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Metastatic Breast Signet Ring Cell Carcinoma

MedGen UID:
233187
•Concept ID:
C1334740
•
Neoplastic Process
Synonyms: Metastatic Breast Signet-Ring Cell Carcinoma; Metastatic Mammary Signet Ring Cell Carcinoma; Metastatic Signet Ring Cell Breast Carcinoma; Metastatic Signet Ring Cell Carcinoma of Breast; Metastatic Signet Ring Cell Carcinoma of the Breast; Metastatic SRC Breast Carcinoma; Metastatic SRC Carcinoma of Breast; Metastatic SRC Carcinoma of the Breast

Definition

A signet ring cell carcinoma that arises from the breast and has metastasized to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Breast Signet Ring Cell Carcinoma

Professional guidelines

PubMed

Metastatic Pleomorphic Lobular Carcinoma of the Breast to the Urinary Bladder: A Report of 10 Cases and Assessment of TRPS1 in the Differential Diagnosis With Plasmacytoid Urothelial Carcinoma.
Zhang GN, Susnik B, Paulsen EJ, Lyons LL, Delma KS, Jorda M, Epstein JI, Kryvenko ON
Arch Pathol Lab Med 2024 Oct 1;148(10):1110-1118. doi: 10.5858/arpa.2023-0379-OA. PMID: 38217332
Signet-ring cell sinus histiocytosis: report of the clinicopathologic characteristics of 4 cases with emphasis on the differential diagnosis of signet-ring cell lesions.
Argyris PP, Koutlas IG, Wakely PE Jr
Hum Pathol 2023 Sep;139:47-54. Epub 2023 Jul 15 doi: 10.1016/j.humpath.2023.07.006. PMID: 37459900
Surgical treatment for patients with different origins of Krukenberg tumors: outcomes and prognostic factors.
Jiang R, Tang J, Cheng X, Zang RY
Eur J Surg Oncol 2009 Jan;35(1):92-7. Epub 2008 Jul 16 doi: 10.1016/j.ejso.2008.05.006. PMID: 18632244

Recent clinical studies

Etiology

Cancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer: a prospective cohort study.
Asif B, Sarvestani AL, Gamble LA, Samaranayake SG, Famiglietti AL, Fasaye GA, Quezado M, Miettinen M, Korman L, Koh C, Heller T, Davis JL
Lancet Oncol 2023 Apr;24(4):383-391. doi: 10.1016/S1470-2045(23)00057-8. PMID: 36990610Free PMC Article
Cytological and molecular characterization of secretory breast carcinoma.
Carretero-Barrio I, Santón A, Caniego Casas T, López Miranda E, Reguero-Callejas ME, Pérez-Mies B, Benito A, Palacios J
Diagn Cytopathol 2022 Jul;50(7):E174-E180. Epub 2022 Feb 14 doi: 10.1002/dc.24945. PMID: 35156343Free PMC Article
Prognostic Outcomes of Signet Ring Cell Carcinoma of the Breast.
Mehdi M, Kong AL, Frebault J, Huang S, Huang CC, Cortina CS
J Surg Res 2021 Aug;264:138-148. Epub 2021 Apr 3 doi: 10.1016/j.jss.2021.02.020. PMID: 33823490Free PMC Article
Immunohistochemical diagnosis of Krukenberg tumors.
Crăciun MI, Domşa I
Rom J Morphol Embryol 2017;58(3):845-849. PMID: 29250663
Signet ring cell carcinoma of the eccrine sweat glands in the eyelid.
Wollensak G, Witschel H, Böhm N
Ophthalmology 1996 Nov;103(11):1788-93. doi: 10.1016/s0161-6420(96)30426-0. PMID: 8942871

