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Immunodeficiency-related disorder

MedGen UID:
232641
•Concept ID:
C1334159
•
Disease or Syndrome
Synonyms: Immunodeficiency-Related Disorder; immunodeficiency-related disorder; Immunodepression-Related Disorder; Immunodepression-related disorder; Immunosuppression disorders; Immunosuppression-Related Disorder; Immunosuppression-related disorder
 
Monarch Initiative: MONDO:0024572

Definition

A non-neoplastic or neoplastic disorder that develops in a patient with immunodeficiency. Representative examples include AIDS-related disorders and disorders that develop following organ transplantation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVImmunodeficiency-related disorder

Professional guidelines

PubMed

Primary immunodeficiency-related bronchiectasis in adults: comparison with bronchiectasis of other etiologies in a French reference center.
Goussault H, Salvator H, Catherinot E, Chabi ML, Tcherakian C, Chabrol A, Didier M, Rivaud E, Fischer A, Suarez F, Hermine O, Lanternier F, Lortholary O, Mahlaoui N, Devillier P, Couderc LJ
Respir Res 2019 Dec 4;20(1):275. doi: 10.1186/s12931-019-1242-4. PMID: 31801528Free PMC Article
Outcomes for Nitazoxanide Treatment in a Case Series of Patients with Primary Immunodeficiencies and Rubella Virus-Associated Granuloma.
Perelygina L, Buchbinder D, Dorsey MJ, Eloit M, Hauck F, Hautala T, Moshous D, Uriarte I, Deripapa E, Icenogle J, Sullivan KE
J Clin Immunol 2019 Jan;39(1):112-117. Epub 2019 Jan 24 doi: 10.1007/s10875-019-0589-0. PMID: 30680653Free PMC Article
Utilization of genomic sequencing for population screening of immunodeficiencies in the newborn.
Pavey AR, Bodian DL, Vilboux T, Khromykh A, Hauser NS, Huddleston K, Klein E, Black A, Kane MS, Iyer RK, Niederhuber JE, Solomon BD
Genet Med 2017 Dec;19(12):1367-1375. Epub 2017 Jun 15 doi: 10.1038/gim.2017.57. PMID: 28617419

Recent clinical studies

Etiology

Diagnostic testing for interstitial lung disease in common variable immunodeficiency: a systematic review.
Bintalib HM, van de Ven A, Jacob J, Davidsen JR, Fevang B, Hanitsch LG, Malphettes M, van Montfrans J, Maglione PJ, Milito C, Routes J, Warnatz K, Hurst JR
Front Immunol 2023;14:1190235. Epub 2023 May 8 doi: 10.3389/fimmu.2023.1190235. PMID: 37223103Free PMC Article
Secondary Immunodeficiency Related to Kidney Disease (SIDKD)-Definition, Unmet Need, and Mechanisms.
Steiger S, Rossaint J, Zarbock A, Anders HJ
J Am Soc Nephrol 2022 Feb;33(2):259-278. Epub 2021 Dec 14 doi: 10.1681/ASN.2021091257. PMID: 34907031Free PMC Article
HIV-associated Burkitt lymphoma.
Atallah-Yunes SA, Murphy DJ, Noy A
Lancet Haematol 2020 Aug;7(8):e594-e600. doi: 10.1016/S2352-3026(20)30126-5. PMID: 32735838
Epstein-Barr Virus-Positive Extranodal Marginal Zone Lymphoma of Bronchial-Associated Lymphoid Tissue in the Posttransplant Setting: An Immunodeficiency-Related (Posttransplant) Lymphoproliferative Disorder?
Cassidy DP, Vega F, Chapman JR
Am J Clin Pathol 2017 Dec 20;149(1):42-49. doi: 10.1093/ajcp/aqx134. PMID: 29228090
Granulomatous lymphocytic interstitial lung disease.
Fernández Pérez ER
Immunol Allergy Clin North Am 2012 Nov;32(4):621-32. Epub 2012 Sep 12 doi: 10.1016/j.iac.2012.08.003. PMID: 23102069

