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Lacrimal gland carcinoma

MedGen UID:
233606
•Concept ID:
C1334358
•
Neoplastic Process
Synonyms: Carcinoma of Lacrimal Gland; carcinoma of lacrimal gland; Carcinoma of the Lacrimal Gland; carcinoma of the lacrimal gland; Lacrimal Gland Carcinoma; lacrimal gland carcinoma
 
Monarch Initiative: MONDO:0002463

Definition

A carcinoma that arises from the lacrimal glands. Representative examples include adenocarcinoma, carcinoma ex pleomorphic adenoma, squamous cell carcinoma, adenoid cystic carcinoma, and mucoepidermoid carcinoma. [from NCI]

Professional guidelines

PubMed

Current treatment of lacrimal gland carcinoma.
Woo KI, Kim YD, Sa HS, Esmaeli B
Curr Opin Ophthalmol 2016 Sep;27(5):449-56. doi: 10.1097/ICU.0000000000000301. PMID: 27273588
Eye-sparing multidisciplinary approach for the management of lacrimal gland carcinoma.
Esmaeli B, Yin VT, Hanna EY, Kies MS, William WN Jr, Bell D, Frank SJ
Head Neck 2016 Aug;38(8):1258-62. Epub 2016 Mar 29 doi: 10.1002/hed.24433. PMID: 27027275
Management of Lacrimal Gland Carcinoma: Lessons From the Literature in the Past 40 Years.
Woo KI, Yeom A, Esmaeli B
Ophthalmic Plast Reconstr Surg 2016 Jan-Feb;32(1):1-10. doi: 10.1097/IOP.0000000000000531. PMID: 26291539

Recent clinical studies

Etiology

Visual outcome and ocular complications in patients with lacrimal gland carcinoma after eye-sparing surgery and adjuvant radiation therapy.
Zhao Z, Frank SJ, Ning J, Zhao J, Jiang X, Wang XA, Schefler AC, Hanna E, Moreno A, Gunn B, Ferrarotto R, Esmaeli B
Br J Ophthalmol 2023 Nov 22;107(12):1914-1919. doi: 10.1136/bjo-2022-321889. PMID: 36229179Free PMC Article
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Eye-Preserving Surgery Followed by Adjuvant Radiotherapy for Lacrimal Gland Carcinoma: Outcomes in 37 Patients.
Woo KI, Sagiv O, Han J, Frank SJ, Kim YD, Esmaeli B
Ophthalmic Plast Reconstr Surg 2018 Nov/Dec;34(6):570-574. doi: 10.1097/IOP.0000000000001106. PMID: 29634603
Current treatment of lacrimal gland carcinoma.
Woo KI, Kim YD, Sa HS, Esmaeli B
Curr Opin Ophthalmol 2016 Sep;27(5):449-56. doi: 10.1097/ICU.0000000000000301. PMID: 27273588
Eye-sparing multidisciplinary approach for the management of lacrimal gland carcinoma.
Esmaeli B, Yin VT, Hanna EY, Kies MS, William WN Jr, Bell D, Frank SJ
Head Neck 2016 Aug;38(8):1258-62. Epub 2016 Mar 29 doi: 10.1002/hed.24433. PMID: 27027275

Diagnosis

Risk and Lag-time for Development of Lacrimal Gland Carcinoma Expleomorphic Adenoma: Observations and Conjectural Study.
Rose GE, Vahdani K, Lewis J, Rose AM
Ophthalmic Plast Reconstr Surg 2022 Nov-Dec 01;38(6):563-566. Epub 2022 May 13 doi: 10.1097/IOP.0000000000002203. PMID: 35550483
Cranio-orbital Resection Does Not Appear to Improve Survival of Patients With Lacrimal Gland Carcinoma.
Rose GE, Gore SK, Plowman NP
Ophthalmic Plast Reconstr Surg 2019 Jan/Feb;35(1):77-84. doi: 10.1097/IOP.0000000000001177. PMID: 30130333
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Primary Secretory Carcinoma of the Lacrimal Gland: Report of a New Entity.
Hyrcza MD, Andreasen S, Melchior LC, Tucker T, Heegaard S, White VA
Am J Ophthalmol 2018 Sep;193:178-183. Epub 2018 Jun 28 doi: 10.1016/j.ajo.2018.06.019. PMID: 29963997
Management of Lacrimal Gland Carcinoma: Lessons From the Literature in the Past 40 Years.
Woo KI, Yeom A, Esmaeli B
Ophthalmic Plast Reconstr Surg 2016 Jan-Feb;32(1):1-10. doi: 10.1097/IOP.0000000000000531. PMID: 26291539

