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Cutaneous tuberculosis

MedGen UID:
22515
•Concept ID:
C0041309
•
Disease or Syndrome
Synonyms: Skin Tuberculosis; Tuberculosis, Cutaneous
SNOMED CT: Tuberculosis of skin (66986005); Tuberculosis cutis (66986005); Tuberculoderma (66986005); Cutaneous tuberculosis (66986005)
 
Monarch Initiative: MONDO:0021948

Definition

Tuberculosis of the skin. It includes scrofuloderma and tuberculid, but not LUPUS VULGARIS. [from MeSH]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCutaneous tuberculosis

Professional guidelines

PubMed

Cutaneous tuberculosis. Part II: Complications, diagnostic workup, histopathologic features, and treatment.
Kaul S, Jakhar D, Mehta S, Singal A
J Am Acad Dermatol 2023 Dec;89(6):1107-1119. Epub 2022 Feb 8 doi: 10.1016/j.jaad.2021.12.064. PMID: 35149148
Cutaneous tuberculosis overview and current treatment regimens.
van Zyl L, du Plessis J, Viljoen J
Tuberculosis (Edinb) 2015 Dec;95(6):629-638. Epub 2014 Dec 25 doi: 10.1016/j.tube.2014.12.006. PMID: 26616847
Management of cutaneous tuberculosis.
Handog EB, Gabriel TG, Pineda RT
Dermatol Ther 2008 May-Jun;21(3):154-61. doi: 10.1111/j.1529-8019.2008.00186.x. PMID: 18564245

Recent clinical studies

Etiology

Mycobacterial skin infection.
Gardini G, Gregori N, Matteelli A, Castelli F
Curr Opin Infect Dis 2022 Apr 1;35(2):79-87. doi: 10.1097/QCO.0000000000000820. PMID: 35067521Free PMC Article
Scrofuloderma.
Oberhelman S, Watchmaker J, Phillips T
JAMA Dermatol 2019 May 1;155(5):610. doi: 10.1001/jamadermatol.2018.5651. PMID: 30942835
Cutaneous Mycobacterial Infections.
Franco-Paredes C, Marcos LA, Henao-Martínez AF, Rodríguez-Morales AJ, Villamil-Gómez WE, Gotuzzo E, Bonifaz A
Clin Microbiol Rev 2018 Jan;32(1) Epub 2018 Nov 14 doi: 10.1128/CMR.00069-18. PMID: 30429139Free PMC Article
Tropical Skin Diseases in Children: A Review-Part II.
García-Romero MT, Lara-Corrales I, Kovarik CL, Pope E, Arenas R
Pediatr Dermatol 2016 May;33(3):264-74. Epub 2016 Apr 4 doi: 10.1111/pde.12778. PMID: 27039881
Tattoos: dermatological complications.
Kazandjieva J, Tsankov N
Clin Dermatol 2007 Jul-Aug;25(4):375-82. doi: 10.1016/j.clindermatol.2007.05.012. PMID: 17697920

Diagnosis

Papulonecrotic tuberculid.
Zhang LW, Wu J, Chen T
CMAJ 2024 Feb 11;196(5):E158. doi: 10.1503/cmaj.231460. PMID: 38346781Free PMC Article
Cutaneous tuberculosis. Part I: Pathogenesis, classification, and clinical features.
Kaul S, Kaur I, Mehta S, Singal A
J Am Acad Dermatol 2023 Dec;89(6):1091-1103. Epub 2022 Feb 8 doi: 10.1016/j.jaad.2021.12.063. PMID: 35149149
Cutaneous tuberculosis. Part II: Complications, diagnostic workup, histopathologic features, and treatment.
Kaul S, Jakhar D, Mehta S, Singal A
J Am Acad Dermatol 2023 Dec;89(6):1107-1119. Epub 2022 Feb 8 doi: 10.1016/j.jaad.2021.12.064. PMID: 35149148
Papulonecrotic tuberculid.
Palaniappan V, Sadhasivamohan A, Karthikeyan K
Clin Exp Dermatol 2022 Oct;47(10):1820-1828. Epub 2022 Aug 3 doi: 10.1111/ced.15302. PMID: 35724330
Scrofuloderma.
Oberhelman S, Watchmaker J, Phillips T
JAMA Dermatol 2019 May 1;155(5):610. doi: 10.1001/jamadermatol.2018.5651. PMID: 30942835

