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Grade II Penile Intraepithelial Neoplasia

MedGen UID:
232565
•Concept ID:
C1333863
•
Neoplastic Process
Synonyms: Grade 2 Penile Intraepithelial Neoplasia; Grade II PeIN

Definition

Penile intraepithelial neoplasia characterized by the proliferation of transformed basaloid cells that occupy the lower two thirds of the epithelial thickness. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade II Penile Intraepithelial Neoplasia

Recent clinical studies

Etiology

The Accuracy of Sequential Urethral Frozen Section and its Impact on Urethral Recurrence After Radical Cystectomy.
Gakis G, Schmid MA, Hassan F, Stenzl A, Renninger M
Clin Genitourin Cancer 2022 Oct;20(5):e390-e395. Epub 2022 Apr 22 doi: 10.1016/j.clgc.2022.04.007. PMID: 35577732
Morphological features of epithelial abnormalities and precancerous lesions of the penis.
Cubilla AL, Meijer CJ, Young RH
Scand J Urol Nephrol Suppl 2000;(205):215-9. PMID: 11144900
Peoscopic diagnosis of flat condyloma and penile intraepithelial neoplasia. Clinical manifestation.
Cardamakis E, Kotoulas IG, Relakis K, Metalinos K, Stathopoulos E, Diamantis A, Korantzis A, Michopoulos J, Mantouvalos C, Tzingounis V
Gynecol Obstet Invest 1997;43(4):255-60. doi: 10.1159/000291868. PMID: 9194625
Human papillomavirus infection and intraepithelial, in situ, and invasive carcinoma of penis.
Malek RS, Goellner JR, Smith TF, Espy MJ, Cupp MR
Urology 1993 Aug;42(2):159-70. doi: 10.1016/0090-4295(93)90640-v. PMID: 8396280
Laser microsurgery for superficial lesions of the penis.
Bandieramonte G, Lepera P, Marchesini R, Andreola S, Pizzocaro G
J Urol 1987 Aug;138(2):315-9. doi: 10.1016/s0022-5347(17)43132-6. PMID: 3599247

Diagnosis

Prospective evaluation of surgical margins in non-muscle invasive bladder cancer following primary transurethral resection.
Özsoy Ç, Demir Y, Yılmaz K, Ölçücü MT, Kılıç Ş, Ateş M
Fr J Urol 2024 Sep;34(9):102705. Epub 2024 Jul 24 doi: 10.1016/j.fjurol.2024.102705. PMID: 39059766
The Accuracy of Sequential Urethral Frozen Section and its Impact on Urethral Recurrence After Radical Cystectomy.
Gakis G, Schmid MA, Hassan F, Stenzl A, Renninger M
Clin Genitourin Cancer 2022 Oct;20(5):e390-e395. Epub 2022 Apr 22 doi: 10.1016/j.clgc.2022.04.007. PMID: 35577732
Penile intraepithelial neoplasia: Nomenclature, incidence and progression to malignancy in the Netherlands.
Hoekstra RJ, Trip EJ, Ten Kate FJ, Horenblas S, Lock MT
Int J Urol 2019 Mar;26(3):353-357. Epub 2018 Dec 3 doi: 10.1111/iju.13871. PMID: 30508877
Squamous cell carcinoma of the penis: multivariate analysis of prognostic factors and natural history in monocentric study with a conservative policy.
Soria JC, Fizazi K, Piron D, Kramar A, Gerbaulet A, Haie-Meder C, Perrin JL, Court B, Wibault P, Théodore C
Ann Oncol 1997 Nov;8(11):1089-98. doi: 10.1023/a:1008248319036. PMID: 9426328
Peoscopic diagnosis of flat condyloma and penile intraepithelial neoplasia. Clinical manifestation.
Cardamakis E, Kotoulas IG, Relakis K, Metalinos K, Stathopoulos E, Diamantis A, Korantzis A, Michopoulos J, Mantouvalos C, Tzingounis V
Gynecol Obstet Invest 1997;43(4):255-60. doi: 10.1159/000291868. PMID: 9194625

