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Malignant Ovarian Thecoma

MedGen UID:: 83139
•Concept ID:: C0334398
•: Neoplastic Process

Synonyms:	Malignant Ovarian Thecal Cell Neoplasm; Malignant Ovarian Thecal Cell Tumor; Malignant Thecal Cell Neoplasm of Ovary; Malignant Thecal Cell Neoplasm of the Ovary; Malignant Thecal Cell Tumor of Ovary; Malignant Thecal Cell Tumor of the Ovary; Malignant thecoma; Malignant Thecoma of Ovary; Malignant Thecoma of the Ovary; Thecoma, malignant
SNOMED CT:	Malignant thecoma (57622002); Thecoma, malignant (57622002)

Definition

A thecoma of the ovary which may metastasize to another anatomic site. It is usually characterized by nuclear atypia and mitotic activity. Malignant thecomas are rare. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVMalignant Ovarian Thecoma

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Malignant Sex Cord-Stromal Tumor
        Malignant sex cord stromal tumor of ovary
        Malignant Ovarian Thecoma
        Malignant Ovarian Luteinized Thecoma

Professional guidelines

PubMed

Value of diffusion-weighted imaging combined with conventional magnetic resonance imaging in the diagnosis of thecomas and their differential diagnosis with adult granulosa cell tumors.

Fang M, Dong J, Zhong Q, Fang X, Chen Y, Wang C, Yan H
Acta Radiol 2019 Nov;60(11):1532-1542. Epub 2019 Feb 18 doi: 10.1177/0284185119830280. PMID: 30776906

Ovarian sex cord-stromal tumors. Problems in differential diagnosis.

Young RH, Scully RE
Pathol Annu 1988;23 Pt 1:237-96. PMID: 2838794

Management of endocrine disorders in pregnancy. Part II. Pituitary, ovarian and adrenal disease.

van der Spuy ZM, Jacobs HS
Postgrad Med J 1984 May;60(703):312-20. doi: 10.1136/pgmj.60.703.312. PMID: 6330715 Free PMC Article

See all (19)

Recent clinical studies

Etiology

CT review of ovarian fibrothecoma.

Pat JJ, Rothnie KK, Kolomainen D, Sundaresan M, Zhang J, Liyanage SH
Br J Radiol 2022 Aug 1;95(1136):20210790. Epub 2022 Jul 12 doi: 10.1259/bjr.20210790. PMID: 35451310 Free PMC Article

Ovarian sex cord-stromal tumours and their mimics.

Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723

Morcellation and risk of malignancy in presumed ovarian fibromas/fibrothecomas.

Froyman W, Landolfo C, Amant F, Van den Bosch T, Vergote I, Coosemans A, Testa A, Valentin L, Bourne T, Calster BV, Timmerman D
Lancet Oncol 2016 Mar;17(3):273-274. Epub 2016 Mar 2 doi: 10.1016/S1470-2045(16)00022-X. PMID: 26972853

Sex cord-stromal tumours of the ovary.

Fox H
J Pathol 1985 Feb;145(2):127-48. doi: 10.1002/path.1711450202. PMID: 2983057

Luteomas of pregnancy.

Garcia-Bunuel R, Berek JS, Woodruff JD
Obstet Gynecol 1975 Apr;45(4):407-14. PMID: 164641

See all (120)

Diagnosis

Brenner tumors.

Costeira FS, Félix A, Cunha TM
Br J Radiol 2022 Feb 1;95(1130):20210687. Epub 2021 Dec 20 doi: 10.1259/bjr.20210687. PMID: 34928171 Free PMC Article

Ovarian Fibrothecoma.

Schoolmeester JK, Erickson LA
Mayo Clin Proc 2019 Aug;94(8):1652-1653. doi: 10.1016/j.mayocp.2019.04.019. PMID: 31378246

Luteinized Fibrothecoma.

Haghayeghi K, Hansen K, Quddus MR
Int J Surg Pathol 2019 Sep;27(6):654-655. Epub 2018 Dec 6 doi: 10.1177/1066896918817372. PMID: 30520326

Ovarian sex cord-stromal tumours and their mimics.

Young RH
Pathology 2018 Jan;50(1):5-15. Epub 2017 Nov 11 doi: 10.1016/j.pathol.2017.09.007. PMID: 29132723

Luteoma of pregnancy.

Dische FE, Ritchie JM
J Pathol 1970 Jan;100(1):77-8. doi: 10.1002/path.1711000109. PMID: 4319381

See all (273)

Therapy

COMPLETE REMISSION OF MEDICALLY TREATED LUTEINIZED THECOMAS WITH SCLEROSING PERITONITIS.

