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Epidemic louse-borne typhus

MedGen UID:
21744
Concept ID:
C0041473
Disease or Syndrome
Synonyms: Epidemic Louse-Borne Typhus; Epidemic Typhus; Fever, Jail; Infection, Rickettsia prowazekii; Jail Fever; Louse Borne Typhus; Louse-Borne Typhus; Louse-Borne Typhus, Epidemic; Rickettsia prowazekii Infection; Rickettsia prowazekii Infections; Typhus, Epidemic; Typhus, Epidemic Louse Borne; Typhus, Epidemic Louse-Borne; Typhus, Louse-Borne
SNOMED CT: Louse-borne epidemic typhus (39111003); European typhus (39111003); Tabardillo (39111003); Fleckfieber (39111003); Louse-borne typhus fever (39111003); Tifus exanthematico (39111003); Louse-borne typhus (39111003); Epidemic typhus (39111003); Classical typhus (39111003); Typhus due to Rickettsia prowazekii (39111003); Exanthematic typhus (39111003)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0019362
Orphanet: ORPHA83314

Definition

A Rickettsial disease characterized by malaise and vague symptoms before the onset of high fever, headache, severe myalgias and less commonly petechial rash on the trunk and limbs, nausea, vomiting, coughing and pneumonia. Most patients also have some central nervous system disturbances, such as meningeal irritation, confusion, drowsiness, seizures, coma, and hearing loss. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEpidemic louse-borne typhus
Follow this link to review classifications for Epidemic louse-borne typhus in Orphanet.

Professional guidelines

PubMed

Chan C, Demetriades AK
J Med Biogr 2023 Feb;31(1):4-9. Epub 2021 Feb 27 doi: 10.1177/0967772021994560. PMID: 33641510Free PMC Article
Botelho-Nevers E, Socolovschi C, Raoult D, Parola P
Expert Rev Anti Infect Ther 2012 Dec;10(12):1425-37. doi: 10.1586/eri.12.139. PMID: 23253320
Perine PL, Krause DW, Awoke S, McDade JE
Lancet 1974 Sep 28;2(7883):742-4. doi: 10.1016/s0140-6736(74)90940-4. PMID: 4143011

Recent clinical studies

Etiology

Polak A, Pawlikowska-Łagód K, Zagaja A, Grzybowski A
Clin Dermatol 2023 Nov-Dec;41(6):767-771. Epub 2023 Sep 21 doi: 10.1016/j.clindermatol.2023.09.009. PMID: 37741590
Burns JN, Acuna-Soto R, Stahle DW
Emerg Infect Dis 2014 Mar;20(3):442-7. doi: 10.3201/eid2003.131366. PMID: 24564928Free PMC Article
Badiaga S, Brouqui P
Clin Microbiol Infect 2012 Apr;18(4):332-7. Epub 2012 Feb 23 doi: 10.1111/j.1469-0691.2012.03778.x. PMID: 22360386
Baxter JD
Clin Dermatol 1996 May-Jun;14(3):271-8. doi: 10.1016/0738-081x(96)00011-9. PMID: 8727129
Kazár J, Brezina R
Eur J Epidemiol 1991 May;7(3):282-6. doi: 10.1007/BF00145678. PMID: 1884780

Diagnosis

Angelakis E, Bechah Y, Raoult D
Microbiol Spectr 2016 Aug;4(4) doi: 10.1128/microbiolspec.PoH-0010-2015. PMID: 27726780
Dalton J, Shaw R, Democratis J
Lancet 2014 Mar 22;383(9922):1098. doi: 10.1016/S0140-6736(14)60262-2. PMID: 24656202
Littman RJ
Mt Sinai J Med 2009 Oct;76(5):456-67. doi: 10.1002/msj.20137. PMID: 19787658
Bechah Y, Capo C, Mege JL, Raoult D
Lancet Infect Dis 2008 Jul;8(7):417-26. doi: 10.1016/S1473-3099(08)70150-6. PMID: 18582834
Baxter JD
Clin Dermatol 1996 May-Jun;14(3):271-8. doi: 10.1016/0738-081x(96)00011-9. PMID: 8727129

Therapy

Alarcón J, Sanosyan A, Contreras ZA, Ngo VP, Carpenter A, Hacker JK, Probert WS, Terashita D, Balter S, Halai UA
MMWR Morb Mortal Wkly Rep 2023 Aug 4;72(31):838-843. doi: 10.15585/mmwr.mm7231a1. PMID: 37535465Free PMC Article
Warrell CE, Osborne J, Nabarro L, Gibney B, Carter DP, Warner J, Houlihan CF, Brooks TJG, Rampling T
J Infect 2023 May;86(5):446-452. Epub 2023 Mar 21 doi: 10.1016/j.jinf.2023.03.015. PMID: 36948252
Azizi MH, Bahadori M, Azizi F
Arch Iran Med 2016 Oct;19(10):747-750. PMID: 27743443
Botelho-Nevers E, Socolovschi C, Raoult D, Parola P
Expert Rev Anti Infect Ther 2012 Dec;10(12):1425-37. doi: 10.1586/eri.12.139. PMID: 23253320
Perine PL, Krause DW, Awoke S, McDade JE
Lancet 1974 Sep 28;2(7883):742-4. doi: 10.1016/s0140-6736(74)90940-4. PMID: 4143011

Prognosis

Han L, Zhang Y, Jin X, Ren H, Teng Z, Sun Z, Xu J, Qin T
Int J Infect Dis 2024 Mar;140:52-61. Epub 2023 Dec 30 doi: 10.1016/j.ijid.2023.12.013. PMID: 38163619
Yomogida K, Kjemtrup A, Martínez-López B, Ibrahim M, Contreras Z, Ngo V, Halai UA, Balter S, Feaster M, Zahn M, Shearer E, Sorvillo R, Balanji N, Torres C, Prado B, Porse C, Kramer V
Am J Trop Med Hyg 2024 Jan 3;110(1):142-149. Epub 2023 Dec 18 doi: 10.4269/ajtmh.23-0272. PMID: 38109767Free PMC Article
Golshani SA, Mansourbakht G, Alembizar F
Arch Iran Med 2022 Nov 1;25(11):758-764. doi: 10.34172/aim.2022.120. PMID: 37543902Free PMC Article
Littman RJ
Mt Sinai J Med 2009 Oct;76(5):456-67. doi: 10.1002/msj.20137. PMID: 19787658
Perine PL, Chandler BP, Krause DK, McCardle P, Awoke S, Habte-Gabr E, Wisseman CL Jr, McDade JE
Clin Infect Dis 1992 May;14(5):1149-58. doi: 10.1093/clinids/14.5.1149. PMID: 1600020

Clinical prediction guides

Song WY, Lv Y, Yin PW, Yang YY, Guo XG
Parasit Vectors 2023 May 16;16(1):164. doi: 10.1186/s13071-023-05789-y. PMID: 37194039Free PMC Article
Hotez PJ, Booker C
PLoS Negl Trop Dis 2020 Feb;14(2):e0008064. Epub 2020 Feb 27 doi: 10.1371/journal.pntd.0008064. PMID: 32106246Free PMC Article
Robinson D, Leo N, Prociv P, Barker SC
Parasitol Res 2003 Jun;90(3):209-11. Epub 2003 Feb 27 doi: 10.1007/s00436-003-0842-5. PMID: 12783309
Raoult D, Roux V
Clin Infect Dis 1999 Oct;29(4):888-911. doi: 10.1086/520454. PMID: 10589908
Gaon JA, Murray ES
Bull World Health Organ 1966;35(2):133-41. PMID: 5296997Free PMC Article

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