U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Engraftment syndrome

MedGen UID:
214709
•Concept ID:
C0919746
•
Disease or Syndrome
Synonyms: Engraftment Syndrome; engraftment syndrome
SNOMED CT: Engraftment syndrome (426768001)
 
Monarch Initiative: MONDO:0043358

Definition

A toxicity of hematopoietic stem cell transplantation that manifests as fever, rash and pulmonary deterioration which becomes evident at marrow engraftment. It occurs unexpectedly and is occasionally fatal. It can occur after an autogeneic or an allogeneic hematopoietic cell transplantation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEngraftment syndrome

Professional guidelines

PubMed

Transplant-associated thrombotic microangiopathy: Diagnostic challenges and management strategies.
Elemary M, Sabry W, Seghatchian J, Goubran H
Transfus Apher Sci 2019 Jun;58(3):347-350. Epub 2019 May 1 doi: 10.1016/j.transci.2019.04.022. PMID: 31097308
Capillary leak syndrome: etiologies, pathophysiology, and management.
Siddall E, Khatri M, Radhakrishnan J
Kidney Int 2017 Jul;92(1):37-46. Epub 2017 Mar 17 doi: 10.1016/j.kint.2016.11.029. PMID: 28318633
Engraftment Syndrome after Autologous Stem Cell Transplantation: An Update Unifying the Definition and Management Approach.
Cornell RF, Hari P, Drobyski WR
Biol Blood Marrow Transplant 2015 Dec;21(12):2061-2068. Epub 2015 Aug 29 doi: 10.1016/j.bbmt.2015.08.030. PMID: 26327628Free PMC Article

Recent clinical studies

Etiology

Engraftment syndrome following hematopoietic stem cell transplant: A review of the literature.
Grant A, Chapman LRM, Mitchell R, O'Brien TA
Clin Transplant 2020 Jun;34(6):e13875. Epub 2020 Apr 27 doi: 10.1111/ctr.13875. PMID: 32279341
Allogeneic reactivity-mediated endothelial cell complications after HSCT: a plea for consensual definitions.
Pagliuca S, Michonneau D, Sicre de Fontbrune F, Sutra Del Galy A, Xhaard A, Robin M, Peffault de Latour R, Socie G
Blood Adv 2019 Aug 13;3(15):2424-2435. doi: 10.1182/bloodadvances.2019000143. PMID: 31409584Free PMC Article
Transplant-associated thrombotic microangiopathy: Diagnostic challenges and management strategies.
Elemary M, Sabry W, Seghatchian J, Goubran H
Transfus Apher Sci 2019 Jun;58(3):347-350. Epub 2019 May 1 doi: 10.1016/j.transci.2019.04.022. PMID: 31097308
Capillary leak syndrome: etiologies, pathophysiology, and management.
Siddall E, Khatri M, Radhakrishnan J
Kidney Int 2017 Jul;92(1):37-46. Epub 2017 Mar 17 doi: 10.1016/j.kint.2016.11.029. PMID: 28318633
Engraftment Syndrome after Autologous Stem Cell Transplantation: An Update Unifying the Definition and Management Approach.
Cornell RF, Hari P, Drobyski WR
Biol Blood Marrow Transplant 2015 Dec;21(12):2061-2068. Epub 2015 Aug 29 doi: 10.1016/j.bbmt.2015.08.030. PMID: 26327628Free PMC Article

Diagnosis

Diagnosis and management of endothelial disorders following haematopoietic stem cell transplantation.
McEwan A, Greenwood M, Ward C, Ritchie D, Szer J, Gardiner E, Colic A, Sipavicius J, Panek-Hudson Y, Kerridge I
Intern Med J 2023 Dec;53(12):2162-2174. Epub 2023 Aug 1 doi: 10.1111/imj.16188. PMID: 37528613
Engraftment syndrome following Hematopoietic stem cell transplantation: a systematic approach toward diagnosis and management.
Maqbool S, Nadeem M, Shahroz A, Naimat K, Khan I, Tahir H, Rehman A, Anwer F, Iftikhar R, Lee KY
Med Oncol 2022 Dec 2;40(1):36. doi: 10.1007/s12032-022-01894-7. PMID: 36460884Free PMC Article
Engraftment syndrome following hematopoietic stem cell transplant: A review of the literature.
Grant A, Chapman LRM, Mitchell R, O'Brien TA
Clin Transplant 2020 Jun;34(6):e13875. Epub 2020 Apr 27 doi: 10.1111/ctr.13875. PMID: 32279341
Transplant-associated thrombotic microangiopathy: Diagnostic challenges and management strategies.
Elemary M, Sabry W, Seghatchian J, Goubran H
Transfus Apher Sci 2019 Jun;58(3):347-350. Epub 2019 May 1 doi: 10.1016/j.transci.2019.04.022. PMID: 31097308
Capillary leak syndrome: etiologies, pathophysiology, and management.
Siddall E, Khatri M, Radhakrishnan J
Kidney Int 2017 Jul;92(1):37-46. Epub 2017 Mar 17 doi: 10.1016/j.kint.2016.11.029. PMID: 28318633