Wehbe K, Duminil L, Bertrand A, Kianmanesh R, Graesslin O, Raimond E
J Gynecol Obstet Hum Reprod 2021 Jun;50(6):101734. Epub 2020 Apr 10 doi: 10.1016/j.jogoh.2020.101734. PMID: 32283225

Granulosa and theca cell tumor in rat's ovary after modified Biskind operation.

Shamrai D, Koshik E, Melnyk N
Exp Oncol 2020 Dec;42(4):306-309. doi: 10.32471/exp-oncology.2312-8852.vol-42-no-4.15424. PMID: 33355865

Morcellation and risk of malignancy in presumed ovarian fibromas/fibrothecomas.

Steroid hormone-producing tumors in man.

Freeman DA
Endocr Rev 1986 May;7(2):204-20. doi: 10.1210/edrv-7-2-204. PMID: 3013606

Management of endocrine disorders in pregnancy. Part II. Pituitary, ovarian and adrenal disease.

van der Spuy ZM, Jacobs HS
Postgrad Med J 1984 May;60(703):312-20. doi: 10.1136/pgmj.60.703.312. PMID: 6330715 Free PMC Article

See all (33)

Prognosis

Incidental FOXL2 mutated adult granulosa cell tumour of the ovary with thecoma-like foci.

Fischer AK, Schömig-Markiefka B, Heydt C, Ratiu D, Mallmann P, Meinel J, Büttner R, Schmidt D, Quaas A
Virchows Arch 2023 Jul;483(1):117-124. Epub 2022 Nov 18 doi: 10.1007/s00428-022-03452-y. PMID: 36399188 Free PMC Article

Ovarian Fibrothecoma.

Schoolmeester JK, Erickson LA
Mayo Clin Proc 2019 Aug;94(8):1652-1653. doi: 10.1016/j.mayocp.2019.04.019. PMID: 31378246

Morcellation and risk of malignancy in presumed ovarian fibromas/fibrothecomas.

Steroid hormone-producing tumors in man.

Freeman DA
Endocr Rev 1986 May;7(2):204-20. doi: 10.1210/edrv-7-2-204. PMID: 3013606

Luteomas of pregnancy.

Garcia-Bunuel R, Berek JS, Woodruff JD
Obstet Gynecol 1975 Apr;45(4):407-14. PMID: 164641

See all (89)

Clinical prediction guides

MRI combined with clinical features to differentiate ovarian thecoma-fibroma with cystic degeneration from ovary adenofibroma.

Bo J, Sun M, Wei C, Wei L, Fu B, Shi B, Fang X, Dong J
Br J Radiol 2024 May 7;97(1157):1057-1065. doi: 10.1093/bjr/tqae046. PMID: 38402483 Free PMC Article

Ovarian sex cord stromal tumours: analysis of the clinical and sonographic characteristics of different histopathologic subtypes.

Jiang MJ, Le Q, Yang BW, Yuan F, Chen H
J Ovarian Res 2021 Apr 17;14(1):53. doi: 10.1186/s13048-021-00805-0. PMID: 33865445 Free PMC Article

Preliminary observations and diagnostic value of lipid peak in ovarian thecomas/fibrothecomas using in vivo proton MR spectroscopy at 3T.

Takeuchi M, Matsuzaki K, Harada M
J Magn Reson Imaging 2012 Oct;36(4):907-11. Epub 2012 May 14 doi: 10.1002/jmri.23711. PMID: 22585396

Transplantation of reproductive organs.

Lee S, Mao L, Wang Y, D'Silva M, Yoo CH, Wolf P, Chung WS, Takahashi E, Chung DY, Gittes RF
Microsurgery 1995;16(4):191-8. doi: 10.1002/micr.1920160406. PMID: 7674907

Trisomy 12 and 4 in a thecoma of the ovary.

Mrózek K, Limon J, Debniak J, Emerich J
Gynecol Oncol 1992 Apr;45(1):66-8. doi: 10.1016/0090-8258(92)90493-3. PMID: 1318257

See all (72)

Recent systematic reviews

Luteinized thecoma (thecomatosis) with sclerosing peritonitis: a systematic review of the literature of the last 25 years.

Muratori L, Trevisi E, Delcuratolo MD, Sperone P, Di Maio M
Expert Rev Anticancer Ther 2021 Jan;21(1):23-32. Epub 2020 Oct 22 doi: 10.1080/14737140.2021.1837629. PMID: 33053314

Feto-maternal outcomes of pregnancy complicated by ovarian sex-cord stromal tumor: a systematic review of literature.

Blake EA, Carter CM, Kashani BN, Kodama M, Mabuchi S, Yoshino K, Matsuo K
Eur J Obstet Gynecol Reprod Biol 2014 Apr;175:1-7. Epub 2013 Dec 25 doi: 10.1016/j.ejogrb.2013.12.025. PMID: 24439718

See all (2)

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Malignant Ovarian Thecoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

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