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Vitamin K deficiency

MedGen UID:
22672
•Concept ID:
C0042880
•
Disease or Syndrome
Synonyms: Deficiencies, Vitamin K; Deficiency, Vitamin K; Vitamin K Deficiencies; Vitamin K Deficiency
SNOMED CT: Deficiency of vitamin K (52675005); Vitamin K deficiency (52675005)

Definition

Deficiency of vitamin K. It may lead to bleeding, manifested with ecchymoses, petechiae, and hematomas. In infants it may cause hemorrhagic disease of newborn with intracranial and retroperitoneal bleeding. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVitamin K deficiency

Professional guidelines

PubMed

Belgian Consensus Recommendations to Prevent Vitamin K Deficiency Bleeding in the Term and Preterm Infant.
Fiesack S, Smits A, Rayyan M, Allegaert K, Alliet P, Arts W, Bael A, Cornette L, De Guchtenaere A, De Mulder N, George I, Henrion E, Keiren K, Kreins N, Raes M, Philippet P, Van Overmeire B, Van Winckel M, Vlieghe V, Vandenplas Y, On Behalf Of The Groups
Nutrients 2021 Nov 16;13(11) doi: 10.3390/nu13114109. PMID: 34836364Free PMC Article
A guide to acquired vitamin K coagulophathy diagnosis and treatment: the Russian perspective.
Wojciechowski VV, Calina D, Tsarouhas K, Pivnik AV, Sergievich AA, Kodintsev VV, Filatova EA, Ozcagli E, Docea AO, Arsene AL, Gofita E, Tsitsimpikou C, Tsatsakis AM, Golokhvast KS
Daru 2017 Apr 17;25(1):10. doi: 10.1186/s40199-017-0175-z. PMID: 28416008Free PMC Article
Prevention of Vitamin K Deficiency Bleeding in Newborn Infants: A Position Paper by the ESPGHAN Committee on Nutrition.
Mihatsch WA, Braegger C, Bronsky J, Campoy C, Domellöf M, Fewtrell M, Mis NF, Hojsak I, Hulst J, Indrio F, Lapillonne A, Mlgaard C, Embleton N, van Goudoever J; ESPGHAN Committee on Nutrition
J Pediatr Gastroenterol Nutr 2016 Jul;63(1):123-9. doi: 10.1097/MPG.0000000000001232. PMID: 27050049

Recent clinical studies

Etiology

Vitamin K Nutrition and Bone Health.
Tsugawa N, Shiraki M
Nutrients 2020 Jun 27;12(7) doi: 10.3390/nu12071909. PMID: 32605143Free PMC Article
Calciphylaxis: Diagnosis, Pathogenesis, and Treatment.
Chang JJ
Adv Skin Wound Care 2019 May;32(5):205-215. doi: 10.1097/01.ASW.0000554443.14002.13. PMID: 31008757
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article
Vitamin K.
Shearer MJ
Lancet 1995 Jan 28;345(8944):229-34. doi: 10.1016/s0140-6736(95)90227-9. PMID: 7823718
Surgical hemostasis.
Owen CA Jr, Bowie EJ
J Neurosurg 1979 Aug;51(2):137-42. doi: 10.3171/jns.1979.51.2.0137. PMID: 376788

Diagnosis

Age-specific causes of upper gastrointestinal bleeding in children.
Kocic M, Rasic P, Marusic V, Prokic D, Savic D, Milickovic M, Kitic I, Mijovic T, Sarajlija A
World J Gastroenterol 2023 Dec 21;29(47):6095-6110. doi: 10.3748/wjg.v29.i47.6095. PMID: 38186684Free PMC Article
Vitamin K Nutrition and Bone Health.
Tsugawa N, Shiraki M
Nutrients 2020 Jun 27;12(7) doi: 10.3390/nu12071909. PMID: 32605143Free PMC Article
Calciphylaxis: Diagnosis, Pathogenesis, and Treatment.
Chang JJ
Adv Skin Wound Care 2019 May;32(5):205-215. doi: 10.1097/01.ASW.0000554443.14002.13. PMID: 31008757
Neonatal coagulation problems.
Chalmers EA
Arch Dis Child Fetal Neonatal Ed 2004 Nov;89(6):F475-8. doi: 10.1136/adc.2004.050096. PMID: 15499133Free PMC Article
Newborn haemostasis.
Montgomery RR, Marlar RA, Gill JC
Clin Haematol 1985 Jun;14(2):443-60. PMID: 3899442

