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Reticulin Fibrosis of the Bone Marrow

MedGen UID:
233921
•Concept ID:
C1335762
•
Finding

Definition

Increased reticular fiber deposition within bone marrow. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVReticulin Fibrosis of the Bone Marrow

Professional guidelines

PubMed

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management.
Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049
Impact of bone marrow pathology on the clinical management of Philadelphia chromosome-negative myeloproliferative neoplasms.
Pozdnyakova O, Hasserjian RP, Verstovsek S, Orazi A
Clin Lymphoma Myeloma Leuk 2015 May;15(5):253-61. Epub 2014 Nov 18 doi: 10.1016/j.clml.2014.11.002. PMID: 25515354

Recent clinical studies

Etiology

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Continuous Indexing of Fibrosis (CIF): improving the assessment and classification of MPN patients.
Ryou H, Sirinukunwattana K, Aberdeen A, Grindstaff G, Stolz BJ, Byrne H, Harrington HA, Sousos N, Godfrey AL, Harrison CN, Psaila B, Mead AJ, Rees G, Turner GDH, Rittscher J, Royston D
Leukemia 2023 Feb;37(2):348-358. Epub 2022 Dec 5 doi: 10.1038/s41375-022-01773-0. PMID: 36470992Free PMC Article
Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management.
Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049
Bone marrow fibrosis in myelofibrosis: pathogenesis, prognosis and targeted strategies.
Zahr AA, Salama ME, Carreau N, Tremblay D, Verstovsek S, Mesa R, Hoffman R, Mascarenhas J
Haematologica 2016 Jun;101(6):660-71. doi: 10.3324/haematol.2015.141283. PMID: 27252511Free PMC Article
Impact of bone marrow pathology on the clinical management of Philadelphia chromosome-negative myeloproliferative neoplasms.
Pozdnyakova O, Hasserjian RP, Verstovsek S, Orazi A
Clin Lymphoma Myeloma Leuk 2015 May;15(5):253-61. Epub 2014 Nov 18 doi: 10.1016/j.clml.2014.11.002. PMID: 25515354

Diagnosis

Morphologic Characteristics of Myelodysplastic Syndromes.
Yuen LD, Hasserjian RP
Clin Lab Med 2023 Dec;43(4):577-596. Epub 2023 Aug 9 doi: 10.1016/j.cll.2023.06.003. PMID: 37865504
Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Validated international definition of the thrombocytopenia, anasarca, fever, reticulin fibrosis, renal insufficiency, and organomegaly clinical subtype (TAFRO) of idiopathic multicentric Castleman disease.
Nishimura Y, Fajgenbaum DC, Pierson SK, Iwaki N, Nishikori A, Kawano M, Nakamura N, Izutsu K, Takeuchi K, Nishimura MF, Maeda Y, Otsuka F, Yoshizaki K, Oksenhendler E, van Rhee F, Sato Y
Am J Hematol 2021 Oct 1;96(10):1241-1252. Epub 2021 Jul 28 doi: 10.1002/ajh.26292. PMID: 34265103Free PMC Article
Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management.
Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049
Bone marrow fibrosis in myelofibrosis: pathogenesis, prognosis and targeted strategies.
Zahr AA, Salama ME, Carreau N, Tremblay D, Verstovsek S, Mesa R, Hoffman R, Mascarenhas J
Haematologica 2016 Jun;101(6):660-71. doi: 10.3324/haematol.2015.141283. PMID: 27252511Free PMC Article

Therapy

Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Continuous Indexing of Fibrosis (CIF): improving the assessment and classification of MPN patients.
Ryou H, Sirinukunwattana K, Aberdeen A, Grindstaff G, Stolz BJ, Byrne H, Harrington HA, Sousos N, Godfrey AL, Harrison CN, Psaila B, Mead AJ, Rees G, Turner GDH, Rittscher J, Royston D
Leukemia 2023 Feb;37(2):348-358. Epub 2022 Dec 5 doi: 10.1038/s41375-022-01773-0. PMID: 36470992Free PMC Article
Pharmacotherapy of Myelofibrosis.
Tremblay D, Marcellino B, Mascarenhas J
Drugs 2017 Sep;77(14):1549-1563. doi: 10.1007/s40265-017-0797-y. PMID: 28791654
MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.
Pikman Y, Lee BH, Mercher T, McDowell E, Ebert BL, Gozo M, Cuker A, Wernig G, Moore S, Galinsky I, DeAngelo DJ, Clark JJ, Lee SJ, Golub TR, Wadleigh M, Gilliland DG, Levine RL
PLoS Med 2006 Jul;3(7):e270. doi: 10.1371/journal.pmed.0030270. PMID: 16834459Free PMC Article
Annotation. Fibrosis of the bone marrow: content and causes.
McCarthy DM
Br J Haematol 1985 Jan;59(1):1-7. doi: 10.1111/j.1365-2141.1985.tb02956.x. PMID: 3882129