Therapy

Treatment of penile intraepithelial neoplasia (PIN) with interferon alpha-2a, CO2 laser (vaporization) and 5-fluorouracil 5% (5-FU).
Cardamakis E, Relakis K, Ginopoulos P, Korantzis A, Metalinos K, Stathopoulos E, Papathanasiou Z, Michopoulos J, Mantouvalos H, Kotoulas IG, Tzingounis V
Eur J Gynaecol Oncol 1997;18(5):410-3. PMID: 9378164

Prognosis

The Accuracy of Sequential Urethral Frozen Section and its Impact on Urethral Recurrence After Radical Cystectomy.
Gakis G, Schmid MA, Hassan F, Stenzl A, Renninger M
Clin Genitourin Cancer 2022 Oct;20(5):e390-e395. Epub 2022 Apr 22 doi: 10.1016/j.clgc.2022.04.007. PMID: 35577732
Penile intraepithelial neoplasia: Nomenclature, incidence and progression to malignancy in the Netherlands.
Hoekstra RJ, Trip EJ, Ten Kate FJ, Horenblas S, Lock MT
Int J Urol 2019 Mar;26(3):353-357. Epub 2018 Dec 3 doi: 10.1111/iju.13871. PMID: 30508877
Peoscopic diagnosis of flat condyloma and penile intraepithelial neoplasia. Clinical manifestation.
Cardamakis E, Kotoulas IG, Relakis K, Metalinos K, Stathopoulos E, Diamantis A, Korantzis A, Michopoulos J, Mantouvalos C, Tzingounis V
Gynecol Obstet Invest 1997;43(4):255-60. doi: 10.1159/000291868. PMID: 9194625
Human papillomavirus infection and intraepithelial, in situ, and invasive carcinoma of penis.
Malek RS, Goellner JR, Smith TF, Espy MJ, Cupp MR
Urology 1993 Aug;42(2):159-70. doi: 10.1016/0090-4295(93)90640-v. PMID: 8396280
Laser microsurgery for superficial lesions of the penis.
Bandieramonte G, Lepera P, Marchesini R, Andreola S, Pizzocaro G
J Urol 1987 Aug;138(2):315-9. doi: 10.1016/s0022-5347(17)43132-6. PMID: 3599247

Clinical prediction guides

Prospective evaluation of surgical margins in non-muscle invasive bladder cancer following primary transurethral resection.
Özsoy Ç, Demir Y, Yılmaz K, Ölçücü MT, Kılıç Ş, Ateş M
Fr J Urol 2024 Sep;34(9):102705. Epub 2024 Jul 24 doi: 10.1016/j.fjurol.2024.102705. PMID: 39059766
The Accuracy of Sequential Urethral Frozen Section and its Impact on Urethral Recurrence After Radical Cystectomy.
Gakis G, Schmid MA, Hassan F, Stenzl A, Renninger M
Clin Genitourin Cancer 2022 Oct;20(5):e390-e395. Epub 2022 Apr 22 doi: 10.1016/j.clgc.2022.04.007. PMID: 35577732
Post-transcriptional induction of p21cip1 protein in condylomata and dysplasias is inversely related to human papillomavirus activities.
Schmidt-Grimminger DC, Wu X, Jian Y, Broker TR, Chow LT
Am J Pathol 1998 Apr;152(4):1015-24. PMID: 9546362Free PMC Article
Squamous cell carcinoma of the penis: multivariate analysis of prognostic factors and natural history in monocentric study with a conservative policy.
Soria JC, Fizazi K, Piron D, Kramar A, Gerbaulet A, Haie-Meder C, Perrin JL, Court B, Wibault P, Théodore C
Ann Oncol 1997 Nov;8(11):1089-98. doi: 10.1023/a:1008248319036. PMID: 9426328
Carcinoma of the penis: analysis of 192 consecutive cases at the Instituto Nacional de Enfermedades Neoplasicas.
Pow-Sang J, Ojeda J, Ramirez G, Olivares L, Benavente V, Sanchez L
Int Adv Surg Oncol 1979;2:201-21. PMID: 399945

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