U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Brenner Tumor

MedGen UID:
2345
•Concept ID:
C0006160
•
Neoplastic Process

Definition

A tumor composed of solid and cystic nests of neoplastic urothelial-type cells in an abundant stromal component that is dense and fibroblastic in nature. It arises from the ovary and very rarely the paratesticular structures. It includes benign Brenner tumor, borderline Brenner tumor, and malignant Brenner tumor. [from NCI]

Professional guidelines

PubMed

Comparison of performance between O-RADS, IOTA simple rules risk assessment and ADNEX model in the discrimination of ovarian Brenner tumors.
Shang J, Lei T, Wu L, Lin M, Xie H
Arch Gynecol Obstet 2023 Sep;308(3):961-970. Epub 2023 Apr 26 doi: 10.1007/s00404-022-06903-8. PMID: 37186266
Brenner tumor of the ovary - ultrasound features and clinical management of a rare ovarian tumor mimicking ovarian cancer.
Weinberger V, Minář L, Felsinger M, Ovesná P, Bednaříková M, Číhalová M, Jandáková E, Hausnerová J, Chaloupková B, Zikán M
Ginekol Pol 2018;89(7):357-363. doi: 10.5603/GP.a2018.0061. PMID: 30091444
CT and MR imaging of ovarian tumors with emphasis on differential diagnosis.
Jung SE, Lee JM, Rha SE, Byun JY, Jung JI, Hahn ST
Radiographics 2002 Nov-Dec;22(6):1305-25. doi: 10.1148/rg.226025033. PMID: 12432104

Recent clinical studies

Etiology

Brenner Tumor of the Ovary: A 10-Year Single Institution Experience and Comprehensive Review of the Literature.
Alloush F, Bahmad HF, Lutz B, Poppiti R, Recine M, Alghamdi S, Goldenberg LE
Med Sci (Basel) 2023 Feb 7;11(1) doi: 10.3390/medsci11010018. PMID: 36810485Free PMC Article
Detailed overview on rare malignant ovarian tumors.
Aust S, Eberst L, Tredan O, Rousset-Jablonski C, Treilleux I, Méeus P, Chopin N, Beurrier F, Charreton A, Véronique D, Hallouz A, Coulon A, Ricoeur A, Mastier C, Bouhamama A, Racadot S, Devouassoux-Shisheboran M, Haddad V, Ray-Coquard I
Bull Cancer 2020 Mar;107(3):385-390. Epub 2020 Feb 27 doi: 10.1016/j.bulcan.2020.01.011. PMID: 32115180
Borderline Brenner Tumor: A Review of the Literature.
Zheng R, Heller DS
Arch Pathol Lab Med 2019 Oct;143(10):1278-1280. Epub 2019 Feb 19 doi: 10.5858/arpa.2018-0285-RS. PMID: 30779594
Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer.
Ramalingam P
Oncology (Williston Park) 2016 Feb;30(2):166-76. PMID: 26892153
Different staining patterns of ovarian Brenner tumor and the associated mucinous tumor.
Roma AA, Masand RP
Ann Diagn Pathol 2015 Feb;19(1):29-32. Epub 2014 Dec 20 doi: 10.1016/j.anndiagpath.2014.12.002. PMID: 25596159

Diagnosis

Brenner tumors.
Costeira FS, Félix A, Cunha TM
Br J Radiol 2022 Feb 1;95(1130):20210687. Epub 2021 Dec 20 doi: 10.1259/bjr.20210687. PMID: 34928171Free PMC Article
Multimodality Imaging Approach to Ovarian Neoplasms with Pathologic Correlation.
Taylor EC, Irshaid L, Mathur M
Radiographics 2021 Jan-Feb;41(1):289-315. Epub 2020 Nov 13 doi: 10.1148/rg.2021200086. PMID: 33186060
Borderline Brenner Tumor: A Review of the Literature.
Zheng R, Heller DS
Arch Pathol Lab Med 2019 Oct;143(10):1278-1280. Epub 2019 Feb 19 doi: 10.5858/arpa.2018-0285-RS. PMID: 30779594
Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer.
Ramalingam P
Oncology (Williston Park) 2016 Feb;30(2):166-76. PMID: 26892153
Vaginal brenner tumor.
Shaco-Levy R, Benharroch D
Int J Gynecol Pathol 2013 Mar;32(2):238-41. doi: 10.1097/PGP.0b013e3182590ae8. PMID: 23370647

