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Hard Palate Monomorphic Adenoma

MedGen UID:
234335
•Concept ID:
C1333937
•
Neoplastic Process
Synonyms: Monomorphic Adenoma of Hard Palate; Monomorphic Adenoma of the Hard Palate

Definition

A benign epithelial neoplasm arising from the minor salivary glands in the hard palate. It is characterized by the presence of a monomorphic cellular infiltrate. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHard Palate Monomorphic Adenoma

Professional guidelines

PubMed

Review of 109 cases of primary malignant orofacial lesions seen at a Nigerian Tertiary Hospital.
Adesina OM, Soyele OO, Oyetola EO, Fatusi OA
Niger Postgrad Med J 2018 Oct-Dec;25(4):246-251. doi: 10.4103/npmj.npmj_115_18. PMID: 30588946
Differential diagnosis between adenoid cystic carcinoma and pleomorphic adenoma of the minor salivary glands of palate.
Cerulli G, Renzi G, Perugini M, Becelli R
J Craniofac Surg 2004 Nov;15(6):1056-60. doi: 10.1097/00001665-200411000-00036. PMID: 15547405
Oral carcinoma of the upper jaw. Results of radiation treatment.
Shibuya H, Horiuchi J, Suzuki S, Amagasa M, Mashima K
Acta Radiol Oncol 1984;23(5):331-5. doi: 10.3109/02841868409136029. PMID: 6095603

Recent clinical studies

Etiology

An Unusual Cause of Dyspnea.
Grzesik P, Passik C, Mahfoozi A
Ann Thorac Surg 2016 Oct;102(4):e333-4. doi: 10.1016/j.athoracsur.2016.02.051. PMID: 27645975
Auto flow-through technique for anterolateral thigh flaps.
Haffey TM, Lamarre ED, Fritz MA
JAMA Facial Plast Surg 2014 Mar-Apr;16(2):147-50. doi: 10.1001/jamafacial.2013.2263. PMID: 24384810
Pleomorphic adenoma: a rare intraoral pediatric tumor.
MacIsaac ZM, Naran S, Losee JE
J Craniofac Surg 2013 Mar;24(2):669-71. doi: 10.1097/SCS.0b013e3182802485. PMID: 23524774
Ectomesenchymal chondromyxoid tumor of the hard palate--a case report.
Nigam S, Dhingra KK, Gulati A
J Oral Pathol Med 2006 Feb;35(2):126-8. doi: 10.1111/j.1600-0714.2006.00368.x. PMID: 16430745
Massive tumour arising from the hard palate after excision of a pleomorphic adenoma.
Sasaki T, Imai Y, Iwase H, Takimoto T
Br J Oral Maxillofac Surg 2003 Oct;41(5):360-2. doi: 10.1016/s0266-4356(03)00137-2. PMID: 14581038

Diagnosis

Pleomorphic adenoma of hard palate: a case report.
Yousra Z, Saliha C
Pan Afr Med J 2021;38:146. Epub 2021 Feb 9 doi: 10.11604/pamj.2021.38.146.26508. PMID: 33912316Free PMC Article
Sialadenoma Papilliferum.
Hsieh MS, Bishop JA, Yu Fong Chang J
Surg Pathol Clin 2021 Mar;14(1):43-51. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.006. PMID: 33526222
Canalicular adenoma: A systematic review.
Peraza AJ, Wright J, Gómez R
J Craniomaxillofac Surg 2017 Oct;45(10):1754-1758. Epub 2017 Aug 3 doi: 10.1016/j.jcms.2017.07.020. PMID: 28890252
Pleomorphic adenoma of the hard palate.
Gupta M, Gupta M
BMJ Case Rep 2013 Apr 9;2013 doi: 10.1136/bcr-2013-008969. PMID: 23576659Free PMC Article
Pleomorphic adenoma of the hard palate.
Lowry TR, Heichel DJ
Otolaryngol Head Neck Surg 2004 Nov;131(5):793. doi: 10.1016/j.otohns.2004.03.020. PMID: 15523471

Therapy

Canalicular adenoma of a minor salivary gland on the palate: a case presentation.
Werder P, Altermatt HJ, Zbären P, Bornstein MM
Quintessence Int 2009 Sep;40(8):623-6. PMID: 19639085
Closure of palatal defects following excision of palatal pleomorphic adenomas.
Alkan A, Inal S
J Contemp Dent Pract 2008 Sep 1;9(6):99-107. PMID: 18784865

