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Combined small cell lung carcinoma

MedGen UID:
234167
•Concept ID:
C1333125
•
Neoplastic Process
Synonyms: Combined Lung Small Cell Carcinoma; Combined Small and Large Cell Lung Cancer; combined small and large cell lung cancer; Combined Small and Large Cell Lung Carcinoma; combined small and large cell lung carcinoma; Combined Small Cell and Large Cell Lung Carcinoma; combined small cell and large cell lung carcinoma; Combined Small Cell Carcinoma; Combined Small Cell Carcinoma of Lung; combined small cell carcinoma of lung; Combined Small Cell Carcinoma of the Lung; combined small cell carcinoma of the lung; combined small cell lung cancer; Combined Small Cell Lung Carcinoma; combined small cell lung carcinoma; Combined Small Cell-Adenocarcinoma; Combined Small Cell-Large Carcinoma; Combined Type Small Cell Carcinoma of Lung; combined type small cell carcinoma of lung; Combined Type Small Cell Carcinoma of the Lung; combined type small cell carcinoma of the lung; Combined Type Small Cell Lung Carcinoma; combined type small cell lung carcinoma; CSCLC; lung combined type small cell carcinoma; Mixed Small Cell and Large Cell Carcinoma of Lung; mixed small cell and large cell carcinoma of lung; Mixed Small Cell and Large Cell Carcinoma of the Lung; mixed small cell and large cell carcinoma of the lung; Mixed Small Cell and Large Cell Lung Carcinoma; mixed small cell and large cell lung carcinoma; Small Cell and Large Cell Carcinoma of Lung; small cell and large cell carcinoma of lung; Small Cell and Large Cell Carcinoma of the Lung; small cell and large cell carcinoma of the lung; Small Cell and Large Cell Lung Carcinoma; small cell and large cell lung carcinoma
 
Monarch Initiative: MONDO:0003438

Definition

A morphologic variant of small cell lung carcinoma in combination with a non-small cell carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCombined small cell lung carcinoma

Professional guidelines

PubMed

Non-small cell lung cancer (NSCLC): A review of risk factors, diagnosis, and treatment.
Alduais Y, Zhang H, Fan F, Chen J, Chen B
Medicine (Baltimore) 2023 Feb 22;102(8):e32899. doi: 10.1097/MD.0000000000032899. PMID: 36827002Free PMC Article
Non-Small Cell Lung Cancer: Epidemiology, Screening, Diagnosis, and Treatment.
Duma N, Santana-Davila R, Molina JR
Mayo Clin Proc 2019 Aug;94(8):1623-1640. doi: 10.1016/j.mayocp.2019.01.013. PMID: 31378236
Lung cancer: diagnosis and management.
Collins LG, Haines C, Perkel R, Enck RE
Am Fam Physician 2007 Jan 1;75(1):56-63. PMID: 17225705

Recent clinical studies

Etiology

Clinical features and prognostic factors of IV combined small cell lung cancer: A propensity score matching analysis.
Cai S, Yang W, Luo H, Li Z, Huang X, Li J, Ye X
PLoS One 2024;19(11):e0313221. Epub 2024 Nov 8 doi: 10.1371/journal.pone.0313221. PMID: 39514581Free PMC Article
Molecular subtype expression and genomic profiling differ between surgically resected pure and combined small cell lung carcinoma.
Zhu Y, Li S, Wang H, Chi K, Ren W, Huang X, Zhuo M, Lin D
Hum Pathol 2023 Nov;141:118-129. Epub 2023 Aug 14 doi: 10.1016/j.humpath.2023.08.003. PMID: 37586462
Combined SCLC clinical and pathological aspects.
Çimen F, Düzgün S, Atikcan S
Monaldi Arch Chest Dis 2022 Jun 8;93(1) doi: 10.4081/monaldi.2022.2226. PMID: 35678533
Integrative molecular analysis of combined small-cell lung carcinomas identifies major subtypes with different therapeutic opportunities.
Simbolo M, Centonze G, Ali G, Garzone G, Taormina S, Sabella G, Ciaparrone C, Mafficini A, Grillo F, Mangogna A, Volante M, Mastracci L, Fontanini G, Pilotto S, Bria E, Infante M, Capella C, Rolli L, Pastorino U, Milella M, Milione M, Scarpa A
ESMO Open 2022 Feb;7(1):100308. Epub 2021 Dec 21 doi: 10.1016/j.esmoop.2021.100308. PMID: 34952268Free PMC Article
Case report: combined small cell lung cancer in a lung transplant recipient.
Moniodis A, Racila E, Divo M
Transplant Proc 2015 Apr;47(3):852-4. doi: 10.1016/j.transproceed.2015.01.019. PMID: 25891746

