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Adenoma of small intestine

MedGen UID:
226995
•Concept ID:
C1302392
•
Neoplastic Process
Synonyms: Adenoma of Small Bowel; adenoma of small bowel; Adenoma of Small Intestine; adenoma of small intestine; Adenoma of the Small Bowel; adenoma of the small bowel; Adenoma of the Small Intestine; adenoma of the small intestine; Non-Ampullary Adenoma; Small Bowel Adenoma; small bowel adenoma; Small Intestinal Adenoma; small intestinal adenoma; small intestine adenoma
SNOMED CT: Adenoma of small intestine (399422005)
 
Monarch Initiative: MONDO:0021303

Definition

A neoplasm that arises from the glandular epithelium of the small intestine. It is a polypoid or flat circumscribed lesion. Morphologically, it is characterized by a proliferation of neoplastic glandular cells and it is associated with dysplasia. According to the growth pattern, it may be classified as tubular, villous, or tubulovillous. [from NCI]

Professional guidelines

PubMed

Updates in the diagnosis and management of non-ampullary small-bowel polyposis.
Lucaciu L, Yano T, Saurin JC
Best Pract Res Clin Gastroenterol 2023 Jun-Aug;64-65:101852. Epub 2023 Jul 22 doi: 10.1016/j.bpg.2023.101852. PMID: 37652652
Management of pouch neoplasia: consensus guidelines from the International Ileal Pouch Consortium.
Kiran RP, Kochhar GS, Kariv R, Rex DK, Sugita A, Rubin DT, Navaneethan U, Hull TL, Ko HM, Liu X, Kachnic LA, Strong S, Iacucci M, Bemelman W, Fleshner P, Safyan RA, Kotze PG, D'Hoore A, Faiz O, Lo S, Ashburn JH, Spinelli A, Bernstein CN, Kane SV, Cross RK, Schairer J, McCormick JT, Farraye FA, Chang S, Scherl EJ, Schwartz DA, Bruining DH, Philpott J, Bentley-Hibbert S, Tarabar D, El-Hachem S, Sandborn WJ, Silverberg MS, Pardi DS, Church JM, Shen B
Lancet Gastroenterol Hepatol 2022 Sep;7(9):871-893. Epub 2022 Jul 5 doi: 10.1016/S2468-1253(22)00039-5. PMID: 35798022
Endoscopic management of ampullary tumors: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Vanbiervliet G, Strijker M, Arvanitakis M, Aelvoet A, Arnelo U, Beyna T, Busch O, Deprez PH, Kunovsky L, Larghi A, Manes G, Moss A, Napoleon B, Nayar M, Pérez-Cuadrado-Robles E, Seewald S, Barthet M, van Hooft JE
Endoscopy 2021 Apr;53(4):429-448. Epub 2021 Mar 16 doi: 10.1055/a-1397-3198. PMID: 33728632

Recent clinical studies

Etiology

Preemptive purse-string suturing technique-assisted endoscopic papillectomy of ampullary adenoma.
Liu D, Hao MM, Zhang L, Tang TQ, Ou X, Yang Z, Liu WH
Endoscopy 2023 Dec;55(S 01):E167-E168. Epub 2022 Oct 28 doi: 10.1055/a-1948-1931. PMID: 36307077Free PMC Article
Cold versus hot EMR for large duodenal adenomas.
Repici A, Capogreco A, Spadaccini M, Maselli R, Galtieri PA, Fugazza A, Carrara S, Colombo M, Schachschal G, Creutzfeldt A, Aslam SP, Alkandari A, Bhandari P, Meining A, Hassan C, Rösch T
Gut 2022 Sep;71(9):1763-1765. Epub 2022 Jul 4 doi: 10.1136/gutjnl-2022-327171. PMID: 35788060
Endoscopic management of ampullary tumors: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Vanbiervliet G, Strijker M, Arvanitakis M, Aelvoet A, Arnelo U, Beyna T, Busch O, Deprez PH, Kunovsky L, Larghi A, Manes G, Moss A, Napoleon B, Nayar M, Pérez-Cuadrado-Robles E, Seewald S, Barthet M, van Hooft JE
Endoscopy 2021 Apr;53(4):429-448. Epub 2021 Mar 16 doi: 10.1055/a-1397-3198. PMID: 33728632
Continuing Advancements in Diagnosis and Management of Ampullary Adenoma.
Sanford Z, Adkins J, Knight C, Lahiry S
Am Surg 2017 Aug 1;83(8):e302-304. PMID: 28822368
Total pancreatectomy.
ReMine WH, Priestley JT, Judd ES, King JN
Ann Surg 1970 Oct;172(4):595-604. doi: 10.1097/00000658-197010000-00006. PMID: 4318798Free PMC Article