Therapy

Vitamin K prophylaxis in newborns.
Jullien S
BMC Pediatr 2021 Sep 8;21(Suppl 1):350. doi: 10.1186/s12887-021-02701-4. PMID: 34496783Free PMC Article
Vitamin K Deficiency Bleeding in Infancy.
Araki S, Shirahata A
Nutrients 2020 Mar 16;12(3) doi: 10.3390/nu12030780. PMID: 32187975Free PMC Article
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article
Vitamin K.
Suttie JW, Booth SL
Adv Nutr 2011 Sep;2(5):440-1. Epub 2011 Sep 6 doi: 10.3945/an.111.000786. PMID: 22332085Free PMC Article
Vitamin K.
Shearer MJ
Lancet 1995 Jan 28;345(8944):229-34. doi: 10.1016/s0140-6736(95)90227-9. PMID: 7823718

Prognosis

Vitamin K and the Newborn Infant.
Hand I, Noble L, Abrams SA
Pediatrics 2022 Mar 1;149(3) doi: 10.1542/peds.2021-056036. PMID: 35190810
PIVKA-II serves as a potential biomarker that complements AFP for the diagnosis of hepatocellular carcinoma.
Feng H, Li B, Li Z, Wei Q, Ren L
BMC Cancer 2021 Apr 13;21(1):401. doi: 10.1186/s12885-021-08138-3. PMID: 33849479Free PMC Article
Calciphylaxis.
Nigwekar SU
Curr Opin Nephrol Hypertens 2017 Jul;26(4):276-281. doi: 10.1097/MNH.0000000000000328. PMID: 28375870Free PMC Article
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article
Surgical hemostasis.
Owen CA Jr, Bowie EJ
J Neurosurg 1979 Aug;51(2):137-42. doi: 10.3171/jns.1979.51.2.0137. PMID: 376788

Clinical prediction guides

The Role of Gut Dysbiosis in the Bone-Vascular Axis in Chronic Kidney Disease.
Evenepoel P, Dejongh S, Verbeke K, Meijers B
Toxins (Basel) 2020 Apr 29;12(5) doi: 10.3390/toxins12050285. PMID: 32365480Free PMC Article
The Relationship between Vitamin K and Osteoarthritis: A Review of Current Evidence.
Chin KY
Nutrients 2020 Apr 25;12(5) doi: 10.3390/nu12051208. PMID: 32344816Free PMC Article
Multicenter Randomized Controlled Trial of Vitamin K Antagonist Replacement by Rivaroxaban with or without Vitamin K2 in Hemodialysis Patients with Atrial Fibrillation: the Valkyrie Study.
De Vriese AS, Caluwé R, Pyfferoen L, De Bacquer D, De Boeck K, Delanote J, De Surgeloose D, Van Hoenacker P, Van Vlem B, Verbeke F
J Am Soc Nephrol 2020 Jan;31(1):186-196. Epub 2019 Nov 8 doi: 10.1681/ASN.2019060579. PMID: 31704740Free PMC Article
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article
Haemophilia and the newborn.
Chalmers EA
Blood Rev 2004 Jun;18(2):85-92. doi: 10.1016/S0268-960X(03)00062-6. PMID: 15010147

Recent systematic reviews

Hyperemesis gravidarum and vitamin K deficiency: a systematic review.
Nijsten K, van der Minnen L, Wiegers HMG, Koot MH, Middeldorp S, Roseboom TJ, Grooten IJ, Painter RC
Br J Nutr 2022 Jul 14;128(1):30-42. Epub 2021 Jul 30 doi: 10.1017/S0007114521002865. PMID: 34325760Free PMC Article
Vitamin K-what is known regarding bariatric surgery patients: a systematic review.
Sherf-Dagan S, Goldenshluger A, Azran C, Sakran N, Sinai T, Ben-Porat T
Surg Obes Relat Dis 2019 Aug;15(8):1402-1413. Epub 2019 Jun 5 doi: 10.1016/j.soard.2019.05.031. PMID: 31353233
Prophylactic vitamin K for the prevention of vitamin K deficiency bleeding in preterm neonates.
Ardell S, Offringa M, Ovelman C, Soll R
Cochrane Database Syst Rev 2018 Feb 5;2(2):CD008342. doi: 10.1002/14651858.CD008342.pub2. PMID: 29401369Free PMC Article
Vitamin K supplementation for cystic fibrosis.
Jagannath VA, Thaker V, Chang AB, Price AI
Cochrane Database Syst Rev 2017 Aug 22;8(8):CD008482. doi: 10.1002/14651858.CD008482.pub5. PMID: 28829533Free PMC Article
Vitamin K prophylaxis for prevention of vitamin K deficiency bleeding: a systematic review.
Sankar MJ, Chandrasekaran A, Kumar P, Thukral A, Agarwal R, Paul VK
J Perinatol 2016 May;36 Suppl 1(Suppl 1):S29-35. doi: 10.1038/jp.2016.30. PMID: 27109090Free PMC Article

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