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Rickettsiosis

MedGen UID:: 20584
•Concept ID:: C0035585
•: Disease or Syndrome

Synonym:	Rickettsial disease
SNOMED CT:	Rickettsial disease (37246009); Rickettsiosis (416829003); Disease caused by rickettsiae (37246009); Rickettsial infectious disease (409904000); Rickettsial infection (409904000); Disease caused by Rickettsia (416829003); Disease caused by Rickettsiales (409904000)

Monarch Initiative:	MONDO:0006956
Orphanet:	ORPHA102021

Definition

A group of infectious diseases that is caused by Rickettsia. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVRickettsiosis

Pathological Conditions, Signs and Symptoms
- Clinical finding
  - Finding by Cause
    - Infection
      - Bacterial Infections and Mycoses
        Bacterial infectious disease
        Rickettsiosis
        Ehrlichiosis
        Heartwater Disease
        Endemic typhus
        Epidemic louse-borne typhus
        Brill-Zinsser disease
        Relapsing epidemic typhus
        Rocky Mountain spotted fever
        Spotted fevers
        Boutonneuse fever
        Tick-borne relapsing fever

Professional guidelines

PubMed

Patient characteristics, treatment patterns, and outcomes of Rickettsial diseases among a commercially insured population in the United States, 2005-2017.

Binder AM, Armstrong PA
Sci Rep 2021 Sep 15;11(1):18382. doi: 10.1038/s41598-021-96463-9. PMID: 34526545 Free PMC Article

Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis.

Figoni J, Chirouze C, Hansmann Y, Lemogne C, Hentgen V, Saunier A, Bouiller K, Gehanno JF, Rabaud C, Perrot S, Caumes E, Eldin C, de Broucker T, Jaulhac B, Roblot F, Toubiana J, Sellal F, Vuillemet F, Sordet C, Fantin B, Lina G, Gocko X, Dieudonné M, Picone O, Bodaghi B, Gangneux JP, Degeilh B, Partouche H, Lenormand C, Sotto A, Raffetin A, Monsuez JJ, Michel C, Boulanger N, Cathebras P, Tattevin P; endorsed by scientific societies
Med Mal Infect 2019 Aug;49(5):318-334. Epub 2019 May 13 doi: 10.1016/j.medmal.2019.04.381. PMID: 31097370

Antibiotic treatment of rickettsiosis, recent advances and current concepts.

Raoult D
Eur J Epidemiol 1991 May;7(3):276-81. doi: 10.1007/BF00145677. PMID: 1884779

See all (13)

Recent clinical studies

Etiology

Mapping the global distribution of spotted fever group rickettsiae: a systematic review with modelling analysis.

Zhang YY, Sun YQ, Chen JJ, Teng AY, Wang T, Li H, Hay SI, Fang LQ, Yang Y, Liu W
Lancet Digit Health 2023 Jan;5(1):e5-e15. Epub 2022 Nov 21 doi: 10.1016/S2589-7500(22)00212-6. PMID: 36424337 Free PMC Article

Rickettsia-Host-Tick Interactions: Knowledge Advances and Gaps.

Kim HK
Infect Immun 2022 Sep 15;90(9):e0062121. Epub 2022 Aug 22 doi: 10.1128/iai.00621-21. PMID: 35993770 Free PMC Article

Emerging and re-emerging rickettsial infections.

Adem PV
Semin Diagn Pathol 2019 May;36(3):146-151. Epub 2019 Apr 16 doi: 10.1053/j.semdp.2019.04.005. PMID: 31101391

Rickettsioses in Europe.

Portillo A, Santibáñez S, García-Álvarez L, Palomar AM, Oteo JA
Microbes Infect 2015 Nov-Dec;17(11-12):834-8. Epub 2015 Sep 16 doi: 10.1016/j.micinf.2015.09.009. PMID: 26384814

Neglected bacterial zoonoses.