Diagnosis

Clinical features and prognostic factors of IV combined small cell lung cancer: A propensity score matching analysis.
Cai S, Yang W, Luo H, Li Z, Huang X, Li J, Ye X
PLoS One 2024;19(11):e0313221. Epub 2024 Nov 8 doi: 10.1371/journal.pone.0313221. PMID: 39514581Free PMC Article
Combined SCLC clinical and pathological aspects.
Çimen F, Düzgün S, Atikcan S
Monaldi Arch Chest Dis 2022 Jun 8;93(1) doi: 10.4081/monaldi.2022.2226. PMID: 35678533
Integrative molecular analysis of combined small-cell lung carcinomas identifies major subtypes with different therapeutic opportunities.
Simbolo M, Centonze G, Ali G, Garzone G, Taormina S, Sabella G, Ciaparrone C, Mafficini A, Grillo F, Mangogna A, Volante M, Mastracci L, Fontanini G, Pilotto S, Bria E, Infante M, Capella C, Rolli L, Pastorino U, Milella M, Milione M, Scarpa A
ESMO Open 2022 Feb;7(1):100308. Epub 2021 Dec 21 doi: 10.1016/j.esmoop.2021.100308. PMID: 34952268Free PMC Article
Case report: combined small cell lung cancer in a lung transplant recipient.
Moniodis A, Racila E, Divo M
Transplant Proc 2015 Apr;47(3):852-4. doi: 10.1016/j.transproceed.2015.01.019. PMID: 25891746
A rare case of combined small-cell lung cancer with unusual soft tissue metastasis.
Hsiao HH, Tsai HJ, Liu YC, Tseng YT, Tseng SB, Chai CY, Lin SF
Kaohsiung J Med Sci 2006 Jul;22(7):352-6. doi: 10.1016/S1607-551X(09)70322-5. PMID: 16849104

Therapy

Abscopal effect of radiation therapy and nivolumab in a patient with combined small-cell lung cancer: a case report.
Wang W, Li L, Wu S, Shen J, Huang C, Chen Y, Li S
Immunotherapy 2022 Aug;14(12):909-914. Epub 2022 Jul 5 doi: 10.2217/imt-2021-0050. PMID: 35787148
Durable response to durvalumab-based immunochemotherapy in small-cell lung carcinoma transformation from EGFR-mutant non-small cell lung cancer: A case report.
Li YC
Thorac Cancer 2022 Mar;13(5):775-779. Epub 2022 Jan 27 doi: 10.1111/1759-7714.14325. PMID: 35088537Free PMC Article
Case report: combined small cell lung cancer in a lung transplant recipient.
Moniodis A, Racila E, Divo M
Transplant Proc 2015 Apr;47(3):852-4. doi: 10.1016/j.transproceed.2015.01.019. PMID: 25891746

Prognosis

Molecular subtype expression and genomic profiling differ between surgically resected pure and combined small cell lung carcinoma.
Zhu Y, Li S, Wang H, Chi K, Ren W, Huang X, Zhuo M, Lin D
Hum Pathol 2023 Nov;141:118-129. Epub 2023 Aug 14 doi: 10.1016/j.humpath.2023.08.003. PMID: 37586462
Autopsy case of a patient with rapidly progressive combined small-cell lung carcinoma with spindle-shaped cell tumor.
Morimoto T, Yamasaki K, Shingu T, Sato T, Uryu T, Jotatsu T, Kato K, Kawabata H, Nishida C, Yatera K
Thorac Cancer 2022 Aug;13(15):2279-2282. Epub 2022 Jun 28 doi: 10.1111/1759-7714.14559. PMID: 35762505Free PMC Article
Combined SCLC clinical and pathological aspects.
Çimen F, Düzgün S, Atikcan S
Monaldi Arch Chest Dis 2022 Jun 8;93(1) doi: 10.4081/monaldi.2022.2226. PMID: 35678533
Combined small cell lung carcinoma harboring ALK rearrangement: A case report and literature review.
Niitsu T, Shiroyama T, Miyake K, Noda Y, Kido K, Hara R, Enomoto T, Adachi Y, Amiya S, Suga Y, Fukushima K, Koyama S, Iwahori K, Hirata H, Nagatomo I, Takeda Y, Kumanogoh A
Thorac Cancer 2020 Dec;11(12):3625-3630. Epub 2020 Oct 25 doi: 10.1111/1759-7714.13716. PMID: 33103386Free PMC Article
Case report: combined small cell lung cancer in a lung transplant recipient.
Moniodis A, Racila E, Divo M
Transplant Proc 2015 Apr;47(3):852-4. doi: 10.1016/j.transproceed.2015.01.019. PMID: 25891746

Clinical prediction guides

The expression of YAP1 and other transcription factors contributes to lineage plasticity in combined small cell lung carcinoma.
Jimbo N, Ohbayashi C, Fujii T, Takeda M, Mitsui S, Tanaka Y, Itoh T, Maniwa Y
J Pathol Clin Res 2024 Sep;10(5):e70001. doi: 10.1002/2056-4538.70001. PMID: 39283755Free PMC Article
Molecular subtype expression and genomic profiling differ between surgically resected pure and combined small cell lung carcinoma.
Zhu Y, Li S, Wang H, Chi K, Ren W, Huang X, Zhuo M, Lin D
Hum Pathol 2023 Nov;141:118-129. Epub 2023 Aug 14 doi: 10.1016/j.humpath.2023.08.003. PMID: 37586462
Combined SCLC clinical and pathological aspects.
Çimen F, Düzgün S, Atikcan S
Monaldi Arch Chest Dis 2022 Jun 8;93(1) doi: 10.4081/monaldi.2022.2226. PMID: 35678533
A case of combined small cell lung carcinoma with unique morphology: Investigation of tumorigenesis.
Asahina M, Fukumura Y, Mamat O, Saito T, Hayashi T, Uekusa T, Suzuki K, Yao T
Pathol Int 2018 Nov;68(11):618-623. Epub 2018 Oct 12 doi: 10.1111/pin.12726. PMID: 30311995
Small cell lung carcinoma with marked bronchial epithelial involvement.
Rosen Y, Durie NM
Int J Surg Pathol 2011 Aug;19(4):538-43. Epub 2011 Jun 1 doi: 10.1177/1066896911408722. PMID: 21632633

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