Prognosis

Morphologic Characteristics of Myelodysplastic Syndromes.
Yuen LD, Hasserjian RP
Clin Lab Med 2023 Dec;43(4):577-596. Epub 2023 Aug 9 doi: 10.1016/j.cll.2023.06.003. PMID: 37865504
Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Continuous Indexing of Fibrosis (CIF): improving the assessment and classification of MPN patients.
Ryou H, Sirinukunwattana K, Aberdeen A, Grindstaff G, Stolz BJ, Byrne H, Harrington HA, Sousos N, Godfrey AL, Harrison CN, Psaila B, Mead AJ, Rees G, Turner GDH, Rittscher J, Royston D
Leukemia 2023 Feb;37(2):348-358. Epub 2022 Dec 5 doi: 10.1038/s41375-022-01773-0. PMID: 36470992Free PMC Article
Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management.
Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049
Bone marrow fibrosis in myelofibrosis: pathogenesis, prognosis and targeted strategies.
Zahr AA, Salama ME, Carreau N, Tremblay D, Verstovsek S, Mesa R, Hoffman R, Mascarenhas J
Haematologica 2016 Jun;101(6):660-71. doi: 10.3324/haematol.2015.141283. PMID: 27252511Free PMC Article

Clinical prediction guides

Prognostic significance of bone marrow fibrosis in diffuse large B-cell lymphoma.
Cetintepe T, Ozkan G, Kucukzeybek BP, Cetintepe L, Unal DK, Solmaz S, Aygun K, Acar AG, Bener S, Çallı AO, Payzın KB
Int J Lab Hematol 2024 Jun;46(3):523-530. Epub 2024 Feb 15 doi: 10.1111/ijlh.14249. PMID: 38361314
Primary myelofibrosis: 2023 update on diagnosis, risk-stratification, and management.
Tefferi A
Am J Hematol 2023 May;98(5):801-821. Epub 2023 Feb 6 doi: 10.1002/ajh.26857. PMID: 36680511
Continuous Indexing of Fibrosis (CIF): improving the assessment and classification of MPN patients.
Ryou H, Sirinukunwattana K, Aberdeen A, Grindstaff G, Stolz BJ, Byrne H, Harrington HA, Sousos N, Godfrey AL, Harrison CN, Psaila B, Mead AJ, Rees G, Turner GDH, Rittscher J, Royston D
Leukemia 2023 Feb;37(2):348-358. Epub 2022 Dec 5 doi: 10.1038/s41375-022-01773-0. PMID: 36470992Free PMC Article
Primary myelofibrosis: 2021 update on diagnosis, risk-stratification and management.
Tefferi A
Am J Hematol 2021 Jan;96(1):145-162. Epub 2020 Dec 2 doi: 10.1002/ajh.26050. PMID: 33197049
Histopathology in the diagnosis and classification of acute myeloid leukemia, myelodysplastic syndromes, and myelodysplastic/myeloproliferative diseases.
Orazi A
Pathobiology 2007;74(2):97-114. doi: 10.1159/000101709. PMID: 17587881

Recent systematic reviews

TAFRO syndrome: A severe manifestation of Sjogren's syndrome? A systematic review.
Grange L, Chalayer E, Boutboul D, Paul S, Galicier L, Gramont B, Killian M
Autoimmun Rev 2022 Aug;21(8):103137. Epub 2022 Jul 6 doi: 10.1016/j.autrev.2022.103137. PMID: 35803499
Bone marrow findings of idiopathic Multicentric Castleman disease: A histopathologic analysis and systematic literature review.
Belyaeva E, Rubenstein A, Pierson SK, Dalldorf D, Frank D, Lim MS, Fajgenbaum DC
Hematol Oncol 2022 Apr;40(2):191-201. Epub 2022 Feb 18 doi: 10.1002/hon.2969. PMID: 35104370Free PMC Article

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