Diagnosis

Primary immunodeficiency-related genes and varicella-zoster virus reactivation syndrome: a Mendelian randomization study.
Wang H, Chen G, Gong Q, Wu J, Chen P
Front Immunol 2024;15:1403429. Epub 2024 Aug 26 doi: 10.3389/fimmu.2024.1403429. PMID: 39253091Free PMC Article
EBV-Associated Lymphoproliferative Disorders: Update in Classification.
Rezk SA, Weiss LM
Surg Pathol Clin 2019 Sep;12(3):745-770. doi: 10.1016/j.path.2019.03.002. PMID: 31352986
Pulmonary Hypertension in HIV.
Basyal B, Jarrett H, Barnett CF
Can J Cardiol 2019 Mar;35(3):288-298. doi: 10.1016/j.cjca.2019.01.005. PMID: 30825951
Gastrointestinal Manifestations and Complications of Primary Immunodeficiency Disorders.
Agarwal S, Cunningham-Rundles C
Immunol Allergy Clin North Am 2019 Feb;39(1):81-94. doi: 10.1016/j.iac.2018.08.006. PMID: 30466774Free PMC Article
Epstein-Barr Virus-Positive Extranodal Marginal Zone Lymphoma of Bronchial-Associated Lymphoid Tissue in the Posttransplant Setting: An Immunodeficiency-Related (Posttransplant) Lymphoproliferative Disorder?
Cassidy DP, Vega F, Chapman JR
Am J Clin Pathol 2017 Dec 20;149(1):42-49. doi: 10.1093/ajcp/aqx134. PMID: 29228090

Therapy

Primary immunodeficiency-related genes and varicella-zoster virus reactivation syndrome: a Mendelian randomization study.
Wang H, Chen G, Gong Q, Wu J, Chen P
Front Immunol 2024;15:1403429. Epub 2024 Aug 26 doi: 10.3389/fimmu.2024.1403429. PMID: 39253091Free PMC Article
Neutralization of Rubella Vaccine Virus and Immunodeficiency-Related Vaccine-Derived Rubella Viruses by Intravenous Immunoglobulins.
Chen MH, Perelygina L, Hao L, Beard RS, Lackner C, Farcet MR, Karbiener M, Icenogle J, Kreil TR
J Infect Dis 2024 Oct 16;230(4):e938-e942. doi: 10.1093/infdis/jiae182. PMID: 38592952Free PMC Article
Burkitt and Burkitt-Like Lymphomas: a Systematic Review.
Saleh K, Michot JM, Camara-Clayette V, Vassetsky Y, Ribrag V
Curr Oncol Rep 2020 Mar 6;22(4):33. doi: 10.1007/s11912-020-0898-8. PMID: 32144513
EBV-Associated Lymphoproliferative Disorders: Update in Classification.
Rezk SA, Weiss LM
Surg Pathol Clin 2019 Sep;12(3):745-770. doi: 10.1016/j.path.2019.03.002. PMID: 31352986
Epstein-Barr Virus-Positive Extranodal Marginal Zone Lymphoma of Bronchial-Associated Lymphoid Tissue in the Posttransplant Setting: An Immunodeficiency-Related (Posttransplant) Lymphoproliferative Disorder?
Cassidy DP, Vega F, Chapman JR
Am J Clin Pathol 2017 Dec 20;149(1):42-49. doi: 10.1093/ajcp/aqx134. PMID: 29228090

Prognosis

Development of a novel multi-epitope mRNA vaccine candidate to combat HMPV virus.
Ma S, Zhu F, Xu Y, Wen H, Rao M, Zhang P, Peng W, Cui Y, Yang H, Tan C, Chen J, Pan P
Hum Vaccin Immunother 2023 Dec 15;19(3):2293300. Epub 2024 Jan 3 doi: 10.1080/21645515.2023.2293300. PMID: 38172569Free PMC Article
HIV-associated Burkitt lymphoma.
Atallah-Yunes SA, Murphy DJ, Noy A
Lancet Haematol 2020 Aug;7(8):e594-e600. doi: 10.1016/S2352-3026(20)30126-5. PMID: 32735838
EBV-Associated Lymphoproliferative Disorders: Update in Classification.
Rezk SA, Weiss LM
Surg Pathol Clin 2019 Sep;12(3):745-770. doi: 10.1016/j.path.2019.03.002. PMID: 31352986
Epstein-Barr virus (EBV)-associated lymphoid proliferations, a 2018 update.
Rezk SA, Zhao X, Weiss LM
Hum Pathol 2018 Sep;79:18-41. Epub 2018 Jun 6 doi: 10.1016/j.humpath.2018.05.020. PMID: 29885408
Granulomatous lymphocytic interstitial lung disease.
Fernández Pérez ER
Immunol Allergy Clin North Am 2012 Nov;32(4):621-32. Epub 2012 Sep 12 doi: 10.1016/j.iac.2012.08.003. PMID: 23102069