Diagnosis

Cancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer: a prospective cohort study.
Asif B, Sarvestani AL, Gamble LA, Samaranayake SG, Famiglietti AL, Fasaye GA, Quezado M, Miettinen M, Korman L, Koh C, Heller T, Davis JL
Lancet Oncol 2023 Apr;24(4):383-391. doi: 10.1016/S1470-2045(23)00057-8. PMID: 36990610Free PMC Article
Prognostic Outcomes of Signet Ring Cell Carcinoma of the Breast.
Mehdi M, Kong AL, Frebault J, Huang S, Huang CC, Cortina CS
J Surg Res 2021 Aug;264:138-148. Epub 2021 Apr 3 doi: 10.1016/j.jss.2021.02.020. PMID: 33823490Free PMC Article
Breast Metastases Masquerading as Cellulitis.
Papudesu C, Burkat CN, Potter HAD
Ophthalmology 2019 May;126(5):722. doi: 10.1016/j.ophtha.2019.02.019. PMID: 31005191
Metastatic lobular breast carcinoma mimicking primary signet ring adenocarcinoma in a patient with a suspected CDH1 mutation.
Mahmud N, Ford JM, Longacre TA, Parent R, Norton JA
J Clin Oncol 2015 Feb 1;33(4):e19-21. Epub 2014 Mar 3 doi: 10.1200/JCO.2013.49.1159. PMID: 24590638
Signet-ring cell adenocarcinoma of rectum with breast metastases diagnosed on FNA cytology: case report and literature review.
Shaaban H, Kapila K, Mostafa EK, Amanguno H, Hebbar GH, Francis I
Cytopathology 2013 Dec;24(6):396-8. Epub 2012 Mar 19 doi: 10.1111/j.1365-2303.2012.00968.x. PMID: 22429319

Therapy

Cancer surveillance as an alternative to prophylactic total gastrectomy in hereditary diffuse gastric cancer: a prospective cohort study.
Asif B, Sarvestani AL, Gamble LA, Samaranayake SG, Famiglietti AL, Fasaye GA, Quezado M, Miettinen M, Korman L, Koh C, Heller T, Davis JL
Lancet Oncol 2023 Apr;24(4):383-391. doi: 10.1016/S1470-2045(23)00057-8. PMID: 36990610Free PMC Article
Clinics and pathology of Krukenberg tumor: a systematic review and meta-analysis.
Lionetti R, DE Luca M, Raffone A, Travaglino A, Coppellotti A, Peltrini R, Bracale U, D'Ambra M, Insabato L, Zullo F, D'Armiento M, Corcione F
Minerva Obstet Gynecol 2022 Aug;74(4):356-363. Epub 2021 May 4 doi: 10.23736/S2724-606X.21.04797-7. PMID: 33944524
Prognostic Outcomes of Signet Ring Cell Carcinoma of the Breast.
Mehdi M, Kong AL, Frebault J, Huang S, Huang CC, Cortina CS
J Surg Res 2021 Aug;264:138-148. Epub 2021 Apr 3 doi: 10.1016/j.jss.2021.02.020. PMID: 33823490Free PMC Article
Breast metastasis of gastric signet-ring cell carcinoma: a case report and literature review.
He CL, Chen P, Xia BL, Xiao Q, Cai FL
World J Surg Oncol 2015 Mar 26;13:120. doi: 10.1186/s12957-015-0538-1. PMID: 25890325Free PMC Article
Clinically occult cutaneous metastases.
Resnik KS, DiLeonardo M, Gibbons G
J Am Acad Dermatol 2006 Dec;55(6):1044-7. doi: 10.1016/j.jaad.2006.05.011. PMID: 17110220

