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Unresectable Hepatocellular Carcinoma

MedGen UID:
207269
Concept ID:
C1112459
Neoplastic Process
Synonym: Non-Resectable Hepatocellular Carcinoma

Definition

A hepatocellular carcinoma that is not amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Hepatocellular Carcinoma

Professional guidelines

PubMed

Nakabori T, Higashi S, Abe Y, Mukai K, Ikawa T, Konishi K, Maeda N, Nakanishi K, Hasegawa S, Wada H, Ohkawa K
Curr Oncol 2024 Mar 15;31(3):1543-1555. doi: 10.3390/curroncol31030117. PMID: 38534950Free PMC Article
Su D, Wu B, Shi L
JAMA Netw Open 2021 Feb 1;4(2):e210037. doi: 10.1001/jamanetworkopen.2021.0037. PMID: 33625508Free PMC Article
Bismuth H, Samuel D, Engerran L
N Engl J Med 1995 Sep 28;333(13):878. doi: 10.1056/NEJM199509283331314. PMID: 7544440

Recent clinical studies

Etiology

Abou-Alfa GK, Lau G, Kudo M, Chan SL, Kelley RK, Furuse J, Sukeepaisarnjaroen W, Kang YK, Van Dao T, De Toni EN, Rimassa L, Breder V, Vasilyev A, Heurgué A, Tam VC, Mody K, Thungappa SC, Ostapenko Y, Yau T, Azevedo S, Varela M, Cheng AL, Qin S, Galle PR, Ali S, Marcovitz M, Makowsky M, He P, Kurland JF, Negro A, Sangro B
NEJM Evid 2022 Aug;1(8):EVIDoa2100070. Epub 2022 Jun 6 doi: 10.1056/EVIDoa2100070. PMID: 38319892
Cheng AL, Qin S, Ikeda M, Galle PR, Ducreux M, Kim TY, Lim HY, Kudo M, Breder V, Merle P, Kaseb AO, Li D, Verret W, Ma N, Nicholas A, Wang Y, Li L, Zhu AX, Finn RS
J Hepatol 2022 Apr;76(4):862-873. Epub 2021 Dec 11 doi: 10.1016/j.jhep.2021.11.030. PMID: 34902530
Li QJ, He MK, Chen HW, Fang WQ, Zhou YM, Xu L, Wei W, Zhang YJ, Guo Y, Guo RP, Chen MS, Shi M
J Clin Oncol 2022 Jan 10;40(2):150-160. Epub 2021 Oct 14 doi: 10.1200/JCO.21.00608. PMID: 34648352
Finn RS, Qin S, Ikeda M, Galle PR, Ducreux M, Kim TY, Kudo M, Breder V, Merle P, Kaseb AO, Li D, Verret W, Xu DZ, Hernandez S, Liu J, Huang C, Mulla S, Wang Y, Lim HY, Zhu AX, Cheng AL; IMbrave150 Investigators
N Engl J Med 2020 May 14;382(20):1894-1905. doi: 10.1056/NEJMoa1915745. PMID: 32402160
Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, Baron A, Park JW, Han G, Jassem J, Blanc JF, Vogel A, Komov D, Evans TRJ, Lopez C, Dutcus C, Guo M, Saito K, Kraljevic S, Tamai T, Ren M, Cheng AL
Lancet 2018 Mar 24;391(10126):1163-1173. doi: 10.1016/S0140-6736(18)30207-1. PMID: 29433850

Diagnosis

Abou-Alfa GK, Lau G, Kudo M, Chan SL, Kelley RK, Furuse J, Sukeepaisarnjaroen W, Kang YK, Dao TV, De Toni EN, Rimassa L, Breder V, Vasilyev A, Heurgué A, Tam VC, Mody K, Thungappa SC, Ostapenko Y, Yau T, Azevedo S, Varela M, Cheng AL, Qin S, Galle PR, Ali S, Gupta C, Makowsky M, Kurland JF, Negro A, Sangro B
Future Oncol 2023 Dec;19(38):2505-2516. Epub 2023 Sep 6 doi: 10.2217/fon-2023-0486. PMID: 37671641
Ren Z, Xu J, Bai Y, Xu A, Cang S, Du C, Li Q, Lu Y, Chen Y, Guo Y, Chen Z, Liu B, Jia W, Wu J, Wang J, Shao G, Zhang B, Shan Y, Meng Z, Wu J, Gu S, Yang W, Liu C, Shi X, Gao Z, Yin T, Cui J, Huang M, Xing B, Mao Y, Teng G, Qin Y, Wang J, Xia F, Yin G, Yang Y, Chen M, Wang Y, Zhou H, Fan J; ORIENT-32 study group
Lancet Oncol 2021 Jul;22(7):977-990. Epub 2021 Jun 15 doi: 10.1016/S1470-2045(21)00252-7. PMID: 34143971
Su D, Wu B, Shi L
JAMA Netw Open 2021 Feb 1;4(2):e210037. doi: 10.1001/jamanetworkopen.2021.0037. PMID: 33625508Free PMC Article
Melchiorre F, Patella F, Pescatori L, Pesapane F, Fumarola E, Biondetti P, Brambillasca P, Monaco C, Ierardi AM, Franceschelli G, Carrafiello G
Future Oncol 2018 Dec;14(28):2969-2984. Epub 2018 Jul 10 doi: 10.2217/fon-2018-0136. PMID: 29987957
Ramsey DE, Kernagis LY, Soulen MC, Geschwind JF
J Vasc Interv Radiol 2002 Sep;13(9 Pt 2):S211-21. doi: 10.1016/s1051-0443(07)61789-8. PMID: 12354839

