang Y, Chen Y, Li H, Zhang J, Li Y, Ling J, Yang K
Sleep Med Rev 2019 Dec;48:101215. Epub 2019 Sep 24 doi: 10.1016/j.smrv.2019.101215. PMID: 31630016

Clinical prediction guides

Yeast Beta-Glucan Supplementation with Multivitamins Attenuates Cognitive Impairments in Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled Trial.
Lacasa M, Alegre-Martin J, Sentañes RS, Varela-Sende L, Jurek J, Castro-Marrero J
Nutrients 2023 Oct 24;15(21) doi: 10.3390/nu15214504. PMID: 37960157Free PMC Article
Association between insomnia and frailty in older population: A meta-analytic evaluation of the observational studies.
Wen Q, Yan X, Ren Z, Wang B, Liu Y, Jin X
Brain Behav 2023 Jan;13(1):e2793. Epub 2022 Dec 14 doi: 10.1002/brb3.2793. PMID: 36519213Free PMC Article
Sleep duration and sleep difficulties as predictors of occupational injuries: a cohort study.
Alhainen M, Härmä M, Pentti J, Ervasti JM, Kivimäki M, Vahtera J, Stenholm S
Occup Environ Med 2022 Apr;79(4):224-232. Epub 2021 Oct 14 doi: 10.1136/oemed-2021-107516. PMID: 34650000
A randomized, double blind, placebo controlled study to evaluate the effects of ashwagandha (Withania somnifera) extract on sleep quality in healthy adults.
Deshpande A, Irani N, Balkrishnan R, Benny IR
Sleep Med 2020 Aug;72:28-36. Epub 2020 Mar 21 doi: 10.1016/j.sleep.2020.03.012. PMID: 32540634
Low-grade chronic inflammation mediated by mast cells in fibromyalgia: role of IL-37.
Mastrangelo F, Frydas I, Ronconi G, Kritas SK, Tettamanti L, Caraffa Al, D Ovidio C, Younes A, Gallenga CE, Conti P
J Biol Regul Homeost Agents 2018 Mar-Apr;32(2):195-198. PMID: 29684996

Recent systematic reviews

Insomnia and risk of mortality from all-cause, cardiovascular disease, and cancer: Systematic review and meta-analysis of prospective cohort studies.
Ge L, Guyatt G, Tian J, Pan B, Chang Y, Chen Y, Li H, Zhang J, Li Y, Ling J, Yang K
Sleep Med Rev 2019 Dec;48:101215. Epub 2019 Sep 24 doi: 10.1016/j.smrv.2019.101215. PMID: 31630016
Does Elite Sport Degrade Sleep Quality? A Systematic Review.
Gupta L, Morgan K, Gilchrist S
Sports Med 2017 Jul;47(7):1317-1333. doi: 10.1007/s40279-016-0650-6. PMID: 27900583Free PMC Article
Sleep disturbances in irritable bowel syndrome: a systematic review.
Tu Q, Heitkemper MM, Jarrett ME, Buchanan DT
Neurogastroenterol Motil 2017 Mar;29(3) Epub 2016 Sep 28 doi: 10.1111/nmo.12946. PMID: 27683238
Leg actigraphy to quantify periodic limb movements of sleep: a systematic review and meta-analysis.
Plante DT
Sleep Med Rev 2014 Oct;18(5):425-34. Epub 2014 Feb 17 doi: 10.1016/j.smrv.2014.02.004. PMID: 24726711Free PMC Article

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