Chikeka I, Dumler JS
Clin Microbiol Infect 2015 May;21(5):404-15. Epub 2015 May 8 doi: 10.1016/j.cmi.2015.04.022. PMID: 25964152 Free PMC Article

See all (511)

Diagnosis

Mapping the global distribution of spotted fever group rickettsiae: a systematic review with modelling analysis.

Emerging and re-emerging rickettsial infections.

Adem PV
Semin Diagn Pathol 2019 May;36(3):146-151. Epub 2019 Apr 16 doi: 10.1053/j.semdp.2019.04.005. PMID: 31101391

Francisella tularensis aortitis.

Briere M, Kaladji A, Douane F, Breux JP, Touroult-Jupin P, Boisset S, Edouard S, Biron C, Boutoille D
Infection 2016 Apr;44(2):263-5. Epub 2015 Jul 20 doi: 10.1007/s15010-015-0824-4. PMID: 26189939

Rickettsioses in Europe.

Portillo A, Santibáñez S, García-Álvarez L, Palomar AM, Oteo JA
Microbes Infect 2015 Nov-Dec;17(11-12):834-8. Epub 2015 Sep 16 doi: 10.1016/j.micinf.2015.09.009. PMID: 26384814

Neglected bacterial zoonoses.

Chikeka I, Dumler JS
Clin Microbiol Infect 2015 May;21(5):404-15. Epub 2015 May 8 doi: 10.1016/j.cmi.2015.04.022. PMID: 25964152 Free PMC Article

See all (421)

Therapy

African Tick-Bite Fever.

Fralish MS, Mangalindan KE, Farris CM, Jiang J, Green MC, Blaylock JM
Am J Med 2020 Sep;133(9):1051-1053. Epub 2020 Apr 20 doi: 10.1016/j.amjmed.2020.03.031. PMID: 32325042

Revisiting doxycycline in pregnancy and early childhood--time to rebuild its reputation?

Cross R, Ling C, Day NP, McGready R, Paris DH
Expert Opin Drug Saf 2016;15(3):367-82. Epub 2016 Jan 25 doi: 10.1517/14740338.2016.1133584. PMID: 26680308 Free PMC Article

Francisella tularensis aortitis.

Briere M, Kaladji A, Douane F, Breux JP, Touroult-Jupin P, Boisset S, Edouard S, Biron C, Boutoille D
Infection 2016 Apr;44(2):263-5. Epub 2015 Jul 20 doi: 10.1007/s15010-015-0824-4. PMID: 26189939

Rickettsia parkeri Rickettsiosis, Argentina.

Romer Y, Seijo AC, Crudo F, Nicholson WL, Varela-Stokes A, Lash RR, Paddock CD
Emerg Infect Dis 2011 Jul;17(7):1169-73. doi: 10.3201/eid1707.101857. PMID: 21762568 Free PMC Article

Childhood rickettsiosis.

Kulkarni A
Indian J Pediatr 2011 Jan;78(1):81-7. Epub 2010 Oct 22 doi: 10.1007/s12098-010-0255-2. PMID: 20967515

See all (96)

Prognosis

Clinical Characteristics and Diagnostic Prediction of Severe Fever with Thrombocytopenia Syndrome and Rickettsiosis in the Co-Endemic Wakayama Prefecture, Japan.

Teramoto K, Tamura S, Yoshida K, Inada Y, Yamashita Y, Morimoto M, Mushino T, Koreeda D, Miyamoto K, Komiya N, Nakano Y, Takagaki Y, Koizumi Y
Medicina (Kaunas) 2023 Nov 17;59(11) doi: 10.3390/medicina59112024. PMID: 38004073 Free PMC Article

Mapping the global distribution of spotted fever group rickettsiae: a systematic review with modelling analysis.

Analysis of Orientia tsutsugamushi promoter activity.

