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Non-Neoplastic Gonadal Disorder

MedGen UID:
233774
Concept ID:
C1335012
Disease or Syndrome

Definition

A non-neoplastic disorder that affects the testis or the ovary. Representative examples include gonadal agenesis, dysgenesis, and hypogonadism. [from NCI]

Professional guidelines

PubMed

Ramanan VE, Radhakrishnan R
Homeopathy 2022 Aug;111(3):194-201. Epub 2021 Dec 27 doi: 10.1055/s-0041-1735849. PMID: 34959245
Thummalakunta PL, Panditi S
J Obstet Gynaecol Res 2012 Nov;38(11):1342. Epub 2012 Aug 13 doi: 10.1111/j.1447-0756.2012.01971.x. PMID: 22889457
Irving JA, McCluggage WG
Adv Anat Pathol 2007 Sep;14(5):305-19. doi: 10.1097/PAP.0b013e3180ca8a5b. PMID: 17717430

Recent clinical studies

Etiology

Wang Y, Sundfeldt K, Mateoiu C, Shih IeM, Kurman RJ, Schaefer J, Silliman N, Kinde I, Springer S, Foote M, Kristjansdottir B, James N, Kinzler KW, Papadopoulos N, Diaz LA, Vogelstein B
Elife 2016 Jul 15;5 doi: 10.7554/eLife.15175. PMID: 27421040Free PMC Article
Chiaffarino F, Pelucchi C, Negri E, Parazzini F, Franceschi S, Talamini R, Montella M, Ramazzotti V, La Vecchia C
Gynecol Oncol 2005 Aug;98(2):304-8. doi: 10.1016/j.ygyno.2005.05.006. PMID: 15975644
Chiaffarino F, Parazzini F, Decarli A, Franceschi S, Talamini R, Montella M, La Vecchia C
Gynecol Oncol 2005 May;97(2):318-22. doi: 10.1016/j.ygyno.2005.01.030. PMID: 15863124
Makhija P, Rameshkumar K, Nirmala V
Indian J Cancer 2000 Jun-Sep;37(2-3):79-84. PMID: 11876614
Levin HS
Urol Clin North Am 2000 Aug;27(3):543-51, x. doi: 10.1016/s0094-0143(05)70101-4. PMID: 10985153

Diagnosis

Przybycin CG, Williamson SR, Kao CS, Reyes-Múgica M, Ulbright TM, McKenney JK
Am J Surg Pathol 2022 Feb 1;46(2):220-225. doi: 10.1097/PAS.0000000000001775. PMID: 34881635
Sharbidre KG, Lockhart ME
Abdom Radiol (NY) 2020 Jul;45(7):2087-2108. doi: 10.1007/s00261-019-02395-4. PMID: 31919649
Secil M, Bertolotto M, Rocher L, Pekindil G, Stocca T, Richenberg J, Ramchandani P, Derchi LE; European Society of Urogenital Radiology Scrotal Imaging Subcommittee
J Ultrasound Med 2017 Jul;36(7):1487-1509. Epub 2017 Apr 3 doi: 10.7863/ultra.16.07015. PMID: 28370138
Lalwani N, Patel S, Ha KY, Shanbhogue AK, Nagar AM, Chintapalli KN, Prasad SR
Br J Radiol 2012 May;85(1013):477-86. Epub 2012 Jan 17 doi: 10.1259/bjr/92819127. PMID: 22253351Free PMC Article
Ugaki H, Enomoto T, Tokugawa Y, Kimura T
J Obstet Gynaecol Res 2009 Oct;35(5):991-3. doi: 10.1111/j.1447-0756.2009.01046.x. PMID: 20149054