Therapy

Sangro B, Chan SL, Kelley RK, Lau G, Kudo M, Sukeepaisarnjaroen W, Yarchoan M, De Toni EN, Furuse J, Kang YK, Galle PR, Rimassa L, Heurgué A, Tam VC, Van Dao T, Thungappa SC, Breder V, Ostapenko Y, Reig M, Makowsky M, Paskow MJ, Gupta C, Kurland JF, Negro A, Abou-Alfa GK; HIMALAYA investigators
Ann Oncol 2024 May;35(5):448-457. Epub 2024 Feb 19 doi: 10.1016/j.annonc.2024.02.005. PMID: 38382875
Abou-Alfa GK, Lau G, Kudo M, Chan SL, Kelley RK, Furuse J, Sukeepaisarnjaroen W, Kang YK, Van Dao T, De Toni EN, Rimassa L, Breder V, Vasilyev A, Heurgué A, Tam VC, Mody K, Thungappa SC, Ostapenko Y, Yau T, Azevedo S, Varela M, Cheng AL, Qin S, Galle PR, Ali S, Marcovitz M, Makowsky M, He P, Kurland JF, Negro A, Sangro B
NEJM Evid 2022 Aug;1(8):EVIDoa2100070. Epub 2022 Jun 6 doi: 10.1056/EVIDoa2100070. PMID: 38319892
Cheng AL, Qin S, Ikeda M, Galle PR, Ducreux M, Kim TY, Lim HY, Kudo M, Breder V, Merle P, Kaseb AO, Li D, Verret W, Ma N, Nicholas A, Wang Y, Li L, Zhu AX, Finn RS
J Hepatol 2022 Apr;76(4):862-873. Epub 2021 Dec 11 doi: 10.1016/j.jhep.2021.11.030. PMID: 34902530
Finn RS, Qin S, Ikeda M, Galle PR, Ducreux M, Kim TY, Kudo M, Breder V, Merle P, Kaseb AO, Li D, Verret W, Xu DZ, Hernandez S, Liu J, Huang C, Mulla S, Wang Y, Lim HY, Zhu AX, Cheng AL; IMbrave150 Investigators
N Engl J Med 2020 May 14;382(20):1894-1905. doi: 10.1056/NEJMoa1915745. PMID: 32402160
Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, Baron A, Park JW, Han G, Jassem J, Blanc JF, Vogel A, Komov D, Evans TRJ, Lopez C, Dutcus C, Guo M, Saito K, Kraljevic S, Tamai T, Ren M, Cheng AL
Lancet 2018 Mar 24;391(10126):1163-1173. doi: 10.1016/S0140-6736(18)30207-1. PMID: 29433850

Prognosis

Sangro B, Chan SL, Kelley RK, Lau G, Kudo M, Sukeepaisarnjaroen W, Yarchoan M, De Toni EN, Furuse J, Kang YK, Galle PR, Rimassa L, Heurgué A, Tam VC, Van Dao T, Thungappa SC, Breder V, Ostapenko Y, Reig M, Makowsky M, Paskow MJ, Gupta C, Kurland JF, Negro A, Abou-Alfa GK; HIMALAYA investigators
Ann Oncol 2024 May;35(5):448-457. Epub 2024 Feb 19 doi: 10.1016/j.annonc.2024.02.005. PMID: 38382875
Lee PC, Wu CJ, Hung YW, Lee CJ, Chi CT, Lee IC, Yu-Lun K, Chou SH, Luo JC, Hou MC, Huang YH
J Immunother Cancer 2022 Jun;10(6) doi: 10.1136/jitc-2022-004779. PMID: 35738801Free PMC Article
Su D, Wu B, Shi L
JAMA Netw Open 2021 Feb 1;4(2):e210037. doi: 10.1001/jamanetworkopen.2021.0037. PMID: 33625508Free PMC Article
Kudo M, Ueshima K, Ikeda M, Torimura T, Tanabe N, Aikata H, Izumi N, Yamasaki T, Nojiri S, Hino K, Tsumura H, Kuzuya T, Isoda N, Yasui K, Aino H, Ido A, Kawabe N, Nakao K, Wada Y, Yokosuka O, Yoshimura K, Okusaka T, Furuse J, Kokudo N, Okita K, Johnson PJ, Arai Y; TACTICS study group
Gut 2020 Aug;69(8):1492-1501. Epub 2019 Dec 4 doi: 10.1136/gutjnl-2019-318934. PMID: 31801872Free PMC Article
Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, Baron A, Park JW, Han G, Jassem J, Blanc JF, Vogel A, Komov D, Evans TRJ, Lopez C, Dutcus C, Guo M, Saito K, Kraljevic S, Tamai T, Ren M, Cheng AL
Lancet 2018 Mar 24;391(10126):1163-1173. doi: 10.1016/S0140-6736(18)30207-1. PMID: 29433850