Clinical prediction guides

Epstein-Barr virus latency patterns in polymorphic lymphoproliferative disorders and lymphomas in immunodeficiency settings: Diagnostic implications.
Volaric AK, Saleem A, Younes SF, Zhao S, Natkunam Y
Ann Diagn Pathol 2024 Jun;70:152286. Epub 2024 Feb 29 doi: 10.1016/j.anndiagpath.2024.152286. PMID: 38447253
Comprehensive analysis revealed the immunoinflammatory targets of rheumatoid arthritis based on intestinal flora, miRNA, transcription factors, and RNA-binding proteins databases, GSEA and GSVA pathway observations, and immunoinfiltration typing.
Guan Y, Zhang Y, Zhao X, Wang Y
Hereditas 2024 Jan 25;161(1):6. doi: 10.1186/s41065-024-00310-6. PMID: 38273392Free PMC Article
Development of a novel multi-epitope mRNA vaccine candidate to combat HMPV virus.
Ma S, Zhu F, Xu Y, Wen H, Rao M, Zhang P, Peng W, Cui Y, Yang H, Tan C, Chen J, Pan P
Hum Vaccin Immunother 2023 Dec 15;19(3):2293300. Epub 2024 Jan 3 doi: 10.1080/21645515.2023.2293300. PMID: 38172569Free PMC Article
Integrating Clinics, Laboratory, and Imaging for the Diagnosis of Common Variable Immunodeficiency-Related Granulomatous-Lymphocytic Interstitial Lung Disease.
Cabanero-Navalon MD, Garcia-Bustos V, Forero-Naranjo LF, Baettig-Arriagada EJ, Núñez-Beltrán M, Cañada-Martínez AJ, Forner Giner MJ, Catalán-Cáceres N, Martínez Francés M, Moral Moral P
Front Immunol 2022;13:813491. Epub 2022 Feb 23 doi: 10.3389/fimmu.2022.813491. PMID: 35281075Free PMC Article
Therapeutic application of calf thymus extract (TFX).
Skotnicki AB
Med Oncol Tumor Pharmacother 1989;6(1):31-43. doi: 10.1007/BF02985221. PMID: 2657248

Recent systematic reviews

Diagnostic testing for interstitial lung disease in common variable immunodeficiency: a systematic review.
Bintalib HM, van de Ven A, Jacob J, Davidsen JR, Fevang B, Hanitsch LG, Malphettes M, van Montfrans J, Maglione PJ, Milito C, Routes J, Warnatz K, Hurst JR
Front Immunol 2023;14:1190235. Epub 2023 May 8 doi: 10.3389/fimmu.2023.1190235. PMID: 37223103Free PMC Article
Burkitt and Burkitt-Like Lymphomas: a Systematic Review.
Saleh K, Michot JM, Camara-Clayette V, Vassetsky Y, Ribrag V
Curr Oncol Rep 2020 Mar 6;22(4):33. doi: 10.1007/s11912-020-0898-8. PMID: 32144513
Immunodeficiency-related vaccine-derived poliovirus (iVDPV) cases: a systematic review and implications for polio eradication.
Guo J, Bolivar-Wagers S, Srinivas N, Holubar M, Maldonado Y
Vaccine 2015 Mar 3;33(10):1235-42. Epub 2015 Jan 16 doi: 10.1016/j.vaccine.2015.01.018. PMID: 25600519Free PMC Article

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