Therapy

A report of twenty cases of ovarian Brenner tumor and literature review: a case series study.
Lou Z, Mei L, Wan Z, Zhang W, Gao J
BMC Womens Health 2024 Aug 27;24(1):471. doi: 10.1186/s12905-024-03316-4. PMID: 39192213Free PMC Article
Peritoneal tuberculosis with benign ovarian tumor.
Lata Verma M, Tripathi V, Singh U, Agarwal P, Sachan R, Lata Sankwar P
Indian J Tuberc 2019 Oct;66(4):499-501. Epub 2019 Jan 4 doi: 10.1016/j.ijtb.2018.12.001. PMID: 31813439
The value of random biopsies, omentectomy, and hysterectomy in operations for borderline ovarian tumors.
Kristensen GS, Schledermann D, Mogensen O, Jochumsen KM
Int J Gynecol Cancer 2014 Jun;24(5):874-9. doi: 10.1097/IGC.0000000000000140. PMID: 24844221
Malignant Brenner tumor with transition from benign to malignant components: computed tomographic and magnetic resonance imaging findings with pathological correlation.
Takeuchi M, Matsuzaki K, Sano N, Furumoto H, Nishitani H
J Comput Assist Tomogr 2008 Jul-Aug;32(4):553-4. doi: 10.1097/RCT.0b013e3181506643. PMID: 18664841
Borderline ovarian tumors: a review of treatment.
Chambers JT
Yale J Biol Med 1989 Jul-Aug;62(4):351-65. PMID: 2556863Free PMC Article

Prognosis

Borderline Brenner Tumor of the Ovary Coexisting With an Ovarian Mucinous Cystadenoma With Focal Atypical Epithelial Proliferation: A Rare Case With Review of the Literature.
Salibay CJ, Zanfagnin V, Miller H, Walia S, Brunette LL, Wang T
Int J Surg Pathol 2021 Oct;29(7):788-793. Epub 2021 Feb 26 doi: 10.1177/1066896921999459. PMID: 33635096
Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer.
Ramalingam P
Oncology (Williston Park) 2016 Feb;30(2):166-76. PMID: 26892153
Management and prognosis of borderline ovarian Brenner tumors.
Uzan C, Dufeu-Lefebvre M, Fauvet R, Gouy S, Duvillard P, Darai E, Morice P
Int J Gynecol Cancer 2012 Oct;22(8):1332-6. doi: 10.1097/IGC.0b013e318267db2f. PMID: 22954784
Ovarian Brenner tumors and transitional cell carcinoma: recent developments.
Roth LM, Gersell DJ, Ulbright TM
Int J Gynecol Pathol 1993 Apr;12(2):128-33. doi: 10.1097/00004347-199304000-00007. PMID: 8463036
Ovarian Brenner tumors. II. Malignant.
Roth LM, Czernobilsky B
Cancer 1985 Aug 1;56(3):592-601. doi: 10.1002/1097-0142(19850801)56:3<592::aid-cncr2820560328>3.0.co;2-a. PMID: 4005816

Clinical prediction guides

Brenner tumor associated with rete ovarii: a histologic and immunohistochemical analysis of six cases exploring the relationship between these entities.
Siatecka H, Masand RP
Hum Pathol 2021 Jul;113:84-91. Epub 2021 Apr 1 doi: 10.1016/j.humpath.2021.03.010. PMID: 33812844
Clinical and morphological features of the ovarian brenner tumour: current state of the problem.
Myroshnychenko MS, Dyadyk OO, Urzhumov VD, Kapustnyk NV, Borzenkova IV, Selivanova LI, Torianyk II, Fedulenkova YY, Kalashnyk IM, Tkachenko PV, Hryhorenko VR, Molodan DV, Myroshnychenko SS
Wiad Lek 2020;73(7):1420-1426. PMID: 32759431
Extraovarian Brenner tumor in the uterus: a case report and review of literature.
Hu RY, Deng YJ, Zhu HH, Zhou J, Hu M, Liang XQ, Xiao QJ, Zhou L, Peng XY, Zhang XW, Ji N, Deng H
Diagn Pathol 2020 Mar 12;15(1):22. doi: 10.1186/s13000-019-0906-1. PMID: 32164751Free PMC Article
Morphologic, Immunophenotypic, and Molecular Features of Epithelial Ovarian Cancer.
Ramalingam P
Oncology (Williston Park) 2016 Feb;30(2):166-76. PMID: 26892153
Ovarian Brenner tumors. II. Malignant.
Roth LM, Czernobilsky B
Cancer 1985 Aug 1;56(3):592-601. doi: 10.1002/1097-0142(19850801)56:3<592::aid-cncr2820560328>3.0.co;2-a. PMID: 4005816

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...