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Malignant Ovarian Luteinized Thecoma

MedGen UID:
233666
•Concept ID:
C1334608
•
Neoplastic Process
Synonyms: Malignant Luteinized Thecal Cell Neoplasm of Ovary; Malignant Luteinized Thecal Cell Neoplasm of the Ovary; Malignant Luteinized Thecal Cell Tumor of Ovary; Malignant Luteinized Thecal Cell Tumor of the Ovary; Malignant Luteinized Thecoma of Ovary; Malignant Luteinized Thecoma of the Ovary; Malignant Ovarian Luteinized Thecal Cell Neoplasm; Malignant Ovarian Luteinized Thecal Cell Tumor

Definition

A thecoma of the ovary that contains lutein cells and may metastasize to other anatomic sites. It is usually characterized by nuclear atypia and mitotic activity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMalignant Ovarian Luteinized Thecoma

Professional guidelines

PubMed

Luteinized thecomatosis and other conditions associated with sclerosing peritonitis: a problem in causation, management, and nomenclature.
Roth LM
Expert Rev Anticancer Ther 2021 Mar;21(3):239-240. Epub 2020 Dec 8 doi: 10.1080/14737140.2021.1853530. PMID: 33290110

Recent clinical studies

Etiology

Ovarian Sex Cord-Stromal Tumors: Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD.
Young RH
Arch Pathol Lab Med 2018 Dec;142(12):1459-1484. doi: 10.5858/arpa.2018-0291-RA. PMID: 30500284
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Luteinized thecoma with sclerosing peritonitis.
Werness BA
Arch Pathol Lab Med 1996 Mar;120(3):303-6. PMID: 8629912
Ovarian stromal tumors with minor sex cord elements: a report of seven cases.
Young RH, Scully RE
Int J Gynecol Pathol 1983;2(3):227-34. doi: 10.1097/00004347-198303000-00001. PMID: 6315609
Granulosa theca cell tumors in premenarchal girls: a clinical and pathologic study of ten cases.
Lack EE, Perez-Atayde AR, Murthy AS, Goldstein DP, Crigler JF Jr, Vawter GF
Cancer 1981 Oct 15;48(8):1846-54. doi: 10.1002/1097-0142(19811015)48:8<1846::aid-cncr2820480823>3.0.co;2-t. PMID: 6269727

Diagnosis

Pathological discrimination between luteinized thecoma associated with sclerosing peritonitis and thecoma.
Liu J, Wei J, Yang Y, Wei J
Medicine (Baltimore) 2023 Jun 9;102(23):e33911. doi: 10.1097/MD.0000000000033911. PMID: 37335673Free PMC Article
Adolescent ovarian thecoma presenting as progressive hyperandrogenism: case report and review of the literature.
Gaspari L, Paris F, Taourel P, Soyer-Gobillard MO, Kalfa N, Sultan C
Gynecol Endocrinol 2020 Sep;36(9):839-842. Epub 2020 Mar 16 doi: 10.1080/09513590.2020.1739265. PMID: 32174224
Luteinized Fibrothecoma.
Haghayeghi K, Hansen K, Quddus MR
Int J Surg Pathol 2019 Sep;27(6):654-655. Epub 2018 Dec 6 doi: 10.1177/1066896918817372. PMID: 30520326
Ovarian sex cord-stromal tumours and their mimics.
Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723
Luteinized thecoma with sclerosing peritonitis.
Werness BA
Arch Pathol Lab Med 1996 Mar;120(3):303-6. PMID: 8629912

Therapy

COMPLETE REMISSION OF MEDICALLY TREATED LUTEINIZED THECOMAS WITH SCLEROSING PERITONITIS.
Wehbe K, Duminil L, Bertrand A, Kianmanesh R, Graesslin O, Raimond E
J Gynecol Obstet Hum Reprod 2021 Jun;50(6):101734. Epub 2020 Apr 10 doi: 10.1016/j.jogoh.2020.101734. PMID: 32283225
Mitotically active cellular luteinized thecoma of the ovary and luteinized thecomatosis associated with sclerosing peritonitis: case studies, comparison, and review of the literature.
Mellembakken JR, Engh V, Tanbo T, Czernobilsky B, Edelstein E, Lunde O, Roth LM
Pathol Res Pract 2010 Nov 15;206(11):744-8. Epub 2010 Aug 8 doi: 10.1016/j.prp.2010.07.001. PMID: 20696537
A case of luteinizing thecoma with sclerosing peritonitis: revisiting a link with anti-epileptic drugs.
Nauen DW, Martin A, Katz A, Cohen D, Ranganathan S
Pediatr Blood Cancer 2010 Mar;54(3):470-2. doi: 10.1002/pbc.22325. PMID: 19847882
Sclerosing peritonitis associated with bilateral luteinized thecoma, linked to anticonvulsant therapy.
Levavi H, Sabah G, Heifetz M, Feinmesser M
Eur J Gynaecol Oncol 2009;30(6):695-700. PMID: 20099509
Remission of acanthosis nigricans associated with polycystic ovarian disease and a stromal luteoma.
Givens JR, Kerber IJ, Wiser WL, Andersen RN, Coleman SA, Fish SA
J Clin Endocrinol Metab 1974 Mar;38(3):347-55. doi: 10.1210/jcem-38-3-347. PMID: 4360917