Hunt JR, Carlyon JA
Pathog Dis 2021 Sep 23;79(7) doi: 10.1093/femspd/ftab044. PMID: 34515306 Free PMC Article

Neglected bacterial zoonoses.

Chikeka I, Dumler JS
Clin Microbiol Infect 2015 May;21(5):404-15. Epub 2015 May 8 doi: 10.1016/j.cmi.2015.04.022. PMID: 25964152 Free PMC Article

Rickettsia parkeri Rickettsiosis, Argentina.

Romer Y, Seijo AC, Crudo F, Nicholson WL, Varela-Stokes A, Lash RR, Paddock CD
Emerg Infect Dis 2011 Jul;17(7):1169-73. doi: 10.3201/eid1707.101857. PMID: 21762568 Free PMC Article

See all (122)

Clinical prediction guides

Clinical Characteristics and Diagnostic Prediction of Severe Fever with Thrombocytopenia Syndrome and Rickettsiosis in the Co-Endemic Wakayama Prefecture, Japan.

Mapping the global distribution of spotted fever group rickettsiae: a systematic review with modelling analysis.

Analysis of Orientia tsutsugamushi promoter activity.

Hunt JR, Carlyon JA
Pathog Dis 2021 Sep 23;79(7) doi: 10.1093/femspd/ftab044. PMID: 34515306 Free PMC Article

Distinguishing Japanese Spotted Fever and Scrub Typhus, Central Japan, 2004- 2015.

Sando E, Suzuki M, Katoh S, Fujita H, Taira M, Yaegashi M, Ariyoshi K
Emerg Infect Dis 2018 Sep;24(9):1633-1641. doi: 10.3201/eid2409.171436. PMID: 30124190 Free PMC Article

Imported rickettsioses in Italy.

Beltrame A, Angheben A, Casolari S, Castelli F, Magnani G, Gaiera G, Brillo F, Cattani G, Anselmi M, Tomasoni L, Prati F, Norberto C, Socolovschi C, Bisoffi Z, Raoult D, Parola P
Travel Med Infect Dis 2012 Jul;10(4):201-4. Epub 2012 Jun 26 doi: 10.1016/j.tmaid.2012.05.003. PMID: 22738934

See all (110)

Recent systematic reviews

Rickettsiales in the WHO European Region: an update from a One Health perspective.

Guccione C, Colomba C, Iaria C, Cascio A
Parasit Vectors 2023 Jan 30;16(1):41. doi: 10.1186/s13071-022-05646-4. PMID: 36717936 Free PMC Article

Mapping the global distribution of spotted fever group rickettsiae: a systematic review with modelling analysis.

Laboratory Methods for Detection of Infectious Agents and Serological Response in Humans With Tick-Borne Infections: A Systematic Review of Evaluations Based on Clinical Patient Samples.

Henningsson AJ, Aase A, Bavelaar H, Flottorp S, Forsberg P, Kirkehei I, Lövmar M, Nilsson K, Nyman D, Ornstein K, Sjöwall J, Skogman BH, Tjernberg I, Aaberge I
Front Public Health 2021;9:580102. Epub 2021 Sep 20 doi: 10.3389/fpubh.2021.580102. PMID: 34616701 Free PMC Article

Clinical, epidemiological, and laboratory features of Rickettsia parkeri rickettsiosis: A systematic review.

Silva-Ramos CR, Hidalgo M, Faccini-Martínez ÁA
Ticks Tick Borne Dis 2021 Jul;12(4):101734. Epub 2021 May 1 doi: 10.1016/j.ttbdis.2021.101734. PMID: 33989945

Revisiting doxycycline in pregnancy and early childhood--time to rebuild its reputation?

Cross R, Ling C, Day NP, McGready R, Paris DH
Expert Opin Drug Saf 2016;15(3):367-82. Epub 2016 Jan 25 doi: 10.1517/14740338.2016.1133584. PMID: 26680308 Free PMC Article

See all (14)

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Rickettsiosis

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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