Prognosis

Sialadenoma Papilliferum.
Hsieh MS, Bishop JA, Yu Fong Chang J
Surg Pathol Clin 2021 Mar;14(1):43-51. Epub 2021 Jan 5 doi: 10.1016/j.path.2020.09.006. PMID: 33526222
An Unusual Cause of Dyspnea.
Grzesik P, Passik C, Mahfoozi A
Ann Thorac Surg 2016 Oct;102(4):e333-4. doi: 10.1016/j.athoracsur.2016.02.051. PMID: 27645975
Auto flow-through technique for anterolateral thigh flaps.
Haffey TM, Lamarre ED, Fritz MA
JAMA Facial Plast Surg 2014 Mar-Apr;16(2):147-50. doi: 10.1001/jamafacial.2013.2263. PMID: 24384810
Ectomesenchymal chondromyxoid tumor of the hard palate--a case report.
Nigam S, Dhingra KK, Gulati A
J Oral Pathol Med 2006 Feb;35(2):126-8. doi: 10.1111/j.1600-0714.2006.00368.x. PMID: 16430745
Massive tumour arising from the hard palate after excision of a pleomorphic adenoma.
Sasaki T, Imai Y, Iwase H, Takimoto T
Br J Oral Maxillofac Surg 2003 Oct;41(5):360-2. doi: 10.1016/s0266-4356(03)00137-2. PMID: 14581038

Clinical prediction guides

Intraoral Salivary Gland Cystadenomas: A Case Series Study and Literature Review.
de Paiva JPG, Roldán DG, Bezerra HKF, Santos-Silva AR, Lopes MA, Vargas PA, Jorge J
Head Neck Pathol 2024 Jun 9;18(1):45. doi: 10.1007/s12105-024-01661-2. PMID: 38853193Free PMC Article
Auto flow-through technique for anterolateral thigh flaps.
Haffey TM, Lamarre ED, Fritz MA
JAMA Facial Plast Surg 2014 Mar-Apr;16(2):147-50. doi: 10.1001/jamafacial.2013.2263. PMID: 24384810
Extra-major salivary gland pleomorphic adenoma of the head and neck: a 10-year experience and review of the literature.
Kuo YL, Tu TY, Chang CF, Li WY, Chang SY, Shiao AS, Chu PY, Chan KT, Tai SK, Wang YF, Kao SC, Kao SY, Lo WL, Wu CH, Shu WH, Ma S, Wang TH
Eur Arch Otorhinolaryngol 2011 Jul;268(7):1035-40. Epub 2010 Dec 1 doi: 10.1007/s00405-010-1437-2. PMID: 21120660
Ectomesenchymal chondromyxoid tumor of the hard palate--a case report.
Nigam S, Dhingra KK, Gulati A
J Oral Pathol Med 2006 Feb;35(2):126-8. doi: 10.1111/j.1600-0714.2006.00368.x. PMID: 16430745
Collagenous crystalloids in a fine needle aspirate of a pleomorphic adenoma of the minor salivary gland. A case report.
Sugihara K, Hirokawa M, Shimizu M, Manabe T, Kanahara T
Acta Cytol 1998 May-Jun;42(3):751-3. doi: 10.1159/000331839. PMID: 9622700

Recent systematic reviews

Systematic Review of Clinical and Radiographic Signs of Pediatric Pleomorphic Adenoma of Minor Salivary Glands.
Alsufyani NA, Altowaijri AA, Alshehri BM, Alsadhan MS
J Contemp Dent Pract 2021 Sep 1;22(9):1063-1068. PMID: 35000954
Why is the histomorphological diagnosis of tumours of minor salivary glands much more difficult?
Ihrler S, Agaimy A, Guntinas-Lichius O, Haas CJ, Mollenhauer M, Sandison A, Greber L
Histopathology 2021 Nov;79(5):779-790. Epub 2021 Aug 18 doi: 10.1111/his.14421. PMID: 34042205
Canalicular adenoma: A systematic review.
Peraza AJ, Wright J, Gómez R
J Craniomaxillofac Surg 2017 Oct;45(10):1754-1758. Epub 2017 Aug 3 doi: 10.1016/j.jcms.2017.07.020. PMID: 28890252

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