Therapy

Visual outcome and ocular complications in patients with lacrimal gland carcinoma after eye-sparing surgery and adjuvant radiation therapy.
Zhao Z, Frank SJ, Ning J, Zhao J, Jiang X, Wang XA, Schefler AC, Hanna E, Moreno A, Gunn B, Ferrarotto R, Esmaeli B
Br J Ophthalmol 2023 Nov 22;107(12):1914-1919. doi: 10.1136/bjo-2022-321889. PMID: 36229179Free PMC Article
Outcomes in patients with lacrimal gland carcinoma treated with definitive radiotherapy or eye-sparing surgery followed by adjuvant radiotherapy.
Lin YH, Huang SM, Yap WK, Yang JW, Yeung L, Tsan DL, Chang JT, Chen LC
Radiat Oncol 2020 Jun 22;15(1):156. doi: 10.1186/s13014-020-01601-8. PMID: 32571366Free PMC Article
Corneal complications after orbital radiotherapy for primary epithelial malignancies of the lacrimal gland.
Gore SK, Plowman NP, Dharmasena A, Verity DH, Rose GE
Br J Ophthalmol 2018 Jul;102(7):882-884. Epub 2017 Oct 19 doi: 10.1136/bjophthalmol-2017-311134. PMID: 29051324
The "Wedge Sign": An Imaging Sign for Aggressive Lacrimal Gland Disease.
Lorenzano D, Rose GE
Ophthalmology 2017 Jul;124(7):1081-1083. Epub 2017 Mar 31 doi: 10.1016/j.ophtha.2017.03.004. PMID: 28372859
CORE needle biopsy of orbital tumors.
Yarovoy AA, Bulgakova ES, Shatskikh AV, Uzunyan DG, Kleyankina SS, Golubeva OV
Graefes Arch Clin Exp Ophthalmol 2013 Aug;251(8):2057-61. Epub 2013 Mar 21 doi: 10.1007/s00417-013-2315-6. PMID: 23515750

Prognosis

Visual outcome and ocular complications in patients with lacrimal gland carcinoma after eye-sparing surgery and adjuvant radiation therapy.
Zhao Z, Frank SJ, Ning J, Zhao J, Jiang X, Wang XA, Schefler AC, Hanna E, Moreno A, Gunn B, Ferrarotto R, Esmaeli B
Br J Ophthalmol 2023 Nov 22;107(12):1914-1919. doi: 10.1136/bjo-2022-321889. PMID: 36229179Free PMC Article
Cranio-orbital Resection Does Not Appear to Improve Survival of Patients With Lacrimal Gland Carcinoma.
Rose GE, Gore SK, Plowman NP
Ophthalmic Plast Reconstr Surg 2019 Jan/Feb;35(1):77-84. doi: 10.1097/IOP.0000000000001177. PMID: 30130333
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Eye-sparing multidisciplinary approach for the management of lacrimal gland carcinoma.
Esmaeli B, Yin VT, Hanna EY, Kies MS, William WN Jr, Bell D, Frank SJ
Head Neck 2016 Aug;38(8):1258-62. Epub 2016 Mar 29 doi: 10.1002/hed.24433. PMID: 27027275
Management of Lacrimal Gland Carcinoma: Lessons From the Literature in the Past 40 Years.
Woo KI, Yeom A, Esmaeli B
Ophthalmic Plast Reconstr Surg 2016 Jan-Feb;32(1):1-10. doi: 10.1097/IOP.0000000000000531. PMID: 26291539

Clinical prediction guides

Risk and Lag-time for Development of Lacrimal Gland Carcinoma Expleomorphic Adenoma: Observations and Conjectural Study.
Rose GE, Vahdani K, Lewis J, Rose AM
Ophthalmic Plast Reconstr Surg 2022 Nov-Dec 01;38(6):563-566. Epub 2022 May 13 doi: 10.1097/IOP.0000000000002203. PMID: 35550483
CORE needle biopsy of orbital tumors.
Yarovoy AA, Bulgakova ES, Shatskikh AV, Uzunyan DG, Kleyankina SS, Golubeva OV
Graefes Arch Clin Exp Ophthalmol 2013 Aug;251(8):2057-61. Epub 2013 Mar 21 doi: 10.1007/s00417-013-2315-6. PMID: 23515750
Metastatic orbital tumors in southern China during an 18-year period.
Yan J, Gao S
Graefes Arch Clin Exp Ophthalmol 2011 Sep;249(9):1387-93. Epub 2011 Apr 6 doi: 10.1007/s00417-011-1660-6. PMID: 21468734
Clinicopathological analysis of periocular sebaceous gland carcinoma.
Yoon JS, Kim SH, Lee CS, Lew H, Lee SY
Ophthalmologica 2007;221(5):331-9. doi: 10.1159/000104764. PMID: 17728556

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