U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rectal Undifferentiated Carcinoma

MedGen UID:
234451
Concept ID:
C1336864
Neoplastic Process
Synonyms: Anaplastic Carcinoma of Rectum; Anaplastic Carcinoma of the Rectum; Carcinoma Simplex of the Rectum.; Rectal Anaplastic Carcinoma; Undifferentiated Carcinoma of Rectum; Undifferentiated Carcinoma of the Rectum; Undifferentiated Rectal Carcinoma

Definition

An invasive malignant epithelial tumor that arises from the rectum. There is no morphologic, immunophenotypic, or molecular biological evidence of glandular or squamous differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRectal Undifferentiated Carcinoma

Professional guidelines

PubMed

Gonzalez RS
Surg Pathol Clin 2020 Sep;13(3):377-397. doi: 10.1016/j.path.2020.04.002. PMID: 32773190
Stewart DB, Gaertner WB, Glasgow SC, Herzig DO, Feingold D, Steele SR; Prepared on Behalf of the Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons
Dis Colon Rectum 2018 Jul;61(7):755-774. doi: 10.1097/DCR.0000000000001114. PMID: 29878949
Goddard AF, James MW, McIntyre AS, Scott BB; British Society of Gastroenterology
Gut 2011 Oct;60(10):1309-16. Epub 2011 May 11 doi: 10.1136/gut.2010.228874. PMID: 21561874

Recent clinical studies

Etiology

Cercek A, Roxburgh CSD, Strombom P, Smith JJ, Temple LKF, Nash GM, Guillem JG, Paty PB, Yaeger R, Stadler ZK, Seier K, Gonen M, Segal NH, Reidy DL, Varghese A, Shia J, Vakiani E, Wu AJ, Crane CH, Gollub MJ, Garcia-Aguilar J, Saltz LB, Weiser MR
JAMA Oncol 2018 Jun 14;4(6):e180071. doi: 10.1001/jamaoncol.2018.0071. PMID: 29566109Free PMC Article
Bhatti ABH, Zaheer S, Shafique K
J Coll Physicians Surg Pak 2017 Nov;27(11):714-718. PMID: 29132485
Fornaro L, Caparello C, Vivaldi C, Rotella V, Musettini G, Falcone A, Baldini E, Masi G
World J Gastroenterol 2014 May 28;20(20):6081-91. doi: 10.3748/wjg.v20.i20.6081. PMID: 24876730Free PMC Article
Pegios W, Vogl J, Mack MG, Hünerbein M, Hintze H, Balzer JO, Lobeck H, Wust P, Schlag P, Felix R
Abdom Imaging 1996 May-Jun;21(3):211-8. doi: 10.1007/s002619900048. PMID: 8661545
Smith DE, Muff NS, Shetabi H
Am J Surg 1982 May;143(5):595-8. doi: 10.1016/0002-9610(82)90171-4. PMID: 7081568

Diagnosis

Maffione AM, Montesi G, Caroli P, Colletti PM, Rubello D, Matteucci F
Clin Nucl Med 2020 Aug;45(8):611-617. doi: 10.1097/RLU.0000000000003132. PMID: 32558716
Stewart DB, Gaertner WB, Glasgow SC, Herzig DO, Feingold D, Steele SR; Prepared on Behalf of the Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons
Dis Colon Rectum 2018 Jul;61(7):755-774. doi: 10.1097/DCR.0000000000001114. PMID: 29878949
Fornaro L, Caparello C, Vivaldi C, Rotella V, Musettini G, Falcone A, Baldini E, Masi G
World J Gastroenterol 2014 May 28;20(20):6081-91. doi: 10.3748/wjg.v20.i20.6081. PMID: 24876730Free PMC Article
Egan L, D'Inca R, Jess T, Pellino G, Carbonnel F, Bokemeyer B, Harbord M, Nunes P, Van der Woude J, Selvaggi F, Triantafillidis J
J Crohns Colitis 2014 Jan;8(1):19-30. Epub 2013 May 7 doi: 10.1016/j.crohns.2013.04.009. PMID: 23664498
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639