Diagnosis

Endoscopic Papillectomy.
Campos ST, Bruno MJ
Gastrointest Endosc Clin N Am 2022 Jul;32(3):545-562. Epub 2022 May 11 doi: 10.1016/j.giec.2022.01.005. PMID: 35691696
Continuing Advancements in Diagnosis and Management of Ampullary Adenoma.
Sanford Z, Adkins J, Knight C, Lahiry S
Am Surg 2017 Aug 1;83(8):e302-304. PMID: 28822368
The role of endoscopy in ampullary and duodenal adenomas.
ASGE Standards of Practice Committee, Chathadi KV, Khashab MA, Acosta RD, Chandrasekhara V, Eloubeidi MA, Faulx AL, Fonkalsrud L, Lightdale JR, Salztman JR, Shaukat A, Wang A, Cash BD, DeWitt JM
Gastrointest Endosc 2015 Nov;82(5):773-81. Epub 2015 Aug 7 doi: 10.1016/j.gie.2015.06.027. PMID: 26260385
Brunner's gland hyperplasia.
Peetz ME, Moseley HS
Am Surg 1989 Jul;55(7):474-7. PMID: 2662841
Benign and malignant tumors of the small intestine.
Garvin PJ, Herrmann V, Kaminski DL, Willman VL
Curr Probl Cancer 1979 Mar;3(9):1-46. doi: 10.1016/s0147-0272(79)80037-9. PMID: 391492

Therapy

Colonic polypectomy (with videos).
Burgess NG, Bahin FF, Bourke MJ
Gastrointest Endosc 2015 Apr;81(4):813-35. doi: 10.1016/j.gie.2014.12.027. PMID: 25805461
Endoscopic papillectomy.
Hernandez LV, Catalano MF
Curr Opin Gastroenterol 2008 Sep;24(5):617-22. doi: 10.1097/MOG.0b013e3283088e12. PMID: 19122504
Enteroscopy.
Mönkemüller K, Bellutti M, Fry LC, Malfertheiner P
Best Pract Res Clin Gastroenterol 2008;22(5):789-811. doi: 10.1016/j.bpg.2008.05.005. PMID: 18790433
Diagnostic ERCP.
Ponchon T, Pilleul F
Endoscopy 2002 Jan;34(1):29-42. doi: 10.1055/s-2002-19397. PMID: 11778128
Total pancreatectomy.
ReMine WH, Priestley JT, Judd ES, King JN
Ann Surg 1970 Oct;172(4):595-604. doi: 10.1097/00000658-197010000-00006. PMID: 4318798Free PMC Article

Prognosis

Glucose-6-phosphatase deficiency.
Froissart R, Piraud M, Boudjemline AM, Vianey-Saban C, Petit F, Hubert-Buron A, Eberschweiler PT, Gajdos V, Labrune P
Orphanet J Rare Dis 2011 May 20;6:27. doi: 10.1186/1750-1172-6-27. PMID: 21599942Free PMC Article
Endoscopic papillectomy.
Hernandez LV, Catalano MF
Curr Opin Gastroenterol 2008 Sep;24(5):617-22. doi: 10.1097/MOG.0b013e3283088e12. PMID: 19122504
Enteroscopy.
Mönkemüller K, Bellutti M, Fry LC, Malfertheiner P
Best Pract Res Clin Gastroenterol 2008;22(5):789-811. doi: 10.1016/j.bpg.2008.05.005. PMID: 18790433
Endoscopic ampullectomy.
Baillie J
Am J Gastroenterol 2005 Nov;100(11):2379-81. doi: 10.1111/j.1572-0241.2005.00332.x. PMID: 16279887
Total pancreatectomy.
ReMine WH, Priestley JT, Judd ES, King JN
Ann Surg 1970 Oct;172(4):595-604. doi: 10.1097/00000658-197010000-00006. PMID: 4318798Free PMC Article