Therapy

Engraftment syndrome following Hematopoietic stem cell transplantation: a systematic approach toward diagnosis and management.
Maqbool S, Nadeem M, Shahroz A, Naimat K, Khan I, Tahir H, Rehman A, Anwer F, Iftikhar R, Lee KY
Med Oncol 2022 Dec 2;40(1):36. doi: 10.1007/s12032-022-01894-7. PMID: 36460884Free PMC Article
Engraftment Syndrome and Acute Graft-versus-Host Disease: A Meta-Analysis.
Poonsombudlert K, Kewcharoen J, Prueksapraopong C, Limpruttidham N
Hawaii J Health Soc Welf 2020 Jun 1;79(6):194-201. PMID: 32524098Free PMC Article
Engraftment syndrome following hematopoietic stem cell transplant: A review of the literature.
Grant A, Chapman LRM, Mitchell R, O'Brien TA
Clin Transplant 2020 Jun;34(6):e13875. Epub 2020 Apr 27 doi: 10.1111/ctr.13875. PMID: 32279341
Capillary leak syndrome: etiologies, pathophysiology, and management.
Siddall E, Khatri M, Radhakrishnan J
Kidney Int 2017 Jul;92(1):37-46. Epub 2017 Mar 17 doi: 10.1016/j.kint.2016.11.029. PMID: 28318633
Engraftment Syndrome after Autologous Stem Cell Transplantation: An Update Unifying the Definition and Management Approach.
Cornell RF, Hari P, Drobyski WR
Biol Blood Marrow Transplant 2015 Dec;21(12):2061-2068. Epub 2015 Aug 29 doi: 10.1016/j.bbmt.2015.08.030. PMID: 26327628Free PMC Article

Prognosis

Capillary leak syndrome: etiologies, pathophysiology, and management.
Siddall E, Khatri M, Radhakrishnan J
Kidney Int 2017 Jul;92(1):37-46. Epub 2017 Mar 17 doi: 10.1016/j.kint.2016.11.029. PMID: 28318633
Procalcitonin and cytokine profiles in engraftment syndrome in pediatric stem cell transplantation.
Shah NN, Watson TM, Yates B, Liewehr DJ, Steinberg SM, Jacobsohn D, Fry TJ
Pediatr Blood Cancer 2017 Mar;64(3) Epub 2016 Oct 20 doi: 10.1002/pbc.26273. PMID: 27762068Free PMC Article
Raiders of the lost mark - endothelial cells and their role in transplantation for hematologic malignancies.
Blix ES, Husebekk A
Leuk Lymphoma 2016 Dec;57(12):2752-2762. Epub 2016 Jul 10 doi: 10.1080/10428194.2016.1201566. PMID: 27396981
Engraftment syndrome in hematopoietic stem cell transplantations.
Thoele K
Clin J Oncol Nurs 2014 Jun;18(3):349-54. doi: 10.1188/14.CJON.349-354. PMID: 24867116
Peri-engraftment syndrome in allogeneic hematopoietic SCT.
Hong KT, Kang HJ, Kim NH, Kim MS, Lee JW, Kim H, Park KD, Shin HY, Ahn HS
Bone Marrow Transplant 2013 Apr;48(4):523-8. Epub 2012 Sep 24 doi: 10.1038/bmt.2012.171. PMID: 23000648

Clinical prediction guides

Engraftment syndrome following Hematopoietic stem cell transplantation: a systematic approach toward diagnosis and management.
Maqbool S, Nadeem M, Shahroz A, Naimat K, Khan I, Tahir H, Rehman A, Anwer F, Iftikhar R, Lee KY
Med Oncol 2022 Dec 2;40(1):36. doi: 10.1007/s12032-022-01894-7. PMID: 36460884Free PMC Article
Incidence and characteristics of engraftment syndrome after autologous hematopoietic cell transplantation in light chain amyloidosis.
Badar T, Khan MA, Szabo A, Drobyski W, Chhabra S, Dhakal B, Fenske TS, Hamadani M, Hari P, Jerkins JH, Shah NN, Shaw BE, D'Souza A
Amyloid 2019 Dec;26(4):210-215. Epub 2019 Jul 26 doi: 10.1080/13506129.2019.1645001. PMID: 31347424
Capillary leak syndrome: etiologies, pathophysiology, and management.
Siddall E, Khatri M, Radhakrishnan J
Kidney Int 2017 Jul;92(1):37-46. Epub 2017 Mar 17 doi: 10.1016/j.kint.2016.11.029. PMID: 28318633
Pre-engraftment syndrome after unrelated cord blood transplantation: a predictor of engraftment and acute graft-versus-host disease.
Park M, Lee SH, Lee YH, Yoo KH, Sung KW, Koo HH, Kang HJ, Park KD, Shin HY, Ahn HS, Chung NG, Cho B, Kim HK, Koh KN, Im HJ, Seo JJ, Han DK, Baek HJ, Kook H, Hwang TJ, Lee EK, Hah JO, Lim YJ, Jung HJ, Park JE, Jang MJ, Chong SY, Oh D; Korean Cord Blood Transplantation Working Party
Biol Blood Marrow Transplant 2013 Apr;19(4):640-6. Epub 2013 Feb 1 doi: 10.1016/j.bbmt.2013.01.014. PMID: 23380345
Engraftment syndrome following hematopoietic stem cell transplantation.
Spitzer TR
Bone Marrow Transplant 2001 May;27(9):893-8. doi: 10.1038/sj.bmt.1703015. PMID: 11436099

Recent systematic reviews

Engraftment syndrome after allogeneic stem cell transplantation: a systematic review and meta-analysis.
ElGohary G, Toor AA, Gergis U
Bone Marrow Transplant 2023 Jan;58(1):1-9. Epub 2022 Oct 25 doi: 10.1038/s41409-022-01849-6. PMID: 36284212
Engraftment Syndrome and Acute Graft-versus-Host Disease: A Meta-Analysis.
Poonsombudlert K, Kewcharoen J, Prueksapraopong C, Limpruttidham N
Hawaii J Health Soc Welf 2020 Jun 1;79(6):194-201. PMID: 32524098Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...