Therapy

Fiegl H, Hagenbuchner J, Kyvelidou C, Seeber B, Sopper S, Tsibulak I, Wieser V, Reiser E, Roessler J, Huhtinen K, Carpén O, Parson W, Sprung S, Marth C, Ausserlechner MJ, Zeimet AG
Gynecol Oncol 2022 Apr;165(1):129-136. Epub 2022 Jan 13 doi: 10.1016/j.ygyno.2022.01.008. PMID: 35033381
Micheli DC, Jammal MP, Martins-Filho A, Côrtes JRXM, Souza CN, Nomelini RS, Murta EFC, Tavares-Murta BM
Biomarkers 2020 Sep;25(6):474-482. Epub 2020 Jun 28 doi: 10.1080/1354750X.2020.1783574. PMID: 32544350
Burke AJ, Garrido P, Johnson C, Sullivan FJ, Glynn SA
Antioxid Redox Signal 2017 Jun 20;26(18):1078-1090. Epub 2017 Mar 22 doi: 10.1089/ars.2017.7004. PMID: 28326819
Abbas PI, Dietrich JE, Francis JA, Brandt ML, Cass DL, Lopez ME
J Pediatr Adolesc Gynecol 2016 Oct;29(5):506-510. Epub 2016 Apr 11 doi: 10.1016/j.jpag.2016.03.009. PMID: 27079914
Navai N, Yap RL, Gupta R, Fraser TG, Gonzalez CM
Int J Urol 2005 Apr;12(4):424-6. doi: 10.1111/j.1442-2042.2005.01065.x. PMID: 15948738

Prognosis

Przybycin CG, Williamson SR, Kao CS, Reyes-Múgica M, Ulbright TM, McKenney JK
Am J Surg Pathol 2022 Feb 1;46(2):220-225. doi: 10.1097/PAS.0000000000001775. PMID: 34881635
Tenuta M, Sesti F, Bonaventura I, Mazzotta P, Pofi R, Gianfrilli D, Pozza C
Andrology 2021 Sep;9(5):1369-1382. Epub 2021 Jun 11 doi: 10.1111/andr.13057. PMID: 34043256Free PMC Article
Machairiotis N, Stylianaki A, Kouroutou P, Sarli P, Alexiou NK, Efthymiou E, Maras A, Alexiou NG, Nikolaou SE, Courcoutsakis N, Papakonstantinou E, Zarogoulidis P, Barbetakis N, Paliouras D, Gogakos A, Machairiotis C
Diagn Pathol 2016 Feb 3;11:18. doi: 10.1186/s13000-016-0469-3. PMID: 26843454Free PMC Article
Makhija P, Rameshkumar K, Nirmala V
Indian J Cancer 2000 Jun-Sep;37(2-3):79-84. PMID: 11876614
Yazawa S, Madiyalakan R, Izawa H, Asao T, Furukawa K, Matta KL
Cancer 1988 Aug 1;62(3):516-20. doi: 10.1002/1097-0142(19880801)62:3<516::aid-cncr2820620313>3.0.co;2-4. PMID: 3390792

Clinical prediction guides

Xue N, Zhang S, Wang G
BMC Urol 2022 Dec 22;22(1):210. doi: 10.1186/s12894-022-01163-9. PMID: 36550425Free PMC Article
Tenuta M, Sesti F, Bonaventura I, Mazzotta P, Pofi R, Gianfrilli D, Pozza C
Andrology 2021 Sep;9(5):1369-1382. Epub 2021 Jun 11 doi: 10.1111/andr.13057. PMID: 34043256Free PMC Article
Zimmermann U, Junker H, Krämer F, Balabanov S, Kleist B, Kammer W, Nordheim A, Walther R
Biol Chem 2006 Apr;387(4):437-40. doi: 10.1515/BC.2006.058. PMID: 16606342
Makhija P, Rameshkumar K, Nirmala V
Indian J Cancer 2000 Jun-Sep;37(2-3):79-84. PMID: 11876614
Mennemeyer RP, Mason JT
J Urol 1979 Mar;121(3):373-5. doi: 10.1016/s0022-5347(17)56793-2. PMID: 430640

Recent systematic reviews

Bertolotto M, Campo I, Pavan N, Buoite Stella A, Cantisani V, Drudi FM, Cova MA, Derchi LE
Eur Urol Focus 2023 Mar;9(2):361-370. Epub 2022 Oct 17 doi: 10.1016/j.euf.2022.10.001. PMID: 36257887
Tng EL, Tan JM
Gynecol Endocrinol 2021 Jul;37(7):600-608. Epub 2021 Mar 4 doi: 10.1080/09513590.2021.1897099. PMID: 33660585
Pinto SPS, Huang DY, Dinesh AA, Sidhu PS, Ahmed K
Urology 2021 Aug;154:16-23. Epub 2021 Feb 20 doi: 10.1016/j.urology.2021.02.012. PMID: 33621585

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