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Abnormal circulating inhibin B concentration

MedGen UID:
1864203
•Concept ID:
C5936893
•
Finding
HPO: HP:0430147

Definition

The concentration of inhibin B in the blood circulation is outside the limits of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating inhibin B concentration

Recent clinical studies

Etiology

Circulating Zinc and Copper Levels are Associated with Sperm Quality in Obese Men after Metabolic Surgery: A Pilot Study.
Calderón B, Gómez-Martín JM, Cuadrado-Ayuso M, Cobeta P, Vega-Piñero B, Mateo R, Galindo J, Botella-Carretero JI
Nutrients 2020 Oct 30;12(11) doi: 10.3390/nu12113354. PMID: 33143218Free PMC Article
Lack of Improvement of Sperm Characteristics in Obese Males After Obesity Surgery Despite the Beneficial Changes Observed in Reproductive Hormones.
Calderón B, Huerta L, Galindo J, González Casbas JM, Escobar-Morreale HF, Martín-Hidalgo A, Botella-Carretero JI
Obes Surg 2019 Jul;29(7):2045-2050. doi: 10.1007/s11695-019-03798-4. PMID: 30806913
Testicular function in a birth cohort of young men.
Hart RJ, Doherty DA, McLachlan RI, Walls ML, Keelan JA, Dickinson JE, Skakkebaek NE, Norman RJ, Handelsman DJ
Hum Reprod 2015 Dec;30(12):2713-24. Epub 2015 Sep 25 doi: 10.1093/humrep/dev244. PMID: 26409015
Impaired folliculogenesis and ovulation in older reproductive aged women.
Santoro N, Isaac B, Neal-Perry G, Adel T, Weingart L, Nussbaum A, Thakur S, Jinnai H, Khosla N, Barad D
J Clin Endocrinol Metab 2003 Nov;88(11):5502-9. doi: 10.1210/jc.2002-021839. PMID: 14602797
Abnormal umbilical artery Doppler waveforms and cord blood inhibin a and inhibin B levels.
Florio P, Severi FM, Luisi S, Ignacchiti E, Calonaci G, Bocchi C, Petraglia F
Biol Neonate 2003;84(4):281-6. doi: 10.1159/000073635. PMID: 14593237

Diagnosis

Lack of Improvement of Sperm Characteristics in Obese Males After Obesity Surgery Despite the Beneficial Changes Observed in Reproductive Hormones.
Calderón B, Huerta L, Galindo J, González Casbas JM, Escobar-Morreale HF, Martín-Hidalgo A, Botella-Carretero JI
Obes Surg 2019 Jul;29(7):2045-2050. doi: 10.1007/s11695-019-03798-4. PMID: 30806913
Regulation of biologically active dimeric inhibin A and B from infancy to adulthood in the male.
Byrd W, Bennett MJ, Carr BR, Dong Y, Wians F, Rainey W
J Clin Endocrinol Metab 1998 Aug;83(8):2849-54. doi: 10.1210/jcem.83.8.5008. PMID: 9709958

Therapy

Congenital hypogonadotropic hypogonadism and Kallmann syndrome as models for studying hormonal regulation of human testicular endocrine functions.
Trabado S, Lamothe S, Maione L, Bouvattier C, Sarfati J, Brailly-Tabard S, Young J
Ann Endocrinol (Paris) 2014 May;75(2):79-87. Epub 2014 May 9 doi: 10.1016/j.ando.2014.04.011. PMID: 24815726
Sex differences in FSH-regulatory peptides in pubertal age boys and girls and effects of sex steroid treatment.
Foster CM, Olton PR, Racine MS, Phillips DJ, Padmanabhan V
Hum Reprod 2004 Jul;19(7):1668-76. Epub 2004 May 20 doi: 10.1093/humrep/deh284. PMID: 15155605
Inverse relationship between serum inhibin B and FSH levels in prepubertal boys with cryptorchidism.
Raivio T, Dunkel L
Pediatr Res 1999 Nov;46(5):496-500. doi: 10.1203/00006450-199911000-00002. PMID: 10541309

Prognosis

Circulating Zinc and Copper Levels are Associated with Sperm Quality in Obese Men after Metabolic Surgery: A Pilot Study.
Calderón B, Gómez-Martín JM, Cuadrado-Ayuso M, Cobeta P, Vega-Piñero B, Mateo R, Galindo J, Botella-Carretero JI
Nutrients 2020 Oct 30;12(11) doi: 10.3390/nu12113354. PMID: 33143218Free PMC Article
Lack of Improvement of Sperm Characteristics in Obese Males After Obesity Surgery Despite the Beneficial Changes Observed in Reproductive Hormones.
Calderón B, Huerta L, Galindo J, González Casbas JM, Escobar-Morreale HF, Martín-Hidalgo A, Botella-Carretero JI
Obes Surg 2019 Jul;29(7):2045-2050. doi: 10.1007/s11695-019-03798-4. PMID: 30806913

Clinical prediction guides

Lack of Improvement of Sperm Characteristics in Obese Males After Obesity Surgery Despite the Beneficial Changes Observed in Reproductive Hormones.
Calderón B, Huerta L, Galindo J, González Casbas JM, Escobar-Morreale HF, Martín-Hidalgo A, Botella-Carretero JI
Obes Surg 2019 Jul;29(7):2045-2050. doi: 10.1007/s11695-019-03798-4. PMID: 30806913
Impaired folliculogenesis and ovulation in older reproductive aged women.
Santoro N, Isaac B, Neal-Perry G, Adel T, Weingart L, Nussbaum A, Thakur S, Jinnai H, Khosla N, Barad D
J Clin Endocrinol Metab 2003 Nov;88(11):5502-9. doi: 10.1210/jc.2002-021839. PMID: 14602797

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