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Residual schizophrenia

MedGen UID:: 20665
•Concept ID:: C0036351
•: Mental or Behavioral Dysfunction

Synonyms:	Residual Type Schizophrenia; Restzustand
SNOMED CT:	Restzustand (26025008); Residual schizophrenia (26025008)

Definition

A subtype of schizophrenia in which the individual has suffered an episode of schizophrenia but there are no longer any delusions, hallucinations, disorganized speech or behavior. Residual symptoms are seen in the form of negative symptoms (such as flat affect or avolition) or attenuated positive symptoms (such as odd beliefs). [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVResidual schizophrenia

Abnormality of the nervous system
- Abnormal nervous system physiology
  - Abnormality of mental function
    - Atypical behavior
      - Diagnostic behavioral phenotype
        Schizophrenia
        Residual schizophrenia
        Chronic residual schizophrenia
        Subchronic residual schizophrenia

Professional guidelines

PubMed

Executive function assessment of patients with schizophrenic disorder residual type in olanzapine treatment: an open study.

Stratta P, Donda P, Rossi A, Rossi A
Hum Psychopharmacol 2005 Aug;20(6):401-8. doi: 10.1002/hup.703. PMID: 15991259

Low-dose zotepine in the maintenance treatment of schizophrenia.

Fleischhacker WW, Stuppäck C, Barnas C, Unterweger B, Hinterhuber H
Pharmacopsychiatry 1987 Feb;20(1 Spec No):61-3. doi: 10.1055/s-2007-1017132. PMID: 2883685

The risks of long-term neuroleptic treatment of schizophrenia: especially depression and akinesia.

Rifkin A
Acta Psychiatr Scand Suppl 1981;291:129-36. doi: 10.1111/j.1600-0447.1981.tb02465.x. PMID: 6113730

See all (4)

Recent clinical studies

Etiology

Main characteristics of dermatoglypics associated with schizophrenia and its clinical subtypes.

Norovsambuu O, Tsend-Ayush A, Lkhagvasuren N, Jav S
PLoS One 2021;16(6):e0252831. Epub 2021 Jun 10 doi: 10.1371/journal.pone.0252831. PMID: 34111156 Free PMC Article

Glutathione and glutamate in schizophrenia: a 7T MRS study.

Kumar J, Liddle EB, Fernandes CC, Palaniyappan L, Hall EL, Robson SE, Simmonite M, Fiesal J, Katshu MZ, Qureshi A, Skelton M, Christodoulou NG, Brookes MJ, Morris PG, Liddle PF
Mol Psychiatry 2020 Apr;25(4):873-882. Epub 2018 Jun 22 doi: 10.1038/s41380-018-0104-7. PMID: 29934548 Free PMC Article

Ribosomal DNA transcription in the dorsal raphe nucleus is increased in residual but not in paranoid schizophrenia.

Krzyżanowska M, Steiner J, Brisch R, Mawrin C, Busse S, Braun K, Jankowski Z, Bernstein HG, Bogerts B, Gos T
Eur Arch Psychiatry Clin Neurosci 2015 Mar;265(2):117-26. Epub 2014 Aug 5 doi: 10.1007/s00406-014-0518-4. PMID: 25091423 Free PMC Article

Clozapine maintenance therapy in schizophrenia.

Gaszner P, Makkos Z
Prog Neuropsychopharmacol Biol Psychiatry 2004 May;28(3):465-9. doi: 10.1016/j.pnpbp.2003.11.011. PMID: 15093952

"Postpsychotic depression" and residual schizophrenia in a mental health hospital.

Mauri MC, Laini V, Barone R, Clemente A, Volonteri LS, Cerveri G, Steinhilber C, Fornier M
Encephale 2000 Nov-Dec;26(6):21-6. PMID: 11217534

See all (26)

Diagnosis

Main characteristics of dermatoglypics associated with schizophrenia and its clinical subtypes.

Norovsambuu O, Tsend-Ayush A, Lkhagvasuren N, Jav S
PLoS One 2021;16(6):e0252831. Epub 2021 Jun 10 doi: 10.1371/journal.pone.0252831. PMID: 34111156 Free PMC Article

Ribosomal DNA transcription in the dorsal raphe nucleus is increased in residual but not in paranoid schizophrenia.

Clozapine maintenance therapy in schizophrenia.

Gaszner P, Makkos Z
Prog Neuropsychopharmacol Biol Psychiatry 2004 May;28(3):465-9. doi: 10.1016/j.pnpbp.2003.11.011. PMID: 15093952

"Postpsychotic depression" and residual schizophrenia in a mental health hospital.

Mauri MC, Laini V, Barone R, Clemente A, Volonteri LS, Cerveri G, Steinhilber C, Fornier M
Encephale 2000 Nov-Dec;26(6):21-6. PMID: 11217534

Classical subtypes for schizophrenia: literature review for DSM-IV.