Therapy

Tuberculous Mastitis.
Boland-Rodríguez E, Parra-Herrera JL, Romero-González I
JAMA Dermatol 2024 Aug 1;160(8):888. doi: 10.1001/jamadermatol.2024.1838. PMID: 38959015
Tuberculosis Verrucosa Cutis.
Wang J, Liu J
N Engl J Med 2024 Jun 13;390(22):e58. doi: 10.1056/NEJMicm2313828. PMID: 38865663
Cutaneous tuberculosis. Part II: Complications, diagnostic workup, histopathologic features, and treatment.
Kaul S, Jakhar D, Mehta S, Singal A
J Am Acad Dermatol 2023 Dec;89(6):1107-1119. Epub 2022 Feb 8 doi: 10.1016/j.jaad.2021.12.064. PMID: 35149148
Scrofuloderma.
Oberhelman S, Watchmaker J, Phillips T
JAMA Dermatol 2019 May 1;155(5):610. doi: 10.1001/jamadermatol.2018.5651. PMID: 30942835
Cutaneous tuberculosis.
MacGregor RR
Clin Dermatol 1995 May-Jun;13(3):245-55. doi: 10.1016/0738-081x(95)00019-c. PMID: 8521366

Prognosis

Mycobacterial skin infection.
Gardini G, Gregori N, Matteelli A, Castelli F
Curr Opin Infect Dis 2022 Apr 1;35(2):79-87. doi: 10.1097/QCO.0000000000000820. PMID: 35067521Free PMC Article
Scrofuloderma.
Oberhelman S, Watchmaker J, Phillips T
JAMA Dermatol 2019 May 1;155(5):610. doi: 10.1001/jamadermatol.2018.5651. PMID: 30942835
Mycobacterial skin and soft tissue infections: TB or not TB?
van Mechelen M, van der Hilst J, Gyssens IC, Messiaen P
Neth J Med 2018 Aug;76(6):269-274. PMID: 30152403
Tuberculosis verrucosa cutis.
Afshar K, Mundi M
Mayo Clin Proc 2004 Dec;79(12):1562. doi: 10.4065/79.12.1562. PMID: 15595342
Cutaneous tuberculosis.
MacGregor RR
Clin Dermatol 1995 May-Jun;13(3):245-55. doi: 10.1016/0738-081x(95)00019-c. PMID: 8521366

Clinical prediction guides

Clinical profile of cutaneous tuberculosis at Nashik.
Jadhav VM, Waghmare MT
Acta Dermatovenerol Alp Pannonica Adriat 2021 Dec;30(4):137-140. PMID: 34929989
Cutaneous tuberculosis of the pinna.
Ramesh V, Gupta J
Int J Dermatol 2021 Mar;60(3):363-367. Epub 2020 Nov 30 doi: 10.1111/ijd.15249. PMID: 33251595
Interferon-γ Release Assay and Reverse Blot Hybridization Assay: Diagnostic Role in Cutaneous Tuberculosis.
Chung HC, Kim BK, Hong H, Wang HY, Kim Y, Lee H, Eom M, Choi EH
Acta Derm Venereol 2016 Jan;96(1):126-7. doi: 10.2340/00015555-2182. PMID: 26084370
Cutaneous tuberculosis in children.
Sethuraman G, Ramesh V
Pediatr Dermatol 2013 Jan-Feb;30(1):7-16. Epub 2012 Nov 22 doi: 10.1111/j.1525-1470.2012.01794.x. PMID: 23173930
Is micropapular sarcoidosis tuberculosis?
Ridgway HA, Ryan TJ
J R Soc Med 1981 Feb;74(2):140-4. doi: 10.1177/014107688107400210. PMID: 7205849Free PMC Article

Recent systematic reviews

Post-tuberculosis sequelae in children and adolescents: a systematic review.
Igbokwe V, Ruby LC, Sultanli A, Bélard S
Lancet Infect Dis 2023 Apr;23(4):e138-e150. doi: 10.1016/S1473-3099(23)00004-X. PMID: 36963920

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