Clinical prediction guides

Sangro B, Chan SL, Kelley RK, Lau G, Kudo M, Sukeepaisarnjaroen W, Yarchoan M, De Toni EN, Furuse J, Kang YK, Galle PR, Rimassa L, Heurgué A, Tam VC, Van Dao T, Thungappa SC, Breder V, Ostapenko Y, Reig M, Makowsky M, Paskow MJ, Gupta C, Kurland JF, Negro A, Abou-Alfa GK; HIMALAYA investigators
Ann Oncol 2024 May;35(5):448-457. Epub 2024 Feb 19 doi: 10.1016/j.annonc.2024.02.005. PMID: 38382875
Chiang CL, Chiu KWH, Chan KSK, Lee FAS, Li JCB, Wan CWS, Dai WC, Lam TC, Chen W, Wong NSM, Cheung ALY, Lee VWY, Lau VWH, El Helali A, Man K, Kong FMS, Lo CM, Chan AC
Lancet Gastroenterol Hepatol 2023 Feb;8(2):169-178. Epub 2022 Dec 15 doi: 10.1016/S2468-1253(22)00339-9. PMID: 36529152
Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Cheng AL, Vogel A, Tovoli F, Ueshima K, Aikata H, López CL, Pracht M, Meng Z, Daniele B, Park JW, Palmer D, Tamai T, Saito K, Dutcus CE, Lencioni R
J Hepatol 2023 Jan;78(1):133-141. Epub 2022 Sep 20 doi: 10.1016/j.jhep.2022.09.006. PMID: 36341767
Yamashita T, Kudo M, Ikeda K, Izumi N, Tateishi R, Ikeda M, Aikata H, Kawaguchi Y, Wada Y, Numata K, Inaba Y, Kuromatsu R, Kobayashi M, Okusaka T, Tamai T, Kitamura C, Saito K, Haruna K, Okita K, Kumada H
J Gastroenterol 2020 Jan;55(1):113-122. Epub 2019 Nov 12 doi: 10.1007/s00535-019-01642-1. PMID: 31720835Free PMC Article
Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, Baron A, Park JW, Han G, Jassem J, Blanc JF, Vogel A, Komov D, Evans TRJ, Lopez C, Dutcus C, Guo M, Saito K, Kraljevic S, Tamai T, Ren M, Cheng AL
Lancet 2018 Mar 24;391(10126):1163-1173. doi: 10.1016/S0140-6736(18)30207-1. PMID: 29433850

Recent systematic reviews

Xu H, Zhang H, Li B, Chen K, Wei Y
BMC Cancer 2024 Aug 14;24(1):1008. doi: 10.1186/s12885-024-12772-y. PMID: 39143584Free PMC Article
Abdel-Rahman O, Elsayed Z
Cochrane Database Syst Rev 2020 Nov 16;11(11):CD011313. doi: 10.1002/14651858.CD011313.pub4. PMID: 33197051Free PMC Article
Abdel-Rahman O, Elsayed Z
Cochrane Database Syst Rev 2017 Mar 7;3(3):CD011314. doi: 10.1002/14651858.CD011314.pub2. PMID: 28267205Free PMC Article
Lobo L, Yakoub D, Picado O, Ripat C, Pendola F, Sharma R, ElTawil R, Kwon D, Venkat S, Portelance L, Yechieli R
Cardiovasc Intervent Radiol 2016 Nov;39(11):1580-1588. Epub 2016 Sep 1 doi: 10.1007/s00270-016-1426-y. PMID: 27586657
Abdel-Rahman OM, Elsayed Z
Cochrane Database Syst Rev 2016 Feb 16;2:CD011313. doi: 10.1002/14651858.CD011313.pub2. PMID: 26905230

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