McGlashan TH, Fenton WS
Schizophr Bull 1991;17(4):609-32. doi: 10.1093/schbul/17.4.609. PMID: 1822677

See all (28)

Therapy

Tardive dyskinesia and DRD2, DRD3, DRD4, 5-HT2A variants in schizophrenia: an association study with repeated assessment.

Lattuada E, Cavallaro R, Serretti A, Lorenzi C, Smeraldi E
Int J Neuropsychopharmacol 2004 Dec;7(4):489-93. Epub 2004 Sep 22 doi: 10.1017/S1461145704004614. PMID: 15383158

Clozapine maintenance therapy in schizophrenia.

Gaszner P, Makkos Z
Prog Neuropsychopharmacol Biol Psychiatry 2004 May;28(3):465-9. doi: 10.1016/j.pnpbp.2003.11.011. PMID: 15093952

"Postpsychotic depression" and residual schizophrenia in a mental health hospital.

Mauri MC, Laini V, Barone R, Clemente A, Volonteri LS, Cerveri G, Steinhilber C, Fornier M
Encephale 2000 Nov-Dec;26(6):21-6. PMID: 11217534

Rehabilitative effect of music therapy for residual schizophrenia. A one-month randomised controlled trial in Shanghai.

Tang W, Yao X, Zheng Z
Br J Psychiatry Suppl 1994 Aug;(24):38-44. PMID: 7946230

The risks of long-term neuroleptic treatment of schizophrenia: especially depression and akinesia.

Rifkin A
Acta Psychiatr Scand Suppl 1981;291:129-36. doi: 10.1111/j.1600-0447.1981.tb02465.x. PMID: 6113730

See all (24)

Prognosis

Different distribution patterns of lymphocytes and microglia in the hippocampus of patients with residual versus paranoid schizophrenia: further evidence for disease course-related immune alterations?

Busse S, Busse M, Schiltz K, Bielau H, Gos T, Brisch R, Mawrin C, Schmitt A, Jordan W, Müller UJ, Bernstein HG, Bogerts B, Steiner J
Brain Behav Immun 2012 Nov;26(8):1273-9. Epub 2012 Aug 14 doi: 10.1016/j.bbi.2012.08.005. PMID: 22917959

Rehabilitative effect of music therapy for residual schizophrenia. A one-month randomised controlled trial in Shanghai.

Tang W, Yao X, Zheng Z
Br J Psychiatry Suppl 1994 Aug;(24):38-44. PMID: 7946230

The DSM-III concepts of schizophrenic disorder and schizophreniform disorder. A clinical and prognostic evaluation.

Makanjuola RO, Adedapo SA
Br J Psychiatry 1987 Nov;151:611-8. doi: 10.1192/bjp.151.5.611. PMID: 3446304

Zotepine in the treatment of negative symptoms in chronic schizophrenia.

Fleischhacker WW, Barnas C, Stuppäck C, Unterweger B, Hinterhuber H
Pharmacopsychiatry 1987 Feb;20(1 Spec No):58-60. doi: 10.1055/s-2007-1017131. PMID: 2883684

Anxiety in schizophrenic psychoses.

Strian F, Klicpera C
Arch Psychiatr Nervenkr (1970) 1983;233(5):347-57. doi: 10.1007/BF00346085. PMID: 6651499

See all (9)

Clinical prediction guides

Main characteristics of dermatoglypics associated with schizophrenia and its clinical subtypes.

Norovsambuu O, Tsend-Ayush A, Lkhagvasuren N, Jav S
PLoS One 2021;16(6):e0252831. Epub 2021 Jun 10 doi: 10.1371/journal.pone.0252831. PMID: 34111156 Free PMC Article

Glutathione and glutamate in schizophrenia: a 7T MRS study.

Research on the Effect of the Foot Bath and Foot Massage on Residual Schizophrenia Patients.

Kito K, Suzuki K
Arch Psychiatr Nurs 2016 Jun;30(3):375-81. Epub 2016 Jan 11 doi: 10.1016/j.apnu.2016.01.002. PMID: 27256944

Relationship between spirituality/religiousness and coping in patients with residual schizophrenia.

Shah R, Kulhara P, Grover S, Kumar S, Malhotra R, Tyagi S
Qual Life Res 2011 Sep;20(7):1053-60. Epub 2011 Jan 11 doi: 10.1007/s11136-010-9839-6. PMID: 21222165

Clozapine maintenance therapy in schizophrenia.

Gaszner P, Makkos Z
Prog Neuropsychopharmacol Biol Psychiatry 2004 May;28(3):465-9. doi: 10.1016/j.pnpbp.2003.11.011. PMID: 15093952

See all (23)

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Residual schizophrenia

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Supplemental Content

Table of contents

Practice guidelines

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