Prognosis

An ovarian stromal tumor with luteinized cells: an unusual recurrence of an unusual tumor.
Duncan TJ, Lee S, Acheson AG, Hammond RH
Int J Gynecol Cancer 2008 Jan-Feb;18(1):172-5. Epub 2007 Nov 12 doi: 10.1111/j.1525-1438.2007.00957.x. PMID: 17999678
Luteinizing hormone in peritoneal and ovarian cyst fluids: a predictor of ovarian carcinoma.
Halperin R, Pansky M, Vaknin Z, Zehavi S, Bukovsky I, Schneider D; Sackler Faculty of Medicine, Tel Aviv University, Israel
Eur J Obstet Gynecol Reprod Biol 2003 Oct 10;110(2):207-10. doi: 10.1016/s0301-2115(03)00122-2. PMID: 12969585
Luteinized thecoma with sclerosing peritonitis.
Werness BA
Arch Pathol Lab Med 1996 Mar;120(3):303-6. PMID: 8629912
Ovarian stromal tumors with minor sex cord elements: a report of seven cases.
Young RH, Scully RE
Int J Gynecol Pathol 1983;2(3):227-34. doi: 10.1097/00004347-198303000-00001. PMID: 6315609
Granulosa theca cell tumors in premenarchal girls: a clinical and pathologic study of ten cases.
Lack EE, Perez-Atayde AR, Murthy AS, Goldstein DP, Crigler JF Jr, Vawter GF
Cancer 1981 Oct 15;48(8):1846-54. doi: 10.1002/1097-0142(19811015)48:8<1846::aid-cncr2820480823>3.0.co;2-t. PMID: 6269727

Clinical prediction guides

Ovarian Sex Cord-Stromal Tumors: Reflections on a 40-Year Experience With a Fascinating Group of Tumors, Including Comments on the Seminal Observations of Robert E. Scully, MD.
Young RH
Arch Pathol Lab Med 2018 Dec;142(12):1459-1484. doi: 10.5858/arpa.2018-0291-RA. PMID: 30500284
Involuting luteinized thecoma of the ovary.
Roth LM, Gaba AR, Linden MD, Sandusky GE
Int J Gynecol Pathol 2014 Jan;33(1):23-9. doi: 10.1097/PGP.0b013e31827db06f. PMID: 24300531
Mitotically active cellular luteinized thecoma of the ovary and luteinized thecomatosis associated with sclerosing peritonitis: case studies, comparison, and review of the literature.
Mellembakken JR, Engh V, Tanbo T, Czernobilsky B, Edelstein E, Lunde O, Roth LM
Pathol Res Pract 2010 Nov 15;206(11):744-8. Epub 2010 Aug 8 doi: 10.1016/j.prp.2010.07.001. PMID: 20696537
Isolated luteinizing hormone (LH) elevation in a woman with secondary amenorrhea: a clue to the diagnosis of an inhibin B-producing thecoma and insights into the influence of inhibin B on LH.
Donovan LE, Brain PH, Duggan MA
Fertil Steril 2010 Aug;94(3):1097.e9-1097.e12. Epub 2010 Mar 23 doi: 10.1016/j.fertnstert.2010.02.016. PMID: 20334861
An ovarian stromal tumor with luteinized cells: an unusual recurrence of an unusual tumor.
Duncan TJ, Lee S, Acheson AG, Hammond RH
Int J Gynecol Cancer 2008 Jan-Feb;18(1):172-5. Epub 2007 Nov 12 doi: 10.1111/j.1525-1438.2007.00957.x. PMID: 17999678

Recent systematic reviews

Luteinized thecoma (thecomatosis) with sclerosing peritonitis: a systematic review of the literature of the last 25 years.
Muratori L, Trevisi E, Delcuratolo MD, Sperone P, Di Maio M
Expert Rev Anticancer Ther 2021 Jan;21(1):23-32. Epub 2020 Oct 22 doi: 10.1080/14737140.2021.1837629. PMID: 33053314

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