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Gastric Germ Cell Tumor

MedGen UID:
234296
Concept ID:
C1333769
Neoplastic Process
Synonyms: Gastric Germ Cell Neoplasm; Germ Cell Neoplasm of Stomach; Germ Cell Neoplasm of the Stomach; Germ Cell Tumor of Stomach; Germ Cell Tumor of the Stomach; Stomach Germ Cell Neoplasm; Stomach Germ Cell Tumor

Definition

A benign or malignant germ cell tumor that arises from the stomach. Representative examples include teratoma and choriocarcinoma. [from NCI]

Professional guidelines

PubMed

Pavel M, Öberg K, Falconi M, Krenning EP, Sundin A, Perren A, Berruti A; ESMO Guidelines Committee. Electronic address: [email protected]
Ann Oncol 2020 Jul;31(7):844-860. Epub 2020 Apr 6 doi: 10.1016/j.annonc.2020.03.304. PMID: 32272208
Delle Fave G, O'Toole D, Sundin A, Taal B, Ferolla P, Ramage JK, Ferone D, Ito T, Weber W, Zheng-Pei Z, De Herder WW, Pascher A, Ruszniewski P; Vienna Consensus Conference participants
Neuroendocrinology 2016;103(2):119-24. Epub 2016 Jan 19 doi: 10.1159/000443168. PMID: 26784901
Garcia-Carbonero R, Sorbye H, Baudin E, Raymond E, Wiedenmann B, Niederle B, Sedlackova E, Toumpanakis C, Anlauf M, Cwikla JB, Caplin M, O'Toole D, Perren A; Vienna Consensus Conference participants
Neuroendocrinology 2016;103(2):186-94. Epub 2016 Jan 5 doi: 10.1159/000443172. PMID: 26731334

Recent clinical studies

Etiology

Zhou Y, Li JW, Uedo N
Best Pract Res Clin Gastroenterol 2024 Feb;68:101889. Epub 2024 Feb 2 doi: 10.1016/j.bpg.2024.101889. PMID: 38522885
Sok C, Ajay PS, Tsagkalidis V, Kooby DA, Shah MM
Ann Surg Oncol 2024 Mar;31(3):1509-1518. Epub 2023 Dec 7 doi: 10.1245/s10434-023-14712-9. PMID: 38062290Free PMC Article
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Pavel M, Öberg K, Falconi M, Krenning EP, Sundin A, Perren A, Berruti A; ESMO Guidelines Committee. Electronic address: [email protected]
Ann Oncol 2020 Jul;31(7):844-860. Epub 2020 Apr 6 doi: 10.1016/j.annonc.2020.03.304. PMID: 32272208
Longcroft-Wheaton G, Bhandari P
Expert Rev Gastroenterol Hepatol 2015 May;9(5):659-69. Epub 2015 Jan 29 doi: 10.1586/17474124.2015.1003366. PMID: 25634074

Diagnosis

Panzuto F, Ramage J, Pritchard DM, van Velthuysen MF, Schrader J, Begum N, Sundin A, Falconi M, O'Toole D
J Neuroendocrinol 2023 Aug;35(8):e13306. Epub 2023 Jul 4 doi: 10.1111/jne.13306. PMID: 37401795
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Engstrand L, Graham DY
Dig Dis Sci 2020 Mar;65(3):865-873. doi: 10.1007/s10620-020-06101-z. PMID: 32040665Free PMC Article
Albshesh A, Kaufmann MI, Levy I
Clin Gastroenterol Hepatol 2020 Nov;18(12):e142-e143. Epub 2019 Aug 21 doi: 10.1016/j.cgh.2019.08.027. PMID: 31445167
Dias AR, Azevedo BC, Alban LBV, Yagi OK, Ramos MFKP, Jacob CE, Barchi LC, Cecconello I, Ribeiro U Jr, Zilberstein B
Arq Bras Cir Dig 2017 Apr-Jun;30(2):150-154. doi: 10.1590/0102-6720201700020016. PMID: 29257854Free PMC Article