Prognosis

Lobular Carcinoma of the Breast Metastatic to the Ovary: A Clinicopathologic Study of 38 Cases.
Chuang AY, Watkins JC, Young RH, Lerwill MF
Am J Surg Pathol 2022 Feb 1;46(2):179-189. doi: 10.1097/PAS.0000000000001812. PMID: 34931622
Prognostic Outcomes of Signet Ring Cell Carcinoma of the Breast.
Mehdi M, Kong AL, Frebault J, Huang S, Huang CC, Cortina CS
J Surg Res 2021 Aug;264:138-148. Epub 2021 Apr 3 doi: 10.1016/j.jss.2021.02.020. PMID: 33823490Free PMC Article
Imaging in secondary tumors of the ovary.
Karaosmanoglu AD, Onur MR, Salman MC, Usubutun A, Karcaaltincaba M, Ozmen MN, Akata D
Abdom Radiol (NY) 2019 Apr;44(4):1493-1505. doi: 10.1007/s00261-018-1809-4. PMID: 30361868
Breast metastasis of gastric signet-ring cell carcinoma.
Wei LY, Kong M, Zhang Z, Zhang XC
J Zhejiang Univ Sci B 2017 Nov.;18(11):1026-1030. doi: 10.1631/jzus.B1700159. PMID: 29119740Free PMC Article
Breast metastasis of gastric signet-ring cell carcinoma: a case report and literature review.
He CL, Chen P, Xia BL, Xiao Q, Cai FL
World J Surg Oncol 2015 Mar 26;13:120. doi: 10.1186/s12957-015-0538-1. PMID: 25890325Free PMC Article

Clinical prediction guides

Clinicopathologic Review of Metastatic Breast Cancer to the Gynecologic Tract.
Braun A, Reddy S, Cheng L, Gattuso P, Yan L
Int J Gynecol Pathol 2023 Jul 1;42(4):414-420. Epub 2022 Oct 10 doi: 10.1097/PGP.0000000000000920. PMID: 36563298
Cytological and molecular characterization of secretory breast carcinoma.
Carretero-Barrio I, Santón A, Caniego Casas T, López Miranda E, Reguero-Callejas ME, Pérez-Mies B, Benito A, Palacios J
Diagn Cytopathol 2022 Jul;50(7):E174-E180. Epub 2022 Feb 14 doi: 10.1002/dc.24945. PMID: 35156343Free PMC Article
Lobular Carcinoma of the Breast Metastatic to the Ovary: A Clinicopathologic Study of 38 Cases.
Chuang AY, Watkins JC, Young RH, Lerwill MF
Am J Surg Pathol 2022 Feb 1;46(2):179-189. doi: 10.1097/PAS.0000000000001812. PMID: 34931622
Prognostic Outcomes of Signet Ring Cell Carcinoma of the Breast.
Mehdi M, Kong AL, Frebault J, Huang S, Huang CC, Cortina CS
J Surg Res 2021 Aug;264:138-148. Epub 2021 Apr 3 doi: 10.1016/j.jss.2021.02.020. PMID: 33823490Free PMC Article
Differentiating breast carcinoma with signet ring features from gastrointestinal signet ring carcinoma: assessment of immunohistochemical markers.
Hui Y, Wang Y, Nam G, Fanion J, Sturtevant A, Lombardo KA, Resnick MB
Hum Pathol 2018 Jul;77:11-19. Epub 2018 Jan 6 doi: 10.1016/j.humpath.2018.01.002. PMID: 29317235Free PMC Article

Recent systematic reviews

Gastric signet ring cell adenocarcinoma metastatic to the breast. Systematic review of the literature, regarding a case.
Guío-Ávila JI, Soler-Perilla AY, Briceño-Morales X, Briceño-Morales C
Rev Colomb Obstet Ginecol 2024 Sep 2;75(2) doi: 10.18597/rcog.4187. PMID: 39470266Free PMC Article
Clinics and pathology of Krukenberg tumor: a systematic review and meta-analysis.
Lionetti R, DE Luca M, Raffone A, Travaglino A, Coppellotti A, Peltrini R, Bracale U, D'Ambra M, Insabato L, Zullo F, D'Armiento M, Corcione F
Minerva Obstet Gynecol 2022 Aug;74(4):356-363. Epub 2021 May 4 doi: 10.23736/S2724-606X.21.04797-7. PMID: 33944524

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