Therapy

Boustani J, Huguet F, Vendrely V
Cancer Radiother 2023 Dec;27(8):768-777. Epub 2023 Oct 26 doi: 10.1016/j.canrad.2023.08.001. PMID: 38415359
Stewart DB, Gaertner WB, Glasgow SC, Herzig DO, Feingold D, Steele SR; Prepared on Behalf of the Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons
Dis Colon Rectum 2018 Jul;61(7):755-774. doi: 10.1097/DCR.0000000000001114. PMID: 29878949
DE Manzini N, Bellio G, Corleone P, Troian M
Minerva Chir 2018 Apr;73(2):239-245. Epub 2018 Feb 21 doi: 10.23736/S0026-4733.18.07624-1. PMID: 29471616
Hu KS, Harrison LB
Semin Surg Oncol 2000 Dec;19(4):336-49. doi: 10.1002/ssu.4. PMID: 11241916
Busse PM, Ng A, Recht A
Semin Surg Oncol 1998 Sep;15(2):120-5. doi: 10.1002/(sici)1098-2388(199809)15:2<120::aid-ssu9>3.0.co;2-1. PMID: 9730418

Prognosis

Bhatti ABH, Zaheer S, Shafique K
J Coll Physicians Surg Pak 2017 Nov;27(11):714-718. PMID: 29132485
Messick CA, Rodriguez-Bigas MA
Surg Oncol Clin N Am 2017 Jan;26(1):33-43. doi: 10.1016/j.soc.2016.07.005. PMID: 27889035
Inra JA, Syngal S
Dig Dis Sci 2015 Mar;60(3):722-33. Epub 2014 Dec 6 doi: 10.1007/s10620-014-3464-0. PMID: 25480403
Segawa N, Tsuji M, Nishida T, Takahara K, Azuma H, Katsuoka Y
Int J Urol 2008 Jun;15(6):557-9. doi: 10.1111/j.1442-2042.2008.02040.x. PMID: 18489650
Kessler H, Hermanek P Jr, Wiebelt H
Int J Colorectal Dis 1993 Sep;8(3):158-66. doi: 10.1007/BF00341191. PMID: 8245673

Clinical prediction guides

Williams H, Omer DM, Thompson HM, Lin ST, Verheij FS, Miranda J, Yuval JB, Buckley J, Marco MR, Qin LX, Dombroski DA, Kedar R, Oto A, Korngold E, Veniero JC, Gandhi S, Krishnaraj A, Jagtiani M, Ohanian K, Vu D, Hope TA, Lee S, Wasnik AP, Madhuripan N, Gollub MJ, Garcia-Aguilar J; OPRA Consortium
Radiology 2024 Sep;312(3):e232748. doi: 10.1148/radiol.232748. PMID: 39225603Free PMC Article
Liang JA, Kuo YC, Chao KSC, Chen WT, Ke TW, Chou SH, Li CC, Chien CR
Anticancer Res 2022 Feb;42(2):1143-1150. doi: 10.21873/anticanres.15578. PMID: 35093918
Traverso A, Kazmierski M, Shi Z, Kalendralis P, Welch M, Nissen HD, Jaffray D, Dekker A, Wee L
Phys Med 2019 May;61:44-51. Epub 2019 Apr 28 doi: 10.1016/j.ejmp.2019.04.009. PMID: 31151578
Yau TO, Wu CW, Tang CM, Chen Y, Fang J, Dong Y, Liang Q, Ng SS, Chan FK, Sung JJ, Yu J
Oncotarget 2016 Jan 12;7(2):1559-68. doi: 10.18632/oncotarget.6403. PMID: 26621842Free PMC Article
Kallinowski F, Eble MJ, Buhr HJ, Wannenmacher M, Herfarth C
Eur J Surg Oncol 1995 Apr;21(2):191-4. doi: 10.1016/s0748-7983(95)90501-4. PMID: 7720895

Recent systematic reviews

Di Y, Ding L, Gao L, Huang H
BMC Cancer 2023 Aug 23;23(1):782. doi: 10.1186/s12885-023-11218-1. PMID: 37612616Free PMC Article
Yuan S, Sun J, Lu Y, Xu F, Li D, Jiang F, Wan Z, Li X, Qin LQ, Larsson SC
BMC Med 2022 Nov 23;20(1):455. doi: 10.1186/s12916-022-02658-w. PMID: 36424608Free PMC Article
Falz R, Bischoff C, Thieme R, Lässing J, Mehdorn M, Stelzner S, Busse M, Gockel I
J Cancer Res Clin Oncol 2022 Sep;148(9):2187-2213. Epub 2022 Jun 13 doi: 10.1007/s00432-022-04088-w. PMID: 35695931Free PMC Article
Farvid MS, Sidahmed E, Spence ND, Mante Angua K, Rosner BA, Barnett JB
Eur J Epidemiol 2021 Sep;36(9):937-951. Epub 2021 Aug 29 doi: 10.1007/s10654-021-00741-9. PMID: 34455534
Bhatti ABH, Zaheer S, Shafique K
J Coll Physicians Surg Pak 2017 Nov;27(11):714-718. PMID: 29132485

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...