Therapy

Singh S, Halperin D, Myrehaug S, Herrmann K, Pavel M, Kunz PL, Chasen B, Tafuto S, Lastoria S, Capdevila J, García-Burillo A, Oh DY, Yoo C, Halfdanarson TR, Falk S, Folitar I, Zhang Y, Aimone P, de Herder WW, Ferone D; all the NETTER-2 Trial Investigators
Lancet 2024 Jun 29;403(10446):2807-2817. Epub 2024 Jun 5 doi: 10.1016/S0140-6736(24)00701-3. PMID: 38851203
Kouvaras S, Rokkas T, Goga H, Gakiopoulou H, Arapantoni P, Haliotis G, Mantas D
J Gastrointestin Liver Dis 2019 Jun 1;28:237-240. doi: 10.15403/jgld-185. PMID: 31204403
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
Janmohamed S, Bloom SR
Postgrad Med J 1997 Apr;73(858):207-14. doi: 10.1136/pgmj.73.858.207. PMID: 9156122Free PMC Article
Tilson MD
Surg Clin North Am 1974 Apr;54(2):409-23. doi: 10.1016/s0039-6109(16)40288-4. PMID: 4593912

Prognosis

Siegel RL, Giaquinto AN, Jemal A
CA Cancer J Clin 2024 Jan-Feb;74(1):12-49. Epub 2024 Jan 17 doi: 10.3322/caac.21820. PMID: 38230766
Sok C, Ajay PS, Tsagkalidis V, Kooby DA, Shah MM
Ann Surg Oncol 2024 Mar;31(3):1509-1518. Epub 2023 Dec 7 doi: 10.1245/s10434-023-14712-9. PMID: 38062290Free PMC Article
Panzuto F, Ramage J, Pritchard DM, van Velthuysen MF, Schrader J, Begum N, Sundin A, Falconi M, O'Toole D
J Neuroendocrinol 2023 Aug;35(8):e13306. Epub 2023 Jul 4 doi: 10.1111/jne.13306. PMID: 37401795
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Dias AR, Azevedo BC, Alban LBV, Yagi OK, Ramos MFKP, Jacob CE, Barchi LC, Cecconello I, Ribeiro U Jr, Zilberstein B
Arq Bras Cir Dig 2017 Apr-Jun;30(2):150-154. doi: 10.1590/0102-6720201700020016. PMID: 29257854Free PMC Article

Clinical prediction guides

Fazio N, La Salvia A
Best Pract Res Clin Endocrinol Metab 2023 Sep;37(5):101794. Epub 2023 Jun 28 doi: 10.1016/j.beem.2023.101794. PMID: 37414651
Mastracci L, Rindi G, Grillo F, Solcia E, Campora M, Fassan M, Parente P, Vanoli A, La Rosa S
Pathologica 2021 Feb;113(1):5-11. doi: 10.32074/1591-951X-229. PMID: 33686305Free PMC Article
Cives M, Strosberg JR
CA Cancer J Clin 2018 Nov;68(6):471-487. Epub 2018 Oct 8 doi: 10.3322/caac.21493. PMID: 30295930
Chintalacheruvu LM, Shaw T, Buddam A, Diab O, Kassim T, Mukherjee S, Lynch HT
J Gastrointestin Liver Dis 2017 Jun;26(2):157-163. doi: 10.15403/jgld.2014.1121.262.maj. PMID: 28617886
Sweeney EC, McDonnell LM
Histopathology 1980 Mar;4(2):215-24. doi: 10.1111/j.1365-2559.1980.tb02914.x. PMID: 7358349

Recent systematic reviews

Robertson D, Ng SK, Baade PD, Lam AK
Int J Colorectal Dis 2022 Mar;37(3):541-551. Epub 2022 Feb 12 doi: 10.1007/s00384-022-04105-x. PMID: 35152308Free PMC Article
Janjic O, Labgaa I, Hübner M, Demartines N, Joliat GR
Eur J Surg Oncol 2022 Apr;48(4):822-833. Epub 2021 Oct 10 doi: 10.1016/j.ejso.2021.10.004. PMID: 34656391
Joish VN, Shah S, Tierce JC, Patel D, McKee C, Lapuerta P, Zacks J
Future Oncol 2019 Apr;15(12):1397-1406. Epub 2019 Feb 8 doi: 10.2217/fon-2018-0960. PMID: 30734573
Herzberg M, Beer M, Anupindi S, Vollert K, Kröncke T
J Pediatr Surg 2018 Sep;53(9):1862-1870. Epub 2018 Mar 29 doi: 10.1016/j.jpedsurg.2018.03.022. PMID: 29685489
Fotakopoulos G, Vagkopoulos K, Gatos C, Kotlia P, Brotis A
J Med Case Rep 2014 Dec 18;8:438. doi: 10.1186/1752-1947-8-438. PMID: 25519213Free PMC Article

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