Clinical prediction guides

Endoscopic papillectomy for ampullary lesions of minor papilla.
Vu Trung K, Heise C, Abou-Ali E, Auriemma F, Karam E, van der Wiel SE, Bruno MJ, Caillol F, Giovannini M, Masaryk V, Will U, Anderloni A, Pérez-Cuadrado-Robles E, Dugic A, Meier B, Paik WH, Petrone MC, Wichmann D, Dinis-Ribeiro M, Gonçalves TC, Wedi E, Schmidt A, Gulla A, Hoffmeister A, Rosendahl J, Ratone JP, Saadeh R, Repici A, Deprez P, Sauvanet A, Souche FR, Fabre JM, Muehldorfer S, Caca K, Löhr M, Michl P, Krug S, Regner S, Gaujoux S, Hollenbach M
Gastrointest Endosc 2024 Apr;99(4):587-595.e1. Epub 2023 Nov 10 doi: 10.1016/j.gie.2023.10.040. PMID: 37951279
Analysis of clinical and histopathological findings in Russell body gastritis and duodenitis.
Altindag SD, Cakir E, Ekinci N, Avci A, Dilek FH
Ann Diagn Pathol 2019 Jun;40:66-71. Epub 2019 Apr 3 doi: 10.1016/j.anndiagpath.2019.04.003. PMID: 31031217
Hippo pathway regulation of gastrointestinal tissues.
Yu FX, Meng Z, Plouffe SW, Guan KL
Annu Rev Physiol 2015;77:201-27. Epub 2014 Sep 29 doi: 10.1146/annurev-physiol-021014-071733. PMID: 25293527
Diagnosis of ampullary cancer.
Ito K, Fujita N, Noda Y, Kobayashi G, Horaguchi J
Dig Surg 2010;27(2):115-8. Epub 2010 Jun 10 doi: 10.1159/000286607. PMID: 20551654
Enteroscopy.
Mönkemüller K, Bellutti M, Fry LC, Malfertheiner P
Best Pract Res Clin Gastroenterol 2008;22(5):789-811. doi: 10.1016/j.bpg.2008.05.005. PMID: 18790433

Recent systematic reviews

Long-term recurrence after endoscopic versus surgical ampullectomy of sporadic ampullary adenomas: a systematic review and meta-analysis.
Garg R, Thind K, Bhalla J, Simonson MT, Simons-Linares CR, Singh A, Joyce D, Chahal P
Surg Endosc 2023 Jul;37(7):5022-5044. Epub 2023 May 23 doi: 10.1007/s00464-023-10083-0. PMID: 37221416
Clinicopathological Features and Management of Appendiceal Mucoceles: A Systematic Review.
Morano WF, Gleeson EM, Sullivan SH, Padmanaban V, Mapow BL, Shewokis PA, Esquivel J, Bowne WB
Am Surg 2018 Feb 1;84(2):273-281. PMID: 29580358
Endoscopic versus surgical treatment of ampullary adenomas: a systematic review and meta-analysis.
Mendonça EQ, Bernardo WM, Moura EG, Chaves DM, Kondo A, Pu LZ, Baracat FI
Clinics (Sao Paulo) 2016 Jan;71(1):28-35. doi: 10.6061/clinics/2016(01)06. PMID: 26872081Free PMC Article
Review of the investigation and surgical management of resectable ampullary adenocarcinoma.
Askew J, Connor S
HPB (Oxford) 2013 Nov;15(11):829-38. Epub 2013 Jan 10 doi: 10.1111/hpb.12038. PMID: 23458317Free PMC Article
Chemoprevention of colorectal cancer: systematic review and economic evaluation.
Cooper K, Squires H, Carroll C, Papaioannou D, Booth A, Logan RF, Maguire C, Hind D, Tappenden P
Health Technol Assess 2010 Jun;14(32):1-206. doi: 10.3310/hta14320. PMID: 20594533

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